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Development of ultrasound field viewer using novel technique without Schlieren opticls

Research Project

Project/Area Number 23300182
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Medical systems
Research InstitutionHokkaido University

Principal Investigator

KUDO Nobuki  北海道大学, 情報科学研究科, 准教授 (30271638)

Co-Investigator(Kenkyū-buntansha) SHIMIZU Koichi  北海道大学, 大学院・情報科学研究科, 教授 (30125322)
NISHIDA Mutsumi  北海道大学, 大学病院, 臨床検査副技師長,超音波センター副部長 (90404722)
Research Collaborator MIZOJIRI Jun  溝尻光学工業所, 代表取締役
OBARA Koki  
SEKINE Daiki  
SUMIYOSHI Koki  北海道大学, 大学院・情報科学研究科, 修士課程学生
Project Period (FY) 2011-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2013: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2012: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥10,920,000 (Direct Cost: ¥8,400,000、Indirect Cost: ¥2,520,000)
Keywords超音波音場 / 可視化 / シュリーレン法 / 超音波診断装置 / 超音波治療装置 / シャドーグラフ
Research Abstract

Ultrasound techniques have been playing important roles both in diagnosis and therapy. As a basic technology to support development of these applications, improvements are also required for evaluation techniques of ultrasound fields. In this study, an ultrasound field visualization system using image subtraction Schlieren technique was designed and fabricated with corroboration of an experienced manufacture. The developed system was used for visualization of ultrasound fields generated by clinically used diagnostic and therapeutic ultrasound equipment. Short-pulsed ultrasound fields for diagnostic applications and continuous-wave high-intensity focused ultrasound fields for therapeutic applications were successfully visualized, indicating practical usefulness of our technique as basic technology to support further progress of ultrasound applications in medicine.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • Research Products

    (49 results)

All 2014 2013 2012 2011 Other

All Journal Article (26 results) (of which Peer Reviewed: 13 results) Presentation (23 results) (of which Invited: 8 results)

  • [Journal Article] Effects of cell culture scaffold stiffness on cell membrane damage induced by sonoporation.2014

    • Author(s)
      Kudo N, Kinoshita Y.
    • Journal Title

      Journal of Medical Ultrasonics

      Volume: 42

    • NAID

      130005139699

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of cell culture scaffold stiffness on cell membrane damage induced by sonoporation2013

    • Author(s)
      Kudo N, Kinoshita Y
    • Journal Title

      Journal of Medical Ultrasonics

      Volume: (in print)

    • NAID

      130005139699

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Ultrasound image-guided therapy enhances antitumor effect of cisplatin2013

    • Author(s)
      Sasaki N, Kudo N, Nakamura K, Lima SY, Murakami M, Kumara WRB, Tamura Y, Ohta H, Yamasaki M, and Takiguchi M
    • Journal Title

      Journal of Medical Ultrasonics

      Volume: 41(1) Pages: 11-21

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Basic studies on sonoporation with size- and position-controlled microbubbles adjacent to cells2013

    • Author(s)
      Kudo N, Tanaka Y and Uchida K
    • Journal Title

      IEEE Ultrasonics Symposium Proceedings

      Pages: 53-56

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Relation between cell membrane tension and repair of membrane damaged during sonoporation2013

    • Author(s)
      Tanaka Y, and Kudo N
    • Journal Title

      IEEE Ultrasonics Symposium Proceedings

      Pages: 1777-170

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 画像差分シュリーレン装置の改良と超音波診断装置音場の可視化2013

    • Author(s)
      関根大輝, 工藤信樹, 清水孝一
    • Journal Title

      電子情報通信学会技術研究報告

      Volume: 113(103) Pages: 39-44

    • NAID

      10031182614

    • Related Report
      2013 Final Research Report
  • [Journal Article] Ultrasound image-guided therapy enhances antitumor effect of cisplatin2013

    • Author(s)
      Sasaki N, Kudo N, Nakamura K, Lima SY, Murakami M, Kumara WRB, Tamura Y, Ohta H, Yamasaki M, Takiguchi M.
    • Journal Title

      Journal of Medical Ultrasonics

      Volume: 41 Issue: 1 Pages: 11-21

    • DOI

      10.1007/s10396-013-0475-y

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Basic studies on sonoporation with size- and position-controlled microbubbles adjacent to cells.2013

    • Author(s)
      Kudo N, Tanaka Y, Uchida K.
    • Journal Title

      IEEE International Ultrasonics Symposium Proceedings

      Volume: 2013 Pages: 53-56

    • DOI

      10.1109/ultsym.2013.0014

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relation between cell membrane tension and repair of membrane damaged during sonoporation.2013

    • Author(s)
      Tanaka Y, Kudo N.
    • Journal Title

      IEEE International Ultrasonics Symposium Proceedings

      Volume: 2013 Pages: 1777-1780

    • DOI

      10.1109/ultsym.2013.0453

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of in vivo measurement system for temperature rise in animal tissue under exposure to ultrasound with acoustic radiation force2013

    • Author(s)
      Nitta N, Kudo N, Kamakura T, Ishiguro Y, Sasanuma H, Taniguchi N, Akiyama I.
    • Journal Title

      IEEE International Ultrasonics Symposium Proceedings

      Volume: 2013 Pages: 386-389

    • DOI

      10.1109/ultsym.2013.0100

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 微小気泡位置制御システムの開発と高速度撮影によるソノポレーション機序の検討2013

    • Author(s)
      内田和輝,工藤信樹
    • Journal Title

      日本超音波医学会基礎技術研究会資料

      Volume: 2013 Pages: 23-28

    • Related Report
      2013 Annual Research Report
  • [Journal Article] 細胞の張力がソノポレーションにおける膜修復に与える影響2013

    • Author(s)
      田中裕人,工藤信樹
    • Journal Title

      日本超音波医学基礎技術研究会資料

      Volume: 2013 Pages: 40-45

    • Related Report
      2013 Annual Research Report
  • [Journal Article] 画像差分シュリーレン装置の改良と超音波診断装置音場の可視化2013

    • Author(s)
      関根大輝,工藤信樹,清水孝一
    • Journal Title

      電子情報通信学会技術研究報告

      Volume: 113 Pages: 39-44

    • NAID

      10031182614

    • Related Report
      2013 Annual Research Report
  • [Journal Article] A study on sonoporation of cells cultured on a soft collagen gel scaffold2012

    • Author(s)
      Kudo N, and Kinoshita Y
    • Journal Title

      AIP Conference Proceedings 2012

      Volume: 1503 Pages: 61-64

    • DOI

      10.1063/1.4769918

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Activation of microbubbles by short-pulsed ultrasound enhances the cytotoxic effect of cisdiamminedichloroplatinum (II) in a canine thyroid adenocarcinoma cell line in vitro2012

    • Author(s)
      Sasaki N, Kudo N, Nakamura K, Lim SY, Murakami M, Kumara WRB, Tamura Y, Ohta H, Yamasaki M, and Takiguchi M
    • Journal Title

      Ultrasound in Medicine and Biology

      Volume: 38(1) Pages: 109-118

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 画像差分型シュリーレン法を用いた超音波音場の可視化2012

    • Author(s)
      工藤信樹
    • Journal Title

      日本超音波医学会基礎技術研究会資料

      Volume: 2012(2) Pages: 49-52

    • Related Report
      2013 Final Research Report
  • [Journal Article] Transmission electron microscopy study on the effects of the ultrasound contrast agent Levovist on hepatic cells2012

    • Author(s)
      Etsuo Takada
    • Journal Title

      J. Med. Ultrasonics

      Volume: Vol. 39 Issue: 3 Pages: 107-113

    • DOI

      10.1007/s10396-012-0349-8

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Temperature elevation of biological tissue model exposed by focused ultrasound with acoustic radiation force.2012

    • Author(s)
      Nitta N, Kudo N, Akiyama I.
    • Journal Title

      AIP Conference Proceedings

      Volume: 1474 Pages: 263-266

    • DOI

      10.1063/1.4749346

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 超音波照射と電気刺激による期外収縮発生に関する培養心筋細胞を用いた検討2012

    • Author(s)
      水内美里,工藤信樹
    • Journal Title

      日本超音波医学会基礎技術研究会資料

      Volume: 2012(2) Pages: 38-43

    • Related Report
      2012 Annual Research Report
  • [Journal Article] パルス超音波を用いたソノポレーションにおける薬物付着型微小気泡の有用性に関する基礎的検討2012

    • Author(s)
      吉松幸里,工藤信樹,鈴木 亮,丸山一雄
    • Journal Title

      日本超音波医学会基礎技術研究会資料

      Volume: 2012(2) Pages: 44-48

    • Related Report
      2012 Annual Research Report
  • [Journal Article] 画像差分シュリーレン法による治療用超音波音場の可視化~シャーレ内の定在波音場の可視化~2011

    • Author(s)
      小原浩貴, 工藤信樹, 清水孝一
    • Journal Title

      電子情報通信学会技術研究報告

      Volume: 111(88) Pages: 31-35

    • NAID

      110008746055

    • Related Report
      2013 Final Research Report
  • [Journal Article] Sonoporationによる抗がん剤の効果増強の多角的評価2011

    • Author(s)
      松井智子
    • Journal Title

      日本超音波医学会基礎技術研究会資料

      Volume: 2011(4) Pages: 17-22

    • Related Report
      2011 Annual Research Report
  • [Journal Article] ゲル上に培養した細胞へのソノポレーション効果に関する検討2011

    • Author(s)
      木下勇人
    • Journal Title

      日本超音波医学会基礎技術研究会資料

      Volume: 2011(2) Pages: 47-52

    • Related Report
      2011 Annual Research Report
  • [Journal Article] 診断装置によるソノポレーションの特徴と条件設定2011

    • Author(s)
      佐々木東
    • Journal Title

      日本超音波医学会基礎技術研究会資料

      Volume: 2011(2) Pages: 53-55

    • Related Report
      2011 Annual Research Report
  • [Journal Article] 画像差分シュリーレン法による治療用超音波音場の可視化~シャーレ内の定在波音場の可視化~2011

    • Author(s)
      小原浩貴
    • Journal Title

      日本超音波医学会基礎技術研究会資料/電子情報通信学会技術研究報告

      Volume: 2011(2)/111(88) Pages: 31-35

    • NAID

      110008746055

    • Related Report
      2011 Annual Research Report
  • [Journal Article] 光ピンセットを用いた超音波造影剤微小気泡の位置制御装置の開発2011

    • Author(s)
      奥山学
    • Journal Title

      電子情報通信学会技術研究報告

      Volume: 111(84) Pages: 7-12

    • Related Report
      2011 Annual Research Report
  • [Presentation] 画像差分型シュリーレン法による超音波音場可視化2013

    • Author(s)
      工藤信樹
    • Organizer
      第6回超音波とマイクロバブルの相互作用に関するシンポジウム
    • Place of Presentation
      滋賀医科大学看護第四講義室(滋賀県大津市)
    • Year and Date
      2013-12-20
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] 画像差分型シュリーレン法による超音波音場可視化の原理2013

    • Author(s)
      工藤信樹
    • Organizer
      日本超音波医学会平成25年度第3回光超音波画像研究会
    • Place of Presentation
      東北大学工学部(仙台市青葉区)
    • Year and Date
      2013-10-03
    • Related Report
      2013 Final Research Report
  • [Presentation] Experimental system for sonoporation with size- and location-controlled microbubbles2013

    • Author(s)
      Kudo N, Tanaka Y, and Uchida K
    • Organizer
      International Conference on Biomedical Ultrasound
    • Place of Presentation
      Taipei University (Taipei, Taiwan)
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] Safety of ultrasound contrast agent2013

    • Author(s)
      Kudo N
    • Organizer
      5th Asian Conference on Ultrasound Contrast Imaging
    • Place of Presentation
      Veterans General Hospital (Taipei, Taiwan)
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Invited
  • [Presentation] Effects of water surface conditions on standing wave fields generated inside a small chamber2013

    • Author(s)
      Kudo N
    • Organizer
      Focused Ultrasound Therapy- Second European Symposium
    • Place of Presentation
      Roma Eventi - Fontana di Trevi (Rome, Itary)
    • Related Report
      2013 Final Research Report
  • [Presentation] Cell damage and repair during sonoporation2013

    • Author(s)
      Kudo N
    • Organizer
      Artimino Ultrasound Conference 2013
    • Place of Presentation
      Windermere House, Lake Rosseau (0ntario, Canada)
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] Experimental system for sonoporation with size- and location-controlled microbubbles.2013

    • Author(s)
      Kudo N, Tanaka Y, Uchida K.
    • Organizer
      2013 International Conference on Biomedical Ultrasound (ICBM)
    • Place of Presentation
      Taipei Uniersity (Taipei, Taiwan)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Effects of water surface conditions on standing wave fields generated inside a small chamber2013

    • Author(s)
      Kudo N
    • Organizer
      Focused Ultrasound Therapy - Second European Symposium
    • Place of Presentation
      Roma Eventi - Fontana di Trevi (Rome, Itary)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 画像差分型シュリーレン法を用いた超音波音場の可視化2012

    • Author(s)
      工藤信樹
    • Organizer
      日本超音波医学会基礎技術研究会
    • Place of Presentation
      北海道大学工学部(札幌市北区)
    • Year and Date
      2012-08-03
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] 超音波造影剤微少気泡の制御とソノポレーション研究への応用2012

    • Author(s)
      奥山学
    • Organizer
      日本超音波医学会第4回超音波分子診断治療研究会
    • Place of Presentation
      福岡大学(福岡)
    • Year and Date
      2012-03-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] ソノポレーション機序解明のためのマイクロバブル位置制御2012

    • Author(s)
      工藤信樹
    • Organizer
      日本ソノケミストリー学会第4回超音波とマイクロバブルの相互作用に関するシンポジウム
    • Place of Presentation
      名古屋駅前イノベーションハブ(名古屋)(招待講演)
    • Year and Date
      2012-01-20
    • Related Report
      2011 Annual Research Report
  • [Presentation] Visualization of therapeutic ultrasound fields in small chamber using image subtraction Schlieren technique2012

    • Author(s)
      Obara K, Kudo N, and Shimizu K
    • Organizer
      Symposium on Ultrasonic Electronics
    • Place of Presentation
      Chiba University (Inage-ku, Chiba)
    • Related Report
      2013 Final Research Report
  • [Presentation] Visualization of therapeutic ultrasound fields in small chamber using image subtraction schlieren technique2012

    • Author(s)
      Obara K, Kudo N, Shimizu K.
    • Organizer
      Proceedings of Symposium on Ultrasonic Electronics
    • Place of Presentation
      Chiba University (Inage-ku, Chiba)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Visualization of ultrasound fields ins ide a smal l chamber used for sonoporation study2011

    • Author(s)
      Kudo N
    • Organizer
      13th World Congress of Ultrasound in Medicine and Biology
    • Place of Presentation
      Austria Center Vienna (Vienna, Austria)
    • Year and Date
      2011-08-26
    • Related Report
      2013 Final Research Report
  • [Presentation] Visualization of ultrasound fields inside a small chamber used for sonoporation study2011

    • Author(s)
      Kudo, N.
    • Organizer
      13th World Congress of Ultrasound in Medicine and Biology
    • Place of Presentation
      Austria Center Vienna (Vienna, Austria)
    • Year and Date
      2011-08-26
    • Related Report
      2011 Annual Research Report
  • [Presentation] Evaluation of tissue exposed by pulsed ultrasound with acoustic radiation force2011

    • Author(s)
      Nitta, N.
    • Organizer
      13th World Congress of Ultrasound in Medicine and Biology
    • Place of Presentation
      Austria Center Vienna (Vienna, Austria)
    • Year and Date
      2011-08-26
    • Related Report
      2011 Annual Research Report
  • [Presentation] 微小気泡捕捉機能を有する高速度顕微観察システムの開発

    • Author(s)
      工藤信樹,内田和輝
    • Organizer
      平成25年度第4回超音波分子診断治療研究会
    • Place of Presentation
      福岡大学医学部(福岡市城南区)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 細胞形状と膜流動性の変化がソノポレーションにおける細胞の損傷と修復に与える影響

    • Author(s)
      田中裕人,工藤信樹
    • Organizer
      平成25年度第4回超音波分子診断治療研究会
    • Place of Presentation
      福岡大学医学部(福岡市城南区)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 画像差分型シュリーレン法による超音波音場可視化(特別講演)

    • Author(s)
      工藤信樹
    • Organizer
      平成25年度第3回超音波分子診断治療研究会/日本ソノケミストリー学会第6回超音波とマイクロバブルの相互作用に関するシンポジウム
    • Place of Presentation
      滋賀医科大学看護第四講義室(滋賀県大津市)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 画像差分型シュリーレン法による超音波音場可視化の原理

    • Author(s)
      工藤信樹
    • Organizer
      日本超音波医学会平成25年度第3回光超音波画像研究会
    • Place of Presentation
      東北大学工学部(仙台市青葉区)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 微小気泡の薬物付加法や膜特性がソノポレーション現象に与える影響

    • Author(s)
      吉松幸里,工藤信樹,鈴木 亮,丸山一雄
    • Organizer
      日本超音波医学会平成24年度第4回超音波分子診断治療研究会
    • Place of Presentation
      福岡大学医学部(福岡市城南区)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 細胞培養の足場硬さによるソノポレーション現象の違い

    • Author(s)
      工藤信樹,田中裕人
    • Organizer
      平成24年度第3回超音波分子診断治療研究会/日本ソノケミストリー学会第5回超音波とマイクロバブルの相互作用に関するシンポジウム
    • Place of Presentation
      帝京大学薬学部(東京都板橋区)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 画像差分型シュリーレン法を用いた超音波音場の可視化

    • Author(s)
      工藤信樹
    • Organizer
      日本超音波医学会基礎技術研究会
    • Place of Presentation
      北海道大学工学部(札幌市北区)
    • Related Report
      2012 Annual Research Report
    • Invited

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Published: 2011-04-06   Modified: 2019-07-29  

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