Longitudinal study for the effect of genetic polymorphism of BRAP, TLR4, APOB gene on the incidence risk of lifestyle related diseases

• Project/Area Number: 23300252
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Applied health science
• Research Institution: Chiba University
• Principal Investigator: SUWAZONO Yasushi 千葉大学, 医学(系)研究科(研究院), 准教授 (90302546)
• Co-Investigator(Kenkyū-buntansha): NOGAWA Kazuhiro 千葉大学, 大学院・医学研究院, 助教 (00612194) ; WATANABE Miyuki 千葉大学, 大学院・医学研究院, 技術職員 (70571355)
• Project Period (FY): 2011-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000); Fiscal Year 2013: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2012: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000); Fiscal Year 2011: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
• Keywords: 遺伝子多型 / メタボリック症候群 / 高脂血症 / 糖尿病 / 追跡調査

Research Abstract

The aim of this study was to evaluate the effect of genetic polymorphism for BRCA1 associated protein (BRAP), toll-like receptor 4 (TLR4), apolipoprotein B(APOB) gene on the incidence risk of lifestyle related diseases in a large-scale longitudinal cohort study. Based on the incidences of hypertension, diabetes mellitus, obesity, dyslipidemia, hyperuricemia and high serum gamma-GTP level and the serial change in those related physiological and laboratory results, BRAP gene polymorphism (rs11066001) was shown to have significant effect on the onset of diabetes mellitus and HbA1c level.