|Budget Amount *help
¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2013: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2012: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
Fiscal Year 2011: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
The aim of this study was to evaluate the effect of genetic polymorphism for BRCA1 associated protein (BRAP), toll-like receptor 4 (TLR4), apolipoprotein B(APOB) gene on the incidence risk of lifestyle related diseases in a large-scale longitudinal cohort study. Based on the incidences of hypertension, diabetes mellitus, obesity, dyslipidemia, hyperuricemia and high serum gamma-GTP level and the serial change in those related physiological and laboratory results, BRAP gene polymorphism (rs11066001) was shown to have significant effect on the onset of diabetes mellitus and HbA1c level.