| Project/Area Number |
23300275
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | Nara Women's University |
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Principal Investigator |
MORIMOTO Keiko 奈良女子大学, 生活環境科学系, 教授 (30220081)
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| Co-Investigator(Kenkyū-buntansha) |
KOJO Shosuke 放送大学, 教養学部, 教授 (10108988)
TAKAMATA Akira 奈良女子大学, 生活環境科学系, 教授 (00264755)
NEGISHI Hiroko 奈良女子大学, 生活環境科学系, 助教 (50523841)
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| Co-Investigator(Renkei-kenkyūsha) |
YOSHIDA Ken-ichi 東京大学, 大学院・医学系研究科, 教授 (40166947)
YANO Shigenobu 奈良先端科学技術大学院大学, 物質創成科学研究科, 教授 (60011186)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2013: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2011: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
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| Keywords | 精神性ストレス / エストロゲン / 女性 / 抗酸化ビタミン / 葛蔓イソフラボン / 閉経 / ストレス性昇圧 / 血管内皮機能 / 機能性食品 / 血圧調節 / 若年女性 / 閉経モデルラット / 植物エストロゲン / 閉経後女性 / 血管収縮反応 |
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| Research Abstract |
Menopause or mental stress is a risk factor for cardiovascular events. We examined the mechanisms accounting for suppressive effects of estrogen on stress-induced cardiovascular responses in ovariectomized (OVX) rats and complementary nutrients for postmenopausal women.
In animal model, estrogen replacement attenuated pressor response to the cage-switch stress by suppressing the renin-angiotensin system in OVX rats. However, Kudzu root extracts had no effects on the stress-induced pressor responses in OVX rats.
In human experiments, mental stress evoked by the Color Word Test induced the elevation in the vascular resistance of brachial artery in postmenopausal women compared with middle-aged premenopausal women. In addition, basal endothelial function was impaired in postmenopausal women compared with premenopausal women. However, the oral pretreatment of vitamin C restored these impairments in the postmenopausal women.
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