| Budget Amount *help |
¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2013: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2012: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
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| Research Abstract |
To secure genome integrity of the cells DNA damage signals are amplified and persists, if DNA double strand breaks are remained. This study demonstrated that , G9a, a histone H3 dimethylase, is involved in persisted DNA damage signal amplification. G9a was found to be relocated to the chromatin regions harboring DNA damage, and it executed dimethylation of histone H3 at Lysine 9. Dimethylated histone H3 at Lysine 9 was recognized by 53BP1 through its so-called Tudor domain, thereby amplified 53BP1 foci formation was maintained. The study indicated that dimethylation of histone H3 at Lysine 9 by recruted G9a to DNA damage sites is essential for the persistence of amplified DNA damage signals.
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