Characterization of nuclear pore complex re-assembly dynamics in cell cycle
Project/Area Number |
23310151
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Living organism molecular science
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Research Institution | Kanazawa University |
Principal Investigator |
WONG W・Richard 金沢大学, 自然システム学系, 教授 (30464035)
|
Co-Investigator(Kenkyū-buntansha) |
橋爪 智恵子 金沢大学, 自然システム学系, 研究員 (70564128)
船坂 龍善 金沢大学, 自然システム学系, 研究員 (60564127)
|
Project Period (FY) |
2011-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2014: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
|
Keywords | 核膜孔複合体 / 細胞周期 / オートファジー / Tpr / Nup62 / Nup358 / 中心体 / p53 / Nup98 / Rae1 / 有糸分裂 / 物質輸送 / 異数化 / 紡錘体 / 有糸分裂期 |
Outline of Final Research Achievements |
The nuclear pore complex (NPC) is the major gatekeeper of macromolecular traffic between the nucleus and cytoplasm. It is composed of multiple subunits comprising ≈30 proteins called nucleoporins. During cell division, transmembrane nucleoporins and nuclear envelope membrane fragments move to the endoplasmic reticulum, while other nucleoporins are disassembled into subcomplexes that are distributed throughout the mitotic cytoplasm to kinetochore, spindle and centrosome regions. In this project, we are investigating the association of NPC proteins assembly and disassembly during cell division. We constantly published peer-reviewed papers with impact factor 5 and our graduate students all received awards in the society or conferences.
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Report
(5 results)
Research Products
(66 results)
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[Journal Article] TRAM is involved in IL-18 signaling and functions as a sorting adaptor for MyD88.2012
Author(s)
Ohnishi H, Tochio H, Kato Z, Kawamoto N, Kimura T, Kubota K, Yamamoto T, Funasaka T, Nakano H, Wong RW, Shirakawa M, Kondo N.
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Journal Title
PLoS One.
Volume: 7
Issue: 6
Pages: e38423-e38423
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] RNA export factor RAE1 contributes to NUP98-HOXA9-mediated leukemogenesis2011
Author(s)
Funasaka T, Nakano H, Wu Y, Hashizume C, Gu L, Nakamura T, Wang W, Zhou P, Moore M, Sato H, Wong RW
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Journal Title
Cell Cycle
Volume: 10
Issue: 9
Pages: 1456-1467
DOI
Related Report
Peer Reviewed
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[Presentation] Diverse function of Rae1 in cell cycle2014
Author(s)
Moyori A, Kobayashi A, Imamura K, Tochio H, Minamoto T and Wong RW
Organizer
International Conference of the Korean Society for Molecular and Cellular
Place of Presentation
Seoul, Korea
Year and Date
2014-10-22
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