Creation of Novel Biofunctional Molecules for Target-Selective Photodegradation of Proteins and Carbohydrates

• Project/Area Number: 23310153
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Living organism molecular science
• Research Institution: Keio University
• Principal Investigator: KAZUNOBU Toshima 慶應義塾大学, 理工学部, 教授 (60217502)
• Project Period (FY): 2011-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000); Fiscal Year 2013: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000); Fiscal Year 2012: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000); Fiscal Year 2011: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
• Keywords: 生体機能分子 / 光分解 / タンパク / 糖鎖 / 有機合成 / 細胞 / KDO / LPS / ボロン酸 / アントラキノン / マクロファージ / ベロ毒素 / ポルフィリン / エイズ / アミロイド / アルツハイマー病 / インフルエンザ / ノイラミニダーゼ / HIV-1プロテア / フラーレン / シアル酸

Research Abstract

Novel light-activatable and biofunction-control molecules, that target-selectively photodegrade certain disease-related proteins and oligosaccharides, were designed and synthesized. Furthermore, it was found the molecules thus developed work not only in test tube but also in disease-related cells. From these studies, a new and innovative approach for the design of molecular-targeted bio-probes and medicines has been established.

Research Products

• [Journal Article] Design, synthesis and evaluation of a boronic acid based artificial receptor for L-DOPA in aqueous media (2013)
  • Author(s): H. Ueno, T. Iwata, N. Koshiba, D. Takahashi, K. Toshima
  • Journal Title: Chemical Communications Volume: 49 Issue: 88 Pages: 10403-10405
  • DOI: 10.1039/c3cc45275a
  • Peer Reviewed
• [Journal Article] Target-selective photodegradation of verotoxin-1 and reduction of its cytotoxicity to Vero cells using porphyrin-globotriose hybrids (2013)
  • Author(s): A. Okochi, S. Tanimoto, D. Takahashi, K. Toshima
  • Journal Title: Chemical Communications Volume: 49 Issue: 54 Pages: 6027-6029
  • DOI: 10.1039/c3cc42957a
  • Peer Reviewed
• [Journal Article] Photodegradation and inhibition of drug-resistant influenza virus neuraminidase using anthraquinone-sialic acid hybrids (2013)
  • Author(s): 青木優介、谷本周穂、高橋大介、戸嶋一敦
  • Journal Title: Chemical Communications Volume: 49 Issue: 12 Pages: 1169-1171
  • DOI: 10.1039/c2cc38742e
  • Peer Reviewed
• [Journal Article] Chemical biology based on target-selective degradation of proteins and carbohydarates using light-activable organic molecules (2013)
  • Author(s): K. Toshima
  • Journal Title: Molecular BioSystems Volume: 9 Issue: 5 Pages: 834-854
  • DOI: 10.1039/c2mb25416f
  • Peer Reviewed
• [Journal Article] Total synthesis of vineomycin B2 (2013)
  • Author(s): S. Kusumi, S. Tomono, S. Okuzawa, E. Kaneko, T. Ueda, K. Sasaki, D. Takahashi, K. Toshima
  • Journal Title: Journal of the American Chemical Society Volume: 135 Issue: 42 Pages: 15909-15912
  • DOI: 10.1021/ja407827n
  • Peer Reviewed
• [Journal Article] Chiral Bronsted acid-mediated glycosylation with recognition of alcohol chirality (2013)
  • Author(s): T. Kimura, M. Sekine, D. Takahashi, K. Toshima
  • Journal Title: Angewandte Chemie International Edition Volume: 52 Issue: 46 Pages: 12131-12134
  • DOI: 10.1002/anie.201304830
  • Peer Reviewed
• [Journal Article] Light-induced O-glycosylation of unprotected deoxythioglycosyl donors (2013)
  • Author(s): M. Nakanishi, D. Takahashi, K. Toshima
  • Journal Title: Organic & Biomolecular Chemistry Volume: 11 Issue: 31 Pages: 5079-5082
  • DOI: 10.1039/c3ob41143e
  • Peer Reviewed
• [Journal Article] Improved total synthesis of incednam (2013)
  • Author(s): A. Takada, K. Uda, T. Ohtani, S. Tsukamoto, D. Takahashi, K. Toshima
  • Journal Title: The Journal of Antibiotics Volume: 66 Issue: 3 Pages: 155-159
  • DOI: 10.1038/ja.2013.4
  • NAID: 10031163115
  • Peer Reviewed
• [Journal Article] Carbohydrate recognition and photodegradation by an anthracene-Kemp's acid hybrid (2012)
  • Author(s): M. Nishibu, D. Takahashi, K. Toshima
  • Journal Title: Organic & Biomolecular Chemistry Volume: 10 Issue: 42 Pages: 8393-8395
  • DOI: 10.1039/c2ob26417j
  • Peer Reviewed
• [Journal Article] Photodegradation of lipopolysaccharides and the inhibition of macrophage activation by anthraquinone-boronic acid hybrids (2012)
  • Author(s): D. Takahashi, T. Miura, K. Toshima
  • Journal Title: Chemical Communications Volume: 48 Issue: 61 Pages: 7595-7597
  • DOI: 10.1039/c2cc33559j
  • Peer Reviewed
• [Journal Article] Target-selective photodegradation of HIV-1 protease and inhibition of HIV-1 replication in living cells by designed fullerene-sugar hybrids (2012)
  • Author(s): 谷本周穂
  • Journal Title: Chemistry-An Asian Journal Volume: (掲載確定) Issue: 5 Pages: 911-914
  • DOI: 10.1002/asia.201101043
  • Peer Reviewed
• [Journal Article] Chemistry Based Approach for Degradation of Target-Oligosaccharides Using Photo-Activatable Organic Small Molecules (2012)
  • Author(s): D. Takahashi, K. Toshima
  • Journal Title: Trends in Glycoscience and Glycotechnology Volume: 24 Issue: 140 Pages: 258-276
  • DOI: 10.4052/tigg.24.258
  • NAID: 10031146678
  • ISSN: 0915-7352, 1883-2113
  • Peer Reviewed
• [Journal Article] Creation of novel biofunctional molecules for target-selective photodegradation of proteins and carbohydrates : a synthetic and chemical, biological study for the post-genome era (2012)
  • Author(s): K. Toshima, D.Takahashi, S. Tanimoto
  • Journal Title: Journal of Synthetic Organic Chemistry Volume: 70 Pages: 1187-1195
  • NAID: 10031131198
  • URL: https://www.jstage.jst.go.jp/article/yukigoseikyokaishi/70/11/70_1187/_pdf
  • Peer Reviewed
• [Journal Article] Design, synthesis and evaluation of light-activatable organic molecules that target-selectively degrade DNA, proteins and carbohydrates; an interdisciplinary challenge for a synthetic organic chemist (2012)
  • Author(s): K. Toshima
  • Journal Title: Synlett Volume: 23 Issue: 14 Pages: 2025-2052
  • DOI: 10.1055/s-0032-1316639
  • Peer Reviewed
• [Journal Article] Chemical methods for degradation of target proteins using designed light-activatable organic molecules (2012)
  • Author(s): 谷本周穂、高橋大介、戸崎一敦
  • Journal Title: Chemical Communications Volume: 48 Issue: 62 Pages: 7569-7671
  • DOI: 10.1039/c2cc30831b
  • Peer Reviewed
• [Journal Article] Chemical methods for degradation of target oligosaccharides using designed light-activatable organic molecules (2012)
  • Author(s): 高橋大介
  • Journal Title: Chemical Communications Volume: 48 Issue: 37 Pages: 4397-4407
  • DOI: 10.1039/c2cc17384k
  • Peer Reviewed
• [Journal Article] Degradation of target oligosaccharides by anthraquinone-lectin hybrids with light switching (2012)
  • Author(s): Y. Imai, S. Hirono, H. Matsuba, T. Suzuki, Y. Kobayashi, H. Kawagishi, D. Takahashi, K. Toshima
  • Journal Title: Chemistry-An Asian Journal Volume: 7 Issue: 1 Pages: 97-104
  • DOI: 10.1002/asia.201100586
  • Peer Reviewed
• [Journal Article] Creation of novel biofunctional molecules for target-selective photodegradation of proteins and carbohydrates: a synthetic and chemical, biological study for the post-genome era (2012)
  • Author(s): K. Toshima, D.Takahashi, S. Tanimoto
  • Journal Title: Journal of Synthetic Organic Chemistry Volume: 70 Pages: 1187-1195
  • NAID: 10031131198
  • Peer Reviewed
• [Journal Article] エイズの原因物質を光で狙い撃ち (2012)
  • Author(s): 谷本周穂、高橋大介、戸嶋一敦
  • Journal Title: 光アライアンス Volume: 23 Pages: 50-53
• [Journal Article] Target-selective photodegradation of oligosaccharides by a fullerene-boronic acid hybrid upon visible light irradiation (2011)
  • Author(s): 高橋大介
  • Journal Title: Chemical Communications Volume: 47 Issue: 42 Pages: 11712-11714
  • DOI: 10.1039/c1cc15646b
  • Peer Reviewed
• [Journal Article] Molecular design, chemical synthesis, and biological evaluation of agents that selectively photo-degrade the transcription factor estrogen receptor-α (2011)
  • Author(s): 津村加奈
  • Journal Title: Organic & biomolecular Chemistry Volume: 9 Issue: 18 Pages: 6537-6366
  • DOI: 10.1039/c1ob05629h
  • Peer Reviewed
• [Journal Article] Inhibition of amyloid ・aggregation and cytotoxicity by photodegradation using a designed fullerene derivative (2011)
  • Author(s): Y. Ishida, T. Fujii, K. Oka, D. Takahashi, K. Toshima
  • Journal Title: Chemistry-An Asian Journal Volume: 6 Issue: 9 Pages: 2312-2315
  • DOI: 10.1002/asia.201100421
  • Peer Reviewed
• [Journal Article] アルツハイマー病の原因物質を光で狙い撃ち (2011)
  • Author(s): 戸嶋一敦
  • Journal Title: 光アライアンス Volume: 22 Pages: 22-25
• [Journal Article] フラーレン誘導体を用いたアルツハイマー病原因物質の光分解 (2011)
  • Author(s): 戸嶋一敦
  • Journal Title: NEW DIAMOND Volume: 27 Pages: 24-26
  • NAID: 40019173394
• [Journal Article] フラーレンのアルツハイマー病治療薬といての可能性 (2011)
  • Author(s): 戸嶋一敦
  • Journal Title: バイオインダストリー Volume: 29 Pages: 7-12
• [Presentation] インドールアルカロイド系天然物セロトニンおよびハルミンによるタンパクの光分解 (2014)
  • Author(s): 村田誠治, 増田奏衣, 高橋大介, 戸嶋一敦
  • Organizer: 日本化学会第94春季年会
  • Place of Presentation: 名古屋大学東山キャンパス
  • Year and Date: 2014-03-28
• [Presentation] 神経伝達物質L-DOPA を選択的に認識するボロン酸含有人工低分子レセプターの創製 (2014)
  • Author(s): 上野晴菜, 岩田崇志, 小柴望実, 高橋大介, 戸嶋一敦
  • Organizer: 日本化学会第94春季年会
  • Place of Presentation: 名古屋大学東山キャンパス
  • Year and Date: 2014-03-28
• [Presentation] アントラセン-シクロデキストリンハイブリッドによる単糖の選択的光分解 (2014)
  • Author(s): 宮崎友紀恵, 西部美幸希, 高橋大介, 戸嶋一敦
  • Organizer: 日本化学会第94春季年会
  • Place of Presentation: 名古屋大学東山キャンパス
  • Year and Date: 2014-03-28
• [Presentation] Recent topics on synthetic and chemical biological studies of biofunctional molecules (2014)
  • Author(s): K. Toshima
  • Organizer: The 2nd Mini-Symposium on Cutting-Edge Chemistry between Keio University and National Tsing Hua University
  • Place of Presentation: MXIC Building, Hsinchu, Taiwan
  • Year and Date: 2014-03-13
• [Presentation] Recent topics on synthetic and chemical biological studies of biofunctional molecules (2014)
  • Author(s): K. Toshima
  • Organizer: The 2nd Mini-Symposium on Cutting-Edge Chemistry between Keio University and National Tsing Hua University
  • Place of Presentation: 国立精華大学（台湾）
• [Presentation] インドールアルカロイド系天然物セロトニンおよびハルミンによるタンパクの光分解 (2014)
  • Author(s): 村田誠治、増田奏衣、高橋大介、戸嶋一敦
  • Organizer: 日本化学会第94春季年会
  • Place of Presentation: 名古屋大学
• [Presentation] 神経伝達物質L-DOPAを選択的に認識するボロン酸含有人工低分子レセプターの創製 (2014)
  • Author(s): 上野晴菜、岩田崇志、小柴望実、高橋大介、戸嶋一敦
  • Organizer: 日本化学会第94春季年会
  • Place of Presentation: 名古屋大学
• [Presentation] アントラセン-シクロデキストリンハイブリッドによる単糖の選択的光分解 (2014)
  • Author(s): 宮崎友紀恵、西部美幸希、高橋大介、戸嶋一敦
  • Organizer: 日本化学会第94春季年会
  • Place of Presentation: 名古屋大学
• [Presentation] Photodegradation and inhibition of drug-resistant influenza virus neuraminidase using anthraquinone-sialic acid hybrids (2013)
  • Author(s): K. Toshima
  • Organizer: The 15th Asian Chemical Congress
  • Place of Presentation: Resorts World Sentosa Singapore, Singapore
  • Year and Date: 2013-08-22
• [Presentation] 神経伝達物質L-DOPAを選択的に認識する人工低分子レセプターの創製 (2013)
  • Author(s): 上野晴菜, 岩田崇志, 高橋大介, 戸嶋一敦
  • Organizer: 日本ケミカルバイオロジー学会第8回年会
  • Place of Presentation: 東京医科歯科大学M&Dタワー
  • Year and Date: 2013-06-20
• [Presentation] ピロロキノリンキノンによるDNA 光分解及びA431 細胞に対する効果 (2013)
  • Author(s): 蓮見貴大, 高橋大介, 戸嶋一敦
  • Organizer: 日本ケミカルバイオロジー学会第8回年会
  • Place of Presentation: 東京医科歯科大学M&Dタワー
  • Year and Date: 2013-06-20
• [Presentation] ポルフィリン誘導体によるアミロイドβの光分解と神経様細胞PC12 に対する効果 (2013)
  • Author(s): 平林歩, 高橋大介, 戸嶋一敦
  • Organizer: 日本化学会第93春季年会
  • Place of Presentation: 立命館大学びわこ・くさつキャンパス
  • Year and Date: 2013-03-25
• [Presentation] ポルフィリン-グロボトリオース(Gb3)ハイブリッドによる大腸菌O‐157ベロ毒素の選択的光分解 (2013)
  • Author(s): 大河内敦, 谷本周穂 ,高橋大介, 戸嶋一敦
  • Organizer: 日本化学会第93春季年会
  • Place of Presentation: 立命館大学びわこ・くさつキャンパス
• [Presentation] Chemical glycosylation with recognition of alcohol chirality (2013)
  • Author(s): K. Toshima
  • Organizer: International Symposium on Organic Reaction - 11
  • Place of Presentation: 台北（台湾）
  • Invited
• [Presentation] Target-selective photo-degradation of verotoxin-1 and reduction of its cytotoxicity to Vero cells using porphyrin-globotriose hybrids (2013)
  • Author(s): K. Toshima
  • Organizer: The 2nd International Symposium on Chemical Biology of Natural Products : Target ID and Regulation of Bioactivity
  • Place of Presentation: パシフィコ横浜
• [Presentation] Chemical glycosylation with recognition of alcohol chirality and its application to natural product synthesis (2013)
  • Author(s): K. Toshima
  • Organizer: The 9th Yonsei CBMH - Keio LCC Joint Symposium, Yonsei University
  • Place of Presentation: 延世大学（韓国）
• [Presentation] Photodegradation and inhibition of drug-resistant influenza virus neuraminidase using anthraquinone-sialic acid hybrids (2013)
  • Author(s): K. Toshima
  • Organizer: The 15th Asian Chemical Congress
  • Place of Presentation: セントーサ島（シンガポール）
  • Invited
• [Presentation] 神経伝達物質L-DOPAを選択的に認識する人工低分子レセプターの創製 (2013)
  • Author(s): 上野晴菜、岩田崇志、高橋大介、戸嶋一敦
  • Organizer: 日本ケミカルバイオロジー学会第8回年会
  • Place of Presentation: 東京医科歯科大学
• [Presentation] ピロロキノリンキノンによるDNA光分解及びA431細胞に対する効果 (2013)
  • Author(s): 蓮見貴大、高橋大介、戸嶋一敦
  • Organizer: 日本ケミカルバイオロジー学会第8回年会
  • Place of Presentation: 東京医科歯科大学
• [Presentation] ポルフィリン誘導体によるアミロイドβの光分解と神経様細胞PC12に対する効果 (2013)
  • Author(s): 平林歩、高橋大介、戸嶋一敦
  • Organizer: 日本化学会第93春季年会
  • Place of Presentation: 立命館大学
• [Presentation] ポルフィリン－グロボトリオース(Gb3)ハイブリッドによる大腸菌O‐157ベロ毒素の選択的光分解 (2013)
  • Author(s): 大河内敦、谷本周穂、高橋大介、戸嶋一敦
  • Organizer: 日本化学会第93春季年会
  • Place of Presentation: 立命館大学
• [Presentation] Photodegradation of drug-resistant influenza virus neuraminidase using designed anthraquinone-sialic acid hybrids (2012)
  • Author(s): K. Toshima, Y. Aoki, D. Takahashi
  • Organizer: The 12th International Kyoto Conference on New Aspects of Organic Chemistry
  • Place of Presentation: Rihga Royal Hotel KYOTO, Kyoto
  • Year and Date: 2012-11-15
• [Presentation] Target-selective photodegradation of glycolipid LPS and inhibition of macrophage activation by designed anthraquinone-boronic acid hybrids (2012)
  • Author(s): K. Toshima
  • Organizer: 8th Keio LCC - Yonsei CBMH Joint Symposium 2012
  • Place of Presentation: Sapporo, Hokkaido
  • Year and Date: 2012-10-26
• [Presentation] Photodegradation of glycolipid LPS and inhibition of macrophage activation using designed anthraquinoneboronic acid hybrids (2012)
  • Author(s): K. Toshima
  • Organizer: 17th Malaysian Chemical Congress (17MCC) 2012
  • Place of Presentation: Putra World Trade Centre, Kuala Lumpur, Malaysia
  • Year and Date: 2012-10-15
• [Presentation] Target-selective photo-degradation of HIV-1 protease and inhibition of HIV-1 replication in living cells by a fullerene-sugar hybrid (2012)
  • Author(s): S. Tanimoto, D. Takahashi, K. Toshima
  • Organizer: 26 International Carbohydrate Symposium
  • Place of Presentation: Madrid, Spain
  • Year and Date: 2012-07-26
• [Presentation] Photodegradation of target glycolipid LPS and inhibition of macrophage activation by anthraquinone-boronic acid hybrids (2012)
  • Author(s): D. Takahashi, T. Miura, K. Toshima
  • Organizer: 26 International Carbohydrate Symposium
  • Place of Presentation: Madrid, Spain
  • Year and Date: 2012-07-23
• [Presentation] ポルフィリン誘導体によるアミロイドβ の光分解 (2012)
  • Author(s): 平林歩 ,高橋大介, 戸嶋一敦
  • Organizer: 日本ケミカルバイオロジー学会第7回年会
  • Place of Presentation: 京都大学百周年時計台記念館
  • Year and Date: 2012-06-07
• [Presentation] アントラセン-ケンプ酸ハイブリッドによる単糖の認識と光分解 (2012)
  • Author(s): 西部美幸希, 高橋大介, 戸嶋一敦
  • Organizer: 日本ケミカルバイオロジー学会第7回年会
  • Place of Presentation: 京都大学百周年時計台記念館
  • Year and Date: 2012-06-07
• [Presentation] アントラキノン-ボロン酸ハイブリッド分子によるLPS の光分解とマクロファージ活性化抑制 (2012)
  • Author(s): 三浦拓也, 高橋大介, 戸嶋一敦
  • Organizer: 日本化学会第92 春季年会
  • Place of Presentation: 慶應義塾大学
  • Year and Date: 2012-03-28
• [Presentation] アントラキノン-ボロン酸ハイブリッド分子によるLPSの光分解とマクロファージ活性化抑制 (2012)
  • Author(s): 三浦拓也、高橋大介、戸嶋一敦
  • Organizer: 日本化学会第92春季年会
  • Place of Presentation: 慶應義塾大学
  • Year and Date: 2012-03-28
• [Presentation] フラーレン誘導体によるHIV-1 プロテアーゼの選択的光分解とHIV 感染細胞におけるウィルス増殖抑制効果 (2012)
  • Author(s): 谷本周穂, 工藤恵理子 ,岡田誠治, 高橋大介, 戸嶋一敦
  • Organizer: 日本化学会第92春季年会
  • Place of Presentation: 慶應義塾大学
  • Year and Date: 2012-03-26
• [Presentation] リガンドタンパク-アントラキノンハイブリッドによるレセプタータンパクの選択的光分解 (2012)
  • Author(s): 小沼雄介, 高橋大介, 戸嶋一敦
  • Organizer: 日本化学会第92春季年会
  • Place of Presentation: 慶應義塾大学
  • Year and Date: 2012-03-26
• [Presentation] インフルエンザウィルスのノイラミニダーゼを光分解するアントラキノン-シアル酸ハイブリッド分子の創製 (2012)
  • Author(s): 青木優介, 高橋大介, 戸嶋一敦
  • Organizer: 日本化学会第92春季年会
  • Place of Presentation: 慶應義塾大学
  • Year and Date: 2012-03-26
• [Presentation] フラーレン誘導体によるHIV-1プロテアーゼの選択的光分解とHIV感染細胞におけるウィルス増殖抑制効果 (2012)
  • Author(s): 谷本周穂、工藤恵理子、岡田誠治、高橋大介、戸嶋一敦
  • Organizer: 日本化学会第92春季年会
  • Place of Presentation: 慶應義塾大学
  • Year and Date: 2012-03-26
• [Presentation] インフルエンザウィルスのノイラミニダーゼを光分解するアントラキノンーシアル酸ハイブリッド分子の創製 (2012)
  • Author(s): 青木優介、高橋大介、戸嶋一敦
  • Organizer: 日本化学会第92春季年会
  • Place of Presentation: 慶應義塾大学
  • Year and Date: 2012-03-26
• [Presentation] Photodegradation of drug-resistant influenza virus neuraminidase using designed anthraquinone-sialic acid hybrids (2012)
  • Author(s): K. Toshima, Y. Aoki, D. Takahashi
  • Organizer: The 12th International Kyoto Conference on New Aspects of Organic Chemistry
  • Place of Presentation: リーガロイヤルホテル京都
• [Presentation] Target-selective photodegradation of glycolipid LPS and inhibition of macrophage activation by designed anthraquinone-boronic acid hybrids (2012)
  • Author(s): K. Toshima
  • Organizer: 8th Keio LCC - Yonsei CBMH Joint Symposium 2012
  • Place of Presentation: 札幌全日空ホテル
  • Invited
• [Presentation] Photodegradation of glycolipid LPS and inhibition of macrophage activation using designed anthraquinone-boronic acid hybrids (2012)
  • Author(s): K. Toshima
  • Organizer: 17th Malaysian Chemical Congress 2012
  • Place of Presentation: クアラルンプール(マレーシア)
  • Invited
• [Presentation] Photodegradation of target glycolipid LPS and inhibition of macrophage activation by anthraquinone-boronic acid hybrids (2012)
  • Author(s): D. Takahashi, T. Miura, K. Toshima
  • Organizer: 26 International Carbohydrate Symposium
  • Place of Presentation: マドリード(スペイン)
• [Presentation] Target-selective photo-degradation of HIV-1 protease and inhibition of HIV-1 replication in living cells by a fullerene-sugar hybrid (2012)
  • Author(s): S. Tanimoto, D. Takahashi, K. Toshima
  • Organizer: 26 International Carbohydrate Symposium
  • Place of Presentation: マドリード(スペイン)
• [Presentation] ポルフィリン誘導体によるアミロイドβの光分解 (2012)
  • Author(s): 平林歩、高橋大介、戸嶋一敦
  • Organizer: 日本ケミカルバイオロジー学会第7回年会
  • Place of Presentation: 京都大学
• [Presentation] アントラセン－ケンプ酸ハイブリッドによる単糖の認識と光分解 (2012)
  • Author(s): 西部美幸希、高橋大介、戸嶋一敦
  • Organizer: 日本ケミカルバイオロジー学会第7回年会
  • Place of Presentation: 京都大学
• [Presentation] 標的糖鎖を選択的に光分解する化学的手法の開発と生物学的応用 (2011)
  • Author(s): 戸嶋一敦
  • Organizer: GlycoTOKYO 2011 シンポジウム
  • Place of Presentation: 理化学研究所
  • Year and Date: 2011-12-09
• [Presentation] 標的糖鎖を選択的に光分解する化学的手法の開発と生物学的応用 (2011)
  • Author(s): 戸嶋一敦
  • Organizer: GlycoTOKYO 2011シンポジウム
  • Place of Presentation: 理化学研究所(招待講演)
  • Year and Date: 2011-12-09
• [Presentation] Photo-degradation of proteins by fullerene derivatives (2011)
  • Author(s): S. Tanimoto, Y. Ishida, D. Takahashi, K. Toshima
  • Organizer: 8th AFMC International Medicinal Chemistry Symposium-Frontier of Medicinal Science
  • Place of Presentation: Keio Plaza Hotel, Tokyo, Japan
  • Year and Date: 2011-12-01
• [Presentation] Photo-degradation of proteins by fullerene derivatives (2011)
  • Author(s): S.Tanimoto, Y.Ishida, D.Takahashi, K.Toshima
  • Organizer: 8th AFMC International Medicinal Chemistry Symposium-Frontier of Medicinal Science-
  • Place of Presentation: 京王プラザホテル
  • Year and Date: 2011-12-01
• [Presentation] Inhibition of amyloid ・aggregation and cytotoxicity by photo-degradation using designed fullerene derivatives (2011)
  • Author(s): K. Toshima
  • Organizer: The 7th Yonsei CBMH-Keio LCC Joint Symposium
  • Place of Presentation: Jeju, Korea
  • Year and Date: 2011-10-28
• [Presentation] Inhibition of amyloid β aggregation and cytotoxicity by photo-degradation using designed fullerene derivatives (2011)
  • Author(s): K.Toshima
  • Organizer: The 7^<th> Yonsei CBMH-Keio LCC Joint Symposium
  • Place of Presentation: チェジュ(韓国)
  • Year and Date: 2011-10-28
• [Presentation] Target-selective photodegradation of oligosaccharides by light-activated small molecules (2011)
  • Author(s): D. Takahashi, S. Hirono, K. Toshima
  • Organizer: MDF International Workshop : Open-shell Organic Molecules -Synthesis and Electronic Structure Freedom-
  • Place of Presentation: Umeda Sky Building, Osaka
  • Year and Date: 2011-10-07
• [Presentation] Target-selective photodegradation of oligosaccharides by light-activated small molecules (2011)
  • Author(s): D.Takahashi, S.Hirono, K.Toshima
  • Organizer: MDF International Workshop : Open-shell Organic Molecules-Synthesis and Electronic Structure Freedom-
  • Place of Presentation: 梅田スカイビル
  • Year and Date: 2011-10-07
• [Presentation] Development of an innovative method for target-selective photodegradation of oligosaccharides by light-activated small molecules (2011)
  • Author(s): D. Takahashi, S. Hirono, C. Hayashi, M. Igarashi, Y. Nishimura, K. Toshima
  • Organizer: The 31th Naito Conference on Glycan Expression and Regulation [II]
  • Place of Presentation: Chateraise Gateaux Kingdom Sapporo, Hokkaido, Japan
  • Year and Date: 2011-09-14
• [Presentation] Development of an innovative method for target-selective photodegradation of oligosaccharides by light-activated small molecules (2011)
  • Author(s): D.Takahashi, S.Hirono, C.Hayashi, M.Igarashi, Y.Nishimura, K.Toshima
  • Organizer: The 31th Naito Conference on Glycan Expression and Regulation [II]
  • Place of Presentation: ガトーキングダムサッポロ
  • Year and Date: 2011-09-14
• [Presentation] Target-selective degradation of oligosaccharides by photo-activated organic molecules (2011)
  • Author(s): K. Toshima
  • Organizer: 14th Asian Chemical Congress
  • Place of Presentation: Bangkok, Thailand
  • Year and Date: 2011-09-08
• [Presentation] Target-selective degradation of oligosaccharides by photo-activated organic molecules (2011)
  • Author(s): K.Toshima
  • Organizer: 14^<th> Asian Chemical Congress
  • Place of Presentation: バンコク(タイ)(招待講演)
  • Year and Date: 2011-09-08
• [Presentation] Target-selective photodegradation of oligosaccharides by designed small organic molecules (2011)
  • Author(s): K. Toshima
  • Organizer: 21st International Symposium on Glycoconjugates
  • Place of Presentation: Vienna, Austria
  • Year and Date: 2011-08-24
• [Presentation] Target-selective photodegradation of oligosaccharides by designed small organic molecules (2011)
  • Author(s): K.Toshima
  • Organizer: 21^<st> International Symposium on Glycoocnjugates
  • Place of Presentation: ウィーン(オーストリア)(招待講演)
  • Year and Date: 2011-08-24
• [Presentation] アントラキノン-ボロン酸ハイブリッド分子による敗血症関連糖脂質LPS の光分解 (2011)
  • Author(s): 三浦拓也, 高橋大, 戸嶋一敦
  • Organizer: 日本ケミカルバイオロジー学会第6回年会
  • Place of Presentation: 東京工業大学
  • Year and Date: 2011-05-25
• [Presentation] 糖尿病関連タンパクα-グルコシダーゼを選択的に光分解する生体機能分子の創製 (2011)
  • Author(s): 奥澤俊介, 青木優介, 高橋大介, 戸嶋一敦
  • Organizer: 日本ケミカルバイオロジー学会第6回年会
  • Place of Presentation: 東京工業大学
  • Year and Date: 2011-05-25
• [Presentation] アントラキノン-ボロン酸ハイブリッド分子による敗血症関連糖脂質LPSの光分解 (2011)
  • Author(s): 三浦拓也、高橋大介、戸嶋一敦
  • Organizer: 日本ケミカルバイオロジー学会第6回年会
  • Place of Presentation: 東京工業大学
  • Year and Date: 2011-05-25
• [Presentation] フラーレン誘導体によるHIV-1 プロテアーゼの選択的光分解とHIV-1 増殖抑制効果 (2011)
  • Author(s): 谷本周穂, 工藤恵理子, 岡田誠治, 高橋大介, 戸嶋一敦
  • Organizer: 日本ケミカルバイオロジー学会第6回年会
  • Place of Presentation: 東京工業大学
  • Year and Date: 2011-05-23
• [Presentation] フラーレン誘導体によるHIV-1プロテアーゼの選択的光分解とHIV-1増殖抑制効果 (2011)
  • Author(s): 谷本周穂、工藤恵理子、岡田誠治、高橋大介、戸嶋一敦
  • Organizer: 日本ケミカルバイオロジー学会第6回年会
  • Place of Presentation: 東京工業大学
  • Year and Date: 2011-05-23
• [Remarks]
  • URL: http://www.applc.keio.ac.jp/~toshima/
• [Remarks] 2012年4月4日掲載日刊工業新聞朝刊「慶大 インフル抑制分子を開発, 増殖因子に結合, 光で分解, 耐性ウィルスに効果」(新聞掲載)
• [Remarks] 2011年4月13日掲載日刊工業新聞朝刊「アルツハイマーの原因物質光で狙い撃ち, 慶大, フラーレンで複合分子」(新聞掲載)
• [Remarks] 戸嶋研究室（分子生命化学研究室）
  • URL: http://www.applc.keio.ac.jp/&#771;toshima/
• [Remarks] 戸嶋研究室（分子生命化学研究室）
  • URL: http://www.applc.keio.ac.jp/~toshima/
• [Remarks]
  • URL: http://www.applc.keio.ac.jp/~toshima/
• [Patent(Industrial Property Rights)] 光増感剤,タンパク質切断剤,タンパク質切断方法,糖分子切断剤,糖分子切断方法,及び光線力学的治療剤 (2012)
  • Inventor(s): 戸嶋一敦
  • Industrial Property Rights Holder: 学校法人慶應義塾
  • Industrial Property Rights Type: 特許
  • Acquisition Date: 2012-07-27