Creation of Novel Biofunctional Molecules for Target-Selective Photodegradation of Proteins and Carbohydrates
| Project/Area Number |
23310153
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Living organism molecular science
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| Research Institution | Keio University |
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Principal Investigator |
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2013: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2012: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2011: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
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| Keywords | 生体機能分子 / 光分解 / タンパク / 糖鎖 / 有機合成 / 細胞 / KDO / LPS / ボロン酸 / アントラキノン / マクロファージ / ベロ毒素 / ポルフィリン / エイズ / アミロイド / アルツハイマー病 / インフルエンザ / ノイラミニダーゼ / HIV-1プロテア / フラーレン / シアル酸 |
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| Research Abstract |
Novel light-activatable and biofunction-control molecules, that target-selectively photodegrade certain disease-related proteins and oligosaccharides, were designed and synthesized. Furthermore, it was found the molecules thus developed work not only in test tube but also in disease-related cells. From these studies, a new and innovative approach for the design of molecular-targeted bio-probes and medicines has been established.
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Report
(4 results)
Research Products
(93 results)
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[Journal Article] Total synthesis of vineomycin B22013
Author(s)
S. Kusumi, S. Tomono, S. Okuzawa, E. Kaneko, T. Ueda, K. Sasaki, D. Takahashi, K. Toshima
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Journal Title
Journal of the American Chemical Society
Volume: 135
Issue: 42
Pages: 15909-15912
DOI
Related Report
Peer Reviewed
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