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Creation of Novel Biofunctional Molecules for Target-Selective Photodegradation of Proteins and Carbohydrates

Research Project

Project/Area Number 23310153
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Living organism molecular science
Research InstitutionKeio University

Principal Investigator

KAZUNOBU Toshima  慶應義塾大学, 理工学部, 教授 (60217502)

Project Period (FY) 2011-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2013: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2012: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2011: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
Keywords生体機能分子 / 光分解 / タンパク / 糖鎖 / 有機合成 / 細胞 / KDO / LPS / ボロン酸 / アントラキノン / マクロファージ / ベロ毒素 / ポルフィリン / エイズ / アミロイド / アルツハイマー病 / インフルエンザ / ノイラミニダーゼ / HIV-1プロテア / フラーレン / シアル酸
Research Abstract

Novel light-activatable and biofunction-control molecules, that target-selectively photodegrade certain disease-related proteins and oligosaccharides, were designed and synthesized. Furthermore, it was found the molecules thus developed work not only in test tube but also in disease-related cells. From these studies, a new and innovative approach for the design of molecular-targeted bio-probes and medicines has been established.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • Research Products

    (93 results)

All 2014 2013 2012 2011 Other

All Journal Article (25 results) (of which Peer Reviewed: 21 results) Presentation (61 results) (of which Invited: 4 results) Remarks (6 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Design, synthesis and evaluation of a boronic acid based artificial receptor for L-DOPA in aqueous media2013

    • Author(s)
      H. Ueno, T. Iwata, N. Koshiba, D. Takahashi, K. Toshima
    • Journal Title

      Chemical Communications

      Volume: 49 Issue: 88 Pages: 10403-10405

    • DOI

      10.1039/c3cc45275a

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Target-selective photodegradation of verotoxin-1 and reduction of its cytotoxicity to Vero cells using porphyrin-globotriose hybrids2013

    • Author(s)
      A. Okochi, S. Tanimoto, D. Takahashi, K. Toshima
    • Journal Title

      Chemical Communications

      Volume: 49 Issue: 54 Pages: 6027-6029

    • DOI

      10.1039/c3cc42957a

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Photodegradation and inhibition of drug-resistant influenza virus neuraminidase using anthraquinone-sialic acid hybrids2013

    • Author(s)
      青木優介、谷本周穂、高橋大介、戸嶋一敦
    • Journal Title

      Chemical Communications

      Volume: 49 Issue: 12 Pages: 1169-1171

    • DOI

      10.1039/c2cc38742e

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chemical biology based on target-selective degradation of proteins and carbohydarates using light-activable organic molecules2013

    • Author(s)
      K. Toshima
    • Journal Title

      Molecular BioSystems

      Volume: 9 Issue: 5 Pages: 834-854

    • DOI

      10.1039/c2mb25416f

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Total synthesis of vineomycin B22013

    • Author(s)
      S. Kusumi, S. Tomono, S. Okuzawa, E. Kaneko, T. Ueda, K. Sasaki, D. Takahashi, K. Toshima
    • Journal Title

      Journal of the American Chemical Society

      Volume: 135 Issue: 42 Pages: 15909-15912

    • DOI

      10.1021/ja407827n

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chiral Bronsted acid-mediated glycosylation with recognition of alcohol chirality2013

    • Author(s)
      T. Kimura, M. Sekine, D. Takahashi, K. Toshima
    • Journal Title

      Angewandte Chemie International Edition

      Volume: 52 Issue: 46 Pages: 12131-12134

    • DOI

      10.1002/anie.201304830

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Light-induced O-glycosylation of unprotected deoxythioglycosyl donors2013

    • Author(s)
      M. Nakanishi, D. Takahashi, K. Toshima
    • Journal Title

      Organic & Biomolecular Chemistry

      Volume: 11 Issue: 31 Pages: 5079-5082

    • DOI

      10.1039/c3ob41143e

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Improved total synthesis of incednam2013

    • Author(s)
      A. Takada, K. Uda, T. Ohtani, S. Tsukamoto, D. Takahashi, K. Toshima
    • Journal Title

      The Journal of Antibiotics

      Volume: 66 Issue: 3 Pages: 155-159

    • DOI

      10.1038/ja.2013.4

    • NAID

      10031163115

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Carbohydrate recognition and photodegradation by an anthracene-Kemp's acid hybrid2012

    • Author(s)
      M. Nishibu, D. Takahashi, K. Toshima
    • Journal Title

      Organic & Biomolecular Chemistry

      Volume: 10 Issue: 42 Pages: 8393-8395

    • DOI

      10.1039/c2ob26417j

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Photodegradation of lipopolysaccharides and the inhibition of macrophage activation by anthraquinone-boronic acid hybrids2012

    • Author(s)
      D. Takahashi, T. Miura, K. Toshima
    • Journal Title

      Chemical Communications

      Volume: 48 Issue: 61 Pages: 7595-7597

    • DOI

      10.1039/c2cc33559j

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Target-selective photodegradation of HIV-1 protease and inhibition of HIV-1 replication in living cells by designed fullerene-sugar hybrids2012

    • Author(s)
      谷本周穂
    • Journal Title

      Chemistry-An Asian Journal

      Volume: (掲載確定) Issue: 5 Pages: 911-914

    • DOI

      10.1002/asia.201101043

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chemistry Based Approach for Degradation of Target-Oligosaccharides Using Photo-Activatable Organic Small Molecules2012

    • Author(s)
      D. Takahashi, K. Toshima
    • Journal Title

      Trends in Glycoscience and Glycotechnology

      Volume: 24 Issue: 140 Pages: 258-276

    • DOI

      10.4052/tigg.24.258

    • NAID

      10031146678

    • ISSN
      0915-7352, 1883-2113
    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Creation of novel biofunctional molecules for target-selective photodegradation of proteins and carbohydrates : a synthetic and chemical, biological study for the post-genome era2012

    • Author(s)
      K. Toshima, D.Takahashi, S. Tanimoto
    • Journal Title

      Journal of Synthetic Organic Chemistry

      Volume: 70 Pages: 1187-1195

    • NAID

      10031131198

    • URL

      https://www.jstage.jst.go.jp/article/yukigoseikyokaishi/70/11/70_1187/_pdf

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Design, synthesis and evaluation of light-activatable organic molecules that target-selectively degrade DNA, proteins and carbohydrates; an interdisciplinary challenge for a synthetic organic chemist2012

    • Author(s)
      K. Toshima
    • Journal Title

      Synlett

      Volume: 23 Issue: 14 Pages: 2025-2052

    • DOI

      10.1055/s-0032-1316639

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chemical methods for degradation of target proteins using designed light-activatable organic molecules2012

    • Author(s)
      谷本周穂、高橋大介、戸崎一敦
    • Journal Title

      Chemical Communications

      Volume: 48 Issue: 62 Pages: 7569-7671

    • DOI

      10.1039/c2cc30831b

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chemical methods for degradation of target oligosaccharides using designed light-activatable organic molecules2012

    • Author(s)
      高橋大介
    • Journal Title

      Chemical Communications

      Volume: 48 Issue: 37 Pages: 4397-4407

    • DOI

      10.1039/c2cc17384k

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Degradation of target oligosaccharides by anthraquinone-lectin hybrids with light switching2012

    • Author(s)
      Y. Imai, S. Hirono, H. Matsuba, T. Suzuki, Y. Kobayashi, H. Kawagishi, D. Takahashi, K. Toshima
    • Journal Title

      Chemistry-An Asian Journal

      Volume: 7 Issue: 1 Pages: 97-104

    • DOI

      10.1002/asia.201100586

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Creation of novel biofunctional molecules for target-selective photodegradation of proteins and carbohydrates: a synthetic and chemical, biological study for the post-genome era2012

    • Author(s)
      K. Toshima, D.Takahashi, S. Tanimoto
    • Journal Title

      Journal of Synthetic Organic Chemistry

      Volume: 70 Pages: 1187-1195

    • NAID

      10031131198

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] エイズの原因物質を光で狙い撃ち2012

    • Author(s)
      谷本周穂、高橋大介、戸嶋一敦
    • Journal Title

      光アライアンス

      Volume: 23 Pages: 50-53

    • Related Report
      2012 Annual Research Report
  • [Journal Article] Target-selective photodegradation of oligosaccharides by a fullerene-boronic acid hybrid upon visible light irradiation2011

    • Author(s)
      高橋大介
    • Journal Title

      Chemical Communications

      Volume: 47 Issue: 42 Pages: 11712-11714

    • DOI

      10.1039/c1cc15646b

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular design, chemical synthesis, and biological evaluation of agents that selectively photo-degrade the transcription factor estrogen receptor-α2011

    • Author(s)
      津村加奈
    • Journal Title

      Organic & biomolecular Chemistry

      Volume: 9 Issue: 18 Pages: 6537-6366

    • DOI

      10.1039/c1ob05629h

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of amyloid ・aggregation and cytotoxicity by photodegradation using a designed fullerene derivative2011

    • Author(s)
      Y. Ishida, T. Fujii, K. Oka, D. Takahashi, K. Toshima
    • Journal Title

      Chemistry-An Asian Journal

      Volume: 6 Issue: 9 Pages: 2312-2315

    • DOI

      10.1002/asia.201100421

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] アルツハイマー病の原因物質を光で狙い撃ち2011

    • Author(s)
      戸嶋一敦
    • Journal Title

      光アライアンス

      Volume: 22 Pages: 22-25

    • Related Report
      2011 Annual Research Report
  • [Journal Article] フラーレン誘導体を用いたアルツハイマー病原因物質の光分解2011

    • Author(s)
      戸嶋一敦
    • Journal Title

      NEW DIAMOND

      Volume: 27 Pages: 24-26

    • NAID

      40019173394

    • Related Report
      2011 Annual Research Report
  • [Journal Article] フラーレンのアルツハイマー病治療薬といての可能性2011

    • Author(s)
      戸嶋一敦
    • Journal Title

      バイオインダストリー

      Volume: 29 Pages: 7-12

    • Related Report
      2011 Annual Research Report
  • [Presentation] インドールアルカロイド系天然物セロトニンおよびハルミンによるタンパクの光分解2014

    • Author(s)
      村田誠治, 増田奏衣, 高橋大介, 戸嶋一敦
    • Organizer
      日本化学会第94春季年会
    • Place of Presentation
      名古屋大学東山キャンパス
    • Year and Date
      2014-03-28
    • Related Report
      2013 Final Research Report
  • [Presentation] 神経伝達物質L-DOPA を選択的に認識するボロン酸含有人工低分子レセプターの創製2014

    • Author(s)
      上野晴菜, 岩田崇志, 小柴望実, 高橋大介, 戸嶋一敦
    • Organizer
      日本化学会第94春季年会
    • Place of Presentation
      名古屋大学東山キャンパス
    • Year and Date
      2014-03-28
    • Related Report
      2013 Final Research Report
  • [Presentation] アントラセン-シクロデキストリンハイブリッドによる単糖の選択的光分解2014

    • Author(s)
      宮崎友紀恵, 西部美幸希, 高橋大介, 戸嶋一敦
    • Organizer
      日本化学会第94春季年会
    • Place of Presentation
      名古屋大学東山キャンパス
    • Year and Date
      2014-03-28
    • Related Report
      2013 Final Research Report
  • [Presentation] Recent topics on synthetic and chemical biological studies of biofunctional molecules2014

    • Author(s)
      K. Toshima
    • Organizer
      The 2nd Mini-Symposium on Cutting-Edge Chemistry between Keio University and National Tsing Hua University
    • Place of Presentation
      MXIC Building, Hsinchu, Taiwan
    • Year and Date
      2014-03-13
    • Related Report
      2013 Final Research Report
  • [Presentation] Recent topics on synthetic and chemical biological studies of biofunctional molecules2014

    • Author(s)
      K. Toshima
    • Organizer
      The 2nd Mini-Symposium on Cutting-Edge Chemistry between Keio University and National Tsing Hua University
    • Place of Presentation
      国立精華大学(台湾)
    • Related Report
      2013 Annual Research Report
  • [Presentation] インドールアルカロイド系天然物セロトニンおよびハルミンによるタンパクの光分解2014

    • Author(s)
      村田誠治、増田奏衣、高橋大介、戸嶋一敦
    • Organizer
      日本化学会第94春季年会
    • Place of Presentation
      名古屋大学
    • Related Report
      2013 Annual Research Report
  • [Presentation] 神経伝達物質L-DOPAを選択的に認識するボロン酸含有人工低分子レセプターの創製2014

    • Author(s)
      上野晴菜、岩田崇志、小柴望実、高橋大介、戸嶋一敦
    • Organizer
      日本化学会第94春季年会
    • Place of Presentation
      名古屋大学
    • Related Report
      2013 Annual Research Report
  • [Presentation] アントラセン-シクロデキストリンハイブリッドによる単糖の選択的光分解2014

    • Author(s)
      宮崎友紀恵、西部美幸希、高橋大介、戸嶋一敦
    • Organizer
      日本化学会第94春季年会
    • Place of Presentation
      名古屋大学
    • Related Report
      2013 Annual Research Report
  • [Presentation] Photodegradation and inhibition of drug-resistant influenza virus neuraminidase using anthraquinone-sialic acid hybrids2013

    • Author(s)
      K. Toshima
    • Organizer
      The 15th Asian Chemical Congress
    • Place of Presentation
      Resorts World Sentosa Singapore, Singapore
    • Year and Date
      2013-08-22
    • Related Report
      2013 Final Research Report
  • [Presentation] 神経伝達物質L-DOPAを選択的に認識する人工低分子レセプターの創製2013

    • Author(s)
      上野晴菜, 岩田崇志, 高橋大介, 戸嶋一敦
    • Organizer
      日本ケミカルバイオロジー学会第8回年会
    • Place of Presentation
      東京医科歯科大学M&Dタワー
    • Year and Date
      2013-06-20
    • Related Report
      2013 Final Research Report
  • [Presentation] ピロロキノリンキノンによるDNA 光分解及びA431 細胞に対する効果2013

    • Author(s)
      蓮見貴大, 高橋大介, 戸嶋一敦
    • Organizer
      日本ケミカルバイオロジー学会第8回年会
    • Place of Presentation
      東京医科歯科大学M&Dタワー
    • Year and Date
      2013-06-20
    • Related Report
      2013 Final Research Report
  • [Presentation] ポルフィリン誘導体によるアミロイドβの光分解と神経様細胞PC12 に対する効果2013

    • Author(s)
      平林歩, 高橋大介, 戸嶋一敦
    • Organizer
      日本化学会第93春季年会
    • Place of Presentation
      立命館大学びわこ・くさつキャンパス
    • Year and Date
      2013-03-25
    • Related Report
      2013 Final Research Report
  • [Presentation] ポルフィリン-グロボトリオース(Gb3)ハイブリッドによる大腸菌O‐157ベロ毒素の選択的光分解2013

    • Author(s)
      大河内敦, 谷本周穂 ,高橋大介, 戸嶋一敦
    • Organizer
      日本化学会第93春季年会
    • Place of Presentation
      立命館大学びわこ・くさつキャンパス
    • Related Report
      2013 Final Research Report
  • [Presentation] Chemical glycosylation with recognition of alcohol chirality2013

    • Author(s)
      K. Toshima
    • Organizer
      International Symposium on Organic Reaction - 11
    • Place of Presentation
      台北(台湾)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Target-selective photo-degradation of verotoxin-1 and reduction of its cytotoxicity to Vero cells using porphyrin-globotriose hybrids2013

    • Author(s)
      K. Toshima
    • Organizer
      The 2nd International Symposium on Chemical Biology of Natural Products : Target ID and Regulation of Bioactivity
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] Chemical glycosylation with recognition of alcohol chirality and its application to natural product synthesis2013

    • Author(s)
      K. Toshima
    • Organizer
      The 9th Yonsei CBMH - Keio LCC Joint Symposium, Yonsei University
    • Place of Presentation
      延世大学(韓国)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Photodegradation and inhibition of drug-resistant influenza virus neuraminidase using anthraquinone-sialic acid hybrids2013

    • Author(s)
      K. Toshima
    • Organizer
      The 15th Asian Chemical Congress
    • Place of Presentation
      セントーサ島(シンガポール)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 神経伝達物質L-DOPAを選択的に認識する人工低分子レセプターの創製2013

    • Author(s)
      上野晴菜、岩田崇志、高橋大介、戸嶋一敦
    • Organizer
      日本ケミカルバイオロジー学会第8回年会
    • Place of Presentation
      東京医科歯科大学
    • Related Report
      2013 Annual Research Report
  • [Presentation] ピロロキノリンキノンによるDNA光分解及びA431細胞に対する効果2013

    • Author(s)
      蓮見貴大、高橋大介、戸嶋一敦
    • Organizer
      日本ケミカルバイオロジー学会第8回年会
    • Place of Presentation
      東京医科歯科大学
    • Related Report
      2013 Annual Research Report
  • [Presentation] ポルフィリン誘導体によるアミロイドβの光分解と神経様細胞PC12に対する効果2013

    • Author(s)
      平林歩、高橋大介、戸嶋一敦
    • Organizer
      日本化学会第93春季年会
    • Place of Presentation
      立命館大学
    • Related Report
      2012 Annual Research Report
  • [Presentation] ポルフィリン-グロボトリオース(Gb3)ハイブリッドによる大腸菌O‐157ベロ毒素の選択的光分解2013

    • Author(s)
      大河内敦、谷本周穂、高橋大介、戸嶋一敦
    • Organizer
      日本化学会第93春季年会
    • Place of Presentation
      立命館大学
    • Related Report
      2012 Annual Research Report
  • [Presentation] Photodegradation of drug-resistant influenza virus neuraminidase using designed anthraquinone-sialic acid hybrids2012

    • Author(s)
      K. Toshima, Y. Aoki, D. Takahashi
    • Organizer
      The 12th International Kyoto Conference on New Aspects of Organic Chemistry
    • Place of Presentation
      Rihga Royal Hotel KYOTO, Kyoto
    • Year and Date
      2012-11-15
    • Related Report
      2013 Final Research Report
  • [Presentation] Target-selective photodegradation of glycolipid LPS and inhibition of macrophage activation by designed anthraquinone-boronic acid hybrids2012

    • Author(s)
      K. Toshima
    • Organizer
      8th Keio LCC - Yonsei CBMH Joint Symposium 2012
    • Place of Presentation
      Sapporo, Hokkaido
    • Year and Date
      2012-10-26
    • Related Report
      2013 Final Research Report
  • [Presentation] Photodegradation of glycolipid LPS and inhibition of macrophage activation using designed anthraquinoneboronic acid hybrids2012

    • Author(s)
      K. Toshima
    • Organizer
      17th Malaysian Chemical Congress (17MCC) 2012
    • Place of Presentation
      Putra World Trade Centre, Kuala Lumpur, Malaysia
    • Year and Date
      2012-10-15
    • Related Report
      2013 Final Research Report
  • [Presentation] Target-selective photo-degradation of HIV-1 protease and inhibition of HIV-1 replication in living cells by a fullerene-sugar hybrid2012

    • Author(s)
      S. Tanimoto, D. Takahashi, K. Toshima
    • Organizer
      26 International Carbohydrate Symposium
    • Place of Presentation
      Madrid, Spain
    • Year and Date
      2012-07-26
    • Related Report
      2013 Final Research Report
  • [Presentation] Photodegradation of target glycolipid LPS and inhibition of macrophage activation by anthraquinone-boronic acid hybrids2012

    • Author(s)
      D. Takahashi, T. Miura, K. Toshima
    • Organizer
      26 International Carbohydrate Symposium
    • Place of Presentation
      Madrid, Spain
    • Year and Date
      2012-07-23
    • Related Report
      2013 Final Research Report
  • [Presentation] ポルフィリン誘導体によるアミロイドβ の光分解2012

    • Author(s)
      平林歩 ,高橋大介, 戸嶋一敦
    • Organizer
      日本ケミカルバイオロジー学会第7回年会
    • Place of Presentation
      京都大学百周年時計台記念館
    • Year and Date
      2012-06-07
    • Related Report
      2013 Final Research Report
  • [Presentation] アントラセン-ケンプ酸ハイブリッドによる単糖の認識と光分解2012

    • Author(s)
      西部美幸希, 高橋大介, 戸嶋一敦
    • Organizer
      日本ケミカルバイオロジー学会第7回年会
    • Place of Presentation
      京都大学百周年時計台記念館
    • Year and Date
      2012-06-07
    • Related Report
      2013 Final Research Report
  • [Presentation] アントラキノン-ボロン酸ハイブリッド分子によるLPS の光分解とマクロファージ活性化抑制2012

    • Author(s)
      三浦拓也, 高橋大介, 戸嶋一敦
    • Organizer
      日本化学会第92 春季年会
    • Place of Presentation
      慶應義塾大学
    • Year and Date
      2012-03-28
    • Related Report
      2013 Final Research Report
  • [Presentation] アントラキノン-ボロン酸ハイブリッド分子によるLPSの光分解とマクロファージ活性化抑制2012

    • Author(s)
      三浦拓也、高橋大介、戸嶋一敦
    • Organizer
      日本化学会第92春季年会
    • Place of Presentation
      慶應義塾大学
    • Year and Date
      2012-03-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] フラーレン誘導体によるHIV-1 プロテアーゼの選択的光分解とHIV 感染細胞におけるウィルス増殖抑制効果2012

    • Author(s)
      谷本周穂, 工藤恵理子 ,岡田誠治, 高橋大介, 戸嶋一敦
    • Organizer
      日本化学会第92春季年会
    • Place of Presentation
      慶應義塾大学
    • Year and Date
      2012-03-26
    • Related Report
      2013 Final Research Report
  • [Presentation] リガンドタンパク-アントラキノンハイブリッドによるレセプタータンパクの選択的光分解2012

    • Author(s)
      小沼雄介, 高橋大介, 戸嶋一敦
    • Organizer
      日本化学会第92春季年会
    • Place of Presentation
      慶應義塾大学
    • Year and Date
      2012-03-26
    • Related Report
      2013 Final Research Report 2011 Annual Research Report
  • [Presentation] インフルエンザウィルスのノイラミニダーゼを光分解するアントラキノン-シアル酸ハイブリッド分子の創製2012

    • Author(s)
      青木優介, 高橋大介, 戸嶋一敦
    • Organizer
      日本化学会第92春季年会
    • Place of Presentation
      慶應義塾大学
    • Year and Date
      2012-03-26
    • Related Report
      2013 Final Research Report
  • [Presentation] フラーレン誘導体によるHIV-1プロテアーゼの選択的光分解とHIV感染細胞におけるウィルス増殖抑制効果2012

    • Author(s)
      谷本周穂、工藤恵理子、岡田誠治、高橋大介、戸嶋一敦
    • Organizer
      日本化学会第92春季年会
    • Place of Presentation
      慶應義塾大学
    • Year and Date
      2012-03-26
    • Related Report
      2011 Annual Research Report
  • [Presentation] インフルエンザウィルスのノイラミニダーゼを光分解するアントラキノンーシアル酸ハイブリッド分子の創製2012

    • Author(s)
      青木優介、高橋大介、戸嶋一敦
    • Organizer
      日本化学会第92春季年会
    • Place of Presentation
      慶應義塾大学
    • Year and Date
      2012-03-26
    • Related Report
      2011 Annual Research Report
  • [Presentation] Photodegradation of drug-resistant influenza virus neuraminidase using designed anthraquinone-sialic acid hybrids2012

    • Author(s)
      K. Toshima, Y. Aoki, D. Takahashi
    • Organizer
      The 12th International Kyoto Conference on New Aspects of Organic Chemistry
    • Place of Presentation
      リーガロイヤルホテル京都
    • Related Report
      2012 Annual Research Report
  • [Presentation] Target-selective photodegradation of glycolipid LPS and inhibition of macrophage activation by designed anthraquinone-boronic acid hybrids2012

    • Author(s)
      K. Toshima
    • Organizer
      8th Keio LCC - Yonsei CBMH Joint Symposium 2012
    • Place of Presentation
      札幌全日空ホテル
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Photodegradation of glycolipid LPS and inhibition of macrophage activation using designed anthraquinone-boronic acid hybrids2012

    • Author(s)
      K. Toshima
    • Organizer
      17th Malaysian Chemical Congress 2012
    • Place of Presentation
      クアラルンプール(マレーシア)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Photodegradation of target glycolipid LPS and inhibition of macrophage activation by anthraquinone-boronic acid hybrids2012

    • Author(s)
      D. Takahashi, T. Miura, K. Toshima
    • Organizer
      26 International Carbohydrate Symposium
    • Place of Presentation
      マドリード(スペイン)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Target-selective photo-degradation of HIV-1 protease and inhibition of HIV-1 replication in living cells by a fullerene-sugar hybrid2012

    • Author(s)
      S. Tanimoto, D. Takahashi, K. Toshima
    • Organizer
      26 International Carbohydrate Symposium
    • Place of Presentation
      マドリード(スペイン)
    • Related Report
      2012 Annual Research Report
  • [Presentation] ポルフィリン誘導体によるアミロイドβの光分解2012

    • Author(s)
      平林歩、高橋大介、戸嶋一敦
    • Organizer
      日本ケミカルバイオロジー学会第7回年会
    • Place of Presentation
      京都大学
    • Related Report
      2012 Annual Research Report
  • [Presentation] アントラセン-ケンプ酸ハイブリッドによる単糖の認識と光分解2012

    • Author(s)
      西部美幸希、高橋大介、戸嶋一敦
    • Organizer
      日本ケミカルバイオロジー学会第7回年会
    • Place of Presentation
      京都大学
    • Related Report
      2012 Annual Research Report
  • [Presentation] 標的糖鎖を選択的に光分解する化学的手法の開発と生物学的応用2011

    • Author(s)
      戸嶋一敦
    • Organizer
      GlycoTOKYO 2011 シンポジウム
    • Place of Presentation
      理化学研究所
    • Year and Date
      2011-12-09
    • Related Report
      2013 Final Research Report
  • [Presentation] 標的糖鎖を選択的に光分解する化学的手法の開発と生物学的応用2011

    • Author(s)
      戸嶋一敦
    • Organizer
      GlycoTOKYO 2011シンポジウム
    • Place of Presentation
      理化学研究所(招待講演)
    • Year and Date
      2011-12-09
    • Related Report
      2011 Annual Research Report
  • [Presentation] Photo-degradation of proteins by fullerene derivatives2011

    • Author(s)
      S. Tanimoto, Y. Ishida, D. Takahashi, K. Toshima
    • Organizer
      8th AFMC International Medicinal Chemistry Symposium-Frontier of Medicinal Science
    • Place of Presentation
      Keio Plaza Hotel, Tokyo, Japan
    • Year and Date
      2011-12-01
    • Related Report
      2013 Final Research Report
  • [Presentation] Photo-degradation of proteins by fullerene derivatives2011

    • Author(s)
      S.Tanimoto, Y.Ishida, D.Takahashi, K.Toshima
    • Organizer
      8th AFMC International Medicinal Chemistry Symposium-Frontier of Medicinal Science-
    • Place of Presentation
      京王プラザホテル
    • Year and Date
      2011-12-01
    • Related Report
      2011 Annual Research Report
  • [Presentation] Inhibition of amyloid ・aggregation and cytotoxicity by photo-degradation using designed fullerene derivatives2011

    • Author(s)
      K. Toshima
    • Organizer
      The 7th Yonsei CBMH-Keio LCC Joint Symposium
    • Place of Presentation
      Jeju, Korea
    • Year and Date
      2011-10-28
    • Related Report
      2013 Final Research Report
  • [Presentation] Inhibition of amyloid β aggregation and cytotoxicity by photo-degradation using designed fullerene derivatives2011

    • Author(s)
      K.Toshima
    • Organizer
      The 7^<th> Yonsei CBMH-Keio LCC Joint Symposium
    • Place of Presentation
      チェジュ(韓国)
    • Year and Date
      2011-10-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] Target-selective photodegradation of oligosaccharides by light-activated small molecules2011

    • Author(s)
      D. Takahashi, S. Hirono, K. Toshima
    • Organizer
      MDF International Workshop : Open-shell Organic Molecules -Synthesis and Electronic Structure Freedom-
    • Place of Presentation
      Umeda Sky Building, Osaka
    • Year and Date
      2011-10-07
    • Related Report
      2013 Final Research Report
  • [Presentation] Target-selective photodegradation of oligosaccharides by light-activated small molecules2011

    • Author(s)
      D.Takahashi, S.Hirono, K.Toshima
    • Organizer
      MDF International Workshop : Open-shell Organic Molecules-Synthesis and Electronic Structure Freedom-
    • Place of Presentation
      梅田スカイビル
    • Year and Date
      2011-10-07
    • Related Report
      2011 Annual Research Report
  • [Presentation] Development of an innovative method for target-selective photodegradation of oligosaccharides by light-activated small molecules2011

    • Author(s)
      D. Takahashi, S. Hirono, C. Hayashi, M. Igarashi, Y. Nishimura, K. Toshima
    • Organizer
      The 31th Naito Conference on Glycan Expression and Regulation [II]
    • Place of Presentation
      Chateraise Gateaux Kingdom Sapporo, Hokkaido, Japan
    • Year and Date
      2011-09-14
    • Related Report
      2013 Final Research Report
  • [Presentation] Development of an innovative method for target-selective photodegradation of oligosaccharides by light-activated small molecules2011

    • Author(s)
      D.Takahashi, S.Hirono, C.Hayashi, M.Igarashi, Y.Nishimura, K.Toshima
    • Organizer
      The 31th Naito Conference on Glycan Expression and Regulation [II]
    • Place of Presentation
      ガトーキングダムサッポロ
    • Year and Date
      2011-09-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] Target-selective degradation of oligosaccharides by photo-activated organic molecules2011

    • Author(s)
      K. Toshima
    • Organizer
      14th Asian Chemical Congress
    • Place of Presentation
      Bangkok, Thailand
    • Year and Date
      2011-09-08
    • Related Report
      2013 Final Research Report
  • [Presentation] Target-selective degradation of oligosaccharides by photo-activated organic molecules2011

    • Author(s)
      K.Toshima
    • Organizer
      14^<th> Asian Chemical Congress
    • Place of Presentation
      バンコク(タイ)(招待講演)
    • Year and Date
      2011-09-08
    • Related Report
      2011 Annual Research Report
  • [Presentation] Target-selective photodegradation of oligosaccharides by designed small organic molecules2011

    • Author(s)
      K. Toshima
    • Organizer
      21st International Symposium on Glycoconjugates
    • Place of Presentation
      Vienna, Austria
    • Year and Date
      2011-08-24
    • Related Report
      2013 Final Research Report
  • [Presentation] Target-selective photodegradation of oligosaccharides by designed small organic molecules2011

    • Author(s)
      K.Toshima
    • Organizer
      21^<st> International Symposium on Glycoocnjugates
    • Place of Presentation
      ウィーン(オーストリア)(招待講演)
    • Year and Date
      2011-08-24
    • Related Report
      2011 Annual Research Report
  • [Presentation] アントラキノン-ボロン酸ハイブリッド分子による敗血症関連糖脂質LPS の光分解2011

    • Author(s)
      三浦拓也, 高橋大, 戸嶋一敦
    • Organizer
      日本ケミカルバイオロジー学会第6回年会
    • Place of Presentation
      東京工業大学
    • Year and Date
      2011-05-25
    • Related Report
      2013 Final Research Report
  • [Presentation] 糖尿病関連タンパクα-グルコシダーゼを選択的に光分解する生体機能分子の創製2011

    • Author(s)
      奥澤俊介, 青木優介, 高橋大介, 戸嶋一敦
    • Organizer
      日本ケミカルバイオロジー学会第6回年会
    • Place of Presentation
      東京工業大学
    • Year and Date
      2011-05-25
    • Related Report
      2013 Final Research Report 2011 Annual Research Report
  • [Presentation] アントラキノン-ボロン酸ハイブリッド分子による敗血症関連糖脂質LPSの光分解2011

    • Author(s)
      三浦拓也、高橋大介、戸嶋一敦
    • Organizer
      日本ケミカルバイオロジー学会第6回年会
    • Place of Presentation
      東京工業大学
    • Year and Date
      2011-05-25
    • Related Report
      2011 Annual Research Report
  • [Presentation] フラーレン誘導体によるHIV-1 プロテアーゼの選択的光分解とHIV-1 増殖抑制効果2011

    • Author(s)
      谷本周穂, 工藤恵理子, 岡田誠治, 高橋大介, 戸嶋一敦
    • Organizer
      日本ケミカルバイオロジー学会第6回年会
    • Place of Presentation
      東京工業大学
    • Year and Date
      2011-05-23
    • Related Report
      2013 Final Research Report
  • [Presentation] フラーレン誘導体によるHIV-1プロテアーゼの選択的光分解とHIV-1増殖抑制効果2011

    • Author(s)
      谷本周穂、工藤恵理子、岡田誠治、高橋大介、戸嶋一敦
    • Organizer
      日本ケミカルバイオロジー学会第6回年会
    • Place of Presentation
      東京工業大学
    • Year and Date
      2011-05-23
    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.applc.keio.ac.jp/~toshima/

    • Related Report
      2013 Final Research Report
  • [Remarks] 2012年4月4日掲載日刊工業新聞朝刊「慶大 インフル抑制分子を開発, 増殖因子に結合, 光で分解, 耐性ウィルスに効果」(新聞掲載)

    • Related Report
      2013 Final Research Report
  • [Remarks] 2011年4月13日掲載日刊工業新聞朝刊「アルツハイマーの原因物質光で狙い撃ち, 慶大, フラーレンで複合分子」(新聞掲載)

    • Related Report
      2013 Final Research Report
  • [Remarks] 戸嶋研究室(分子生命化学研究室)

    • URL

      http://www.applc.keio.ac.jp/&#771;toshima/

    • Related Report
      2013 Annual Research Report
  • [Remarks] 戸嶋研究室(分子生命化学研究室)

    • URL

      http://www.applc.keio.ac.jp/~toshima/

    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://www.applc.keio.ac.jp/~toshima/

    • Related Report
      2011 Annual Research Report
  • [Patent(Industrial Property Rights)] 光増感剤,タンパク質切断剤,タンパク質切断方法,糖分子切断剤,糖分子切断方法,及び光線力学的治療剤2012

    • Inventor(s)
      戸嶋一敦
    • Industrial Property Rights Holder
      学校法人慶應義塾
    • Industrial Property Rights Type
      特許
    • Acquisition Date
      2012-07-27
    • Related Report
      2013 Final Research Report

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Published: 2011-04-06   Modified: 2019-07-29  

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