| Budget Amount *help |
¥19,760,000 (Direct Cost: ¥15,200,000、Indirect Cost: ¥4,560,000)
Fiscal Year 2013: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2011: ¥14,300,000 (Direct Cost: ¥11,000,000、Indirect Cost: ¥3,300,000)
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| Research Abstract |
Treatment of 4,5-epoxycyclohex-1-ene with ter-butylperbenzoic acid in the presence of Cu (I)-chiral N,N-bidente complex gave the (3S,4S,5S)-3-benzoyloxy-4-epoxycyclohexa-1-en in 54% chemical yield and 84% ee. The ee of this compound could be increased up to 100% ee by recrystalization after derivatization to the corresponding p-nitrobenzoyl derivative.
ring opening of the product epoxide with H2O followed by ozonolysis afforded the acyclic chiral triol. this method is useful for the synthesis of natural product such as oxylipines.
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