Optical Coherence Tomography for Embryology Application

• Project/Area Number: 23360026
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Applied optics/Quantum optical engineering
• Research Institution: Utsunomiya University
• Principal Investigator: YATAGAI Toyohoko 宇都宮大学, オプティクス教育研究センター, 教授 (90087445)
• Co-Investigator(Kenkyū-buntansha): BARRY Cense 宇都宮大学, オプティクス教育研究センター, 准教授 (90566366) ; 松田 勝 宇都宮大学, バイオサイエンス教育研究センター, 准教授 (20414013)
• Co-Investigator(Renkei-kenkyūsha): MATSUD13 Masaru (20414013)
• Project Period (FY): 2011-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥20,800,000 (Direct Cost: ¥16,000,000、Indirect Cost: ¥4,800,000); Fiscal Year 2013: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000); Fiscal Year 2012: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2011: ¥12,740,000 (Direct Cost: ¥9,800,000、Indirect Cost: ¥2,940,000)
• Keywords: OCT / 光干渉断層影像法 / メダカ / 三次元可視化 / 断層像 / ＯＣＴ / 生体観測 / 断層映像 / 生体計測

Research Abstract

Some advanced techniques, such as GFP, enalbe us to make in vivo imaging of biological samples.In this research, an OCT imaging system for 3D imaging of Medaka fish has been developped, by which the eariy state of embriyo and some organs can be imaged without GFP technology. The OCT used in retina imaging is improved to make 3D imaging of moving fish in water.

Research Products

• [Journal Article] Henle fiber layer phase retardation measured with polarization-sensitive optical coherence tomography (2013)
  • Author(s): B.Cense, Q.Wang, S.Lee, L.Zhao, A.E.Elsner, C.Hitzenberger, and D.T.Miller
  • Journal Title: Biomedical Optics Express Volume: 4 (11) Pages: 2296-2306
• [Journal Article] Adaptive optics for optical coherence tomography in retinal imaging: a reflection on past and future developments (2013)
  • Author(s): B.Cense and I.Ibrahim
  • Journal Title: Review of Laser Engineering Volume: 41 (12)
• [Journal Article] Henle fiber layer phase retardation measured with polarization-sensitive optical coherence tomography (2013)
  • Author(s): B. Cense, Q. Wang, S. Lee, L. Zhao, A.E. Elsner, C. Hitzenberger, and D.T. Miller
  • Journal Title: Biomedical Optics Express Volume: 4 Pages: 2296-2306
  • Peer Reviewed
• [Journal Article] Adaptive optics for optical coherence tomography in retinal imaging: a reflection on past and future developments (2013)
  • Author(s): B. Cense and I. Ibrahim
  • Journal Title: Review of Laser Engineering Volume: 41 Pages: 1006-1011
  • Peer Reviewed
• [Journal Article] Ol4E-T, a eukaryotic translation initiation factor 4E-binding protein of medaka fish (Oryzias latipes), can interact with nanos3 and vasa in vitro (2013)
  • Author(s): Zhao H, Guan G, Duan J, Cheng N, Wang J, Matsuda M, Paul-Prasanth B, Nagahama Y
  • Journal Title: J Exp Zool B Mol Dev Evol Volume: 320 Issue: 1 Pages: 10-21
  • DOI: 10.1002/jez.b.22465
  • Peer Reviewed
• [Journal Article] Fast calculation of spherical computer generated hologram using spherical wave spectrum method (2013)
  • Author(s): Boaz Jessie Jackin, Toyohiko Yatagai
  • Journal Title: Optics Express Volume: 21 Pages: 953-948
  • Peer Reviewed
• [Journal Article] Fast calculation method for computer-generated cylindrical holograms based on the three-dimensional Fourier spectrum (2013)
  • Author(s): Yusuke Sando, Daisuke Barada, Boaz Jessie Jackin, Toyohiko Yatagai
  • Journal Title: Optics Letters Volume: 38 Pages: 5172-5175
  • Peer Reviewed
• [Journal Article] Dmrt1 mutation causes a male-to-female sex reversal after the sex determination by Dmy in the medaka (2012)
  • Author(s): Masuyama H, Yamada M, Kamei Y, Fujiwara-Ishikawa T, Todo T, Nagahama Y, Matsuda M
  • Journal Title: Chromosome Res Volume: 20 Pages: 163-76
• [Journal Article] The effect of collimator lenses on the performance of an optical coherence tomography system (2012)
  • Author(s): Pauli Falt, Jakub Czajkowski and Barry Cense
  • Journal Title: Proc. SPIE. Volume: 7885
• [Journal Article] Wide field of view retinal imaging using one-micrometer adaptive optics scanning laser ophthalmoscope (2012)
  • Author(s): Kazuhiro Sasaki, Barry Cense and Yoshiaki Yasuno
  • Journal Title: Proc. SPIE Volume: 7931 Pages: 793106-793106
• [Journal Article] Expression of 3beta-hydroxysteroid dehydrogenase (hsd3b), star and ad4bp/sf-1 during gonadal development in medaka (Oryzias latipes) (2012)
  • Author(s): Nakamoto M, Fukasawa M, Tanaka S, Shimamori K, Suzuki A, Matsuda M, Kobayashi T, Nagahama Y, Shibata N
  • Journal Title: Gen Comp Endocrinol Volume: 176 Pages: 222-230
• [Journal Article] Fast calculation of computer-generated holograms based on 3-D Fourier spectrum for omnidirectional diffraction from a 3-D voxel-based object (2012)
  • Author(s): Yusuke Sando
  • Journal Title: Optics Express Volume: 20 Pages: 20962-20969
  • Peer Reviewed
• [Journal Article] Selectable-wavelength low-coherence digital holography with chromatic phase shifter (2012)
  • Author(s): Quang Duc Pham
  • Journal Title: Optics Express Volume: 20 Pages: 19744-19759
  • Peer Reviewed
• [Journal Article] The effect of collimator lenses on the performance of an optical coherence tomography system (2012)
  • Author(s): Pauli Fait, Jakub Czajkowski, Barry Cense
  • Journal Title: Proc.SPIE Volume: 7885
  • Peer Reviewed
• [Journal Article] Simultaneous twowavelength Doppler phase-shifting digital holography (2011)
  • Author(s): D.Barada, T.Kiire, J.Sugisaka, S.Kawata, and T.Yatagai
  • Journal Title: Appl. Opt. Volume: 50
• [Journal Article] Analysis of sexually dimorphic expression of genes at early gonadogenesis of pejerrey Odontesthes bonariensis using a heterologous microarray (2011)
  • Author(s): Fernandino JI, Popesku JT, Paul-Prasanth B, Xiong H, Hattori RS, Oura M, Strussmann CA, Somoza GM, Matsuda M, Nagahama Y, Trudeau VL
  • Journal Title: Sex Dev Volume: 5 Pages: 89-101
• [Journal Article] Wide field of view retinal imaging using one-micrometer adaptive optics scanning laser ophthalmoscope (2011)
  • Author(s): Kazuhiri Sasaki, Barry Cense, Yoshiaki Yasuno
  • Journal Title: Proc.SPIE Volume: 7931 Pages: 793106-793106
  • Peer Reviewed
• [Journal Article] Simultaneous two-wavelength Doppler phase-shifting digital holography (2011)
  • Author(s): Daisuke Barada, Tomohiro Kiire, Jun-ichiro Sugisaka, Shigeo Kawata, Toyohiko Yatagail
  • Journal Title: Appl.Opt. Volume: 50
  • Peer Reviewed
• [Presentation] In vivo 3D imaging of medaka fish using SD-OCT for gender differentiation (2014)
  • Author(s): F.M.Gladys, Y.Lim, M.Matsuda, and B.Cense
  • Organizer: Optical Methods in Developmental Biology II, Photonics West BIOS
  • Place of Presentation: San Francisco, California, USA
  • Year and Date: 2014-02-01
• [Presentation] Low cost active retinal tracker for optical coherence tomography (2013)
  • Author(s): Y.Lim, R.de Kinkelder, and B.Cense
  • Organizer: Ophthalmic Technologies XXIII, Photonics West BIOS
  • Place of Presentation: San Francisco, California, USA
• [Presentation] Non-invasive in vivo 3D imaging of medaka using ultra high resolution spectral domain optical coherence tomography (2013)
  • Author(s): F.M.Gladys, Y.Lim, M.Matsuda, and B.Cense
  • Organizer: 19^<th> Japanese Medaka and Zebrafish Meeting
  • Place of Presentation: Sendai, Japan
• [Presentation] Detection before damage (2013)
  • Author(s): B.Cense
  • Organizer: Biomedical Engineering
  • Place of Presentation: Twente University, Rotterdam Oogziekenhuis, TU Delft, AMC Amsterdam, Radboud Ziekenhuis Nijmegen, the Netherlands
  • Invited
• [Presentation] Non-invasive in vivo 3D imaging of medaka using ultra high resolution spectral domain optical coherence tomography (2013)
  • Author(s): F.M. Gladys, Y. Lim, M. Matsuda, and B. Cense
  • Organizer: 19th Japanese Medaka and Zebrafish Meeting
  • Place of Presentation: Sendai
• [Presentation] Detection before damage (2013)
  • Author(s): B. Cense
  • Organizer: Biomedical Engineering
  • Place of Presentation: Twente University
  • Invited
• [Presentation] Non-invasive in vivo 3D imaging of medaka using ultra high resolution spectral domain optical coherence tomography (2013)
  • Author(s): F.M. Gladys, Y. Lim, M. Matsuda, and B. Cense
  • Organizer: The Tenth Japan-Finland Joint Symposium on Optics in Engineering
  • Place of Presentation: Utsunomiya, Japan
• [Presentation] In-vivo OCT imaging of Medaka fish (2013)
  • Author(s): F.M. Gladys, Y. Lim, M. Matsuda, and B. Cense
  • Organizer: Optics & Photonics Japan 2013
  • Place of Presentation: Nara, Japan
• [Presentation] Full view-angle computer-generated hologram by a fast calculation method based on rigorous diffraction theory (2012)
  • Author(s): Toyohiko Yatagai
  • Organizer: Workshop on Information Optics
  • Place of Presentation: Quebec, Canada
  • Year and Date: 2012-08-20
  • Invited
• [Presentation] A rigorous diffraction theory for full view-angle computer-generated hologram (2012)
  • Author(s): Toyohiko Yatagai
  • Organizer: Collaborative Conference on 3D Research 2012
  • Place of Presentation: Jeju Island, Korea
  • Invited
• [Presentation] Doppler phase-shifting Digital Hologaphy and its applications (2012)
  • Author(s): Toyohiko Yatagai
  • Organizer: HoloMet 2012
  • Place of Presentation: Utsunomiya, Japan
  • Invited
• [Presentation] 光で生体の断層をみる―光コヒーレンストモグラフィ― (2011)
  • Author(s): 谷田貝豊彦
  • Organizer: 日光シンポジウム
  • Place of Presentation: 日光、栃木県
  • Year and Date: 2011-12-18
  • Invited
• [Presentation] 光で生体の断層をみる-光コヒーレンストモグラフィ- (2011)
  • Author(s): 谷田貝豊彦
  • Organizer: 日光シンポジウム
  • Place of Presentation: 日光、栃木県(招待講演)
  • Year and Date: 2011-12-18
• [Presentation] High-speed high-resolution polarization-sensitive OCT (2011)
  • Author(s): B.Canse and T.Yatagai
  • Organizer: SPIE
  • Place of Presentation: San Francisco, USA
• [Presentation] Sub-micron resolution, high-speed spectral domain optical coherence tomography in quality inspection for printed electronics
  • Author(s): J. Czajkowski, J. Lauri, R. Sliz, P. Fält, T. Fabritius, R. Myllyläa, and B. Cense
  • Organizer: Optical Micro- and Nanometrology, SPIE Photonics Europe, Brussels, Belgium
  • Place of Presentation: Brussels, Belgium
• [Presentation] 人工制限酵素を用いた性分化関連遺伝子の破壊
  • Author(s): 齊野兼太郎, 増山治男, 松田勝
  • Organizer: 第２回宇都宮大学オプト-バイオシンポジウム
  • Place of Presentation: 宇都宮
• [Presentation] 野生メダカ由来の XX 性転換変異体メダカの解析
  • Author(s): 今井拓人, 松島美喜子, 松田勝
  • Organizer: 第２回宇都宮大学オプト-バイオシンポジウム
  • Place of Presentation: 宇都宮
• [Book] 光の事典 (2011)
  • Author(s): 谷田貝豊彦 編集代表
  • Total Pages: 767
  • Publisher: 丸善出版
• [Patent(Industrial Property Rights)] Device for generating three-dimensional retina imag (2013)
  • Inventor(s): B. Cense and R. de Kinkelder
  • Industrial Property Rights Holder: B. Cense and R. de Kinkelder
  • Industrial Property Rights Type: 特許
  • Filing Date: 2013-05-15
  • Overseas
• [Patent(Industrial Property Rights)] 特許 (2011)
  • Inventor(s): 谷田貝豊彦, センズアブラハム
  • Industrial Property Rights Holder: 宇都宮大学
  • Industrial Property Number: 2011-154241
  • Filing Date: 2011-07-12
• [Patent(Industrial Property Rights)] Device for generating three-dimensional retina image
  • Inventor(s): B.Cense and R.de Kinkelder
  • Industrial Property Rights Holder: 宇都宮大学
  • Industrial Property Rights Type: 特許
  • Overseas