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Optical Coherence Tomography for Embryology Application

Research Project

Project/Area Number 23360026
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Applied optics/Quantum optical engineering
Research InstitutionUtsunomiya University

Principal Investigator

YATAGAI Toyohoko  宇都宮大学, オプティクス教育研究センター, 教授 (90087445)

Co-Investigator(Kenkyū-buntansha) BARRY Cense  宇都宮大学, オプティクス教育研究センター, 准教授 (90566366)
松田 勝  宇都宮大学, バイオサイエンス教育研究センター, 准教授 (20414013)
Co-Investigator(Renkei-kenkyūsha) MATSUD13 Masaru   (20414013)
Project Period (FY) 2011-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥20,800,000 (Direct Cost: ¥16,000,000、Indirect Cost: ¥4,800,000)
Fiscal Year 2013: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2012: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2011: ¥12,740,000 (Direct Cost: ¥9,800,000、Indirect Cost: ¥2,940,000)
KeywordsOCT / 光干渉断層影像法 / メダカ / 三次元可視化 / 断層像 / OCT / 生体観測 / 断層映像 / 生体計測
Research Abstract

Some advanced techniques, such as GFP, enalbe us to make in vivo imaging of biological samples.In this research, an OCT imaging system for 3D imaging of Medaka fish has been developped, by which the eariy state of embriyo and some organs can be imaged without GFP technology. The OCT used in retina imaging is improved to make 3D imaging of moving fish in water.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • Research Products

    (39 results)

All 2014 2013 2012 2011 Other

All Journal Article (18 results) (of which Peer Reviewed: 10 results) Presentation (17 results) (of which Invited: 6 results) Book (1 results) Patent(Industrial Property Rights) (3 results) (of which Overseas: 2 results)

  • [Journal Article] Henle fiber layer phase retardation measured with polarization-sensitive optical coherence tomography2013

    • Author(s)
      B.Cense, Q.Wang, S.Lee, L.Zhao, A.E.Elsner, C.Hitzenberger, and D.T.Miller
    • Journal Title

      Biomedical Optics Express

      Volume: 4 (11) Pages: 2296-2306

    • Related Report
      2013 Final Research Report
  • [Journal Article] Adaptive optics for optical coherence tomography in retinal imaging: a reflection on past and future developments2013

    • Author(s)
      B.Cense and I.Ibrahim
    • Journal Title

      Review of Laser Engineering

      Volume: 41 (12)

    • Related Report
      2013 Final Research Report
  • [Journal Article] Henle fiber layer phase retardation measured with polarization-sensitive optical coherence tomography2013

    • Author(s)
      B. Cense, Q. Wang, S. Lee, L. Zhao, A.E. Elsner, C. Hitzenberger, and D.T. Miller
    • Journal Title

      Biomedical Optics Express

      Volume: 4 Pages: 2296-2306

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Adaptive optics for optical coherence tomography in retinal imaging: a reflection on past and future developments2013

    • Author(s)
      B. Cense and I. Ibrahim
    • Journal Title

      Review of Laser Engineering

      Volume: 41 Pages: 1006-1011

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ol4E-T, a eukaryotic translation initiation factor 4E-binding protein of medaka fish (Oryzias latipes), can interact with nanos3 and vasa in vitro2013

    • Author(s)
      Zhao H, Guan G, Duan J, Cheng N, Wang J, Matsuda M, Paul-Prasanth B, Nagahama Y
    • Journal Title

      J Exp Zool B Mol Dev Evol

      Volume: 320 Issue: 1 Pages: 10-21

    • DOI

      10.1002/jez.b.22465

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fast calculation of spherical computer generated hologram using spherical wave spectrum method2013

    • Author(s)
      Boaz Jessie Jackin, Toyohiko Yatagai
    • Journal Title

      Optics Express

      Volume: 21 Pages: 953-948

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fast calculation method for computer-generated cylindrical holograms based on the three-dimensional Fourier spectrum2013

    • Author(s)
      Yusuke Sando, Daisuke Barada, Boaz Jessie Jackin, Toyohiko Yatagai
    • Journal Title

      Optics Letters

      Volume: 38 Pages: 5172-5175

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dmrt1 mutation causes a male-to-female sex reversal after the sex determination by Dmy in the medaka2012

    • Author(s)
      Masuyama H, Yamada M, Kamei Y, Fujiwara-Ishikawa T, Todo T, Nagahama Y, Matsuda M
    • Journal Title

      Chromosome Res

      Volume: 20 Pages: 163-76

    • Related Report
      2013 Final Research Report
  • [Journal Article] The effect of collimator lenses on the performance of an optical coherence tomography system2012

    • Author(s)
      Pauli Falt, Jakub Czajkowski and Barry Cense
    • Journal Title

      Proc. SPIE.

      Volume: 7885

    • Related Report
      2013 Final Research Report
  • [Journal Article] Wide field of view retinal imaging using one-micrometer adaptive optics scanning laser ophthalmoscope2012

    • Author(s)
      Kazuhiro Sasaki, Barry Cense and Yoshiaki Yasuno
    • Journal Title

      Proc. SPIE

      Volume: 7931 Pages: 793106-793106

    • Related Report
      2013 Final Research Report
  • [Journal Article] Expression of 3beta-hydroxysteroid dehydrogenase (hsd3b), star and ad4bp/sf-1 during gonadal development in medaka (Oryzias latipes)2012

    • Author(s)
      Nakamoto M, Fukasawa M, Tanaka S, Shimamori K, Suzuki A, Matsuda M, Kobayashi T, Nagahama Y, Shibata N
    • Journal Title

      Gen Comp Endocrinol

      Volume: 176 Pages: 222-230

    • Related Report
      2013 Final Research Report
  • [Journal Article] Fast calculation of computer-generated holograms based on 3-D Fourier spectrum for omnidirectional diffraction from a 3-D voxel-based object2012

    • Author(s)
      Yusuke Sando
    • Journal Title

      Optics Express

      Volume: 20 Pages: 20962-20969

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Selectable-wavelength low-coherence digital holography with chromatic phase shifter2012

    • Author(s)
      Quang Duc Pham
    • Journal Title

      Optics Express

      Volume: 20 Pages: 19744-19759

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The effect of collimator lenses on the performance of an optical coherence tomography system2012

    • Author(s)
      Pauli Fait, Jakub Czajkowski, Barry Cense
    • Journal Title

      Proc.SPIE

      Volume: 7885

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Simultaneous twowavelength Doppler phase-shifting digital holography2011

    • Author(s)
      D.Barada, T.Kiire, J.Sugisaka, S.Kawata, and T.Yatagai
    • Journal Title

      Appl. Opt.

      Volume: 50

    • Related Report
      2013 Final Research Report
  • [Journal Article] Analysis of sexually dimorphic expression of genes at early gonadogenesis of pejerrey Odontesthes bonariensis using a heterologous microarray2011

    • Author(s)
      Fernandino JI, Popesku JT, Paul-Prasanth B, Xiong H, Hattori RS, Oura M, Strussmann CA, Somoza GM, Matsuda M, Nagahama Y, Trudeau VL
    • Journal Title

      Sex Dev

      Volume: 5 Pages: 89-101

    • Related Report
      2013 Final Research Report
  • [Journal Article] Wide field of view retinal imaging using one-micrometer adaptive optics scanning laser ophthalmoscope2011

    • Author(s)
      Kazuhiri Sasaki, Barry Cense, Yoshiaki Yasuno
    • Journal Title

      Proc.SPIE

      Volume: 7931 Pages: 793106-793106

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Simultaneous two-wavelength Doppler phase-shifting digital holography2011

    • Author(s)
      Daisuke Barada, Tomohiro Kiire, Jun-ichiro Sugisaka, Shigeo Kawata, Toyohiko Yatagail
    • Journal Title

      Appl.Opt.

      Volume: 50

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] In vivo 3D imaging of medaka fish using SD-OCT for gender differentiation2014

    • Author(s)
      F.M.Gladys, Y.Lim, M.Matsuda, and B.Cense
    • Organizer
      Optical Methods in Developmental Biology II, Photonics West BIOS
    • Place of Presentation
      San Francisco, California, USA
    • Year and Date
      2014-02-01
    • Related Report
      2013 Final Research Report
  • [Presentation] Low cost active retinal tracker for optical coherence tomography2013

    • Author(s)
      Y.Lim, R.de Kinkelder, and B.Cense
    • Organizer
      Ophthalmic Technologies XXIII, Photonics West BIOS
    • Place of Presentation
      San Francisco, California, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] Non-invasive in vivo 3D imaging of medaka using ultra high resolution spectral domain optical coherence tomography2013

    • Author(s)
      F.M.Gladys, Y.Lim, M.Matsuda, and B.Cense
    • Organizer
      19^<th> Japanese Medaka and Zebrafish Meeting
    • Place of Presentation
      Sendai, Japan
    • Related Report
      2013 Final Research Report
  • [Presentation] Detection before damage2013

    • Author(s)
      B.Cense
    • Organizer
      Biomedical Engineering
    • Place of Presentation
      Twente University, Rotterdam Oogziekenhuis, TU Delft, AMC Amsterdam, Radboud Ziekenhuis Nijmegen, the Netherlands
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] Non-invasive in vivo 3D imaging of medaka using ultra high resolution spectral domain optical coherence tomography2013

    • Author(s)
      F.M. Gladys, Y. Lim, M. Matsuda, and B. Cense
    • Organizer
      19th Japanese Medaka and Zebrafish Meeting
    • Place of Presentation
      Sendai
    • Related Report
      2013 Annual Research Report
  • [Presentation] Detection before damage2013

    • Author(s)
      B. Cense
    • Organizer
      Biomedical Engineering
    • Place of Presentation
      Twente University
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Non-invasive in vivo 3D imaging of medaka using ultra high resolution spectral domain optical coherence tomography2013

    • Author(s)
      F.M. Gladys, Y. Lim, M. Matsuda, and B. Cense
    • Organizer
      The Tenth Japan-Finland Joint Symposium on Optics in Engineering
    • Place of Presentation
      Utsunomiya, Japan
    • Related Report
      2013 Annual Research Report
  • [Presentation] In-vivo OCT imaging of Medaka fish2013

    • Author(s)
      F.M. Gladys, Y. Lim, M. Matsuda, and B. Cense
    • Organizer
      Optics & Photonics Japan 2013
    • Place of Presentation
      Nara, Japan
    • Related Report
      2013 Annual Research Report
  • [Presentation] Full view-angle computer-generated hologram by a fast calculation method based on rigorous diffraction theory2012

    • Author(s)
      Toyohiko Yatagai
    • Organizer
      Workshop on Information Optics
    • Place of Presentation
      Quebec, Canada
    • Year and Date
      2012-08-20
    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Invited
  • [Presentation] A rigorous diffraction theory for full view-angle computer-generated hologram2012

    • Author(s)
      Toyohiko Yatagai
    • Organizer
      Collaborative Conference on 3D Research 2012
    • Place of Presentation
      Jeju Island, Korea
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Doppler phase-shifting Digital Hologaphy and its applications2012

    • Author(s)
      Toyohiko Yatagai
    • Organizer
      HoloMet 2012
    • Place of Presentation
      Utsunomiya, Japan
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 光で生体の断層をみる―光コヒーレンストモグラフィ―2011

    • Author(s)
      谷田貝豊彦
    • Organizer
      日光シンポジウム
    • Place of Presentation
      日光、栃木県
    • Year and Date
      2011-12-18
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] 光で生体の断層をみる-光コヒーレンストモグラフィ-2011

    • Author(s)
      谷田貝豊彦
    • Organizer
      日光シンポジウム
    • Place of Presentation
      日光、栃木県(招待講演)
    • Year and Date
      2011-12-18
    • Related Report
      2011 Annual Research Report
  • [Presentation] High-speed high-resolution polarization-sensitive OCT2011

    • Author(s)
      B.Canse and T.Yatagai
    • Organizer
      SPIE
    • Place of Presentation
      San Francisco, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] Sub-micron resolution, high-speed spectral domain optical coherence tomography in quality inspection for printed electronics

    • Author(s)
      J. Czajkowski, J. Lauri, R. Sliz, P. Fält, T. Fabritius, R. Myllyläa, and B. Cense
    • Organizer
      Optical Micro- and Nanometrology, SPIE Photonics Europe, Brussels, Belgium
    • Place of Presentation
      Brussels, Belgium
    • Related Report
      2012 Annual Research Report
  • [Presentation] 人工制限酵素を用いた性分化関連遺伝子の破壊

    • Author(s)
      齊野兼太郎, 増山治男, 松田勝
    • Organizer
      第2回宇都宮大学オプト-バイオシンポジウム
    • Place of Presentation
      宇都宮
    • Related Report
      2012 Annual Research Report
  • [Presentation] 野生メダカ由来の XX 性転換変異体メダカの解析

    • Author(s)
      今井拓人, 松島美喜子, 松田勝
    • Organizer
      第2回宇都宮大学オプト-バイオシンポジウム
    • Place of Presentation
      宇都宮
    • Related Report
      2012 Annual Research Report
  • [Book] 光の事典2011

    • Author(s)
      谷田貝豊彦 編集代表
    • Total Pages
      767
    • Publisher
      丸善出版
    • Related Report
      2011 Annual Research Report
  • [Patent(Industrial Property Rights)] Device for generating three-dimensional retina imag2013

    • Inventor(s)
      B. Cense and R. de Kinkelder
    • Industrial Property Rights Holder
      B. Cense and R. de Kinkelder
    • Industrial Property Rights Type
      特許
    • Filing Date
      2013-05-15
    • Related Report
      2013 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 特許2011

    • Inventor(s)
      谷田貝豊彦, センズアブラハム
    • Industrial Property Rights Holder
      宇都宮大学
    • Industrial Property Number
      2011-154241
    • Filing Date
      2011-07-12
    • Related Report
      2011 Annual Research Report
  • [Patent(Industrial Property Rights)] Device for generating three-dimensional retina image

    • Inventor(s)
      B.Cense and R.de Kinkelder
    • Industrial Property Rights Holder
      宇都宮大学
    • Industrial Property Rights Type
      特許
    • Related Report
      2013 Final Research Report
    • Overseas

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Published: 2011-04-06   Modified: 2019-07-29  

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