Implantable gcluose sensor toward fully implantable glucose monitoring system
Project/Area Number |
23360157
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Electron device/Electronic equipment
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Research Institution | Nara Institute of Science and Technology |
Principal Investigator |
Tokuda Takashi 奈良先端科学技術大学院大学, 物質創成科学研究科, 准教授 (50314539)
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Co-Investigator(Renkei-kenkyūsha) |
OHTA Jun 奈良先端科学技術大学院大学, 物質創成科学研究科, 教授 (80304161)
SASAGAWA Kiyotaka 奈良先端科学技術大学院大学, 物質創成科学研究科, 助教 (50392725)
NODA Toshihiko 奈良先端科学技術大学院大学, 物質創成科学研究科, 助教 (20464159)
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Research Collaborator |
TAKEUCHI Shoji 東京大学, 生産技術研究所, 教授 (90343110)
OKITSU Teru 東京大学, 生産技術研究所, 特任教授 (10378672)
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Project Period (FY) |
2011-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2014: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2012: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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Keywords | CMOS / 体内埋め込みデバイス / 血糖値計測 / バイオチップ / 糖尿病 / バイオデバイス / 埋め込み |
Outline of Final Research Achievements |
An implantable glucose sensor was proposed and demonstrated. This sensor is designed based on a concept of fully-implantable glucose monitoring technology. We adopted a glucose-responsive fluorescent hydrogel as a mediator for the implantable glucose sensor. Integrating implantable CMOS imagesensor, fluorescent hydrogel, and mirco-light source (LED) we demonstrated the basic glucose sensing capability. We successfully demonstrated the sensing function in both in vitro and in vivo experiments. We also confirmed a device lifetime longer than 150 days.
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Report
(6 results)
Research Products
(30 results)
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[Journal Article] CMOS-based implantable glucose monitoring device with improved performance and reduced invasiveness2015
Author(s)
T. Kawamura, K. Masuda, T. Hirai, Y. Ohta, M. Motoyama, H. Takehara, T. Noda, K. Sasagawa, T. Tokuda, T. Okitsu, S. Takeuchi and J. Ohta
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Journal Title
Electronics Letters
Volume: 51
Issue: 10
Pages: 738-740
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] CMOS image sensor-based implantable glucose sensor using glucose-responsive fluorescent hydrogel2014
Author(s)
T. Tokuda, M. Takahashi, K. Uejima, K. Masuda, T. Kawamura, Y. Ohta, M. Motoyama, T. Noda, K. Sasagawa, T. Okitsu, S. Takeuchi, J. Ohta
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Journal Title
Biomedical Optics Express
Volume: 5
Issue: 11
Pages: 3859-3870
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] CMOS-Based Implantable Glucose Monitoring Device with Glucose-Responsive Fluorescent Hydrogel2015
Author(s)
T. Kawamura, T. Hirai, Hironari Takehara, Hiroaki Takehara, T. Noda, K. Sasagawa, T. Tokuda, Teru Okitsu, S. Takeuchi, and J. Ohta
Organizer
The 99th OSA Annual Meeting
Place of Presentation
San Jose, CA, USA
Year and Date
2015-10-18
Related Report
Int'l Joint Research
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[Presentation] CMOSバイオイメージセンサ2015
Author(s)
徳田 崇, 竹原 宏明, 野田 俊彦, 笹川 清隆, 太田 淳
Organizer
電子情報通信学会 シリコンフォトニクス研究会
Place of Presentation
湯坂温泉 ホテル賀茂川荘(広島県竹原市)
Year and Date
2015-01-22 – 2015-01-23
Related Report
Invited
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[Presentation] CMOS-BASED IMPLANTABLE GLUCOSE SENSOR USING GLUCOSE-RESPONSIVE FLUORESCENT HYDROGEL2014
Author(s)
Takashi Tokuda, M. Takahashi, Keita Masuda, Toshikazu Kawamura, Yasumi Ohta, Mayumi Motoyama, Toshihiko Noda, Kiyotaka Sasagawa, T. Okitsu, S. Takeuchi, Jun Ohta
Organizer
International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2014)
Place of Presentation
San Antonio, USA
Year and Date
2014-10-26 – 2014-10-30
Related Report
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[Presentation] 生体埋込みCMOSイメージセンサとグルコース応答性蛍光ハイドロゲルによる体内血糖計測デバイス2014
Author(s)
田 啓太, 高橋 正幸, 上嶋 和弘, 河村 敏和, 太田 安美, 元山 真由美, 野田 俊彦, 笹川 清隆, 徳田 崇, 興津 輝, 竹内 昌治, 太田 淳
Organizer
電気学会全国大会
Place of Presentation
愛媛大学 城北キャンパス
Related Report
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[Presentation] CMOSイメージセンサによる蛍光方式生体内グルコース計測技術の開発(II)2014
Author(s)
河村 敏和, 高橋 正幸, 上嶋 和弘, 増田 啓太, 太田 安美, 元山 真由美, 野田 俊彦, 笹川 清隆, 徳田 崇, 興津 輝, 竹内 昌治, 太田 淳
Organizer
応用物理学会春季学術講演会
Place of Presentation
青山学院大学相模原キャンパス
Related Report
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[Presentation] Development of a CMOS-Based Implantable Glucose Monitoring Device Using Glucose-Sensitive Fluorescent Hydrogel2013
Author(s)
Toshikazu Kawamura, Masayuki Takahashi, Kazuhiro Uejima, Yasumi Ohta, Mayumi Motoyama Toshihiko Noda, Kiyotaka Sasagawa, Takashi Tokuda, Teru Okitsu, Shoji Takeuchi, Jun Ohta
Organizer
International Conference on BioSensors, BioElectronics, BioMedical Devices, BioMEMS/NEMS and Applications 2013 (Bio4Apps 2013)
Place of Presentation
Tokyo Medical and Dental University, Japan
Related Report
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[Presentation] グルコース応答性蛍光ハイドロゲル搭載体内埋込みCMOSイメージセンサによるグルコース計測2013
Author(s)
河村 敏和, 高橋 正幸, 上嶋 和弘, 太田 安美, 元山 真由美, 野田 俊彦, 笹川 清隆, 徳田 崇, 興津 輝, 竹内 昌治, 太田 淳
Organizer
映像情報メディア学会冬季大会
Place of Presentation
芝浦工業大学
Related Report
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