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Mechanism of selenium-specific chemical transformation in selenoprotein biosynthesis

Research Project

Project/Area Number 23380060
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Applied biochemistry
Research InstitutionRitsumeikan University

Principal Investigator

Mihara Hisaaki  立命館大学, 生命科学部, 教授 (30324693)

Co-Investigator(Renkei-kenkyūsha) TANI Yasushi  立命館大学, 立命館グローバル・イノベーション研究機構, 專門研究員 (90583295)
SAITO Shigeki  立命館大学, 立命館グローバル・イノベーション研究機構, 專門研究員 (30589908)
Project Period (FY) 2011-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2015: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2014: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2013: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2012: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2011: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
Keywordsセレン / セレンタンパク質 / 蛋白質 / 酵素 / 必須微量元素 / セレン蛋白質 / 微量元素 / インド / タンパク質
Outline of Final Research Achievements

This study was conducted to clarify active selenium species that is formed in selenoprotein biosynthesis. We analyzed the detailed reaction of specific transfer of the active selenium species to selenophosphate synthetase. In addition, we focused on the selenium transfer pathway from inorganic selenium, selenite and selenate, to selenoproteins. Enzymes involved in the selenium transfer pathway have been identified, and their structure and function have been characterized.

Report

(6 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • Research Products

    (52 results)

All 2016 2015 2014 2013 2012 2011 Other

All Int'l Joint Research (1 results) Journal Article (15 results) (of which Peer Reviewed: 13 results,  Acknowledgement Compliant: 1 results) Presentation (32 results) (of which Int'l Joint Research: 3 results,  Invited: 4 results) Book (3 results) Remarks (1 results)

  • [Int'l Joint Research] Thapar University(India)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Purification and properties of 4-methyl-5-hydroxyethylthiazole kinase from Escherichia coli2016

    • Author(s)
      Tani, Y., Kimura, K., and Mihara, H.
    • Journal Title

      Biosci Biotechnol Biochem

      Volume: 80 Issue: 3 Pages: 514-517

    • DOI

      10.1080/09168451.2015.1104239

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Heterologous expression of L-lysine alpha-oxidase from Scomber japonicus in Pichia pastoris and functional characterization of the recombinant enzyme2015

    • Author(s)
      Tani, Y., Omatsu, K., Saito, S., Miyake, R., Kawabata, H., Ueda, M., and Mihara, H.
    • Journal Title

      J Biochem

      Volume: 157 Issue: 4 Pages: 201-210

    • DOI

      10.1093/jb/mvu064

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Functional expression of L-lysine alpha-oxidase from Scomber japonicus in Escherichia coli for one-pot synthesis of L-pipecolic acid from DL-lysine2015

    • Author(s)
      Tani, Y., Miyake, R., Yukami, R., Dekishima, Y., China, H., Saito, S., Kawabata, H., and Mihara, H.
    • Journal Title

      Appl Microbiol Biotechnol

      Volume: 99 Issue: 12 Pages: 5045-5054

    • DOI

      10.1007/s00253-014-6308-0

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Purification and Properties of Glycine Oxidase from <i>Pseudomonas putida</i> KT24402015

    • Author(s)
      Equar, M. Y., Tani, Y., and Mihara, H.
    • Journal Title

      Journal of Nutritional Science and Vitaminology

      Volume: 61 Issue: 6 Pages: 506-510

    • DOI

      10.3177/jnsv.61.506

    • NAID

      130005125489

    • ISSN
      0301-4800, 1881-7742
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Glutathione contributes to the efflux of selenium from hepatoma cells2014

    • Author(s)
      Imai, T., Kurihara, T., Esaki, N., and Mihara, H.
    • Journal Title

      Biosci Biotechnol Biochem

      Volume: 78 Issue: 8 Pages: 1376-1380

    • DOI

      10.1080/09168451.2014.918487

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Global identification of genes affecting iron-sulfur cluster biogenesis and iron homeostasis2014

    • Author(s)
      Hidese R, Mihara H, Kurihara T, Esaki N
    • Journal Title

      J. Bacteriol.

      Volume: 196 Issue: 6 Pages: 1238-1249

    • DOI

      10.1128/jb.01160-13

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novel Neogala-Series Glycosphingolipids with a Terminal Glucose Residue from the Fungus <i>Mariannaea elegans</i>2013

    • Author(s)
      Tani, Y., Nakamura, K., Sawa, R., Nishio, M., Saito, S., Ito, M., Itonori, S., Mihara, H.
    • Journal Title

      Bioscience, Biotechnology, and Biochemistry

      Volume: 77 Issue: 4 Pages: 754-759

    • DOI

      10.1271/bbb.120879

    • NAID

      10031170714

    • ISSN
      0916-8451, 1347-6947
    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pseudomonas putida PydR, a RutR-like transcriptional regulator, represses the dihydropyrimidine dehydrogenase gene in the pyrimidine reductive catabolic pathway2012

    • Author(s)
      Hidese R, Mihara H, Kurihara T, Esaki N.
    • Journal Title

      J. Biochem.

      Volume: 152 Issue: 4 Pages: 341-346

    • DOI

      10.1093/jb/mvs079

    • NAID

      10031166147

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bacterial cysteine desulfurase : versatile key players in biosynthetic path ways of sulfur-containing biofactors2011

    • Author(s)
      Hidese, R., Mihara, H., Esaki, N.
    • Journal Title

      Appl Microbiol Biotechnol

      Volume: 91 Issue: 1 Pages: 47-61

    • DOI

      10.1007/s00253-011-3336-x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Favourable effects of eicosapentaenoic acid on the late step of the cell division in a piezophilic bacterium, Shewanella violacea DSS12, at high-hydrostatic pressures2011

    • Author(s)
      Kawamoto, J., Sato, T., Nakasone, K., Kato, C., Mihara, H., Esaki, N., and Kurihara, T
    • Journal Title

      Environmental Microbiology

      Volume: 13 Issue: 8 Pages: 2293-2298

    • DOI

      10.1111/j.1462-2920.2011.02487.x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mammalian Selenocysteine Lyase Is Involved in Selenoprotein Biosynthesis2011

    • Author(s)
      Kurokawa, S., Takehashi, M., Tanaka, H., Mihara, H., Kurihara, T., Tanaka, S., Hill, K., Burk, R., Esaki, N.
    • Journal Title

      Journal of Nutritional Science and Vitaminology

      Volume: 57 Issue: 4 Pages: 298-305

    • DOI

      10.3177/jnsv.57.298

    • NAID

      130001373002

    • ISSN
      0301-4800, 1881-7742
    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 硫黄・セレン供給酵素群による含硫・含セレンバイオファクターの生成機構2011

    • Author(s)
      三原久明
    • Journal Title

      バイオサイエンスとインダストリー

      Volume: 69 Pages: 471-475

    • NAID

      10029790056

    • Related Report
      2011 Annual Research Report
  • [Journal Article] 鉄硫黄クラスター・セレンタンパク質生合成を司る酵素2011

    • Author(s)
      三原久明
    • Journal Title

      生化学

      Volume: 83 Pages: 1003-1015

    • Related Report
      2011 Annual Research Report
  • [Journal Article] Identification of novel mammalian phospholipids containing threonine, aspartate, and glutamate as the base moiety2011

    • Author(s)
      Omori, T., Honda, A., Mihara, H., Kurihara, T., and Esaki, N
    • Journal Title

      Journal of Chromatography B

      Volume: 879 Issue: 29 Pages: 3296-3302

    • DOI

      10.1016/j.jchromb.2011.04.033

    • NAID

      120003644380

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Selenite Reduction by the Thioredoxin System: Kinetics and Identification of Protein-Bound Selenide2011

    • Author(s)
      Tamura, T., Sato, K., Komori, K., Imai, T., Kuwahara, M., Okugochi, T., Mihara, H., Esaki, N., Inagaki, K.
    • Journal Title

      Bioscience, Biotechnology, and Biochemistry

      Volume: 75 Issue: 6 Pages: 1184-1187

    • DOI

      10.1271/bbb.100847

    • NAID

      10029328515

    • ISSN
      0916-8451, 1347-6947
    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] Bacillus sp. NTP-1株由来マンガンカタラーゼ様タンパク質の機能解析2016

    • Author(s)
      梅村晃弘, 戸部隆太, 田島寛隆, 三原久明
    • Organizer
      日本農芸化学会2016年度大会
    • Place of Presentation
      札幌コンベンションセンター(北海道札幌市)
    • Year and Date
      2016-03-29
    • Related Report
      2015 Annual Research Report
  • [Presentation] Pseudomonas putida由来D-リジントランスポーターの基質結合タンパク質の解析2016

    • Author(s)
      山内美咲, 青木志帆, 近藤和貴, 佐藤大起, 戸部隆太, 三原久明
    • Organizer
      日本農芸化学会2016年度大会
    • Place of Presentation
      札幌コンベンションセンター(北海道札幌市)
    • Year and Date
      2016-03-29
    • Related Report
      2015 Annual Research Report
  • [Presentation] Properties of aspartate aminotransferase from the thermophilic alkaliphilic bacterium Thermobacillus composti2016

    • Author(s)
      Kido, A., Tobe, R., and Mihara, H.
    • Organizer
      Institute for Chemical Research International Symposium 2016
    • Place of Presentation
      京都大学(京都府宇治市)
    • Year and Date
      2016-03-07
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Characterization of a novel putative porin of the metal-reducing bacterium Geobacter sulfurreducens2016

    • Author(s)
      Jahan, M. I., Tobe, R., and Mihara, H.
    • Organizer
      Institute for Chemical Research International Symposium 2016
    • Place of Presentation
      京都大学(京都府宇治市)
    • Year and Date
      2016-03-07
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] システインデスルフラーゼを用いたCdSナノ粒子の酵素的合成2016

    • Author(s)
      綾田真人, 戸部隆太, 田島寛隆, 三原久明
    • Organizer
      日本農芸化学会関西支部第493回講演会
    • Place of Presentation
      京都大学楽友会館(京都府京都市)
    • Year and Date
      2016-02-06
    • Related Report
      2015 Annual Research Report
  • [Presentation] Geobacter sulfurreducens におけるマルチヘムセレンタンパク質の機能解析2015

    • Author(s)
      松嵜佑樹, 杉山慧, 嶌本奈々, 戸部隆太, 谷泰史, 三原久明
    • Organizer
      BMB2015
    • Place of Presentation
      神戸国際展示場(兵庫県神戸市)
    • Year and Date
      2015-12-03
    • Related Report
      2015 Annual Research Report
  • [Presentation] 細菌におけるセレノリン酸合成酵素へのセレン基質供給系の解析2015

    • Author(s)
      清水敦貴, 波北悟, 戸部隆太, 田村隆, 三原久明
    • Organizer
      BMB2015
    • Place of Presentation
      神戸国際展示場(兵庫県神戸市)
    • Year and Date
      2015-12-02
    • Related Report
      2015 Annual Research Report
  • [Presentation] Characterization of a novel putative porin of the metal-reducing bacterium Geobacter sulfurreducens2015

    • Author(s)
      Mihara, H.
    • Organizer
      The 5th International Selenium Seminar (ISS2015)
    • Place of Presentation
      Yaroslavl (Russia)
    • Year and Date
      2015-09-23
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] インドセレン蓄積地帯の土壌より単離したCellulomonas sp. D3aの亜セレン酸還元特性2015

    • Author(s)
      田島寛隆, 山際恭平, 大内田竜大, 山本紘資, 名田イサナ, 谷泰史, 斎藤茂樹, 峯元高志, Prakash, N. T., 三原久明
    • Organizer
      第26回日本微量元素学会学術集会
    • Place of Presentation
      北海道大学(北海道札幌市)
    • Year and Date
      2015-07-04
    • Related Report
      2015 Annual Research Report
  • [Presentation] 細菌におけるセレン・テルルの代謝2015

    • Author(s)
      三原久明
    • Organizer
      第42回日本毒性学会学術年会
    • Place of Presentation
      ホテル日航金沢(石川県金沢市)
    • Year and Date
      2015-07-01
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 大腸菌変異株を用いたセレン微粒子生成関連遺伝子の探索2015

    • Author(s)
      田島寛隆, 大場杏奈, 大内田竜大, 斎藤茂樹, 谷泰史, Prakash, N. T., 三原久明
    • Organizer
      日本農芸化学会2015年度大会
    • Place of Presentation
      岡山大学津島キャンパス(岡山県)
    • Year and Date
      2015-03-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] 高濃度セレン地帯土壌より単離した Cellulomonas sp. D3a の亜セレン酸還元特性2014

    • Author(s)
      田島寛隆, 岡林拓弥, 山際恭平, 山本紘資, 名田イサナ, 斎藤茂樹, 谷泰史, 峯元高志, Prakash, N. T., 三原久明
    • Organizer
      第4回メタロミクス研究フォーラム
    • Place of Presentation
      武蔵野大学(東京都)
    • Year and Date
      2014-11-07
    • Related Report
      2014 Annual Research Report
  • [Presentation] Delivery of selenium to selenoprotein biosynthesis2014

    • Author(s)
      Mihara, H., Imai, T., Kurihara, T., and Esaki, N.
    • Organizer
      The International Selenium Seminar 2014
    • Place of Presentation
      Busan (Korea)
    • Year and Date
      2014-10-17
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 大腸菌のテルル酸還元関連遺伝子の網羅的探索2014

    • Author(s)
      田島寛隆, 安間友香理, 西田亮, 斎藤茂樹, 谷泰史, 三原久明. 大腸菌のテルル酸還元関連遺伝子の網羅的探索
    • Organizer
      第87回日本生化学会大会
    • Place of Presentation
      京都産業大学(京都府)
    • Year and Date
      2014-10-16
    • Related Report
      2014 Annual Research Report
  • [Presentation] Physiological role and reaction mechanism of selenocysteine lyase: unique vitamin B6 enzyme acting specifically on selenocysteine2014

    • Author(s)
      Esaki, N., Kurokawa, S., Omi, R., Hayashi, H., Miyahara, I., Hirotsu, K., Kurihara, T., and Mihara, H.
    • Organizer
      The Fourth International Conference on Cofactor (ICC-04)
    • Place of Presentation
      Parma (Italy)
    • Year and Date
      2014-08-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] The unique multiheme selenoprotein of the metal-reducing anaerobic bacterium Geobacter sulfurreducens2014

    • Author(s)
      Mihara, H., Tani, Y., Shinno, E., Sugiyama, S., Shimamoto, N., Zhang, W., Saito, S., Kurihara, T., and Esaki, N.
    • Organizer
      The Fourth International Conference on Cofactor (ICC-04)
    • Place of Presentation
      Parma (Italy)
    • Year and Date
      2014-08-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] 哺乳類細胞における亜セレン酸代謝2014

    • Author(s)
      三原久明, 今井岳志, 栗原達夫, 江崎信芳
    • Organizer
      第25回日本微量元素学会
    • Place of Presentation
      岡山大学(岡山県)
    • Year and Date
      2014-07-03
    • Related Report
      2014 Annual Research Report
  • [Presentation] グラム陽性細菌のテルル酸還元に関わる遺伝子の同定2014

    • Author(s)
      名田イサナ, 山際恭平, 永野知哉, 田島寛隆, 斎藤茂樹, 谷泰史, Prakash, N. T., 三原久明
    • Organizer
      日本農芸化学会関西支部例会第484回講演会
    • Place of Presentation
      京都府立大学(京都府)
    • Year and Date
      2014-05-24
    • Related Report
      2014 Annual Research Report
  • [Presentation] 亜セレン酸還元経路に関する研究2011

    • Author(s)
      今井岳志, 三原久明, 栗原達夫, 江崎信芳
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      国立京都国際会館(京都府)
    • Year and Date
      2011-09-24
    • Related Report
      2011 Annual Research Report
  • [Presentation] Escherichia coli由来ジヒドロピリミジンデヒドロゲナーゼにおける鉄硫黄クラスターの機能解析2011

    • Author(s)
      吉田吉孝, 秀瀬涼太, 青木明日香, 谷泰史, 斎藤茂樹, 栗原達夫, 江崎信芳, 三原久明
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      国立京都国際会館(京都府)
    • Year and Date
      2011-09-24
    • Related Report
      2011 Annual Research Report
  • [Presentation] 金属還元細菌Geobacter sulfurreducensのマルチヘムセレンタンパク質遺伝子破壊株の解析2011

    • Author(s)
      新野絵梨奈, 谷泰史, 斎藤茂樹, 三原久明
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      国立京都国際会館(京都府)
    • Year and Date
      2011-09-24
    • Related Report
      2011 Annual Research Report
  • [Presentation] チアミン生合成におけるシステインデスルフラーゼの機能解析2011

    • Author(s)
      柳橋良次, 谷泰史, 斎藤茂樹, 三原久明
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      国立京都国際会館(京都府)
    • Year and Date
      2011-09-24
    • Related Report
      2011 Annual Research Report
  • [Presentation] 子嚢菌類Mariannaea elegans由来の新奇ガラ系列糖脂質の構造解析2011

    • Author(s)
      谷泰史, 中村香里, 西尾匡, 澤良太, 斎藤茂樹, 伊藤将弘, 糸乗前, 三原久明
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      国立京都国際会館(京都府)
    • Year and Date
      2011-09-22
    • Related Report
      2011 Annual Research Report
  • [Presentation] ビタミンB1合成酵素群の反応特性の解明2011

    • Author(s)
      柳橋良次, 谷泰史, 斎藤茂樹, 三原久明
    • Organizer
      日本微量栄養素学会第28回学術集会
    • Place of Presentation
      京都リサーチパーク(京都府)
    • Year and Date
      2011-06-11
    • Related Report
      2011 Annual Research Report
  • [Presentation] Function of the unique multiheme selenoprotein of the metal-reducing bacterium Geobacter sulfurreducens

    • Author(s)
      Mihara H, Tani Y, Shinno E, Zhang W, Saito S, Kurihara T, Esaki N
    • Organizer
      10th International Symposium on Selenium in Biology and Medicine
    • Place of Presentation
      Berlin, Germany
    • Related Report
      2013 Annual Research Report
  • [Presentation] Selenocysteine lyase: Delivering selenium in biosynthetic pathway

    • Author(s)
      Mihara H, Kurihara T, Esaki N
    • Organizer
      The 3rd International Conference on Selenium in the Environmental and Human Health
    • Place of Presentation
      Hefei, China
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Role of glutathione in the efflux of selenium from cells

    • Author(s)
      Mihara H, Imai T, Kurihara T
    • Organizer
      10th International Society for Trace Element Research in Humans
    • Place of Presentation
      Keio Plaza Hotel Tokyo, Tokyo
    • Related Report
      2013 Annual Research Report
  • [Presentation] Cellulomonas sp. D3a 株が生成するセレンナノ粒子表面に結合するタンパク質の解析

    • Author(s)
      大内田竜大, 斎藤茂樹, 山本紘資, 谷泰史, 峯元高志, Prakash, N. T., 三原久明
    • Organizer
      第86回日本生化学会大会
    • Place of Presentation
      パシフィコ横浜、神奈川県
    • Related Report
      2013 Annual Research Report
  • [Presentation] Bacillus sp. NTP-1 株における亜セレン酸還元に関与する遺伝子の同定

    • Author(s)
      永野知哉, 奥田華朱美, 斎藤茂樹, 谷泰史, 峯元高志, Prakash, N. T., 三原久明
    • Organizer
      第86回日本生化学会大会
    • Place of Presentation
      パシフィコ横浜、神奈川県
    • Related Report
      2013 Annual Research Report
  • [Presentation] トランスポゾン挿入変異を用いたセレン耐性菌のセレンオキシアニオン還元機構の解明

    • Author(s)
      永野知哉、加藤正嗣、斎藤茂樹、谷泰史、N. Tejo Prakash, 三原久明
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      マリンメッセ福岡,福岡県
    • Related Report
      2012 Annual Research Report
  • [Presentation] Cellulomonas sp. D3a の亜セレン酸還元能の解析

    • Author(s)
      山際恭平,岡林拓弥,谷泰史,斎藤茂樹,N. Tejo Prakash,三原久明
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      マリンメッセ福岡,福岡県
    • Related Report
      2012 Annual Research Report
  • [Presentation] Enterobacter sp. E3b におけるセレンナノ粒子生成機構の解析

    • Author(s)
      大内田竜大、斎藤茂樹、谷泰史、峯元高志、 Prakash N. Tejo、三原久明
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      マリンメッセ福岡,福岡県
    • Related Report
      2012 Annual Research Report
  • [Book] Selenium in the Environment and Human Health2014

    • Author(s)
      Mihara, H., Kurihara, T., and Esaki, N.
    • Total Pages
      224
    • Publisher
      CRC Press
    • Related Report
      2014 Annual Research Report
  • [Book] 地球を救うメタルバイオテクノロジー2014

    • Author(s)
      三原久明
    • Total Pages
      242
    • Publisher
      成山堂
    • Related Report
      2014 Annual Research Report
  • [Book] Selenium in the Environment and Human Health2014

    • Author(s)
      Mihara H, Kurihara T, Esaki N
    • Total Pages
      224
    • Publisher
      CRC Press
    • Related Report
      2013 Annual Research Report
  • [Remarks] 研究者データベース

    • URL

      http://research-db.ritsumei.ac.jp/Profiles/64/0006361/profile.html

    • Related Report
      2015 Annual Research Report

URL: 

Published: 2011-04-06   Modified: 2019-07-29  

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