| Project/Area Number |
23380070
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Tohoku University |
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Principal Investigator |
SHIRAKAWA Hitoshi 東北大学, (連合)農学研究科(研究院), 准教授 (40206280)
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| Co-Investigator(Kenkyū-buntansha) |
KOMAI Michio 東北大学, 大学院農学研究科, 教授 (80143022)
GOTO Tomoko 東北大学, 大学院農学研究科, 助教 (00342783)
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| Project Period (FY) |
2011-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2013: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2012: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | 栄養学 / ビタミンK / メナキノンｰ４ / 生体内変換 / 抗炎症 / テストステロン産生 / 抗糖尿病作用 |
|---|
| Outline of Final Research Achievements |
A part of dietary vitamin K is converted to menaquinone-4, one of vitamin K2, in several organs in animals. However, detail of conversion system and function of synthesized menaquinone-4 have not been well elucidated. In this study, we showed that side chain substrate for menaquinone-4 synthesis is the product of mevalonate pathway. And we also showed that menaquinone-4 enhances formation of signaling complex leading to NFkB activation to express anti-inflammation activity. Vitamin K deficient diet enhanced insulin resistance in liver and showed insufficient glucose-induced insulin secretion. These results indicated that vitamin K deficient condition can promote symptom of diabetes in diabetic model animals.
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