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Development of a new type of cancer vaccine for dog malignancy

Research Project

Project/Area Number 23380186
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Clinical veterinary science
Research InstitutionThe Institute of Physical and Chemical Research

Principal Investigator

SHIMIZU Kanako  独立行政法人理化学研究所, 統合生命医科学研究センター, 上級研究員 (20391980)

Co-Investigator(Kenkyū-buntansha) MIZUNO Takuya  山口大学, 共同獣医学部, 教授 (90398826)
FUJII Shin-ichiro  独立行政法人理化学研究所, 統合生命医科学研究センター, チームリーダー (10392094)
Project Period (FY) 2011-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2013: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2012: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2011: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
Keywords癌ワクチン / 自然免疫 / 獲得免疫 / NKT細胞 / 樹状細胞
Research Abstract

To make a strategy of new type of cancer vaccine for cancer-bearing dogs, we have launched the study of canine-type adjuvant vector cells, which may link between innate and adaptive immunity. In this study, we initially have chosen the canine vector cells and determining the optimal conditions for establishing the cells. Then, when we administered it through intravenous route, we detected the immune response in immunized dogs. These results would demonstrate the important and fundamental information for applying this strategy for canine immunotherapy in future.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • Research Products

    (71 results)

All 2014 2013 2012 2011 Other

All Journal Article (22 results) (of which Peer Reviewed: 19 results) Presentation (35 results) (of which Invited: 6 results) Book (12 results) Remarks (1 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Adoptive cytotoxic T lymphocyte therapy triggers a counter-regulatory immunosuppressive mechanism via recruitment of myeloid-derived suppressor cells.2014

    • Author(s)
      Hosoi A, Matsushita H, Shimizu K, Fujii SI, Ueha S, Abe J, Kurachi M, Maekawa R, Matsushima K, Kakimi K.
    • Journal Title

      Int J Cancer.

      Volume: 134 Issue: 8 Pages: 1810-22

    • DOI

      10.1002/ijc.28506

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] NKT cells as an ideal target for anti-tumor immunotherapy2013

    • Author(s)
      Fujii S, Shimizu K, Okamoto Y, Kunii N, Nakayama T, Motohashi S, Taniguchi M
    • Journal Title

      Front. Immunol

      Volume: 4 Pages: 409-409

    • DOI

      10.3389/fimmu.2013.00409

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Invariant NKT cells induce plasmacytoid DC cross-talk with conventional DCs for efficient memory CD8+ T cell induction2013

    • Author(s)
      Shimizu K, Asakura M, Shinga J, Sato Y, Kitaha Hoshino K, Kaisho T, Schoenberger SP, Ezaki T, Fujii S
    • Journal Title

      J Immunol

      Volume: 190 Issue: 11 Pages: 5609-5619

    • DOI

      10.4049/jimmunol.1300033

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Immunotherapy with artificial adjuvant vector cells (aAVCs) : harnessing both arms of the immune response2013

    • Author(s)
      Fujii S and Shimizu K
    • Journal Title

      OncoImmunol

      Volume: 2

    • URL

      http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3654573/

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Vaccination with antigen-transfected, NKT cell ligand-loaded, human cells elicits robust in situ immune responses by dendritic cells2013

    • Author(s)
      Shimizu K, Mizuno T, Shinga J, Asakura M, Kakimi K, Ishii Y, Masuda K, Maeda T, Sugahara H, Sato Y, Matsushita H, Nishida K, Hanada KI, Dörrie J, Schaft N, Bickham K, Koike H, Ando T, Nagai R, Fujii S
    • Journal Title

      Cancer Res

      Volume: 73 Pages: 62-73

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] NKT Cells as an Ideal Anti-Tumor Immunotherapeutic.2013

    • Author(s)
      Fujii SI, Shimizu K, Okamoto Y, Kunii N, Nakayama T, Motohashi S, Taniguchi M.
    • Journal Title

      Front Immunol.

      Volume: 4 Pages: 409-409

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Immunotherapy with artificial adjuvant vector cells2013

    • Author(s)
      Fujii S and Shimizu K.
    • Journal Title

      OncoImmunology

      Volume: 2

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regeneration of Human Tumor Antigen-Specific T Cells from iPSCs Derived from Mature CD8+ T Cells2013

    • Author(s)
      Vizcardo, R
    • Journal Title

      Cell Stem Cell

      Volume: 12 Issue: 1 Pages: 31-36

    • DOI

      10.1016/j.stem.2012.12.006

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Vaccination with antigen-transfected, NKT cell ligand-loaded, human cells elicits robust in situ immune responses by dendritic cells.2013

    • Author(s)
      Shimizu K, Mizuno T, Shinga J, Asakura M, Kakimi K, Ishii Y, Masuda K, Maeda T, Sugahara H, Sato Y, Matsushita H, Nishida K, Hanada K, Dorrie J, Schaft N, Bickham K, Koike H, Ando T, Nagai R, Fujii S.
    • Journal Title

      Cancer Res.

      Volume: 73(1) Issue: 1 Pages: 62-73

    • DOI

      10.1158/0008-5472.can-12-0759

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Vaccination with antigen-transfected, NKT cell ligand-loaded, human cells elicits robust in situ immune responses by dendritic cells.2013

    • Author(s)
      Shimizu Kanako
    • Journal Title

      Cancer Research

      Volume: 73 Pages: 62-73

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 生体内樹状細胞を標的とする人工アジュバントベクター細胞の開発2013

    • Author(s)
      藤井 眞一郎
    • Journal Title

      医学のあゆみ

      Volume: 244 Pages: 837-842

    • Related Report
      2012 Annual Research Report
  • [Journal Article] Accumulation of Activated Invariant Natural Killer T Cells in the Tumor Microenvironment after α-Galactosylceramide-Pulsed Antigen Presenting Cells.2012

    • Author(s)
      Nagato K, Motohashi S, Ishibashi F, Okita K, Yamasaki K, Moriya Y, Hoshino H, Yoshida S, Hanaoka H, Fujii SI, Taniguchi M, Yoshino I, Nakayama T.
    • Journal Title

      J Clin Immunol.

      Volume: 32 Issue: 5 Pages: 1071-81

    • DOI

      10.1007/s10875-012-9697-9

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Induced pluripotency as a potential path towards iNKT cell-mediated cancer immunotherapy.2012

    • Author(s)
      Watarai H, Yamada D, Fujii S, Taniguchi M, Koseki H.
    • Journal Title

      Int J Hematol.

      Volume: 95 Issue: 6 Pages: 624-31

    • DOI

      10.1007/s12185-012-1091-0

    • NAID

      10030793480

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] <i>Ehrlichia canis</i> Infection in Two Dogs that Emigrated from Endemic Areas2012

    • Author(s)
      Baba K, et al
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: 74 Issue: 6 Pages: 775-778

    • DOI

      10.1292/jvms.11-0401

    • NAID

      130002090067

    • ISSN
      0916-7250, 1347-7439
    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of High-Grade B-Cell Lymphoma Concurrent with T-Cell Chronic Lymphocytic Leukemia in a Dog2012

    • Author(s)
      Okawa T, et al
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: 74 Issue: 5 Pages: 677-680

    • DOI

      10.1292/jvms.11-0453

    • NAID

      130001879878

    • ISSN
      0916-7250, 1347-7439
    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prolonged antitumor NK cell reactivity elicited by CXCL-10-expressing dendritic cells licensed by CD40L^+ CD4^+ memory T cells2011

    • Author(s)
      Shimizu K, Asakura M, Fujii S
    • Journal Title

      J.Immunol.

      Volume: 186 Issue: 10 Pages: 5927-5937

    • DOI

      10.4049/jimmunol.1003351

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CD169-positive macrophages dominate antitumor immunity by crosspresenting dead cell-associated antigens2011

    • Author(s)
      Asano K, et al
    • Journal Title

      Immunity

      Volume: 34 Issue: 1 Pages: 85-95

    • DOI

      10.1016/j.immuni.2010.12.011

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Destruction of salivary and lacrimal glands by T1 polarized reaction in a model of secondary Sjogren' s Syndrome in lupus-prone female NZB_xNZWF_1 mice.2011

    • Author(s)
      Hayashi T, Shimoyama N, Mizuno T.
    • Journal Title

      Inflammation

      Volume: (In press) Issue: 2 Pages: 638-646

    • DOI

      10.1007/s10753-011-9356-y

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neutropenia Associated with Osteomyelitis due to Hepatozoon canis Infection in a Dog2011

    • Author(s)
      Shimokawa Miyama T, et al
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: 73 Issue: 10 Pages: 1389-1393

    • DOI

      10.1292/jvms.11-0202

    • NAID

      130000868268

    • ISSN
      0916-7250, 1347-7439
    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of monoclonal antibodies against canine P-selectin glycoprotein ligand-1 (PSGL-1)2011

    • Author(s)
      Umeki S, et al
    • Journal Title

      Vet Immunol Immunopathol

      Volume: 142(1-2) Issue: 1-2 Pages: 119-125

    • DOI

      10.1016/j.vetimm.2011.04.009

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 樹状細胞によって誘導される長期に持続する抗腫瘍NK細胞機構2011

    • Author(s)
      藤井眞一郎, 清水佳奈子
    • Journal Title

      実験医学

      Volume: 29 Pages: 2760-2766

    • Related Report
      2011 Annual Research Report
  • [Journal Article] 慢性骨髄性白血病の免疫能と免疫増強2011

    • Author(s)
      藤井眞一郎、佐藤悠輔、清水佳奈子
    • Journal Title

      Biotherapy

      Volume: 25 Pages: 723-728

    • Related Report
      2011 Annual Research Report
  • [Presentation] The cross-talk between plasmacytoid DC and conventional DCs shapes the anti-tumor memory CD8^+T cells2013

    • Author(s)
      Shimizu K, Shinga J, Yamasaki S, Sato Y, Asakura M, Fujii S
    • Organizer
      The cross-talk between plasmacytoid DC and conventional DCs shapes the anti-tumor memory CD8+T cells
    • Place of Presentation
      Milan, Italy
    • Related Report
      2013 Final Research Report
  • [Presentation] The cross-talk between plasmacytoid DC and conventional DCs shapes the memory CD8^+ T cells2013

    • Author(s)
      Shimizu K, Sato Y, Yamasaki S, Fujii S
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      (横浜) ワークショップ
    • Related Report
      2013 Final Research Report
  • [Presentation] Long-term memory T cell response induced by adjuvant role of iNKT cells.2013

    • Author(s)
      Kanako Shimizu, Yusuke Sato, Jun Shinga, Miki Asakura, Tsuneyasu Kaisyo, Satoru Yamasaki, Shin-ichiro Fujii.
    • Organizer
      第42回日本免疫学会学術集会
    • Place of Presentation
      幕張
    • Related Report
      2013 Annual Research Report
  • [Presentation] The cross-talk between plasmacytoid DC and conventional DCs shapes the memory CD8⁺ T cells.2013

    • Author(s)
      Kanako Shimizu, Yusuke Sato, Satoru Yamasaki, Shin-ichiro Fujii.
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] 5. Shin-ichiro Fujii, Yusuke Sato, Jun Shinga, Miki Asakura, Kanako Shimizu. Long-term memory T cell response induced by adjuvant role of iNKT cells.2013

    • Author(s)
      Shin-ichiro Fujii, Yusuke Sato, Jun Shinga, Miki Asakura, Kanako Shimizu.
    • Organizer
      7th International symposium on CD1 and NKT cells
    • Place of Presentation
      Tours, France
    • Related Report
      2013 Annual Research Report
  • [Presentation] The cross-talk between plasmacytoid DC and conventional DCs shapes the anti-tumor memory CD8⁺ T cells.2013

    • Author(s)
      Kanako Shimizu, S. Fujii.
    • Organizer
      15th International Congress of Immunology
    • Place of Presentation
      Milan, Italy
    • Related Report
      2013 Annual Research Report
  • [Presentation] The cross-talk between plasmacytoid DC and conventional DCS shapes the anti-tumor memory CD8⁺ T cells.2013

    • Author(s)
      Shin-ichiro Fujii , Kanako Shimizu
    • Organizer
      78th Cold Spring Harbor Symposium on Quantitative Biology Immunity & Tolerance
    • Place of Presentation
      Cold Spring Harbor, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] Licensing by Invariant NKT cells Harnesses the Power of the Dendritic Cells(DCs)2013

    • Author(s)
      Kanako Shimizu and Shin-ichiro Fujii
    • Organizer
      4th JSH International Symposium 2013 in EHIME.
    • Place of Presentation
      松山
    • Related Report
      2013 Annual Research Report
  • [Presentation] 自然免疫と獲得免疫を連結する人工アジュバントベクター細胞の開発.2013

    • Author(s)
      藤井眞一郎
    • Organizer
      サイエンス イン 品川
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 人工アジュバントベクター細胞の開発2012

    • Author(s)
      清水佳奈子*, 朝倉三貴, 信賀順, 佐藤悠輔, 藤井眞一郎
    • Organizer
      第4回造血器腫瘍免疫療法研究会学術集会
    • Place of Presentation
      (金沢)ワークショップ
    • Year and Date
      2012-08-18
    • Related Report
      2013 Final Research Report
  • [Presentation] Vaccination with mRNA-transfected, NKT cell ligand-loaded, human vector cells elicits robust immune responses through in situ dendritic cell (DC) maturation2012

    • Author(s)
      Shimizu K, Mizuno T, Shinga J, Asakura M, Kakimi K, Sato Y, Fujii S
    • Organizer
      12th International Symposium on Dendritic Cells
    • Place of Presentation
      Daegu, Korea
    • Related Report
      2013 Final Research Report
  • [Presentation] Long-term memory T cell response induced by adjuvant role of iNKT cells2012

    • Author(s)
      Shimizu K, Asakura M, Shinga J, Sato Y, Hoshino K, Kaisho T, Ezaki T, Fujii S
    • Organizer
      第41回日本免疫学会学術集会
    • Place of Presentation
      (神戸) ポスター
    • Related Report
      2013 Final Research Report
  • [Presentation] 生体内樹状細胞を標的とした人工アジュバントベクター細胞の開発2012

    • Author(s)
      清水佳奈子, 朝倉三貴, 信賀順, 水野拓也, 垣見和宏, 佐藤悠輔, 藤井眞一郎*
    • Organizer
      第16回日本がん免疫学会総会
    • Place of Presentation
      (札幌)シンポジスト
    • Related Report
      2013 Final Research Report
  • [Presentation] Vaccination with mRNA-transfected, NKT cell ligand-loaded, human vector cells elicits robust immune responses through in situ dendritic cell (DC) maturation2012

    • Author(s)
      Shimizu Kanako
    • Organizer
      The 12th International Symposium on Dendritic Cells Conference
    • Place of Presentation
      Daegu, Korea
    • Related Report
      2012 Annual Research Report
  • [Presentation] Development of anti-tumor artificial adjuvant vector cells targeting in situ dendritic cells2012

    • Author(s)
      Shimizu Kanako
    • Organizer
      日本血液学会
    • Place of Presentation
      京都
    • Related Report
      2012 Annual Research Report
  • [Presentation] New type of anti-tumor immunotherapy using invariant NKT cell-induced DC activation in situ2012

    • Author(s)
      Fujii Shin-ichiro
    • Organizer
      7th RCAI-JSI International Symposium on Immunology 2012
    • Place of Presentation
      Yokoahama
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Prolonged anti-tumor natural killer cell reactivity elicited by CXCL10-expressing dendritic cells licensed by CD4+ effector memory T cells2011

    • Author(s)
      Shimizu K, Asakura M, Fujii S-I
    • Organizer
      第40回日本免疫学会総会学術集会
    • Place of Presentation
      千葉
    • Year and Date
      2011-11-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] 腫瘍増加に伴う腫瘍局所とリンパ組織における骨髄由来抑制細胞の免疫能の評価2011

    • Author(s)
      Sato Y, Shimizu K, Asakura M, Singa J, Sugahara H, Fujii S-I
    • Organizer
      第40回日本免疫学会総会学術集会
    • Place of Presentation
      千葉
    • Year and Date
      2011-11-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] New type of immunotherapy using NKT cell-induced DC activation insitu2011

    • Author(s)
      Fujii S
    • Organizer
      The 73^<rd> Annual Meeting of the Japanese Society of Hematology
    • Place of Presentation
      名古屋(招待講演)
    • Year and Date
      2011-10-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] Development of anti-tumor artificial adjuvant vector cells linking innate and adaptive immunity2011

    • Author(s)
      Shimizu K, et al
    • Organizer
      The 73^<rd> Annual Meeting of the Japanese Society of Hematology
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] New type of immunotherapy using artificial adjuvant vector cells (aAVCs) linking innate and adaptive immunity2011

    • Author(s)
      Fujii S
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋(招待講演)
    • Year and Date
      2011-10-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] Development of anti-tumor artificial adjuvant vector cells linking innate and adaptive immunity2011

    • Author(s)
      Shimizu K, et al
    • Organizer
      第15回日本癌免疫学会総会
    • Place of Presentation
      吹田
    • Year and Date
      2011-06-30
    • Related Report
      2011 Annual Research Report
  • [Presentation] Prolonged anti-tumor natural killer cell reactivity elicited by CXCL10-expressing dendritic cells licensed by CD4+ effector memory T cells2011

    • Author(s)
      Shimizu K, Asakura M, Fujii S
    • Organizer
      第40回日本免疫学会総会学術集会
    • Place of Presentation
      (千葉) ワークショップ
    • Related Report
      2013 Final Research Report
  • [Presentation] Development of anti-tumor artificial adjuvant vector cells linking innate and adaptive immunity2011

    • Author(s)
      Shimizu K, Asakura M, Sugahara H, Shinga J, Fujii S
    • Organizer
      第73回日本血液学会総会
    • Place of Presentation
      (名古屋) ワークショップ
    • Related Report
      2013 Final Research Report
  • [Presentation] 自然免疫賦活による記憶免疫誘導2011

    • Author(s)
      清水佳奈子, 朝倉三貴, 信賀順, 菅原英俊, 佐藤悠輔, 藤井眞一郎
    • Organizer
      第3回造血器腫瘍免疫療法研究会学術集会
    • Place of Presentation
      別府, ワークショップ
    • Related Report
      2013 Final Research Report
  • [Presentation] Development of anti-tumor artificial adjuvant vector cells linking innate and adaptive immunity2011

    • Author(s)
      Shimizu K, Sugahara H, Shinga J, Kakimi K, Mizuno T, Asakura M, Fujii S
    • Organizer
      第15回日本癌免疫学会総会
    • Place of Presentation
      (吹田)ワークショップ
    • Related Report
      2013 Final Research Report
  • [Presentation] Immunotherapy with antigen mRNA transfected, allogeneic cells loaded with NKT cell ligand as artificial adjuvant vector cells (aAVCs) link innate and adaptive immunity2011

    • Author(s)
      Fujii S. Shinga J, et al
    • Organizer
      International Symposium on Synthesizing Life and Biological Systems
    • Place of Presentation
      吹田
    • Related Report
      2011 Annual Research Report
  • [Presentation] Immunotherapy with antigen mRNA transfected, allogeneic human cells loaded with NKT cell ligand as artificial adjuvant vector cells (aAVCs) link innate and adaptive immunity2011

    • Author(s)
      Fujii S, et al
    • Organizer
      6^<th> International Symposium on CD1 and NKT Cells
    • Place of Presentation
      Chicago, IL.USA
    • Related Report
      2011 Annual Research Report
  • [Presentation] 抗原mRNAとNKTリガンドを提示させた人工アジュバントベクター細胞開発による新規免疫療法のコンセプト2011

    • Author(s)
      藤井眞一郎, 他
    • Organizer
      第3回造血器腫瘍免疫療法研究会学術集会
    • Place of Presentation
      別府
    • Related Report
      2011 Annual Research Report
  • [Presentation] 自然免疫賦活による記憶免疫誘導2011

    • Author(s)
      清水佳奈子, 他
    • Organizer
      第3回造血器腫瘍免疫療法研究会学術集会
    • Place of Presentation
      別府
    • Related Report
      2011 Annual Research Report
  • [Presentation] 人工アジュバントベクター細胞の開発

    • Author(s)
      清水佳奈子
    • Organizer
      造血器腫瘍免疫療法研究会
    • Place of Presentation
      金沢
    • Related Report
      2012 Annual Research Report
  • [Presentation] New type of anti-tumor immunotherapy using invariant NKT cell-induced DC activation in situ

    • Author(s)
      Fujii Shin-ichiro
    • Organizer
      Dr. Steinman Memorial Scientific Symposium
    • Place of Presentation
      New York, USA
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 先端的ながん免疫治療となる人工細胞ワクチンの有用性と、その実用化について

    • Author(s)
      藤井眞一郎
    • Organizer
      理研第1回先端社会シンポジウムー科学が紡ぐ未来
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 新規癌ワクチンを目指した人工アジュバントベクター細胞の開発

    • Author(s)
      藤井眞一郎
    • Organizer
      東京薬科大ライフサイエンスセミナー
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 自然免疫と獲得免疫を誘導するワクチンの開発

    • Author(s)
      藤井眞一郎
    • Organizer
      星薬科大セミナーシリーズ
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Book] 人工アジュバントベクター細胞による癌免疫治療 血液フロンティア2013

    • Author(s)
      藤井眞一郎, 信賀順, 清水佳奈子
    • Related Report
      2013 Final Research Report
  • [Book] がん抗原ワクチン 実験医学2013

    • Author(s)
      藤井眞一郎, 山崎哲, 佐藤悠輔, 清水佳奈子
    • Related Report
      2013 Final Research Report
  • [Book] 臨床免疫・アレルギー科2013

    • Author(s)
      藤井眞一郎
    • Total Pages
      10
    • Publisher
      科学評論社
    • Related Report
      2013 Annual Research Report
  • [Book] 血液フロンティア2013

    • Author(s)
      藤井眞一郎、信賀順、清水佳奈子
    • Total Pages
      9
    • Publisher
      医薬ジャーナル社
    • Related Report
      2013 Annual Research Report
  • [Book] 実験医学2013

    • Author(s)
      藤井眞一郎、山崎哲、佐藤悠輔、清水佳奈子
    • Total Pages
      6
    • Publisher
      羊土社
    • Related Report
      2013 Annual Research Report
  • [Book] 医学の歩み2013

    • Author(s)
      藤井眞一郎
    • Total Pages
      6
    • Publisher
      医歯薬出版株式会社
    • Related Report
      2013 Annual Research Report
  • [Book] 樹状細胞によるNK 細胞の長期活性化 臨床免疫・アレルギー科2012

    • Author(s)
      藤井眞一郎, 清水佳奈子
    • Related Report
      2013 Final Research Report
  • [Book] 樹状細胞によるNK 細胞, NKT 細胞の抗腫瘍作用増強 臨床免疫・アレルギー科2012

    • Author(s)
      清水佳奈子, 藤井眞一郎
    • Related Report
      2013 Final Research Report
  • [Book] Natural killer T cells : Balancing the regulation of tumor immunity2012

    • Author(s)
      Fujii S, Shimizu K
    • Publisher
      Springer
    • Related Report
      2011 Annual Research Report
  • [Book] Natural killer T cells : Balancing the regulation of tumor immunity2012

    • Author(s)
      Taniguchi M, Fujii S, Nakayama T, Motohashi S, Dashtsoodol N, Watarai H, Harada M
    • Publisher
      Springer
    • Related Report
      2011 Annual Research Report
  • [Book] 樹状細胞によって誘導される長期に持続する抗腫瘍NK 細胞機構 実験医学2011

    • Author(s)
      藤井眞一郎, 清水佳奈子
    • Related Report
      2013 Final Research Report
  • [Book] 慢性骨髄性白血病の免疫能と免疫増強 Biotherapy2011

    • Author(s)
      藤井眞一郎, 佐藤悠輔, 清水佳奈子
    • Related Report
      2013 Final Research Report
  • [Remarks] プレスリリース 自然免疫と獲得免疫の両方を活性化させるがん免疫療法を開発

    • URL

      http://www.riken.go.jp/pr/press/2012/20121226/

    • Related Report
      2012 Annual Research Report
  • [Patent(Industrial Property Rights)] ウィルムス腫瘍遺伝子産物またはその断片をコードしている改変型核酸構築物を含んでいる細胞、頭蓋細胞の製造方法、当該核酸構築物(改変型ウィルムス腫瘍遺伝子産物またはその断片が導入された細胞)2011

    • Inventor(s)
      藤井眞一郎、清水佳奈子、信賀順
    • Industrial Property Rights Holder
      理化学研究所
    • Industrial Property Number
      2011-167796
    • Filing Date
      2011-07-29
    • Related Report
      2011 Annual Research Report

URL: 

Published: 2011-04-06   Modified: 2019-07-29  

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