Development of a new type of cancer vaccine for dog malignancy
| Project/Area Number |
23380186
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Clinical veterinary science
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
SHIMIZU Kanako 独立行政法人理化学研究所, 統合生命医科学研究センター, 上級研究員 (20391980)
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| Co-Investigator(Kenkyū-buntansha) |
MIZUNO Takuya 山口大学, 共同獣医学部, 教授 (90398826)
FUJII Shin-ichiro 独立行政法人理化学研究所, 統合生命医科学研究センター, チームリーダー (10392094)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2013: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2012: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2011: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
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| Keywords | 癌ワクチン / 自然免疫 / 獲得免疫 / NKT細胞 / 樹状細胞 |
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| Research Abstract |
To make a strategy of new type of cancer vaccine for cancer-bearing dogs, we have launched the study of canine-type adjuvant vector cells, which may link between innate and adaptive immunity. In this study, we initially have chosen the canine vector cells and determining the optimal conditions for establishing the cells. Then, when we administered it through intravenous route, we detected the immune response in immunized dogs. These results would demonstrate the important and fundamental information for applying this strategy for canine immunotherapy in future.
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Report
(4 results)
Research Products
(71 results)
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[Journal Article] Myeloid cell-derived soluble IL-6 receptor diminishes the differentiation of tumor-specific Th1 cells to exacerbate tumor progression2017
Author(s)
Shinojima N, Hossain A, Takezaki T, Fueyo J, Gumin J, Gao F, Nwajei F, Marini FC, Andreeff M, Kuratsu J, Lang FF.
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Journal Title
Cancer Res.
Volume: 73(7)
Pages: 1311-1318
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Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Vaccination with antigen mRNA-transfected, NKT cell ligand-loaded, human vector cells elicits robust in situ immune responses by dendritic cells2013
Author(s)
Shimizu K, Mizuno T, Shinga J, Asakura M, Kakimi K, Ishii Y, Masuda K, Maeda T, Sugahara H, Sato Y, Matsushita H, Nishida K, Hanada K, Dorrie J, Schaft N, Bickham K, Koike H, Ando T, Nagai R, Fujii S.
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Journal Title
Cancer Res
Volume: 73(1)
Pages: 62-73
DOI
Related Report
Peer Reviewed
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[Journal Article] Accumulation of activated invariant natural killer T cells in the tumor microenvironment after α-Galactosylceramide-pulsed antigen presenting cells.2012
Author(s)
Nagato K, Motohashi S, Ishibashi F, Okita K, Yamasaki K, Moriya Y, Hoshino H, Yoshida S, Hanaoka H, Fujii SI, Taniguchi M, Yoshino I, Nakayama T.
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Journal Title
J Clin Immunol
Volume: 32
Pages: 1071-1081
DOI
Related Report
Peer Reviewed
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[Book] 実験医学2013
Author(s)
藤井眞一郎、山崎哲、佐藤悠輔、清水佳奈子
Total Pages
6
Publisher
羊土社
Related Report
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