Positive feedback mechanism for the regulation of intracellular Ca2+ concentration and related ion channels as novel drug targets
| Project/Area Number |
23390020
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Nagoya City University |
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Principal Investigator |
IMAIZUMI Yuji 名古屋市立大学, 薬学研究科(研究院), 教授 (60117794)
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| Co-Investigator(Kenkyū-buntansha) |
OHYA Susumu 京都薬科大学, 薬学部, 教授 (70275147)
YAMAMURA Hisao 名古屋市立大学, 薬学研究科, 准教授 (80398362)
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| Co-Investigator(Renkei-kenkyūsha) |
HIGUCHI Tsunehiko 名古屋市立大学, 薬学研究科, 教授 (50173159)
ASAI Kiyofumi 名古屋市立大学, 医学研究科, 教授 (70212462)
HIRONO Syuichi 北里大学, 薬学部, 教授 (30146328)
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| Project Period (FY) |
2011-11-18 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
Fiscal Year 2013: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
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| Keywords | 薬理学 / イオンチャネル / 非興奮性細胞 / カルシウム活性化カリウムチャネル / 正帰還カルシウム制御機構 / 細胞内カルシウム動態 / 発現調節 / ストア作動性カルシウムチャネル / 薬理 / ストア作動性カルシウム流入 / カリウムチャネル / カルシウムチャネル / イオンチャネル標的創薬 / ストア依存性カルシウム流入 / 分子イメージング |
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| Research Abstract |
The present study revealed that, in non-excitable cells such as endothelial cells, lymphocytes, chondrocytes and airway cilliated cell, Ca2+-activated K+ (KCa) channels and store-operated Ca2+ (SOC) channels play significant roles in the positive feedback mechanism for the regulation of intracellular Ca2+ concentration ([Ca2+]i). This [Ca2+]i elevation elicites cellular responses to various types of stimula under physiological conditions or is involved in pathological processes. In brain capillary endothelial cells and chondrocytes, Ca2+-release activated Ca2+ channel is a major component of SOC channels and regulates cell proliferation. In T lymphocytes isolated from inflammatory disease model mice, the change in expression level of intermediate-conductance KCa channel is related to pathological processes. In ciliated cells, ATP-sensitive K+ channel contribute to the positive feedback mechanism for [Ca2+]i, and facilitate ciliary movement and consequently promote airway clearance.
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Report
(4 results)
Research Products
(138 results)
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[Journal Article] Up-regulation of KCa3.1 K^+ channel in mesenteric lymph node CD4^+ T-lymphocytes from a mouse model of dextran sodium sulfate-induced inflammatory bowel disease2014
Author(s)
Ohya S, Fukuyo Y, Kito H, Shibaoka R, Matsui M, Niguma H, Maeda Y, Yamamura H, Fujii M, Kimura K, Imaizumi Y
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Journal Title
Am J Physiol Gastrointest Liver Physiol
Volume: in press
Issue: 10
Pages: G873-G885
DOI
Related Report
Peer Reviewed
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[Journal Article] Facilitated hyperpolarization signaling in vascular smooth muscle overexpressing TRIC-A channels.2013
Author(s)
Tao, S., Yamazaki, D., Komazaki, S., Zhao, C., Iida, T., Kakizawa, S., Imaizumi, Y. & Takeshima, H.
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Journal Title
J. Biol. Chem.
Volume: 288
Issue: 22
Pages: 15581-15589
DOI
Related Report
Peer Reviewed
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[Journal Article] TRIC-A channels in vascular smooth muscle contribute to blood pressure maintenance2011
Author(s)
Yamazaki D, Tabara Y, Kita S, Hanada H, Komazaki S, Naitou D, Mishima A, Nishi M, Yamamura H, Yamamoto S, Kakizawa S, Miyachi H, Yamamoto S, Miyata T, Kawano Y, Kamide K, Ogihara T, Hata A, Umemura S, Soma M, Takahashi N, Imaizumi Y, Miki T, Iwamoto T, Ta
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Journal Title
Cell Metab
Volume: 14
Issue: 2
Pages: 231-241
DOI
NAID
URL
Related Report
Peer Reviewed
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