| Project/Area Number |
23390028
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Drug development chemistry
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| Research Institution | Kumamoto University |
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Principal Investigator |
OTSUKA Masami 熊本大学, 大学院生命科学研究部(薬), 教授 (40126008)
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| Co-Investigator(Renkei-kenkyūsha) |
FUJITA Mikako 熊本大学, 薬学部, 准教授 (00322256)
OKAMOTO Yoshinari 熊本大学, 大学院・生命科学研究部, 助教 (20194409)
ANRAKU Kensaku 熊本保健科学大学, 保健科学部, 講師 (80389543)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2013: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2012: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2011: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
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| Keywords | ＰＩ３Ｋ／Ａｋｔ経路 / ＴＧＦ‐β／Ｓｍａｄ経路 / 脳保護 / 癌 / 強皮症 / PI3K/Akt経路 / TGF-b/Smad経路 / PI3K/Akt 経路 / TGF-b/Smad 経路 / TGF-β/Smad経路 |
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| Research Abstract |
The present study aimed at the design and synthesis of activators of the PI3K/Akt pathway and inhibitors of the TGF-b/Smad pathway to develop drugs to regulate the crosstalk of the two pathways. Targeting the PI3K/Akt pathway, compounds comprising inositol phosphate and diacyl glycerol moiety were synthesized. Targeting the TGF-b/Smad pathway, compounds comprising the pyridine and metal-binding side chains were synthesized. These compounds could be useful as brain-protecting agents, drugs for diabetes, cancer, cancer metastasis, and scleroderma.
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