| Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2013: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2012: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2011: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
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| Research Abstract |
Various chemicals such as the agrichemicals, industrial materials, and pharmaceuticals have been used in the worldwide. It is important to assess the risk of chemicals for humans. However, the risk assessment using experimental animals could not be enough due to species differences of toxicity between animals and humans. In this study, we conducted the risk assessment using chimeric mice with humanized liver to estimate toxicity in the human liver. It would be possible to estimate the risk assessment (hepatotoxicity) in consideration of plasma concentrations at which hepatotoxicity is observed because the predictability of pharmacokinetics of chemicals (drugs) is good in chimeric mice.
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