| Project/Area Number |
23390146
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Laboratory medicine
|
|---|
| Research Institution | Gunma University |
|---|
Principal Investigator |
MURAKAMI Masami 群馬大学, 医学(系)研究科(研究院), 教授 (30241871)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
SUMINO Hiroyuki 群馬大学, 医学部附属病院, 講師 (10375579)
TSUNEKAWA Katsuhiko 群馬大学, 大学院・医学系研究科, 助教 (30436307)
OGIWARA Takayuki 群馬大学, 医学部附属病院, 助教 (80361377)
ARAKI Osamu 群馬大学, 医学部附属病院, 助教 (80589482)
KIMURA Takao 群馬大学, 大学院・医学系研究科, 講師 (90396656)
NARA Makoto 群馬大学, 医学部附属病院, 助教 (80420165)
森村 匡志 群馬大学, 医学部, 助教 (20436306)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
LEZHAVA Alexander 独立行政法人理化学研究所, 研究員 (40443048)
|
|---|
| Project Period (FY) |
2011-04-01 – 2014-03-31
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥15,470,000 (Direct Cost: ¥11,900,000、Indirect Cost: ¥3,570,000)
Fiscal Year 2013: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
|
|---|
| Keywords | 糖尿病 / 遺伝子 / 一塩基多型 / インスリン / 甲状腺ホルモン |
|---|
| Research Abstract |
Single nucleotide polymorphism (SNP) in type 2 iodothyronine deiodinase (D2) was found to be related to the impairment of insulin secretion and exercise induced improvement of glucose tolerance. We have indntified type 2 and type 3 iodothyronine deiodinase (D2, D3) in a mouse insulinoma cell line (MIN-6). D2 activates thyroid hormone by catalyzing conversion of T4 to T3, and D3 inactivates thyroid hormone by catalyzing conversion of T4 to rT3, and T3 to T2. Glucagon-like peptide 1 (GLP-1) stimulates D3 and D2 in MIN-6 cells. These results suggest GLP-1 regulated thyroid hormone metabolism is involved in the regulation of insulin secretion in pancreatic beta cells, which may be related to the pathophysiology of diabates mellitus.
|
