The model for fragility fracture predictions: a 15-year follow-up study of the Japanese Population-based Osteoporosis (JPOS) Cohort Study.

• Project/Area Number: 23390180
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Public health/Health science
• Research Institution: Osaka Medical College (2013); Kinki University (2011-2012)
• Principal Investigator: TAMAKI Junko 大阪医科大学, 医学部, 教授 (90326356)
• Co-Investigator(Kenkyū-buntansha): IKI Masayuki 近畿大学, 医学部, 教授 (50184388) ; SATO Yuho 仁愛大学, 生活科学学科, 教授 (10337115)
• Project Period (FY): 2011-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2012: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2011: ¥12,480,000 (Direct Cost: ¥9,600,000、Indirect Cost: ¥2,880,000)
• Keywords: 骨折 / 骨粗鬆症 / リスク評価 / 無作為標本 / 前向きコホート研究 / 地域保健

Research Abstract

We conducted the 15-year follow-up survey of JPOS Cohort Study.
Bone microarchitecture assessed by trabecular bone score (TBS) could predict for 10-year risk of major osteoporotic fractures independently of FRAX® score. Neither bone turnover markers were associated with the fracture risk independently of FRAX® score. Lumbar spine bone mineral density, TBS, bone turnover markers, previous fragility fractures, and secondary osteoporosis were significantly associated with a risk of vertebral fractures.

Research Products

• [Journal Article] Cohort Profile : The Japanese Population-based Osteoporosis (JPOS) Cohort Study (2014)
  • Author(s): Iki M, Tamaki J, Sato Y, Morita A, Ikeda Y, Kajita E, Nishino H, Akiba T, Matsumoto T, Kagamimori S, Kagawa Y, Yoneshima H
  • Journal Title: International Journal of Epidemiology Volume: 84 Issue: 2 Pages: 1-10
  • DOI: 10.1093/ije/dyu084
  • Peer Reviewed / Open Access
• [Journal Article] Trabecular bone score (TBS) predicts vertebral fractures in Japanese women over 10 years independently of bone density and prevalent vertebral deformity : the Japanese Population-Based Osteoporosis (JPOS) cohort study (2014)
  • Author(s): Iki M, Tamaki J, Kadowaki E, Sato Y, Dongmei N, Winzenrieth R, Kagamimori S, Kagawa Y, Yoneshima H
  • Journal Title: Journal of Bone and Mineral Research Volume: 29 Issue: 2 Pages: 399-407
  • DOI: 10.1002/jbmr.2048
  • Peer Reviewed
• [Journal Article] Trabecular bone score (TBS) predicts vertebral fractures in Japanese women over 10 years independently of bone density and prevalent vertebral deformity: the Japanese Population-Based Osteoporosis (JPOS) cohort study. (2014)
  • Author(s): Iki M, Tamaki J, Kadowaki E, Sato Y, Dongmei N, Winzenrieth R, Kagamimori S, Kagawa Y, Yoneshima H.
  • Journal Title: J Bone Miner Res. Volume: 29巻 Pages: 399-407
  • Peer Reviewed
• [Journal Article] Biochemical markers for bone turnover predict risk of vertebral fractures in postmenopausal women over 10 years : the Japanese Population-based Osteoporosis (JPOS) Cohort Study (2013)
  • Author(s): Tamaki J, Iki M, Kadowaki E, Sato Y, Chiba Y, Akiba T, Matsumoto T, Nishino H, Kagamimori S, Kagawa Y, Yoneshima H; JPOS Study Group
  • Journal Title: Osteoporosis International Volume: 24 Issue: 3 Pages: 887-897
  • DOI: 10.1007/s00198-012-2106-7
  • Peer Reviewed
• [Journal Article] Biochemical markers for bone turnover predict risk of vertebral fractures in postmenopausal women over 10 years: the Japanese Population-based Osteoporosis (JPOS) Cohort Study. (2013)
  • Author(s): Tamaki J, Iki M, Kadowaki E, Sato Y, Chiba Y, Akiba T, Matsumoto T, Nishino H, Kagamimori S, Kagawa Y, Yoneshima H; JPOS Study Group.
  • Journal Title: Osteoporos Int. Volume: 24巻 Pages: 887-897
  • Peer Reviewed
• [Presentation] 無作為抽出標本の15年間追跡データを用いたFRAX[〇!R]の有用性の検討-JPOS Cohort Study (2014)
  • Author(s): 玉置淳子
  • Organizer: 第24回疫学会総会
  • Place of Presentation: 仙台
  • Year and Date: 2014-01-24
• [Presentation] 体脂肪分布パターンと糖尿病および心血管疾患のリスク要因との関連 : 二重エネルギーX線吸収法による検討 (2013)
  • Author(s): 冬海
  • Organizer: 第23回日本疫学会学術総会
  • Place of Presentation: 吹田市
  • Year and Date: 2013-01-26
• [Presentation] 閉経女性における体組成と骨密度の関連-JPOS Study 15 年次調査による閉経後年数別検討 (2012)
  • Author(s): 玉置淳子
  • Organizer: 第71回日本公衆衛生学会
  • Place of Presentation: 山口市
  • Year and Date: 2012-10-26
• [Presentation] 無作為抽出標本の1５年間追跡データを用いたFRAX®の有用性の検討-JPOS Cohort Study
  • Author(s): 玉置淳子、伊木雅之、由良晶子、梶田悦子、佐藤裕保、鏡森定信、香川芳子、米島秀夫、JPOS Study Group.
  • Organizer: 第24回疫学会総会
  • Place of Presentation: 仙台
• [Presentation] 閉経女性における体組成と骨密度の関連-JPOS Study 15年次調査による閉経後年数別検討
  • Author(s): 玉置淳子、伊木雅之、冬海、由良晶子、甲田勝康、藤田裕規、佐藤裕保、梶田悦子、中谷芳美、鏡森定信、香川芳子、米島秀夫
  • Organizer: 第71回日本公衆衛生学会
  • Place of Presentation: 山口市
• [Presentation] 体脂肪分布パターンと糖尿病および心血管疾患のリスク要因との関連：二重エネルギーＸ線吸収法による検討
  • Author(s): 冬海、甲田勝康、玉置淳子、伊木雅之、鏡森定信、香川芳子、米島秀夫
  • Organizer: 第23回日本疫学会学術総会
  • Place of Presentation: 吹田市
• [Remarks] JPOS 研究のホームページを作成した
  • URL: http://www.med.kindai.ac.jp/pubheal/jpos/index.html
• [Remarks] The JPOS Study
  • URL: http://www.med.kindai.ac.jp/pubheal/jpos/index.htm