Development of cell-based therapy using dedifferentiated fat cells for treatment of intractable diseases in elderly patients
| Project/Area Number |
23390190
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General internal medicine (including Psychosomatic medicine)
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| Research Institution | Nihon University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KANO Koichiro 日本大学, 生物資源科学部, 教授 (80271039)
NORO Chikako 日本大学, 生産工学部, 教授 (80311356)
ISHIGE Mika 日本大学, 医学部, 助教 (90420950)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2013: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
Fiscal Year 2011: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
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| Keywords | 老年医学 / 再生医療 / 脂肪細胞 / 再生医学 / 移植・再生医療 / 脱分化脂肪細胞 / 血管新生 |
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| Research Abstract |
We evaluated the therapeutic effect and safety of dedifferentiated fat (DFAT) cell transplantation in animal models of diseases, mainly occur in elderly people. Autologous implantation of DFAT cells significantly improved blood flow and vascular density in a rabbit and a porcine model of hindlimb ischemia. Autologous DFAT cell transplantation also contributed to bone regeneration in a rabbit bone defect model and an ovariectomy-induced osteoporosis model. Tumor formation or abnormal cell differentiation was not observed in any animal that received DFAT cell transplantation. These results suggest that DFAT cell transplantation is a safe and useful strategy for treatment of intractable diseases in elderly patients.
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Report
(4 results)
Research Products
(91 results)
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[Journal Article] A novel gene regulator, pyrrole-imidazole polyamide targeting ABCA1 gene increases cholesterol efflux from macrophages and plasma HDL concentration2014
Author(s)
Tsunemi A, Ueno T, Fukuda N, Watanabe T, Tahira K, Haketa A, Hatanaka Y, Tanaka S, Matsumoto T, Matsumoto Y, Nagase H, Soma M
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Journal Title
Journal of Molecular Medicine
Volume: 92
Issue: 5
Pages: 509-521
DOI
Related Report
Peer Reviewed
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[Journal Article] Complement 3 activates the renal renin-angiotensin system by induction of epithelial-to mesenchymal transition of the nephrotubulus in mice2013
Author(s)
Zhou X, Fukuda N, Matsuda H, Endo M, Wang X, Saito K, Ueno T, Matsumoto T, Matsumoto K, Soma M, Kobayashi N, Nishiyama A
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Journal Title
American Journal of Physiolosy Renal Physiology
Volume: 305
Issue: 7
Pages: F957-F967
DOI
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Peer Reviewed
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[Journal Article] Effects of the herbal medicine composition "Saiko-ka-ryukotsu-borei-To" on the function of endothelial progenitor cells in hypertensive rats.2012
Author(s)
Iijima H, Daikonya A, Takamatsu S, Kanno A, Magariyama K, Yoshikawa K, Takamiya T, Ueda Y, Yakubo S, Matsumoto T, Ueno T, Yamori Y, Fukuda N, Kitanaka S
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Journal Title
Phytomedicine
Volume: 30
Issue: 3-4
Pages: 196-201
DOI
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Peer Reviewed
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[Presentation] 脱分化脂肪細胞(DFAT細胞)を応用した歯周組織再生2014
Author(s)
秋田大輔, 田村瑛子, 真下貴之, 鶴町仁奈, 新井嘉則, 山中克之, 金子正, 鳥海拓, 秋山祐子, 佐藤桃子, 月村直樹, 加野浩一郎, 松本太郎, 磯川桂太郎, 石上友彦, 本田雅規
Organizer
第13回日本再生医療学会総会
Place of Presentation
京都
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[Presentation] 3D fiber-shaped culture system promotes differentiation of multipotent DFAT cells into smooth muscle-like cells2013
Author(s)
Hsiao AY, Okitsu T, Onoe H, Kiyosawa M, Teramae H, Iwanaga S, Miura S, Kazama T, Matsumoto T, Takeuchi S
Organizer
MicroTAS2013
Place of Presentation
Freiburg, Germany
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[Presentation] 脱分化脂肪細胞(Dedifferentiated fat cells: DFAT)を用いた炎症性腸疾患への治療検討
Author(s)
細川崇, 杉藤公信, 小沼憲祥, 石岡茂樹, 金田英秀, 細田利史, 大橋研介, 池田太郎, 越永従道, 松本太郎, 加野浩一郎
Organizer
第49回日本小児外科学会学術集会
Place of Presentation
横浜
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[Presentation] 高気孔径PLGAブロックを使用した脂肪組織由来間葉系幹細胞による歯周組織再生
Author(s)
秋田大輔, 新井嘉則, 山中克之, 金子正, 諸隈正和, 斉藤瑛子, 真下貴之, 秋山祐子, 月村直樹, 加野浩一郎, 松本太郎, 磯川桂太郎, 本田雅規
Organizer
第33回日本炎症・再生医学会
Place of Presentation
福岡
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