Research Project
Grant-in-Aid for Scientific Research (B)
We examined the transcriptional and epigenomic regulation of cardiac gene expression during the development of heart failure. We found that NRSF-HDAC complex maintains cardiac electrostability by regulating HCN2 and 4 ion channels expression. In addition, we revealed the important role played by MRTF-A, a rho-dependent co-activator of SRF, in pathological cardiac remodeling. Furthermore, we analyzed the therapeutic effect of TRPC3/6 inhibition on pathological cardiac remodeling.
All 2014 2013 2012 2011 Other
All Journal Article (35 results) (of which Peer Reviewed: 13 results, Open Access: 1 results) Presentation (61 results) (of which Invited: 3 results) Book (8 results) Remarks (4 results)
PLoS One
Volume: 9(3)
120007100132
Volume: 25 Issue: 3 Pages: e92314-e92314
10.1371/journal.pone.0092314
Circ Cardiovasc Genet
Volume: 6(6) Pages: 624-33
Circ J
Volume: 77(11) Pages: 2682-6
10031196813
Br J Pharmacol
Volume: 170(7) Pages: 1384-95
Curr Protein Pept Sci
Volume: 14(4) Pages: 256-267
J Am Heart Assoc
Volume: 2(3)
Cardiovasc Res
Volume: 99(4) Pages: 657-64
Volume: 8(1)
120005241437
Genes Cells
Volume: 18(7) Pages: 544-553
Biochem Biophys Res Commun
Volume: 434(2) Pages: 210-6
Intern Med
Volume: 52(2) Pages: 171-7
130003365857
Volume: 77 Pages: 2682-86
British Journal of Pharmacology
Volume: 170(7) Issue: 7 Pages: 1384-1395
10.1111/bph.12328
Curr Protein Pept Sci.
Volume: 14 Pages: 256-267
Journal of the American Heart Association
Volume: 2(3) Issue: 3
10.1161/jaha.113.000150
Cardiovasc Res.
Volume: 99 Issue: 4 Pages: 657-64
10.1093/cvr/cvt128
Biochem Biophys Res Commun.
Volume: 434 Issue: 2 Pages: 210-216
10.1016/j.bbrc.2013.03.040
Heart.
Volume: 99 Pages: 677-679
Nihon Naika Gakkai Zasshi
Volume: 101(9) Pages: 2552-62
Heart
Volume: 99(10) Pages: 677-679
EMBO J
Volume: 31(23) Pages: 4428-40
Plos One
Volume: 7(7)
J Pharmacol Sci. 18
Volume: 119(3) Pages: 198-203
10030986728
Expert Rev Cardiovasc Ther
Volume: 10(5) Pages: 577-83
Volume: 98(2) Pages: 152-61
EMBO J.
Volume: 31 Issue: 23 Pages: 4428-4440
10.1038/emboj.2012.296
Volume: 98 Issue: 2 Pages: 152-161
10.1136/heartjnl-2011-300102
Expert Rev Cardiovasc Ther.
Volume: 10(5) Issue: 5 Pages: 577-83
10.1586/erc.12.34
J Pharmacol Sci. 17
Volume: 116(4) Pages: 337-342
10029895482
Volume: 6(2)
J Cardiol
Volume: 57(2) Pages: 131-140
10031159554
J Mol Cell Cardiol
Volume: 50(6) Pages: 972-981
Journal of Pharmacological Sciences
Volume: 116 Issue: 4 Pages: 337-342
10.1254/jphs.10R28FM
Volume: 6(2) Issue: 2 Pages: e16734-e16734
10.1371/journal.pone.0016734
http://www.kuhp.kyoto-u.ac.jp/~med2/jpn/research/cardio.html
http://www.kuhp.kyoto-u.ac.jp/̃med2/jpn/research/cardio.html
http://www.kuhp.kyoto-u.ac.jp/~med2/index-jp.html