Development of therapy targeting dysregulation of cell cycle and JNK pathway in polyglutamine diseases

• Project/Area Number: 23390230
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Neurology
• Research Institution: Nagoya University
• Principal Investigator: KATSUNO MASAHISA 名古屋大学, 医学(系)研究科(研究院), 准教授 (50402566)
• Co-Investigator(Kenkyū-buntansha): SOBUE Gen 名古屋大学, 医学系研究科, 教授 (20148315) ; TANAKA Fumiaki 横浜市立大学, 医学研究科, 教授 (30378012) ; ADACHI Hiroaki 名古屋大学, 医学系研究科, 寄附講座准教授 (40432257)
• Project Period (FY): 2011-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000); Fiscal Year 2013: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000); Fiscal Year 2012: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000); Fiscal Year 2011: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
• Keywords: ポリグルタミン病 / 球脊髄性筋萎縮症 / 神経変性 / 細胞周期 / JNK / 運動ニューロン / サイクリン依存性キナーゼ / ポリグルタミン / マイクロアレイ / 神経変性疾患 / CGRP1 / naratriptan / 転写障害 / 神経ペプチド / セロトニン受容体

Research Abstract

Polyglutamine diseases are a group of hereditary neurodegenerative disorders caused by an expansion of genomic CAG trinucleotide expansion. Intra-neuronal accumulation of causative protein is construed as a pivotal molecular event in the pathogenesis of polyglutamine diseases. Our study demonstrated that dysregulation of cell cycle and abnormal activation of JNK pathway underlie the motor neuron degeneration in spinal and bulbar muscular atrophy (SBMA). We also showed that pharmacological suppression of JNK ameliorates polyglutamine-mediated neurodegeneration in SBMA.

Research Products

• [Journal Article] Anti-androgen flutamide protects male mice from androgen-dependent toxicity in three models of spinal bulbar muscular atrophy (2014)
  • Author(s): Renier KJ, Troxell-Smith SM, Johansen JA, Katsuno M, Adachi H, Sobue G, Chua JP, Sun Kim H, Lieberman AP, Breedlove SM, Jordan CL
  • Journal Title: Endocrinology Volume: (in press)
  • Peer Reviewed
• [Journal Article] Paeoniflorin eliminates a mutant AR via NF-YA-dependent proteolysis in spinal and bulbar muscular atrophy (2014)
  • Author(s): Tohnai G, Adachi H, Katsuno M, Doi H, Matsumoto S, Kondo N, Miyazaki Y, Iida M, Nakatsuji H, Qiang Q, Ding Y, Watanabe H, Yamamoto M, Ohtsuka K, Sobue G
  • Journal Title: Hum Mol Genet Volume: (in press)
  • Peer Reviewed
• [Journal Article] Transcriptional activation of TFEB/ZKSCAN3 target genes underlies enhanced autophagy in spinobulbar muscular atrophy (2014)
  • Author(s): Chua JP, Reddy SL, Merry DE, Adachi H, Katsuno M, Sobue G, Robins DM, Lieberman AP
  • Journal Title: Hum Mol Genet Volume: (Epub ahead of print) Issue: 5 Pages: 1376-1386
  • DOI: 10.1093/hmg/ddt527
  • Peer Reviewed
• [Journal Article] Tongue pressure as a novel biomarker of spinal and bulbar muscular atrophy (SBMA) (2014)
  • Author(s): Mano T, Katsuno M, Banno H, Suzuki K, Suga N, Hashizume A, Araki A, Watanabe H, Tanaka S, Yamamoto M, Sobue G
  • Journal Title: Neurology Volume: 82 Issue: 3 Pages: 255-262
  • DOI: 10.1212/wnl.0000000000000041
  • Peer Reviewed
• [Journal Article] p62/SQSTM1 differentially removes the toxic mutant androgen receptor via autophagy and inclusion formation in a spinal and bulbar muscular atrophy mouse model (2013)
  • Author(s): Doi H, Adachi H, Katsuno M, Minamiyama M, Matsumoto S, Kondo N, Miyazaki Y, IidaM,Tohnai G, Qiang Q, Tanaka F, Yanagawa T, WarabiE,Ishii T, Sobue G
  • Journal Title: J Neurosci Volume: 33 Issue: 18 Pages: 7710-7727
  • DOI: 10.1523/jneurosci.3021-12.2013
  • Peer Reviewed
• [Journal Article] Genistein, a natural product derived from soybeans, ameliorates polyglutamine-mediated motor neuron disease (2013)
  • Author(s): Qiang Q, Adachi H, Huang Z, Jiang YM, Katsuno M, Minamiyama M, Doi H, Matsumoto S, Kondo N, Miyazaki Y, Iida M, Tohnai G, Sobue G
  • Journal Title: J Neurochem Volume: 126 Issue: 1 Pages: 122-130
  • DOI: 10.1111/jnc.12172
  • Peer Reviewed
• [Journal Article] Heat shock factor-1 influences pathological lesion distribution of polyglutamine-induced neurodegeneration (2013)
  • Author(s): Kondo N, Katsuno M, Adachi H, Minamiyama M, Doi H, Matsumoto S, Miyazaki Y, Iida M, Tohnai G, Nakatsuji H, Ishigaki S, Fujioka Y, Watanabe H, Tanaka F, Nakai A, Sobue G
  • Journal Title: Nat Commun Volume: 4 Issue: 1 Pages: 1405-1405
  • DOI: 10.1038/ncomms2417
  • Peer Reviewed
• [Journal Article] A functional deficiency of TERA/VCP/p97 contributes to impaired DNA repair in multiple polyglutamine diseases. (2013)
  • Author(s): Fujita K, Nakamura Y, Oka T, Ito H, Tamura T, Tagawa K, Sasabe T, Katsuta A, Motoki K, Shiwaku H, Sone M, Yoshida C, Katsuno M, Eishi Y, Murata M, Taylor JP, Wanker EE, Kono K, Tashiro S, Sobue G, La Spada AR, Okazawa H.
  • Journal Title: Nat Commun. Volume: 4 Issue: 1 Pages: 1816-1816
  • DOI: 10.1038/ncomms2828
  • Peer Reviewed
• [Journal Article] Amyotrophic lateral sclerosis: an update on recent genetic insights. (2013)
  • Author(s): Iguchi Y, Katsuno M, Ikenaka K, Ishigaki S, Sobue G.
  • Journal Title: J Neurol. Volume: 260 Issue: 11 Pages: 2917-2927
  • DOI: 10.1007/s00415-013-7112-y
  • Peer Reviewed
• [Journal Article] Naratriptan mitigates CGRP1-associated motor neuron degeneration caused by expanded polyglutamine (2012)
  • Author(s): Minamiyama M, Katsuno M, Adachi H, Doi H, Kondo N, Iida M, Ishigaki S, Fujioka Y, Matsumoto S, Miyazaki Y, Tanaka F, Kurihara H, Sobue G
  • Journal Title: Nat Med Volume: 18 Issue: 10 Pages: 1531-1538
  • DOI: 10.1038/nm.2932
  • Peer Reviewed
• [Journal Article] Pathogenesis and therapy of spinal and bulbar muscular atrophy (SBMA) (2012)
  • Author(s): Katsuno M, Tanaka F, Adachi H, Banno H, Suzuki K, Watanabe H, Sobue G
  • Journal Title: Prog Neurobiol Volume: 99 Issue: 3 Pages: 246-256
  • DOI: 10.1016/j.pneurobio.2012.05.007
  • Peer Reviewed
• [Journal Article] Molecular pathophysiology and disease-Modifying therapies for spinal and bulbar muscular atrophy (2012)
  • Author(s): Katsuno M, Banno H, Suzuki K, Adachi H, Tanaka F, Sobue G
  • Journal Title: Arch Neurol Volume: 69 Issue: 4 Pages: 436-440
  • DOI: 10.1001/archneurol.2011.2308
  • Peer Reviewed
• [Journal Article] IGF-1 administration ameliorates disease manifestations in a mouse model of spinal and bulbar muscular atrophy (2012)
  • Author(s): Rinaldi C, Bott L, Chen K, Harmison G, Katsuno M, Sobue G, Pennuto M, Fischbeck KH
  • Journal Title: Mol Med Volume: 18 Issue: 9 Pages: 1261-1268
  • DOI: 10.2119/molmed.2012.00271
  • Peer Reviewed
• [Journal Article] Cross-sectional and longitudinal analysis of an oxidative stress biomarker for spinal and bulbar muscular atrophy. (2012)
  • Author(s): Mano, T., Katsuno, M., Banno, H., Suzuki, K., Suga, N., Hashizume, A., Tanaka, F., Sobue, G.
  • Journal Title: Muscle Nerve Volume: 46 Issue: 5 Pages: 692-697
  • DOI: 10.1002/mus.23413
  • Peer Reviewed
• [Journal Article] Longitudinal changes of outcome measures in spinal and bulbar muscular atrophy. (2012)
  • Author(s): Hashizume, A., Katsuno, M., Banno, H., Suzuki, K., Suga, N., Mano, T., Atsuta, N., Oe, H., Watanabe, H., Tanaka, F., Sobue, G.
  • Journal Title: Brain Volume: 35 Issue: 9 Pages: 2838-2848
  • DOI: 10.1093/brain/aws170
  • Peer Reviewed
• [Journal Article] Perspectives on molecular targeted therapies and clinical trials for neurodegenerative diseases (2012)
  • Author(s): Katsuno M, Tanaka F, Sobue G
  • Journal Title: J Neurol Neurosurg Psychiatry Volume: 83 Issue: 3 Pages: 329-335
  • DOI: 10.1136/jnnp-2011-301307
  • Peer Reviewed
• [Journal Article] Differential change of clinical outcome measures in spinal and bulbar muscular atrophy: comparison of natural history with placebo-treated group. (2012)
  • Author(s): Hashizume A, Katsuno M, Banno H, Suzuki K, Suga N, Tanaka F, Sobue G.
  • Journal Title: J Neurol. Volume: 259 Issue: 4 Pages: 712-719
  • DOI: 10.1007/s00415-011-6251-2
  • Peer Reviewed
• [Journal Article] Discrimination of spinal and bulbar muscular atrophy from amyotrophic lateral sclerosis using sensory nerve action potentials. (2012)
  • Author(s): Hama T, Hirayama M, Hara T, Nakamura T, Atsuta N, Banno H, Suzuki K, Katsuno M, Tanaka F, Sobue G.
  • Journal Title: Muscle Nerve Volume: 45 Issue: 2 Pages: 169-174
  • DOI: 10.1002/mus.22291
  • Peer Reviewed
• [Journal Article] Defective axonal transport in motor neuron diseases. (2012)
  • Author(s): Ikenaka K, Katsuno M, Kawai K, Ishigaki S, Tanaka F, Sobue G.
  • Journal Title: Int J Mol Sci. Volume: 13 Issue: 1 Pages: 1225-1238
  • DOI: 10.3390/ijms13011225
  • Peer Reviewed
• [Journal Article] Macroautophagy is regulated by the UPR-mediator CHOP and accentuates the phenotype of SBMA mice (2011)
  • Author(s): Yu Z, Wang AM, Adachi H, Katsuno M, Sobue G, Yue Z, Robins DM, Lieberman AP
  • Journal Title: PLoS Genet Volume: 7 Issue: 10 Pages: e1002321-e1002321
  • DOI: 10.1371/journal.pgen.1002321
  • Peer Reviewed
• [Presentation] Pathogenesis of selective neurodegeneration in polyglutamine-mediated motor neuron disease (2014)
  • Author(s): Katsuno M, Sobue G
  • Organizer: International symposium. New Frontier of Molecular Neuropathology 2014
  • Place of Presentation: Tokyo Medical and Dental University, Bunkyo-ku, Tokyo, Japan
• [Presentation] Neurobiological Study of Postmortem Brain from Brain Bank : for the study of spinal disorders (2013)
  • Author(s): Katsuno M
  • Organizer: Neuro2013
  • Place of Presentation: Kyoto International Conference Center, Kyoto City, Japan
  • Year and Date: 2013-06-22
• [Presentation] Genistein, a natural product derived from soybeans, ameliorates polyglutamine-mediated motor neuron disease (2013)
  • Author(s): Adachi H, Qiang Q, Hunag Z, Jinag YM, Katsuno M, Kondo N, Miyazaki Y, Iida M, Tohnai G, Nakatsuji H, Sobue G
  • Organizer: Neuroscience 2013
  • Place of Presentation: San Diego, USA
• [Presentation] Deficits in brain-derived neurotrophic factor may underlie motor dysfunction in spinal bulbar muscular atrophy. (2013)
  • Author(s): Hlievski, K., Henley, C.L., Fu, M., Katsuno, M., Adachi, H., Sobue, G., Breedlove, S.M., Jordan, C.L.
  • Organizer: Neuroscience 2013
  • Place of Presentation: San Diego,USA
• [Presentation] Genistein, a natural product derived from soybeans, ameliorates polyglutamine-mediated motor neuron disease. (2013)
  • Author(s): Adachi, H., Qiang, Q., Hunag, Z., Jinag, Y.M., Katsuno, M., Kondo, N., Miyazaki, Y., Iida, M., Tohnai, G., Nakatsuji, H., Sobue, G.
  • Organizer: Neuroscience 2013
  • Place of Presentation: San Diego, USA
• [Presentation] Heat shock factor-1 (Hsf-1) controls pathological lesion distribution of polyglutamine-induced motor neuron disease. (2013)
  • Author(s): Kondo, N., Katsuno, M., Adachi, H., Minamiyama, M., Matsumoto, S., Nakatsuji, H., Miyazaki, Y., Iida, M., Tohnai, G., Sobue, G.
  • Organizer: The 24th International Symposium on ALS/MND
  • Place of Presentation: Milan, Italy
• [Presentation] Cell cycle dysregulation in motor neurons of spinal and bulbar muscular atrophy (SBMA) (2012)
  • Author(s): Katsuno M, Adachi H, Kondo N, Minamiyama M, Doi H, Matsumoto S, Miyazaki Y, Iida M, Nakatsuji H, Tanaka F, Sobue G
  • Organizer: 23rd International Symposium on ALS/MND
  • Place of Presentation: Chicago, USA
• [Presentation] p62/SQSTM1 removes toxic mutant androgen receptor in spinal bulbar muscular atrophy model mouse (2012)
  • Author(s): Adachi H, Doi H, Katsuno M, Matsumoto S, Kondo N, Miyazaki Y, Tohnai G, Iida M, Tanaka F, Sobue G
  • Organizer: Neuroscience 2012
  • Place of Presentation: New Orleans, USA
• [Presentation] Viral delivery of miR-196a ameliorates the SBMA phenotype via the silencing of CELF2 (2012)
  • Author(s): Miyazaki Y, Adachi H, Katsuno M, Tanaka F, Muramatsu SI, Sobue G
  • Organizer: Neuroscience 2012
  • Place of Presentation: New Orleans, USA
• [Presentation] Naratriptan ameliorates SBMA pathology by the repression of CGRP1-activated JNK pathway (2012)
  • Author(s): Minamiyama M, Katsuno M, Adachi H, Doi H, Kondo N, Iida M, Ishigaki S, Fujioka Y, Matsumoto S, Miyazaki Y, Tanaka F, Kurihara H, Sobue G
  • Organizer: Neuroscience 2012
  • Place of Presentation: New Orleans, USA
• [Presentation] Cell cycle dysregulation in motor neurons of spinal and bulbar muscular atrophy (SBMA). (2012)
  • Author(s): Katsuno M, Adachi H, Kondo N, Minamiyama M, Doi H, Matsumoto S, Miyazaki Y, Iida M, Nakatsuji H, Tanaka F, Sobue G.
  • Organizer: 23rd International Symposium on ALS/MND.
  • Place of Presentation: Chicago, USA
• [Presentation] Longitudinal changes of outcome measures in spinal and bulbar muscular atrophy. (2012)
  • Author(s): Hashizume A, Katsuno M, Banno H, Suzuki K, Suga N, Mano T, Atsuta N, Oe H, Watanabe H, Tanaka F, Sobue G.
  • Organizer: 23rd International Symposium on ALS/MND.
  • Place of Presentation: Chicago, USA
• [Presentation] Naratriptan ameliorates SBMA pathology by the repression of CGRP1-activated JNK pathway. (2012)
  • Author(s): Minamiyama M, Katsuno M, Adachi H, Doi H, Kondo N, Iida M, Ishigaki S, Fujioka Y, Matsumoto S, Miyazaki Y, Tanaka F, Kurihara H, Sobue G.
  • Organizer: Neuroscience 2012
  • Place of Presentation: New Orleans, USA
• [Presentation] CGRP1 is the new therapeutic target for SBMA (Spinal and Bulbar Muscular Atrophy). (2012)
  • Author(s): Minamiyama M, Katsuno M, Adachi H, Doi H, Kondo N, Iida M, Ishigaki S, Fujioka Y, Matsumoto S, Miyazaki Y, Tanaka F, Kurihara H, Sobue G.
  • Organizer: 11th Biennial Meeting of the Asian Pacific Society for Neurochemistry.
  • Place of Presentation: 神戸国際会議場（神戸）
• [Presentation] Elucidation of neuronal death signaling pathways and development of disease-modifying therapies for Kennedy' s disease (2011)
  • Author(s): Katsuno M
  • Organizer: Kennedy' s Disease Association 2011 Annual Conference and Education Symposium
  • Place of Presentation: Coarsegold, USA
  • Year and Date: 2011-11-11
• [Presentation] Elucidation of neuronal death signaling pathways and development of disease-modifying therapies for Kennedy's disease (2011)
  • Author(s): Katsuno, M.
  • Organizer: Kennedy's Disease Association 2011 Annual Conference and Education Symposium
  • Place of Presentation: Bowie, USA(招待)
  • Year and Date: 2011-11-09
• [Presentation] A peony extract enhances protein degradation systems and exerts therapeutic effects in the polyglutamine-mediated motor neuron disease (2011)
  • Author(s): Adachi H, Tohnai G, Katsuno M, Minamiyama M, Doi H, Matsumoto S, Kondo N, Miyazaki Y, Tanaka F, Ohtsuka K, Sobue G
  • Organizer: Neuroscience 2011
  • Place of Presentation: Washington DC, USA
• [Presentation] Heat shock factor-1(Hsf-1) influences distribution of pathogenic androgen receptor aggregations in model mouse of spinal and bulbar muscular atrophy (SBMA) (2011)
  • Author(s): Kondo N, Katsuno M, Adachi H, Minamiyama M, Doi H, Matsumoto S-J, Miyazaki Y, Tanaka F, Sobue G
  • Organizer: Gordon conference on CAG triplet repeat disorders
  • Place of Presentation: Il Ciocco, Italy
• [Presentation] Cell cycle dysregulation in spinal and bulbar muscular atrophy (SBMA) (2011)
  • Author(s): Katsuno M, Adachi H, Kondo N, Minamiyama M, Doi H, Matsumoto S-J, Miyazaki Y, Tanaka F, Sobue G
  • Organizer: Gordon conference on CAG triplet repeat disorders
  • Place of Presentation: Il Ciocco, Italy
• [Presentation] Effect of leuprorelin in patients with spinal and bulbar muscular atrophy (SBMA) : a multicenter, randomized, double-blind, placebo-controlled trial (2011)
  • Author(s): Banno H, Katsuno M, Suzuki K, Takeuchi Y, Kawashima M, Yabe I, Sasaki H, Aoki M, Morita M, Nakano I, Kanai K, Ito S, Ishikawa K, Mizusawa H, Yamamoto T, Tsuji S, Hasegawa K, Shimohata T, Nishizawa M, Miyajima H, Kanda F, Watanabe Y, Nakashima K, Tsujino A, Yamashita T, Uchino M, Fujimoto Y, Tanaka F, Sobue G; for the Japan SBMA Interventional Trial for TAP-144-SR (JASMITT) study group
  • Organizer: 63rd American Academy of Neurology Annual Meeting
  • Place of Presentation: Honolulu, USA
• [Presentation] Long-term effects of the luteinizing hormone-releasing hormone analogues for spinal and bulbar muscular atrophy (2011)
  • Author(s): Ota K, Ishikawa K, Suzuki K, Banno H, Katsuno M, Sobue G, Mizusawa H
  • Organizer: 63rd American Academy of Neurology Annual Meeting
  • Place of Presentation: Honolulu, USA
• [Presentation] Central motor conduction time (CMCT) in patients with spinal and bulbar muscular atrophy (SBMA) (2011)
  • Author(s): Suzuki K, Katsuno M, Banno H, Suga N, Hashizume A, Hara T, Hama T, Nakamura T, Hirayama M, Tanaka F, Sobue G
  • Organizer: 15th Congress of the European Federation of Neurological Societies
  • Place of Presentation: Budapest, Hungary
• [Presentation] Heat shock factor-1 (Hsf-1) influences distribution of pathogenic androgen receptor aggregations in model mouse of spinal and bulbar muscular atrophy (SBMA) (2011)
  • Author(s): Kondo N, Katsuno M, Adachi H, Minamiyama M, Doi H, Matsumoto S-J, Miyazaki Y, Tanaka F, Sobue G
  • Organizer: Gordon conference on CAG triplet repeat disorders
  • Place of Presentation: Il Ciocco, Italy
• [Presentation] 球脊髄性筋萎縮症モデルマウスにおける異常蛋白凝集の病理学的分布はHsf-1の影響を受ける (2011)
  • Author(s): 近藤直英, 勝野雅央, 足立弘明, 南山誠, 土井英樹, 松本慎二郎, 宮崎雄, 飯田円, 田中章景, 祖父江元
  • Organizer: 第52回日本神経学会学術大会
  • Place of Presentation: 名古屋
• [Presentation] 球脊髄性筋萎縮症(SBMA)病態関連遺伝子CGRP1の分子機構 (2011)
  • Author(s): 南山誠, 勝野雅央, 足立弘明, 土井英樹, 近藤直英, 田中章景, 祖父江元, 栗原裕基
  • Organizer: 第52回日本神経学会学術大会
  • Place of Presentation: 名古屋
• [Presentation] Molecular pathology of SBMA (Spinal Bulbar Muscular Atrophy) related gene CGRP1 (2011)
  • Author(s): Minamiyama M, Katsuno M, Adachi H, Doi H, Kondo N, Tanaka F, Sobue G, Kurihara H
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: 横浜
• [Presentation] Heat shock factor-1(HSF-1) influences distribution of pathogenic androgen receptor aggregations in model mouse of spinal and bulbar muscular atrophy (SBMA) (2011)
  • Author(s): Kondo N, Katsuno M, Adachi H, Minamiyama M, Doi H, Matsumoto S, Miyazaki Y, Iida M, Tanaka F, Sobue G
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: 横浜
• [Presentation] Translational research on disease-modifying therapy for neurodegenerative disease.
  • Author(s): Katsuno, M.
  • Organizer: Young Scientist Symposium 2013
  • Place of Presentation: 東京大学本郷キャンパス 伊藤国際学術研究センター、東京都文京区
  • Invited
• [Presentation] Neurobiological Study of Postmortem Brain from Brain Bank: for the study of spinal disorders.
  • Author(s): Katsuno M.
  • Organizer: Neuro2013
  • Place of Presentation: 国立京都国際会館、京都市
  • Invited
• [Presentation] 神経変性疾患に対する分子標的治療法のトランスレーショナルリサーチ：課題と展望.
  • Author(s): 勝野雅央
  • Organizer: 第20回名古屋神経内科セミナー
  • Place of Presentation: 名古屋大学（名古屋）
  • Invited
• [Presentation] Molecular pathogenesis and therapy of polyglutamine-induced motor neuron degeneration.
  • Author(s): Katsuno M, Adachi H, Minamiyama M, Doi H, Kondo N, Miyazaki Y, Iida M, Tanaka F, Sobue G.
  • Organizer: 35th Annual Meeting of the Japan Neuroscience Society.
  • Place of Presentation: 名古屋国際会議場（名古屋）
  • Invited
• [Presentation] 球脊髄性筋萎縮症に対する抗アンドロゲン療法.
  • Author(s): 勝野雅央, 祖父江 元.
  • Organizer: 第53回日本神経学会学術大会シンポジウム
  • Place of Presentation: 東京国際フォーラム（東京）
  • Invited
• [Patent(Industrial Property Rights)] 抗神経変性疾患剤 (2012)
  • Inventor(s): 祖父江 元・勝野 雅央
  • Industrial Property Rights Holder: 祖父江 元・勝野 雅央
  • Industrial Property Rights Type: 特許
  • Filing Date: 2012-09-03