The significance of vaspin in metabolic syndrome and drug discovery

• Project/Area Number: 23390241
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Metabolomics
• Research Institution: Okayama University
• Principal Investigator: WADA Jun 岡山大学, 医歯(薬)学総合研究科, 准教授 (30294408)
• Project Period (FY): 2011-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000); Fiscal Year 2013: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000); Fiscal Year 2012: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000); Fiscal Year 2011: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
• Keywords: メタボリックシンドローム / インスリン抵抗性 / アディポカイン / バスピン / 糖尿病 / 脂質異常症 / 高血圧 / 肥満症 / 肥満

Research Abstract

Vaspin is a novel adipocytokine, which was identified from visceral adipose tissues in obese rats. Vaspin ameliorates the insulin resistance and development of atherosclerosis in metabolic syndrome. Vaspin circulates in the sera of human subjects and it positively correlated with body mass index and degree of insulin resistance. Serum levels of vaspin were higher in patients with type 2 diabetes compared with normal healthy subjects. The regulation of serum concentration of vaspin is different from leptin and adiponectin, and vaspin may be a new therapeutic target for metabolic syndrome.

Research Products

• [Journal Article] Pemt deficiency ameliorates endoplasmic reticulum stress in diabetic nephropathy (2014)
  • Author(s): Watanabe M, Nakatsuka A, Murakami K, Inoue K, Terami T, Higuchi C, Katayama A, Teshigawara S, Eguchi J, Ogawa D, Watanabe E, Wada J, Makino H
  • Journal Title: PLoS ONE Volume: 9(3) Issue: 3 Pages: e92647-e92647
  • DOI: 10.1371/journal.pone.0092647
  • NAID: 120005723281
  • Peer Reviewed
• [Journal Article] Nuclear hormone receptor expression in mouse kidney and renal cell lines (2014)
  • Author(s): Ogawa D, Eguchi J, Wada J, Terami N, Hatanaka T, Tachibana H, Nakatsuka A, Horiguchi CS, Nishii N, Makino H
  • Journal Title: PLoS ONE Volume: 9(1) Issue: 1 Pages: e85594-e85594
  • DOI: 10.1371/journal.pone.0085594
  • NAID: 120005723280
  • Peer Reviewed
• [Journal Article] Metallothionein deficiency exacerbates diabetic nephropathy in streptozotocin-induced diabetic mice (2014)
  • Author(s): Tachibana H, Ogawa D, Sogawa N, Asanuma M, Miyazaki I, Terami N, Hatanaka T, Horigushi CS, Nakatsuka A, Eguchi J, Wada J, Yamada H, Takei K, Makino H
  • Journal Title: Am J Physiol Renal Physiol Volume: 306 Issue: 1 Pages: 105-115
  • DOI: 10.1152/ajprenal.00034.2013
  • Peer Reviewed / Open Access
• [Journal Article] Long-term effect of cinacalcet hydrochloride on abdominal aortic calcification in patients on hemodialysis with secondary hyperparathyroidism (2013)
  • Author(s): Nakayama K, Nakao K, Takatori Y, Inoue J, Kojo S, Akagi S, Fukushima M, Wada J, Makino H
  • Journal Title: Int J Nephrol Renovasc Dis Volume: 7 Pages: 25-33
  • DOI: 10.2147/ijnrd.s54731
  • NAID: 120005468286
  • Peer Reviewed
• [Journal Article] Urinary angiotensinogen is a marker for tubular injuries in patients with type 2 diabetes (2013)
  • Author(s): Terami T, Wada J, Inoue K, Nakatsuka A, Ogawa D, Teshigawara S, Murakami K, Katayama A, Eguchi J, Makino H
  • Journal Title: Int J Nephrol Renovasc Dis Volume: 6 Pages: 233-240
  • DOI: 10.2147/ijnrd.s51829
  • NAID: 120005473080
  • Peer Reviewed
• [Journal Article] Urinary fetuin-A is a novel marker for diabetic neohropathy in type 2 diabetes identified by lectin microarray (2013)
  • Author(s): Inoue K, Wada J, Eguchi J, Nakatsuka A, Teshigawara S, Murakami K, Ogawa D, Terami T, Katayama A, Tone A, Iseda I, Hida K, Yamada M, Ogawa T, Makino H
  • Journal Title: PLoS ONE Volume: 8(10) Issue: 10 Pages: e77118-e77118
  • DOI: 10.1371/journal.pone.0077118
  • Peer Reviewed
• [Journal Article] Serum galectin-9 levels are elevated in the patients with type 2 diabetes and chronic kidney disease. (2013)
  • Author(s): Kurose Y
  • Journal Title: BMC Nephrol Volume: 14 Issue: 1 Pages: 23-23
  • DOI: 10.1186/1471-2369-14-23
  • Peer Reviewed
• [Journal Article] Vaspin inhibits apoptosis of endothelial cells as a ligand for cell-surface GRP78/VDAC complex. (2013)
  • Author(s): Nakatsuka A
  • Journal Title: Cir Res Volume: 112(5) Issue: 5 Pages: 771-780
  • DOI: 10.1161/circresaha.111.300049
  • Peer Reviewed
• [Journal Article] Telmisartan attenuates diabetic nephropathy by suppressing ixidative stress in db/db mice. (2013)
  • Author(s): Sato-Horiguchi C
  • Journal Title: Nephron Exp Nephrol Volume: 121(3-4) Issue: 3-4 Pages: 97-108
  • DOI: 10.1159/000343102
  • Peer Reviewed
• [Journal Article] The effects of telmisartan treatment on the abdominal fat depot in patients with metabolic syndrome and essential hypertension: Abdominal fat Depot Intervention Program of Okayama (ADIPO). (2013)
  • Author(s): Murakami K
  • Journal Title: Diab Vasc Dis Res Volume: 10(1) Issue: 1 Pages: 93-96
  • DOI: 10.1177/1479164112444640
  • Peer Reviewed
• [Journal Article] The serum vaspin levels are reduced in Japanese chronic hemodialysis patients. (2012)
  • Author(s): Inoue J
  • Journal Title: BMC Nephrol Volume: 13(1) Issue: 1 Pages: 163-163
  • DOI: 10.1186/1471-2369-13-163
  • Peer Reviewed
• [Journal Article] Activation of liver x receptor inhibits osteopontin and ameliorates diabetic nephropathy. (2012)
  • Author(s): Tachibana H
  • Journal Title: J Am Soc Nephrol Volume: 23(11) Issue: 11 Pages: 1835-1846
  • DOI: 10.1681/asn.2012010022
  • Peer Reviewed
• [Journal Article] Vaspin is an adipokine ameliorating ER stress in obesity as a ligand for cell-surface GRP78/MTJ-1 complex (2012)
  • Author(s): Nakatsuka A, Wada J, Iseda I, Teshigawara S, Higashio K, Murakami K, Kanzaki M, Inoue K, Terami T, Katayama A, Hida K, Eguchi J, Horiguchi CS, Ogawa D, Matsuki Y, Hiramatsu R, Yagita H, Kakuta S, Iwakura Y, Makino H
  • Journal Title: Diabetes Volume: 61(11) Issue: 11 Pages: 2823-2832
  • DOI: 10.2337/db12-0232
  • NAID: 120005300245
  • Peer Reviewed
• [Journal Article] The therapeutic potential of synthetic human atrial natriuretic peptide in nephrotic syndrome : a randomized controlled trial (2012)
  • Author(s): Kanzaki M, Wada J, Kikumoto Y, Akagi S, Nakao K, Sugiyama H, Makino H
  • Journal Title: Int J Nephrol Renovasc Dis Volume: 5 Pages: 91-96
  • DOI: 10.2147/ijnrd.s32191
  • Peer Reviewed
• [Journal Article] Hydrogen-rich water prevents progression of non-alcoholic steatohepatitis and accompanying hepatocarcinogenesis in mice (2012)
  • Author(s): Kawai D, Takaki A, Nakatsuka A, Wada J, Tamaki N, Yasunaka T, Koike K, Tsuzaki R, Matsumoto K, Miyake Y, Shiraha H, Morita M, Makino H, Yamamoto K
  • Journal Title: Hepatology Volume: 56(3) Issue: 3 Pages: 912-921
  • DOI: 10.1002/hep.25782
  • Peer Reviewed
• [Journal Article] Serum vaspin concentrations are closely related to insulin resistance and rs77060950 at SERPINA12 genetically defines distinct group with higher serum levels in Japanese population. (2012)
  • Author(s): Teshigawara S
  • Journal Title: J Clin Endocrinol Metab Volume: 97(7) Issue: 7 Pages: E1202-E1207
  • DOI: 10.1210/jc.2011-3297
  • Peer Reviewed
• [Journal Article] Galectin-9 and T cell immunoglobulin mucin-3 pathway is a therapeutic target for type 1 diabetes. (2012)
  • Author(s): Kanzaki M
  • Journal Title: Endocrinology Volume: 153(2) Issue: 2 Pages: 612-620
  • DOI: 10.1210/en.2011-1579
  • Peer Reviewed
• [Journal Article] Impact of circulating vaspin levels on metabolic variables in elderly twins. (2012)
  • Author(s): Hida K
  • Journal Title: Diabetologia Volume: 55(2) Issue: 2 Pages: 530-532
  • DOI: 10.1007/s00125-011-2385-0
  • Peer Reviewed
• [Journal Article] RXR antagonism induces G0/G1 cell cycle arrest and ameliorates obesity by up-regulating the p53-p21Cip1 pathway in adipocytes (2012)
  • Author(s): Nakatsuka A, et al
  • Journal Title: J Pathol Volume: 226(5) Issue: 5 Pages: 784-795
  • DOI: 10.1002/path.3001
  • Peer Reviewed
• [Journal Article] Impact of circulating vaspin levels on metabolic in elderly twins (2012)
  • Author(s): Hida K, et al
  • Journal Title: Diabetologia Volume: 55(2) Pages: 530-532
  • Peer Reviewed
• [Journal Article] Galectin-9 and T cell immunoglobulin mucin-3 pathway is a therapeutic target for type 1 diabetes (2012)
  • Author(s): Kanzaki M, et al
  • Journal Title: Endcrinology Volume: 51(6) Pages: 619-623
  • Peer Reviewed
• [Journal Article] High glucose increases metallothionein expression in renal proximal tubular epithelial cells (2011)
  • Author(s): Ogawa, D., et al
  • Journal Title: Exp.Diabetes Res. Volume: 2011 Pages: 534872-534872
  • DOI: 10.1155/2011/534872
  • Peer Reviewed
• [Journal Article] Icodextrin increases technique survival rate in peritoneal dialysis patients with diabetic nephropathy by improving body fluid management : a randomized controlled trial (2011)
  • Author(s): Takatori Y, Akagi S, Sugiyama H, Inoue J, Kojo S, Morinaga H, Nakao K, Wada J, Makino H
  • Journal Title: Clin J Am Soc Nephrol Volume: 6(6) Issue: 6 Pages: 1337-1344
  • DOI: 10.2215/cjn.10041110
  • Peer Reviewed
• [Journal Article] Icodextrin increases technique survival rate in peritoneal dialysis patients with diabetic nephropathy by improving body fluid management: a randomized controlled trial (2011)
  • Author(s): Takatori Y, et al
  • Journal Title: Clin J Am Soc Nephrol Volume: 6(6) Pages: 1337-1344
  • Peer Reviewed
• [Presentation] ACAM (Adipocyte Adhesion Molecule) / CLMP Inhibits Adipocyte Hypertrophy in Obesity (2013)
  • Author(s): Murakami K, Wada J, Eguchi J, Ogawa D, Terami T, Terami N, Makino H
  • Organizer: ADA 73th Scientific Session
  • Place of Presentation: Chicago
  • Year and Date: 2013-06-23
• [Presentation] Phosphatidylethanolamine N-Methyltransferase (PEMT) Deficiency Protects from Obesity and Insulin Resistance but Promote Steatoheptitis with Tumorigenesis (2013)
  • Author(s): Nakatsuka A, Wada J, Murakami K, Terami T, Eguchi J, Ogawa D, Makino H
  • Organizer: ADA 73th Scientific Session
  • Place of Presentation: Chicago
  • Year and Date: 2013-06-23
• [Presentation] Nuclear Hormone Receptor Expression in Mouse Kidney and Renal Cell Lines (2013)
  • Author(s): Ogawa D, Eguchi J, Tachibana H, Sato-Horiguchi C, Hatanaka T, Nakatsuka A , Wada J, Makino H
  • Organizer: ADA 73th Scientific Session
  • Place of Presentation: Chicago
  • Year and Date: 2013-06-22
• [Presentation] T Soluble form of transmembrane protein, Gpnmb, is a novel adipokine with a protective role in fatty liver diseases in obesity (2013)
  • Author(s): Katayama A, Wada J, Nakatsuka A, Eguchi J, Murakami K, Kanzaki M, Teshigawara S, Terami T, Inoue K, Hida K, Makino H
  • Organizer: Keystone Symposia 'Adipose Tissue Biology'
  • Place of Presentation: Keystone, Colorado, USA
• [Presentation] The pathological role of galectin-9 in metabolic syndrome (2013)
  • Author(s): Teshigawara S, Wada J, Kanzaki M, Nakatsuka A, Murakami K, Katayama A, Terami T, Inoue K, Eguchi J, Makino H
  • Organizer: Keystone Symposia 'Adipose Tissue Biology'
  • Place of Presentation: Keystone, Colorado, USA
• [Presentation] Phosphatidylethanolamine N-methyltransferase (PEMT) deficiency improves obesity and insulin resistance associated with unexpected progression of steatoheptitis (2013)
  • Author(s): Nakatsuka A, Wada J, Murakami K, Kanzaki M, Terami T, Katayama A, Eguchi J, Makino H
  • Organizer: Keystone Symposia 'Adipose Tissue Biology'
  • Place of Presentation: Keystone, Colorado, USA
• [Presentation] Nuclear Hormone Receptor Expression in Mouse Kidney and Renal Cell Lines. (2013)
  • Author(s): D Ogawa, J Eguchi, H Tachibana, C Sato-Horiguchi, T. Hatanaka, A Nakatsuka, J Wada, H Makino
  • Organizer: ADA 73th Scientific Session
  • Place of Presentation: Chicago
• [Presentation] Phosphatidylethanolamine N-Methyltransferase (PEMT) Deficiency Protects from Obesity and Insulin Resistance but Promote Steatoheptitis with Tumorigenesis. (2013)
  • Author(s): A Nakatsuka, J Wada, K Murakami, T Terami, J Eguchi, D Ogawa, H Makino
  • Organizer: ADA 73th Scientific Session
  • Place of Presentation: Chicago
• [Presentation] ACAM (Adipocyte Adhesion Molecule) / CLMP Inhibits Adipocyte Hypertrophy in Obesity. (2013)
  • Author(s): K Murakami. J Wada, J Eguchi, D Ogawa, T Terami, N Terami, H Makino.
  • Organizer: ADA 73th Scientific Session
  • Place of Presentation: Chicago
• [Presentation] The pathological role of galectin-9 in metabolic syndrome; Modulation of inflammatory responses in liver and adipose tissue (2012)
  • Author(s): Kanzaki M, Wada J, Nakatsuka A, Murakami K, Teshigawara S, Katayama A, Terami T, Inoue K, Eguchi J, Makino H
  • Organizer: Keystone Symposia, Genetic and Molecular Basis of Obesity and Body Weight Regulation
  • Place of Presentation: Santa Fe, New Mexico, USA
  • Year and Date: 2012-12-01
• [Presentation] Phosphatidylethanolamine N-methyltransferase (PEMT) deficiency protects from obesity and insulin resistance but aggravates non-alcoholic steatoheptitis (NASH) (2012)
  • Author(s): Nakatsuka A, Wada J, Murakami K, Kanzaki M, Terami T, Katayama A, Eguchi J, Makino H
  • Organizer: Keystone Symposia, Genetic and Molecular Basis of Obesity and Body Weight Regulation
  • Place of Presentation: Santa Fe, New Mexico, USA
  • Year and Date: 2012-12-01
• [Presentation] Identification of transmembrnane proteins expressed in adipocytes under obese-state and the roles soluble forms in fat accumulation (2012)
  • Author(s): Wada J
  • Organizer: International Symposium for the Study ofObesity "Translational Science and Epidemiology on Adipomedicine; From Lipodystrophy to Obesity"
  • Place of Presentation: Shiran Kaikan of Kyoto University, Kyoto
  • Invited
• [Presentation] シンポジウムCiliopathies ; Ciliaは細胞のconductorコレクトリンとprimary cilia (2011)
  • Author(s): 和田淳
  • Organizer: 第54回日本腎臓病学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2011-06-15
• [Presentation] Identification of transmembrnane proteins expressed in adipocytes under obese-state and the roles of soluble forms in fat accumulation.
  • Author(s): Wada J
  • Organizer: International Symposium for the Study of Obesity “Translational Science and Epidemiology on Adipomedicine; From Lipodystrophy to Obesity”
  • Place of Presentation: Shiran Kaikan of Kyoto University, Kyoto
  • Invited
• [Presentation] PEMT deficiency protects from obesity and insulin resistance, but induces severe steathepatitis.
  • Author(s): 和田淳
  • Organizer: 第55回日本糖尿病学会年次学術集会
  • Place of Presentation: 横浜
  • Invited
• [Book] 糖尿病×CKD診療ガイド (2012)
  • Author(s): 和田淳
  • Total Pages: 197
  • Publisher: 南山堂