Elucidation of molecular mechanism underlying insulin resistane and inflammation
| Project/Area Number |
23390242
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | Hiroshima University |
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Principal Investigator |
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| Project Period (FY) |
2011-11-18 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
Fiscal Year 2013: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
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| Keywords | Pin1 / プロリン異性化酵素 / 糖尿病 / メタボリックシンドローム / 脂肪肝 / インスリン作用 / 炎症 / ﾒﾀﾎﾞﾘｯｸｼﾝﾄﾞﾛｰﾑ / 代謝 / インスリン抵抗性 / 細胞内シグナル伝達 / 代謝調節 |
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| Research Abstract |
Prolyl isomerase (Pin1) is a unique enzyme which recognizes the pSer/Pro or pThr/Pro motif and changes the conformations of target proteins. We reported that Pin1 binds to Crtc2 and suppresses CRE transcriptional and gluconeogenic activity in the liver. In addition, Pin1 associates with IRS-1, a major insulin receptor substrate, and enhances insulin-induced metabolic actions. These events ultimately contribute to the incorporation of excess nutrients into tissues. These findings suggest that inhibition of Pin1 might provide a novel therapy for NASH.
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Report
(4 results)
Research Products
(101 results)
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[Journal Article] The inflammation-lipocalin 2 axis may contribute to the development of chronic kidney disease.2014
Author(s)
Hashikata A, Yamashita A, Suzuki S, Nagayasu S, Shinjo T, Taniguchi A, Fukushima M, Nakai Y, Nin K, Watanabe N, Asano T, Abiko Y, Kushiyama A, Nagasaka S, Nishimura F.
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Journal Title
Nephrol Dial Transplant.
Volume: 29
Pages: 611-8
Related Report
Peer Reviewed
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[Journal Article] Lactobacillus casei strain Shirota protects against nonalcoholic steatohepatitis development in a rodent model.2014
Author(s)
Okubo H, Sakoda H, Kushiyama A, Fujishiro M, Nakatsu Y, Fukushima T, Matsunaga Y, Kamata H, Asahara T, Yoshida Y, Chonan O, Iwashita M, Nishimura F, Asano T.
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Journal Title
Am J Physiol Gastrointest Liver Physiol.
Volume: 305
Related Report
Peer Reviewed
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[Journal Article] Par14 protein associates with insulin receptor substrate 1 (IRS-1), thereby enhancing insulin-induced IRS-1 phosphorylation and metabolic actions.2013
Author(s)
Zhang J, Nakatsu Y, Shinjo T, Guo Y, Sakoda H, Yamamotoya T, Otani Y, Okubo H, Kushiyama A, Fujishiro M, Fukushima T, Tsuchiya Y, Kamata H, Iwashita M, Nishimura F, Katagiri H, Takahashi S, Kurihara H, Uchida T, Asano T.
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Journal Title
J Biol Chem.
Volume: 288
Pages: 20692-701
Related Report
Peer Reviewed
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[Journal Article] Resistin-like molecule β is abundantly expressed in foam cells and is involved in atherosclerosis development.2013
Author(s)
Kushiyama A, Sakoda H, Oue N, Okubo M, Nakatsu Y, Ono H, Fukushima T, Kamata H, Nishimura F, Kikuchi T, Fujishiro M, Nishiyama K, Aburatani H, Kushiyama S, Iizuka M, Taki N, Encinas J, Sentani K, Ogonuki N, Ogura A, Kawazu S, Yasui W, Higashi Y, Kurihara H, Katagiri H, Asano T.
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Journal Title
Arterioscler Thromb Vasc Biol.
Volume: 33
Pages: 1986-93
Related Report
Peer Reviewed
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[Journal Article] Valsartan restores inflammatory response by macrophages in adipose and hepatic tissues of LPS-infused mice.2013
Author(s)
Iwashita M, Nakatsu Y, Sakoda H, Fujishiro M, Kushiyama A, Fukushima T, Kumamoto S, Shinjo T, Kamata H, Nishimura F, Asano T.
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Journal Title
Adipocyte
Volume: 2
Pages: 28-32
Related Report
Peer Reviewed
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[Journal Article] Integrator complex plays an essential role in adipose differentiation.2013
Author(s)
Otani Y, Nakatsu Y, Sakoda H, Fukushima T, Fujishiro M, Kushiyama A, Okubo H, Tsuchiya Y, Ohno H, Takahashi S, Nishimura F, Kamata H, Katagiri H, Asano T.
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Journal Title
Biochem Biophys Res Commun.
Volume: 434
Pages: 197-202
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[Journal Article] Valsartan, independently of AT1 receptor or PPAR・, suppresses LPS-induced macrophage activation and improves insulin resistance in co-cultured adipocytes2012
Author(s)
Iwashita, M., Sakoda, H.,, Nakatsu, Y., Asano, T. (15人 )
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Journal Title
Am. J. Physiol. Endo. Metab
Volume: 302
Related Report
Peer Reviewed
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[Presentation] 脂肪酸合成酵素におけるPin1の作用2013
Author(s)
山本屋武, 中津祐介, 松永泰花, 新城尊徳, 西村英紀, 迫田秀之, 櫛山暁史, 鎌田 英明, 内田 隆史, 浅野知一郎
Organizer
第56回日本糖尿病学会
Place of Presentation
熊本
Year and Date
2013-05-16
Related Report
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[Presentation] インスリン抵抗性および大血管障害におけるマクロファージ由来resistin like moleculeβの意義2012
Author(s)
櫛山暁史, 大久保博史, 迫田秀之, 菊池貴子, 中津祐介, 山本屋武, 山崎広貴, 藤城緑, 門脇孝, 鎌田英明, 河津捷二, 浅野知一郎
Organizer
第24回分子糖尿病学シンポジウム
Place of Presentation
東京
Year and Date
2012-12-08
Related Report
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[Presentation] Nedd4はインスリン受容体基質(IRS)-2を介したインスリン/インスリン様成長因子(IGF)のシグナル・生理活性を増強する2012
Author(s)
福嶋俊明, 吉原英人, 拍野史彦, 佐拍秦, 田中啓二, 伊藤昭博, 吉田稔, 中津祐介, 迫田秀之, 鎌田英明, 高橋伸一郎, 浅野知一郎
Organizer
55回日本糖尿病学会
Place of Presentation
横浜
Year and Date
2012-05-19
Related Report
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[Presentation] マクロファージとの共培養系において Valsartan が脂肪細胞の遺伝子発現に与える影響2012
Author(s)
藤城緑, 岩下未咲, 中津祐介, 大久保博史, 張君, 大谷裕一郎, 迫田秀之, 櫛山暁史, 菊池貴子, 西村英紀, 門脇孝, 浅野知一郎
Organizer
55回日本糖尿病学会
Place of Presentation
横浜
Year and Date
2012-05-19
Related Report
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[Presentation] プロリン異性化酵素Par14のインスリンシグナルと糖・脂質代謝における役割2011
Author(s)
張君, 郭瑩, 迫田秀之, 中津祐介, 山本屋武, 藤城 緑, 櫛山暁史, 大谷裕一郎, 大久保博史, 福嶋俊明, 高橋伸一郎, 鎌田英明, 浅野知一郎
Organizer
第23回分子糖尿病学シンポジウム
Place of Presentation
熊本
Year and Date
2011-11-26
Related Report
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[Presentation] キサンチンオキシダーゼ経路のマクロファージ泡沫化と動脈硬化への関与2011
Author(s)
櫛山暁史, 菊池貴子, 迫田秀之, 藤城緑, 纐纈優子, 大西由 希子, 佃克則, 櫛山暁史, 佐藤博和, 西山功一, 栗原裕基, 田中健太郎, 大久保博史, 岩下未咲, 熊本園子, 大野晴也, 中津祐介, 河津捷二, 浅野知一郎
Organizer
54回日本糖尿病学会
Place of Presentation
札幌
Year and Date
2011-05-24
Related Report
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