Development of therapeutic approach targeting DNA damage check point
Project/Area Number |
23390271
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Pediatrics
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Research Institution | Tokyo Medical and Dental University |
Principal Investigator |
SHUKI Mizutani 東京医科歯科大学, 医歯(薬)学総合研究科, 教授 (60126175)
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Co-Investigator(Kenkyū-buntansha) |
TAKAGI Masatoshi 東京医科歯科大学, 大学院・医歯学総合研究科, 講師 (10406267)
|
Project Period (FY) |
2011-04-01 – 2014-03-31
|
Project Status |
Completed (Fiscal Year 2013)
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Budget Amount *help |
¥19,500,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥4,500,000)
Fiscal Year 2013: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2011: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
|
Keywords | 小児血液学 / DNA損傷応答 / ATM / BCR/ABL / microRNA / 細胞分化 |
Research Abstract |
Development of therapeutic approach targeting DNA damage check point was investigated. loss of function of ATM was identified in neuroblastoma. It is known that ATM regulated microRNA and contributes down regulation of MYCN. We have identified several microRNAs regulated by ATM. Contribution of loss of ATM function in blastic crisis in chronic myelogenous leukemia was elucidated.
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Report
(4 results)
Research Products
(15 results)
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[Journal Article] Artemis-dependent DNA double-strand break formation at stalled replication forks.2013
Author(s)
Unno J, Takagi M, Piao J, Sugimoto M, Honda F, Maeda D, Masutani M, Kiyono T, Watanabe F, Morio T, Teraoka H, Mizutani S.
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Journal Title
Cancer Sci.
Volume: 104
Issue: 6
Pages: 703-10
DOI
Related Report
Peer Reviewed
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[Journal Article] Successful treatment of diffuse large B cell lymphoma in a patient with ataxia telangiectasia using rituximab2013
Author(s)
Machida S, Tomizawa D, Tamaichi H, Okawa T, Endo A, Imai K, , Nagasawa M, Morio T, Mizutani S, Takagi M
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Journal Title
J Pediatr Hematol Oncol
Volume: 36
Issue: 6
Pages: 482-485
DOI
Related Report
Peer Reviewed
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[Journal Article] Process for immune defect and chromosomal translocation during early thymocyte development lacking ATM2012
Author(s)
Isoda T, Takagi M, Piao J, Nakagama S,Sato M, Masuda K, Ikawa T, Azuma M, Morio T, Kawamoto H, Mizutani S
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Journal Title
Blood
Volume: 120(4)
Issue: 4
Pages: 789-9
DOI
Related Report
Peer Reviewed
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[Journal Article] Onset of quiescence following p53 mediated down-regulation of H2AX in normal cells2011
Author(s)
Atsumi Y, Fujimori H, Fukuda H, Inase A, Shinohe K, Yoshioka Y, Shikanai M, Ichijima Y, Unno J, Mizutani S, Tsuchiya N, Hippo Y, Nakagama H, Masutani M, Teraoka H, Yoshioka K
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Journal Title
Related Report
Peer Reviewed
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[Presentation] Visualization of chromosomal translocation and early T-cell development failure in ATM deficiency2012
Author(s)
Isoda1 T, Takagi M, Piao J, Sato M, Masuda K, Ikawa T, Azuma M, Morio T, Kawamoto H, Mizutani S
Organizer
14th International workshop on Ataxia Telangiectasia
Place of Presentation
Delhi, India
Related Report
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[Presentation] T-Cell Development Failure At β-Selection Checkpoint and TCRα/δ Locus Break Formation Associated with Chromosome 14 Translocation in Ataxia-Telangiectagia Mutated Deficient Mice2012
Author(s)
Isoda T, Takagi M, Piao J, Nakagama S, Sato M, Masuda K, Ikawa T, Azuma M, Morio T, Kawamoto H, Mizutani S
Organizer
53rd American society of hematology, annual meeting
Place of Presentation
San Diego
Related Report
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