Establishment of non-invasive cancer screening paradigm
| Project/Area Number |
23390323
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Okayama University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
藤原 俊義 , 医歯(薬)学総合研究科, 教授 (00304303)
八木 孝仁 大学病院, 教授 (00304353)
貞森 裕 , 医歯(薬)学総合研究科, 准教授 (30362974)
松田 浩明 岡山大学, 岡山大学病院, 講師 (00467747)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000)
Fiscal Year 2013: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥11,440,000 (Direct Cost: ¥8,800,000、Indirect Cost: ¥2,640,000)
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| Keywords | がん検診 / メチル化DNA / バイオマーカー / スクリーニング / DNAメチル化 / 消化器癌 / 肺癌 / miRNA / 検便 / 喀痰 / メチレーション / 大腸癌 / 膵癌 |
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| Outline of Final Research Achievements |
In this study, we developed a new extremely simple procedure of detecting methylated DNA in the 8 CpGs regions in human DNA recovered from very small quantity of feces and sputum.Moreover, the procedure easily modifies the cut-off value suitable for various conditions for screening not only people with lung and colorectal cancer but also other gastrointestinal cancers.
Our technology could provide a possibility of building an effective medical screening strategy. Additionally, we searched for biomarkers of various cancer leading to accumulation of very important knowledge and discover new seeds, affected not only cancer diagnostic paradigm but also cancer treatment system.
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Report
(4 results)
Research Products
(61 results)
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[Journal Article] Unique association between global DNA hypomethylation and chromosomal alterations in human hepatocellular carcinoma.2013
Author(s)
Nishida N, Kudo M, Nishimura T, Arizumi T, Takita M, Kitai S, Yada N, Hagiwara S, Inoue T, Minami Y, Ueshima K, Sakurai T, Yokomichi N, Nagasaka T, Goel A.
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Journal Title
PLoS One
Volume: 8
Issue: 9
Pages: e72312-e72312
DOI
Related Report
Peer Reviewed
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[Journal Article] A genetically engineered oncolytic adenovirus decoys and lethally traps quiescent cancer stem-like cells into S/G2/M-phases.2013
Author(s)
Yano S, Tazawa H, Hashimoto Y, Shirakawa Y, Kuroda S, Nishizaki M, Kishimoto H, Uno F, Nagasaka T, Urata Y, Kagawa S, Hoffman RM, Fujiwara T
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Journal Title
Clin Cancer Res
Volume: 19
Issue: 23
Pages: 6495-6505
DOI
Related Report
Peer Reviewed
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[Presentation] MGMT Methylation As a Novel Biomarker for the Identification of Stage III Colorectal Cancers At High-Risk of Disease Recurrence Following Curative Surgery2013
Author(s)
Mori Y, Nagasaka T, Tazawa H, Umeda Y, Morikawa T, Kubota N, Yoshida K, Takehara Y, Yokomichi N, Takehara K, Shigeyasu K, Nyuya A, Shiwaku R, Suno M, Nishida N, Fujiwara T, Goel A
Organizer
Digestive Disease Week 2013
Place of Presentation
Orlando
Related Report
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[Presentation] Accumulation of Epigenetic Alteration Could Predict Malignant Formation in Intraductal Papillary Mucinous Neoplasm(IPMN)2013
Author(s)
Yoshida K, Nagasaka T, Umeda Y, Yokomichi N, Mori Y, Kubota N, Morikawa T, Takehara Y, Takehara K, Shigeyasu K, Nyuya A, Shiwaku R, Suno M, Nishida N, Fujiwara T, Goel A
Organizer
Digestive Disease Week 2013
Place of Presentation
Orlando
Related Report
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[Presentation] Genetic and Epigenetic Alterations in the Netrin-1 Receptors, UNC5c and DCC, Constitutes a Previously Unrecognized Pathway in Gastric Cancer Progression2013
Author(s)
Kubota N, Nagasaka T, Toda K, Mori Y, Morikawa T, Umeda Y, Yokomichi N, Yoshida K, Takehara Y, Takehara K, Nyuya A, Shiwaku R, Shigeyasu K, Suno M, Nishida N, Fujiwara T, Goel A
Organizer
Digestive Disease Week 2013
Place of Presentation
Orlando
Related Report
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[Presentation] Cytokeratin 19 Staining Is a Novel, Predictive Biomarker for Extra-Hepatic Metastasis in Hepatocellular Carcinoma2013
Author(s)
Yokomichi N, Nagasaka T, Nishida N, Umeda Y, Mori Y, Morikawa T, Kubota N, Yoshida K, Takehara Y, Takehara K, Shigeyasu K, Nyuya A, Shiwaku R, Suno M, Fujiwara T, Goel A
Organizer
Digestive Disease Week 2013
Place of Presentation
Orlando
Related Report
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[Presentation] Fecal DNA Methylation Assay for the Identification of a Multiple Gastrointestinal Cancers Including Pancreatic Cancer2013
Author(s)
Morikawa T, Nagasaka T, Yoshida K, Mori Y, Kubota N, Takehara Y, Yokomichi N, Nishida N, Takehara K, Shigeyasu K, Nyuya A, Shiwaku R, Suno M, Fujiwara T, Goel A
Organizer
Digestive Disease Week 2013
Place of Presentation
Orlando
Related Report
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[Presentation] TREATMENT STRATEGY FOR COLORECTAL LIVER METASTASIS BASED ON GENETIC PROFILES2013
Author(s)
Umeda Y, Nagasaka T, Mori Y, Sadamori H, Shinoura S, Yoshida R, Nobuoka D, Utsumi M, Takagi K, Yagi T, Fujiwara T
Organizer
21st United European Gastroenterology Week
Place of Presentation
Berlin
Related Report
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