| Project/Area Number |
23390349
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Okayama University |
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Principal Investigator |
DATE Isao 岡山大学, 医歯(薬)学総合研究科, 教授 (70236785)
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| Co-Investigator(Kenkyū-buntansha) |
AGARI Takashi 岡山大学, 岡山大学病院, 助教 (60423290)
KAMEDA Masahiro 岡山大学, 医歯薬学総合研究科, 助教 (50586427)
ONO Shigeki 川崎医科大学, 医学部, 教授 (40335625)
眞鍋 博明 岡山大学, 大学病院, 助教 (50598555)
菊池 陽一郎 岡山大学, 大学病院, 医員 (30631337)
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| Co-Investigator(Renkei-kenkyūsha) |
SUGIU Kenji 岡山大学, 岡山大学病院, 准教授 (40325105)
TOKUNAGA Koji 岡山大学, 医歯薬学総合研究科, 准教授 (40294467)
ICHIKAWA Tomotsugu 岡山大学, 医歯薬学総合研究科, 講師 (10362964)
KUROZUMI Kazuhiko 岡山大学, 岡山大学病院, 講師 (20509608)
HISHIKAWA Tomohito 岡山大学, 岡山大学病院, 助教 (60509610)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2013: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2012: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2011: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
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| Keywords | 実験脳外科学 / カプセル化神経幹細胞移植 / カプセル化神経幹細胞 / iPS |
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| Research Abstract |
It is necessary to enhance the survival of encapsulated cells in order to enhance secretion of trophic factor from encapsulated cells. We examined whether GDNF pre-treatment could enhance the survival of neural stem cells. Under the ischemic-like injury by oxygen-glucose deprivation, the number of apoptotic cells was significantly decreased by GDNF pre-treatment. Moreover, the number of survival cells after transplantation for Parkinson's model of rat was significantly increased by GDNF pre-treatment. Based on these results, GDNF pre-treatment enhances the survival of neural stem cells by suppression of apoptosis.
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