Fundamental researches to presentation a new animal models and the therapy development of the osteoarthritis
| Project/Area Number |
23390369
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Kagoshima University |
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Principal Investigator |
IJIRI KOSEI 鹿児島大学, 医歯(薬)学総合研究科, 客員研究員 (00315417)
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| Co-Investigator(Kenkyū-buntansha) |
SETSURO Komiya 鹿児島大学, 医歯学総合研究科, 教授 (30178371)
HARUTOSHI Sakakima 鹿児島大学, 医学部, 教授 (10325780)
SATOSHI Nagano 鹿児島大学, 医歯学総合研究科, 助教 (50373139)
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| Project Period (FY) |
2011-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥15,340,000 (Direct Cost: ¥11,800,000、Indirect Cost: ¥3,540,000)
Fiscal Year 2014: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
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| Keywords | 関節病学 / GADD45β / C/EBPβ / 変形性関節症 / 軟骨細胞 / Gadd45beta / C/EBPbeta / 軟骨 / 肥大化 / 石灰化 / 関節軟骨 / OA |
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| Outline of Final Research Achievements |
Osteoarthritis (OA) is defined as a disease of cartilage, which causes the pain and disability in older adults. Our previous study suggested that Growth arrest and DNA damage-inducible protein 45 β (GADD45β) is overexpressed in chondrocyte clusters in OA cartilage, especially in early stage of progression. CCAAT enhancer binding protein (C/EBP) β is expressed in hypertrophic zone of murine growth plate and with a function in synergy with Gadd45β. Our studies suggested that C/EBPβ plays a central role in controlling GADD45β gene expression in articular chondrocytes and suggest that the interplay between C/EBPβ and GADD45β constitutes a feedback loop with implications in cartilage degradation and osteophyte formation in OA.
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Report
(5 results)
Research Products
(6 results)
