| Budget Amount *help |
¥15,340,000 (Direct Cost: ¥11,800,000、Indirect Cost: ¥3,540,000)
Fiscal Year 2014: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
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| Outline of Final Research Achievements |
Osteoarthritis (OA) is defined as a disease of cartilage, which causes the pain and disability in older adults. Our previous study suggested that Growth arrest and DNA damage-inducible protein 45 β (GADD45β) is overexpressed in chondrocyte clusters in OA cartilage, especially in early stage of progression. CCAAT enhancer binding protein (C/EBP) β is expressed in hypertrophic zone of murine growth plate and with a function in synergy with Gadd45β. Our studies suggested that C/EBPβ plays a central role in controlling GADD45β gene expression in articular chondrocytes and suggest that the interplay between C/EBPβ and GADD45β constitutes a feedback loop with implications in cartilage degradation and osteophyte formation in OA.
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