Re-evaluation of pathophysiology of normal pregnancy and complicated pregnancy from the viewpoint of immune tolerance

• Project/Area Number: 23390386
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Obstetrics and gynecology
• Research Institution: University of Toyama
• Principal Investigator: SAITO SHIGERU 富山大学, 大学院医学薬学研究部(医学), 教授 (30175351)
• Co-Investigator(Kenkyū-buntansha): TAKIZAWA Toshihiro 日本医科大学, 医学系研究科, 教授 (90271220) ; TABUCHI Yoshiaki 富山大学, 生命科学先端研究センター, 教授 (20322109)
• Project Period (FY): 2011-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000); Fiscal Year 2014: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2013: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2012: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2011: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
• Keywords: 制御性T細胞 / 流産 / 妊娠高血圧症候群 / NK細胞 / miRNA / 妊娠維持 / ヒト / マウス / 制御性NK細胞 / 妊娠維持機構 / 胎盤 / 早産

Outline of Final Research Achievements

Regulatory T (Treg) cells play central role for induction and maintenance of tolerance. The frequency of proliferating paternal antigen specific Treg cells was significantly increased in uterine draining lymph nodes before implantation and in pregnant uterus just after implantation. We found that priming by seminal fluid is important for the induction of PA-specific Treg cells.
The frequencies of effector Treg cells and Foxp3+T eff cells in the decidua of miscarriage cases with a normal embryo karyotype were significantly lower and significantly higher than those in normally progressing pregnancies, respectively.
We also showed the same results in preeclampsia. These findings suggest that tolerance system was distracted in miscarriage with a normal embryo karyotype and preeclampsia. We firstly showed miRNA derived from placenta affected mRNA expression in NK cells suggesting that miRNA derived from placenta can affect the maternal NK cells function during pregnancy.

Research Products

• [Journal Article] Helios-positive functional regulatory T cells are decreased in decidua of miscarriage cases with normal fetal chromosomal content. (2015)
  • Author(s): Inada K, Shima T, Ito M, Ushijima A, Saito S.
  • Journal Title: J Reprod Immunol. Volume: 107 Pages: 10-19
  • DOI: 10.1016/j.jri.2014.09.053
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Paternal antigen-specific proliferating regulatory T cells are increased in uterine-draining lymph nodes just before implantation and in pregnant uterus just after implantation by seminal plasma-priming in allogeneic mouse pregnancy. (2015)
  • Author(s): Shima T, Inada K, Nakashima A, Ushijima A, Ito M, Yoshino O, Saito S.
  • Journal Title: J Reprod Immunol. Volume: 108 Pages: 78-82
  • DOI: 10.1016/j.jri.2015.02.005
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Maternal peripheral blood natural killer cells incorporate placenta-associated microRNAs during pregnancy. (2015)
  • Author(s): Ishida Y, Zhao D, Ohkuchi A, Kuwata T, Yoshitake H, Yuge K, Takizawa T, Matsubara S, Suzuki M, Saito S, Takizawa T
  • Journal Title: Int J Mol Med. Volume: 35 Issue: 6 Pages: 1511-1524
  • DOI: 10.3892/ijmm.2015.2157
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] A review of the mechanism for poor placentation in early-onset preeclampsia; the role of autophagy in trophoblast invasion and vascular remodeling. (2014)
  • Author(s): Saito S, Nakashima A
  • Journal Title: J Reprod Immunol Volume: 101-102 Pages: 80-88
  • DOI: 10.1016/j.jri.2013.06.002
  • Peer Reviewed
• [Journal Article] Intestinal microbiota is different in women with preterm birth: results from terminal restriction fragment length polymorphism analysis. (2014)
  • Author(s): Shiozaki A, Yoneda S, Yoneda N, Yonezawa R, Matsubayashi T, Seo G, Saito S.
  • Journal Title: PLoS ONE Volume: 9 Issue: 11 Pages: e111374-e111374
  • DOI: 10.1371/journal.pone.0111374
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Human exosomal placenta-associated miR-517a-3p modulates the expression of PRKG1 mRNA in Jurkat cells. (2014)
  • Author(s): Kambe S, Yoshitake H, Yuge K, Ishida Y, Moksed A, Takizawa T, Kuwata T, Ohkuchi A, Matsubara S, Suzuki M, Takeshita T, Saito S, Takizawa T
  • Journal Title: Biol Reprod Volume: 91 Issue: 5 Pages: 129-129
  • DOI: 10.1095/biolreprod.114.121616
  • Peer Reviewed
• [Journal Article] Multiple pregnancy,short cervix, part-time worker, steroid use, low educational level, and male fetus are risk factors for preterm birth in Japan: A multicenter, prospective study. (2014)
  • Author(s): Shiozaki, A., Yoneda S., Nakabayashi M., Takeda Y., Takeda S., Sugimura M., Yoshida K., Tajima A., Manabe M., Akagi K., Nakagawa S., Tada K., Imafuku N., Ogawa M., Mizunoe T., Kanayama N., Itoh H., Minoura S., Ogino M., Saito S.
  • Journal Title: J Obstet Gynaecol Res. Volume: 40 Issue: 1 Pages: 53-61
  • DOI: 10.1111/jog.12120
  • Peer Reviewed
• [Journal Article] 頸管炎・絨毛膜羊膜炎と早産 (2014)
  • Author(s): 米田 哲, 米田徳子, 齋藤 滋
  • Journal Title: 産科と婦人科 Volume: 81 Pages: 33-37
• [Journal Article] 特集 妊娠高血圧症候群（PIH）の最新知見「PIHと胎児性差」 (2014)
  • Author(s): 塩﨑有宏, 松田義雄, 佐藤昌司, 齋藤 滋.
  • Journal Title: 産婦人科の実際 Volume: 63 Pages: 173-184
• [Journal Article] 腸内フローラと疾病とのかかわり 細菌性腟症および早産 (2014)
  • Author(s): 塩﨑有広、齋藤 滋
  • Journal Title: 臨床と微生物 Volume: 41 Pages: 67-72
• [Journal Article] Comparison of risk factors for gestational hypertension and preeclampsia in Japanese singleton pregnancies. (2013)
  • Author(s): Shiozaki A, Matsuda Y, Satoh S, Saito S.
  • Journal Title: J.Obstet Gynecol Res. Volume: 39 Issue: 2 Pages: 492-499
  • DOI: 10.1111/j.1447-0756.2012.01990.x
  • Peer Reviewed
• [Journal Article] Review: The role of autophagy in extravillous trophoblast function under hypoxia. (2013)
  • Author(s): Saito S, Nakashima A.
  • Journal Title: Placenta, Volume: 27 Pages: S79-S84
  • DOI: 10.1016/j.placenta.2012.11.026
  • Peer Reviewed
• [Journal Article] NKG2D Blockade Inhibits Poly(I:C)-Triggered Fetal Loss in Wild Type but Not IL-10-/- Mice. (2013)
  • Author(s): Thaxton JE, Nevers T, Lippe EO, Blois SM, Saito S, Sharma S.
  • Journal Title: J Immunol Volume: 190 Issue: 7 Pages: 3639-3647
  • DOI: 10.4049/jimmunol.1203488
  • Peer Reviewed
• [Journal Article] Which Types of Regulatory T cells Play Important Roles in Implantation and Pregnancy Maintenance? (2013)
  • Author(s): Saito S., Shima T., Inada K., Nakashima A.
  • Journal Title: Am J Reprod Immunol. Volume: 69 Issue: 4 Pages: 340-345
  • DOI: 10.1111/aji.12101
  • Peer Reviewed
• [Journal Article] Impaired autophagy by soluble endoglin, under physiological hypoxia in early pregnant period, is involved in poor placentation in preeclampsia. (2013)
  • Author(s): Nakashima A, Yamanaka-Tatematsu M, Fujita N, Koizumi K, Shima T, Yoshida T, Nikaido T, Okamoto A, Yoshimori T, Saito S.
  • Journal Title: Autophagy Volume: 9 Issue: 3 Pages: 303-316
  • DOI: 10.4161/auto.22927
  • Peer Reviewed
• [Journal Article] Characterization of regulatory T cells in decidua of miscarriage cases with abnormal or normal fetal chromosomal content. (2013)
  • Author(s): Inada K, Shima T, Nakashima A, Aoki K, Ito M, Saito S.
  • Journal Title: J Reprod Immunol. Volume: 97 Issue: 1 Pages: 104-111
  • DOI: 10.1016/j.jri.2012.12.001
  • Peer Reviewed
• [Journal Article] Granulysin expression and the interplay of granulysin and perforin at the maternal-fetal interface. (2013)
  • Author(s): Veljkovic Vujaklija D, Dominovic M, Gulic T, Mahmutefendic H, Haller H, Saito S, Rukavina D.
  • Journal Title: J Reprod Immunol. Volume: 97 Issue: 2 Pages: 186-196
  • DOI: 10.1016/j.jri.2012.11.003
  • Peer Reviewed
• [Journal Article] Autophagy Induced by HIF1α Overexpression Supports Trophoblast Invasion by Supplying Cellular Energy (2013)
  • Author(s): Yamanaka-Tatematsu M, Nakashima A, Fujita N, Shima T, Yoshimori T, Saito S
  • Journal Title: PLoS One. Volume: 8 Issue: 10 Pages: e76605-e76605
  • DOI: 10.1371/journal.pone.0076605
  • Peer Reviewed / Open Access
• [Journal Article] 妊娠高血圧症候群と自然免疫 (2013)
  • Author(s): 齋藤 滋
  • Journal Title: Hormone Frontier in Gynecology Volume: 20 Pages: 51-56
• [Journal Article] 精液による父方抗原特異的レギュラトリーT細胞の誘導. (2013)
  • Author(s): 齋藤 滋, 島 友子, 稲田貢三子, 中島彰俊.
  • Journal Title: 臨床免疫・アレルギー科 Volume: 59 Pages: 240-244
• [Journal Article] 不育症 Up to date ―不妊症と不育症の境界領域も含めて― (2013)
  • Author(s): 齋藤 滋
  • Journal Title: 日本IVF学会誌 Volume: 16 Pages: 21-25
• [Journal Article] 絨毛外栄養膜細胞のオートファジー抑制を介した妊娠高血圧症候群発症への関与 (2013)
  • Author(s): 中島彰俊, 齋藤滋
  • Journal Title: 産婦人科の実際. Volume: 62 Pages: 1057-1063
• [Journal Article] 不育症と診断されたとき. (2013)
  • Author(s): 齋藤 滋
  • Journal Title: 月刊 母子保健 Volume: 647 Pages: 4-5
• [Journal Article] 妊娠高血圧症候群の病態, 着床の適応不全説. (2013)
  • Author(s): 齋藤 滋, 中島彰俊
  • Journal Title: 血圧 Volume: 20 Pages: 665-670
• [Journal Article] Multiple pregnancy,short cervix, part-time worker, steroid use, low educational level, and male fetus are risk factors for preterm birth in Japan: A multicenter, prospective study. (2013)
  • Author(s): Shiozaki A, Yoneda S, Nakabayashi M, Takeda Y, Takeda S, Sugimura M, Yoshida K, Tajima A, Manabe M, Akagi K, Nakagawa S, Tada K, Imafuku N, Ogawa M, Mizunoe T, Kanayama N, Itoh H, et al.
  • Journal Title: J Obestet Gynecol Res Volume: in press
  • Peer Reviewed
• [Journal Article] A triploid partial mole placenta from paternal isodisomy with a diploid fetus derived from one sperm and one oocyte may have caused angiogenic imbalance leading to preeclampsia-like symptoms at 19 weeks of gestation. (2013)
  • Author(s): Yoneda N, Shiozaki A, Miura K, Yonezawa R, Takemura K, Yoneda S, Masuzaki H, Saito S.
  • Journal Title: Placenta Volume: in press Issue: 7 Pages: 631-634
  • DOI: 10.1016/j.placenta.2013.03.015
  • Peer Reviewed
• [Journal Article] Common gene expression patterns responsive to mild temperature hyperthermia in normal human fibroblastic cells. (2013)
  • Author(s): Tabuchi Y, Furusawa Y, Kariya A, Wada S, Ohtsuka K, Kondo T.
  • Journal Title: Int J Hyperthermia Volume: 29 Issue: 1 Pages: 38-50
  • DOI: 10.3109/02656736.2012.753163
  • Peer Reviewed
• [Journal Article] IFPA meeting 2012 workshop report I: Comparative placentation and animal models, advanced techniques in placental histopathology, human pluripotent stem cells as a model for trophoblast differentiation. (2013)
  • Author(s): Ackerman WE 4th, Carter AM, De Mestre AM, Golos TG, Jeschke U, Kusakabe K, Laurent LC, Parast MM, Roberts RM, Robinson JM, Rutherford J, Soma H, Takizawa T, Ui-Tei K, Lash GE
  • Journal Title: Placenta Volume: 34 Supplement Pages: S3-S5
  • DOI: 10.1016/j.placenta.2012.11.006
  • Peer Reviewed
• [Journal Article] IFPA Meeting 2012 Workshop Report III: Trophoblast deportation, gestational trophoblastic disease, placental insufficiency and fetal growth restriction, trophoblast over-invasion and accreta-related pathologies, placental thrombosis and fibrinolysis. (2013)
  • Author(s): Al-Khan A, Bulmer JN, Chantraine F, Chen CP, Chen Q, Collins S, Cotechini T, Fitzgerald JS, He M, Holland O, Hung TH, Illsley NP, Ino K, Iwaki T, Kanayama N, Kaneki E, Katabuchi H, et al.
  • Journal Title: Placenta Volume: 34 Pages: S11-S16
  • DOI: 10.1016/j.placenta.2012.11.018
  • Peer Reviewed
• [Journal Article] Expression of flotillins in the human placenta: potential implications for placental transcytosis. (2013)
  • Author(s): Walton JR, Frey HA, Vandre DD, Kwiek JJ, Ishikawa T, Takizawa T, Robinson JM, Ackerman WE 4th.
  • Journal Title: Histochem Cell Biol Volume: 139 Issue: 3 Pages: 487-500
  • DOI: 10.1007/s00418-012-1040-2
  • Peer Reviewed
• [Journal Article] Depletion of Invariant NKT Cells Reduces Inflammation-Induced Preterm Delivery in Mice (2012)
  • Author(s): Li LP, Fang YC, Dong GF,Lin Y, Saito S
  • Journal Title: J Immunol Volume: (in press) Issue: 9 Pages: 4681-4689
  • DOI: 10.4049/jimmunol.1102628
  • Peer Reviewed
• [Journal Article] The frequency of peripheral blood CD4+ CD25high FoxP3+ and CD4+ CD25- FoxP3+ regulatory T cells in normal pregnancy and preeclampsia. (2012)
  • Author(s): Toldi G., Saito S., Shima T., Halmos A., Veresh Z., Vásárhelyi B., Rigó J., Molvarec A.
  • Journal Title: Am J Reprod Immunol Volume: 68 Issue: 2 Pages: 175-180
  • DOI: 10.1111/j.1600-0897.2012.01145.x
  • Peer Reviewed
• [Journal Article] Apoptosis Signaling Is Altered in CD4+CD25+FoxP3+ T Regulatory Lymphocytes in Pre-Eclampsia. (2012)
  • Author(s): Darmochwal-Kolarz D., Saito S., Tabarkiewicz J., Kolarz B., Rolinski J., Leszczynska-gorzelak B., Oleszczuk J.
  • Journal Title: Int J Mol Sci Volume: 13 Issue: 6 Pages: 6548-6560
  • DOI: 10.3390/ijms13066548
  • Peer Reviewed
• [Journal Article] The Balance of the Immune System between T Cells and NK Cells in Miscarriage. (2012)
  • Author(s): Nakashima A., Shima T., Inada K., Ito M., Saito S.
  • Journal Title: Am J Reprod Immunol Volume: 67 Pages: 304-310
  • Peer Reviewed
• [Journal Article] わが国の不育症の実態. (2012)
  • Author(s): 齋藤 滋
  • Journal Title: 臨床婦人科産科 Volume: 66 Pages: 216-224
• [Journal Article] 制御性T細胞、制御性NK細胞からみた妊娠維持機構. (2012)
  • Author(s): 齋藤 滋, 島 友子, 中島彰俊
  • Journal Title: 日本臨床免疫学会誌 Volume: 35 Pages: 424-428
  • NAID: 130006948172
• [Journal Article] Plasma level of hydroxysteroid (17-β) dehydrogenase 1 in the second trimester is an independent risk factor for predicting preeclampsia after adjusting for the effects of mean blood pressure, bilateral notching and plasma level of soluble fms-like tyrosine kinase 1/placental growth factor ratio. (2012)
  • Author(s): Ohkuchi A, Ishibashi O, Hirashima C, Takahashi K, Matsubara S, Takizawa T, Suzuki M.
  • Journal Title: Hypertens Res Volume: 35 Issue: 12 Pages: 1152-1158
  • DOI: 10.1038/hr.2012.109
  • Peer Reviewed
• [Journal Article] マイクロRNAの周産期領域への展開 (2012)
  • Author(s): 瀧澤 俊広, 鈴木 光明
  • Journal Title: 今日の移植 Volume: 25 Pages: 214-222
• [Journal Article] 二本鎖RNAセンサーによるリガンド認識とシグナル伝達機構の複雑性 (2012)
  • Author(s): 瀧澤 俊広, 石橋 宰, アリ モハメド
  • Journal Title: 実験医学 Volume: 30 Pages: 1303-1306
• [Journal Article] 臨床・創薬利用が見えてきたmicroRNA 第1章 microRNA診断 16．妊娠におけるmiRNA診断：胎盤特異的miRNAと妊娠高血圧症候群の発症予知 (2012)
  • Author(s): 瀧澤 俊広, 大口 昭英, 右田 真, 松原 茂樹, 竹下 俊行
  • Journal Title: 遺伝子医学MOOK Volume: 23 Pages: 110-115
• [Journal Article] The frequency of peripheral blood CD4+CD25high FoxP3+ and CD4+CD25-FoxP3+ regulatory T cells in normal pregnancy and preeclampsia (2012)
  • Author(s): Toldi G., Saito S, Shima T., Halmos A., Veresh Z., Vasarhelyi B., Rigo J., Molvarec A.
  • Journal Title: Am J Reprod Immunol. Volume: (in press)
  • Peer Reviewed
• [Journal Article] Inhibition of DNA-dependent protein kinase promotes ultrasound -induced cell death including apoptosis in human leukemia cells (2012)
  • Author(s): Furusawa Y, Fujiwara Y, Hassan MA, Tabuchi Y, Morita A, Enomoto A,and Kondo T
  • Journal Title: Cancer Lett Volume: 322 Issue: 1 Pages: 107-112
  • DOI: 10.1016/j.canlet.2012.02.020
  • Peer Reviewed
• [Journal Article] TGF-beta-activated kinase 1 promotes cell cycle arrest and cell survival of X-ray-irradiated HeLa cells dependent on p21 induction but independent of NF-kB, p38 MAPK and ERK phosphorylations (2012)
  • Author(s): Furusawa Y, Wei ZL, Sakurai H, Tabuchi Y, Li P, Zhao QL, Nomura T, Saiki I, Kondo T
  • Journal Title: Rad.Research Volume: (in press)
  • Peer Reviewed
• [Journal Article] Gene networks related to the cell death elicited by hyperthermia (2012)
  • Author(s): Tabuchi Y
  • Journal Title: Int J Mol Med Volume: 29 Pages: 380-386
  • DOI: 10.3892/ijmm.2011.862
  • Peer Reviewed
• [Journal Article] Microarray and gene ontology analyses reveal downregulation of DNA repair and apoptotic pathways in diethylstilbestrol-exposed testicular Leydig cells (2012)
  • Author(s): Warita K, Mitsuhashi T, Tabuchi Y, Ohta K, Suzuki S, Hoshi N, Miki T, Takeuchi Y
  • Journal Title: The Journal of Toxicological Sciences Volume: 37 Issue: 2 Pages: 287-295
  • DOI: 10.2131/jts.37.287
  • NAID: 10030126622
  • ISSN: 0388-1350, 1880-3989
  • Peer Reviewed
• [Journal Article] Mitochondria-Targeted Superoxide Dismutase (SOD2) Regulates Radiation Resistance and Radiation Stress Response in HeLa Cells (2012)
  • Author(s): Hosoki, A., S. Yonekura, Q-L. Zhao, Z-L. Wei, I. Takasaki, Y. Tabuchi, L-L. Wang, S. Hasuike, T. Nomura, A. Tachibana, K. Hashiguchi, S. Yonei, T. Kondo and Q-M. Zhang-Akiyama
  • Journal Title: Journal of Radiation Research Volume: 53 Issue: 1 Pages: 58-71
  • DOI: 10.1269/jrr.11034
  • NAID: 10030023538
  • ISSN: 0449-3060, 1349-9157
  • Peer Reviewed
• [Journal Article] DNA double-strand breaks induced by cavitational mechanical effects of ultrasound in cancer cell lines (2012)
  • Author(s): Furusawa Y., Y. Fujiwara, P. Campbell, Q. L. Zhao, R. Ogawa, M. A. Hassan, Y. Tabuchi, I. Takasaki, A. Takahashi, T. Kondo
  • Journal Title: PLoS ONE Volume: 7 Issue: 1 Pages: e29012-e29012
  • DOI: 10.1371/journal.pone.0029012
  • Peer Reviewed
• [Journal Article] Inhibition of checkpoint kinase 1 abrogates G2/M checkpoint activation and promotes apoptosis under heat stress (2012)
  • Author(s): Furusawa Y, Iizumi T, Fujiwara Y, Zhao Q-L, Tabuchi Y, Nomura T, and Kondo T
  • Journal Title: Apoptosis Volume: 17 Issue: 1 Pages: 102-112
  • DOI: 10.1007/s10495-011-0660-7
  • Peer Reviewed
• [Journal Article] Hydroxysteroid(17-β) dehydrogenase 1 is dysregulated by miR-210 and miR-518c that are aberrantly expressed in preeclamptic placentas : a novel marker for predicting preeclampsia (2012)
  • Author(s): Ishibashi O, Ohkuchi A, Ali MM, Kurashina R, Luo SS, Ishikawa T, Takizawa T, Hirashima C, Takahashi K, Migita M, Ishikawa G, Yoneyama K, Asakura H, Izumi A, Matsubara S, Takeshita T, Takizawa T
  • Journal Title: Hypertension Volume: 59 Issue: 2 Pages: 265-273
  • DOI: 10.1161/hypertensionaha.111.180232
  • Peer Reviewed
• [Journal Article] Increase in the plasma levels of protein Z-dependent protease inhibitor in normal pregnancies but not in non-pregnant patients with unexplained recurrent miscarriage (2011)
  • Author(s): Souri M, ugiura-Ogasawara M, Saito S, Kemkes-Matthes B, Meijers J, Ichinose A
  • Journal Title: Thromb Haemost. Volume: 107 Issue: 03 Pages: 507-512
  • DOI: 10.1160/th11-08-0591
  • Peer Reviewed
• [Journal Article] Reduced stathmin-1 expression in NK cells associated with spontaneous abortion (2011)
  • Author(s): Lin Y., Li C, Shan B., Wang W., Saito S., Xu J., Di J., Zhong Y., Li D.J.
  • Journal Title: Am J Pathol Volume: 178 Issue: 2 Pages: 506-514
  • DOI: 10.1016/j.ajpath.2010.10.005
  • Peer Reviewed
• [Journal Article] Prediction of exact delivery time in patients with preterm labor and intact membranes at admission by amniotic fluid interleukin-8 level and preterm labor index (2011)
  • Author(s): Yoneda S., Shiozaki A., Shima T., Ito M., Yamanaka M., Hidaka T., Sumi S., Saito S.
  • Journal Title: J Obstet Gynecol. Res. Volume: 37 Issue: 7 Pages: 861-866
  • DOI: 10.1111/j.1447-0756.2010.01453.x
  • Peer Reviewed
• [Journal Article] Peripheral blood galectin-1-expressing T and natural killer cells in normal pregnancy and preeclampsia (2011)
  • Author(s): Molvarec A, Blois M S, Stenczer B, Toldi G, Tirado-Gonzalez I, Ito M, Shima T, Yoneda S, Vasarhelyi B, Rigo J., Saito S
  • Journal Title: Clin.Immunol Volume: 139 Issue: 1 Pages: 48-56
  • DOI: 10.1016/j.clim.2010.12.018
  • Peer Reviewed
• [Journal Article] Silica and titanium dioxide nanoparticles cause pregnancy complications in mice (2011)
  • Author(s): 山下浩平、吉岡靖雄
  • Journal Title: Nature Nanotechnology Volume: 6(5) Issue: 5 Pages: 321-328
  • DOI: 10.1038/nnano.2011.41
  • Peer Reviewed
• [Journal Article] Future directions of studies for recurrent miscarriage associated with immune etiologies (2011)
  • Author(s): Saito S., Nakashima A., Shima T.
  • Journal Title: J Reprod Immunol Volume: 90 Issue: 1 Pages: 91-95
  • DOI: 10.1016/j.jri.2011.03.003
  • Peer Reviewed
• [Journal Article] Impact of fetal sex on pregnancy-induced hypertension/pre-eclampsia in Japan (2011)
  • Author(s): Shiozaki A., Matsuda Y., Satoh S., Saito S.
  • Journal Title: J Reprod Immunol. Volume: 89 Issue: 2 Pages: 133-139
  • DOI: 10.1016/j.jri.2010.12.011
  • Peer Reviewed
• [Journal Article] Increased prevalence of peripheral blood granulysin-producing cytotoxic T lymphocytes in preeclampsia (2011)
  • Author(s): Molvarec A., Shiozaki A., Ito M., Toldi G., Stenczer B., Szarka A., Nakashima A., Vasarhelyi B., Rigo J.Jr., Saito S.
  • Journal Title: J Reprod Immunol. Volume: 91 Issue: 1-2 Pages: 56-63
  • DOI: 10.1016/j.jri.2011.03.012
  • Peer Reviewed
• [Journal Article] Clinical implication of recent advances in our understanding of IL-17 and reproductive immunology (2011)
  • Author(s): Saito S, Nakashima A, Ito M, Shima T
  • Journal Title: Expert Rev Clin Immunol Volume: 7 Issue: 5 Pages: 649-657
  • DOI: 10.1586/eci.11.49
  • Peer Reviewed
• [Journal Article] First trimester pregnancy decidual natural killer cells contain and spontaneously release high quantities of granulysin (2011)
  • Author(s): Vujaklija DV, Gulic T, Sucic S, Nagata K, Ogawa K, Laskarin G, Saito S, Haller H, Rukavina D
  • Journal Title: Am J Reprod Immunol. Volume: 66 Issue: 5 Pages: 363-372
  • DOI: 10.1111/j.1600-0897.2011.01015.x
  • Peer Reviewed
• [Journal Article] The Balance of the Immune System between T Cells and NK Cells in Miscarriage (2011)
  • Author(s): Nakashima A, Shima T, Inada K, Ito M, Saito S
  • Journal Title: Am J Reprod Immunol Volume: 67 Issue: 4 Pages: 304-310
  • DOI: 10.1111/j.1600-0897.2012.01115.x
  • Peer Reviewed
• [Journal Article] Silencing heat shock transcription factor 1 using small interfering RNA enhances heat stress sensitivity in human oral squamous carcinoma cells (2011)
  • Author(s): Tabuchi Y., Furusawa Y., Wada S., Ohtsuka K., Kondo T.
  • Journal Title: Thermal Med. Volume: 27 Pages: 99-108
  • Peer Reviewed
• [Journal Article] Distinct roles of transforming growth factor-α-activated kinase 1 (TAK1)-c-Rel and interferon regulatory factor 4 (IRF4) pathways in human T cell lymphotropic virus 1-transformed T helper 17 cells producing interle ukin-9 (2011)
  • Author(s): Refaat A., Zhou Y., Suzuki S., Takasaki I., Koizumi K., Yamaoka S., Tabuchi Y., Saiki I., Sakurai H.
  • Journal Title: J.Biol.Chem. Volume: 286 Issue: 24 Pages: 21092-21099
  • DOI: 10.1074/jbc.m110.200907
  • Peer Reviewed
• [Journal Article] Telmisartan improves insulin resistance and modulates adipose tissue macrophage polarization in high-fat-fed mice (2011)
  • Author(s): Fujisaka S.
  • Journal Title: Endocrinology Volume: 152(5) Issue: 5 Pages: 1789-1799
  • DOI: 10.1210/en.2010-1312
  • Peer Reviewed
• [Presentation] 不育症 (2015)
  • Author(s): 齋藤 滋
  • Organizer: 富山県 不育症・男性不妊症サポーター研修会
  • Place of Presentation: 富山
  • Year and Date: 2015-03-25
• [Presentation] 不妊症、不育症を知ってください. (2015)
  • Author(s): 齋藤 滋
  • Organizer: 男女で考える不育症・不妊症フォーラム
  • Place of Presentation: 富山
  • Year and Date: 2015-02-15
  • Invited
• [Presentation] 早産における最近の話題. (2015)
  • Author(s): 齋藤 滋
  • Organizer: 平成26年度広島県産婦人科研修会
  • Place of Presentation: 広島
  • Year and Date: 2015-02-08
  • Invited
• [Presentation] 不育症の現状と抗リン脂質抗体について. (2015)
  • Author(s): 齋藤 滋
  • Organizer: 日本抗リン脂質抗体標準化ワークショップ 第2回学術集会
  • Place of Presentation: 神戸
  • Year and Date: 2015-02-07
  • Invited
• [Presentation] 不育症の実態、リスク因子のスクリーニングならびに治療法、カウンセリングについて (2014)
  • Author(s): 齋藤 滋
  • Organizer: 不育症・不妊症セミナー
  • Place of Presentation: 堺市
  • Year and Date: 2014-12-25
  • Invited
• [Presentation] 免疫から見た妊娠維持機構とその破綻. (2014)
  • Author(s): 齋藤 滋
  • Organizer: Expert Interactions in Clinical Intelligence(EICI)
  • Place of Presentation: 大阪
  • Year and Date: 2014-12-20
  • Invited
• [Presentation] The interaction between poor placentation and inadequate immunological tolerance in preeclampsia. (2014)
  • Author(s): Saito S.
  • Organizer: 9th International Workshop Reunion Reproductive Immunology, Immunological Tolerance and Immunology of Preeclampsia
  • Place of Presentation: Reunion, France.
  • Year and Date: 2014-12-01 – 2014-12-04
  • Invited
• [Presentation] 不育症の基礎知識～不育の現状と課題～. (2014)
  • Author(s): 齋藤 滋
  • Organizer: 母子保健指導者対象セミナー
  • Place of Presentation: 京都
  • Year and Date: 2014-11-27
  • Invited
• [Presentation] 不育症の実態、リスク因子のスクリーニングならびに治療法、カウンセリングについて. (2014)
  • Author(s): 齋藤 滋
  • Organizer: 平成26年度不育症支援者研修会 第2回,
  • Place of Presentation: 沼津
  • Year and Date: 2014-11-23
  • Invited
• [Presentation] 不育症の実態、リスク因子のスクリーニングならびに治療法、カウンセリングについて (2014)
  • Author(s): 齋藤 滋
  • Organizer: 平成26年度不育症支援者研修会 第1回,
  • Place of Presentation: 静岡
  • Year and Date: 2014-11-22
  • Invited
• [Presentation] The role of autophagy in poor placentation of preeclampsia. (2014)
  • Author(s): Saito S., Nakashima A.
  • Organizer: ISSHP XIX World Congress
  • Place of Presentation: New Orleans, USA.
  • Year and Date: 2014-10-26 – 2014-10-29
• [Presentation] 免疫からみた妊娠高血圧症候群発症機序. (2014)
  • Author(s): 齋藤 滋
  • Organizer: 第37回日本高血圧学会
  • Place of Presentation: 横浜
  • Year and Date: 2014-10-19
  • Invited
• [Presentation] ヒト胎盤と免疫：最新知識レビュー (2014)
  • Author(s): 齋藤 滋
  • Organizer: 第22回日本胎盤学会
  • Place of Presentation: 京都
  • Year and Date: 2014-10-03
  • Invited
• [Presentation] 妊娠高血圧症候群の病態に迫る―胎盤多糖体説から現在に至るまで― (2014)
  • Author(s): 齋藤 滋
  • Organizer: 第70回熊本大学医学部産科婦人科学教室同窓会 記念講演会
  • Place of Presentation: 熊本
  • Year and Date: 2014-09-14
  • Invited
• [Presentation] 不妊治療クリニックにおける不育症診断―生児を得るための病診連携― (2014)
  • Author(s): 齋藤 滋
  • Organizer: 第３２回日本受精着床学会総会・学術集会
  • Place of Presentation: 東京
  • Year and Date: 2014-07-31
  • Invited
• [Presentation] 免疫学的妊娠維持機構から見た自己免疫疾患合併妊娠管理 (2014)
  • Author(s): 齋藤 滋
  • Organizer: リウマチ疾患と妊娠
  • Place of Presentation: 富山
  • Year and Date: 2014-07-24
  • Invited
• [Presentation] 免疫から見た妊娠維持機構とその破綻. (2014)
  • Author(s): 齋藤 滋
  • Organizer: Expert Interactions in Clinical Intelligence(EICI)
  • Place of Presentation: 東京
  • Year and Date: 2014-05-10
  • Invited
• [Presentation] Re-evaluation of the role of regulatory T cell during pregnancy. (2014)
  • Author(s): Saito S.
  • Organizer: 11th Congress of the European Society for Reproductive Immunology
  • Place of Presentation: Budapest, Hungary.
  • Year and Date: 2014-04-01
  • Invited
• [Presentation] T Cells in Reproduction. (2013)
  • Author(s): Saito S
  • Organizer: ISIR2013 / HIV & Post-Grad Workshops
  • Place of Presentation: Boston,USA
  • Invited
• [Presentation] Impaired autophagy in extravillous trophoblast may induce poor placentation in preeclampsia. (2013)
  • Author(s): Saito S
  • Organizer: ISSHP European Congress
  • Place of Presentation: Tromso, Norway
  • Invited
• [Presentation] Which types of regulatory T cells are necessary for maintenance of pregnancy? (2013)
  • Author(s): Saito S
  • Organizer: International Conference on Reproductive Immunology 2013 Shanghai
  • Place of Presentation: Shanghai, China
  • Invited
• [Presentation] 感染/炎症と早産との関連についての最新知見. (2013)
  • Author(s): 齋藤 滋
  • Organizer: 第65回日本産科婦人科学会学術講演会 ランチョンセミナー
  • Place of Presentation: 札幌
  • Invited
• [Presentation] 日本人における妊娠34週未満、 37週未満の早産リスク因子の解析 ～厚生労働研究（多施設共同前方視的早産研究）からの解析～. (2013)
  • Author(s): 齋藤 滋
  • Organizer: 第65回日本産科婦人科学会学術講演会 高得点演題14＜周産期医学5＞
  • Place of Presentation: 札幌
• [Presentation] NK-T-DC cross talk in pregnancy. (2012)
  • Author(s): Saito S.
  • Organizer: Joint International Congress of American Society for Reproductive Immunology (ASRI) and European Society for Reproductive Immunology (ESRI)
  • Place of Presentation: Hamburg, Germany
  • Invited
• [Presentation] Recurrent pregnancy in Japan. (2012)
  • Author(s): Saito S.
  • Organizer: 4th Congress of the Asia Pacific Initiative on Reproduction
  • Place of Presentation: Osaka
  • Invited
• [Presentation] How does the maternal immune system or autophagy system contribute to the development of preeclampsia? (2012)
  • Author(s): Saito S.
  • Organizer: International Federation of Placenta Associations Meeting 2012
  • Place of Presentation: Hiroshima
  • Invited
• [Presentation] Novel methods to detect infection for predicting the prognosis of preterm birth. (2012)
  • Author(s): Saito S.
  • Organizer: American Society for Reproductive Immunology (ASRI) 's Second Clinical Reproductive Immunology Symposium
  • Place of Presentation: Providence, USA
  • Invited
• [Presentation] Impaired autophagy of extravillous trophoblast (EVT) by soluble endoglin may disturb EVT invasion and vascular remodeling. (2012)
  • Author(s): Saito S.
  • Organizer: 8th International Workshop Reunion reproductive immunology, immunological tolerance and immunology of preeclampsia
  • Place of Presentation: Reunion Island, France
  • Invited
• [Presentation] A rare case of partial mole and co-existing normal fetus originated from one embryo shows preeclampsia-like symptoms at 19 weeks gestation: Angiogenic imbalances in molar placenta leading to hypertension, proteinuria and pleural effusion. (2012)
  • Author(s): Shiozaki A., Miura K., Yoneda N., Yonezawa R., Takemura K., Masuzaki H., Saito S.
  • Organizer: 2012 IFPA meeting
  • Place of Presentation: Hiroshima
• [Presentation] Paternal antigen-specific inducible regulatory T cells are increased just before the implantation by seminal fluid-priming. (2012)
  • Author(s): Shima T., Inada K., Nakashima A., Saito S.
  • Organizer: The Joint International Congress of the American Society for Reproductive Immunology (ASRI) and the European Society for Reproductive Immunology (ESRI)
  • Place of Presentation: Hamburg, Germany
• [Presentation] Seminal fluid priming is important for inducing the paternal antigen-specific Tregs resulting in the successful implantation. (ポスター発表） (2012)
  • Author(s): Shima T., Inada K., Nakashima A., Saito S.
  • Organizer: The 13th International Symposium of Immunology of Reproduction (13th ISIR)
  • Place of Presentation: Varna, Bulgaria
  • Invited
• [Presentation] 不育症の診断と治療－ヘパリン在宅自己注射を含めて－. (2012)
  • Author(s): 齋藤 滋
  • Organizer: 第64回日本産科婦人科学会学術講演会 ランチョンセミナー１０
  • Place of Presentation: 神戸
  • Invited
• [Presentation] Strategies to prevent preterm delivery for reducing neonatal morbidity and mortality. (2012)
  • Author(s): 齋藤 滋
  • Organizer: 第64回日本産科婦人科学会学術講演会 FIGO Forum
  • Place of Presentation: 神戸
  • Invited
• [Presentation] 早産管理の最近の話題. (2012)
  • Author(s): 齋藤 滋
  • Organizer: 秋の産婦人科集中セミナー in 長崎
  • Place of Presentation: 長崎
  • Invited
• [Presentation] 生殖免疫の立場から不妊症、不育症を議論する. (2012)
  • Author(s): 齋藤 滋
  • Organizer: 第27回日本生殖免疫学会総会・学術集会
  • Place of Presentation: 大阪
  • Invited
• [Presentation] わが国の単胎妊娠例における妊娠高血圧と妊娠高血圧腎症との相違点 －日産婦DBからの解析－. (2012)
  • Author(s): 塩﨑有宏, 松田義雄, 佐藤昌司, 齋藤 滋
  • Organizer: 第64回日本産科婦人科学会学術講演会
  • Place of Presentation: 神戸
• [Presentation] 母体血および奇胎嚢胞液中のsFlt-1、sEndoglinが異常高値を示した部分胞状奇胎の1例 (2012)
  • Author(s): 塩﨑有宏, 竹村京子, 米澤理可, 米田徳子, 伊東雅美, 伊藤実香, 米田 哲, 津留明彦, 齋藤 滋
  • Organizer: 第48回日本周産期・新生児医学会
  • Place of Presentation: 大宮
• [Presentation] 妊娠19週に高血圧、蛋白尿、肺水腫を呈した胎児共存部分胞状奇胎の病態解析. (2012)
  • Author(s): 塩﨑有宏, 三浦清徳, 鹿児山浩, 田中智子, 津田さやか, 津田 桂, 米澤理可, 伊藤実香, 米田 哲, 増﨑英明, 齋藤 滋
  • Organizer: 第33回妊娠高血圧学会
  • Place of Presentation: 長崎
• [Presentation] 切迫早産例における妊娠36週までの長期tocolysis (maintenance tocolysis)が有効と考えられる症例に関する検討.(ポスター発表） (2012)
  • Author(s): 米田 哲, 米田徳子, 稲田貢三子, 稲坂 淳, 大洞由紀子, 佐藤幹奈, 塩﨑有宏, 齋藤 滋
  • Organizer: 第64回日本産科婦人科学会学術講演会
  • Place of Presentation: 神戸
• [Presentation] 頸管内胎胞形成を伴う切迫早産例に対する黄体ホルモン製剤の有効性に関する検討. (2012)
  • Author(s): 米田 哲, 伊東雅美, 小野洋輔, 米澤理可, 伊藤実香, 塩﨑有宏, 齋藤 滋
  • Organizer: 第48回日本周産期・新生児医学会
  • Place of Presentation: 大宮
• [Presentation] 胎児発育遅延および妊娠高血圧症候群胎盤床ではオートファジーの活性化に違いを認める. (2012)
  • Author(s): 中島彰俊, 島 友子, 稲田貢三子, 塩﨑有宏, 齋藤 滋:
  • Organizer: 第36回日本産科婦人科栄養・代謝研究会 シンポジウム
  • Place of Presentation: 鹿児島
• [Presentation] オートファジー抑制による胎盤形成不全：妊娠高血圧症候群と胎児発育遅延の差異の検討. (2012)
  • Author(s): 中島彰俊, 島 友子, 稲田貢三子, 塩﨑有宏, 齋藤 滋
  • Organizer: 第27回日本生殖免疫学会 シンポジウム
  • Place of Presentation: 大阪
• [Presentation] 精漿により誘導される父親抗原特異的制御性T細胞は着床期、妊娠初期に重要な役割を果たす. (2012)
  • Author(s): 島 友子, 稲田貢三子, 中島彰俊, 齋藤 滋
  • Organizer: 第27回日本生殖免疫学会総会学術集会 シンポジウム
  • Place of Presentation: 大阪
• [Presentation] Global expression profiling of genes induced by heat stress. (2012)
  • Author(s): Tabuchi Y., Furusawa Y., Ohtsuka K., and Kondo T.
  • Organizer: The 11th Int. Congress of Hyperthermic Oncol. & The 29th Jpn. Congress of Thermal Med.
  • Place of Presentation: 京都
• [Presentation] 胎児染色体正常流産例では,着床部において制御性T細胞(Treg)が有意に低下する (2011)
  • Author(s): 稲田貢三子, 島友子, 中島彰俊, 齋藤滋
  • Organizer: 第26回日本生殖免疫学学会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-12-03
• [Presentation] エクソソームmicroRNAを介した胎盤-リンパ球間コミュニケーション:培養細胞を用いたモデル解析 (2011)
  • Author(s): 瀧澤俊広
  • Organizer: 第26回日本生殖免疫学会総会・学術集会
  • Place of Presentation: ウィンクあいち(名古屋)
  • Year and Date: 2011-12-03
• [Presentation] 胎盤特異的microRNA (2011)
  • Author(s): アリ モハメド
  • Organizer: 第56回日本人類遺伝学会
  • Place of Presentation: 幕張メッセ(千葉)
  • Year and Date: 2011-11-10
• [Presentation] 妊娠高血圧腎症(preeclampsia)の病態と予測因子 (2011)
  • Author(s): 齋藤滋, 中島彰俊, 塩崎有宏, 佐々木泰, 島友子, Molvarec A
  • Organizer: 日本高血圧学会合同シンポジウム
  • Place of Presentation: 宇都宮(招待講演)
  • Year and Date: 2011-10-20
• [Presentation] 胎盤由来エクソソームを介した胎盤-母体間コミュニケーション (2011)
  • Author(s): 菊池邦生
  • Organizer: 第19回日本胎盤学会学術集会/第29回日本絨毛性疾患研究会
  • Place of Presentation: 東京ステーションコンファレンス(東京)
  • Year and Date: 2011-10-01
• [Presentation] 胎盤由来のエクソソーム:胎盤特異的microRNAはエクソソームを介して母体循環に分泌される (2011)
  • Author(s): 瀧澤俊広
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 国立京都国際会館(京都)
  • Year and Date: 2011-09-22
• [Presentation] 制御性T細胞、制御性NK細胞からみた妊娠維持機構 (2011)
  • Author(s): 齋藤滋, 島友子, 中島彰俊
  • Organizer: 免疫疾患学会連合2011合同シンポジウム2
  • Place of Presentation: 東京(招待講演)
  • Year and Date: 2011-09-16
• [Presentation] アロ妊娠維持には制御性T(Treg)細胞のみならず制御性NK(NKreg)細胞も重要な役割を果たす (2011)
  • Author(s): 齋藤滋
  • Organizer: 第63回日本産科婦人科学会学術講演会
  • Place of Presentation: 大阪
  • Year and Date: 2011-08-29
• [Presentation] 不育症に関する新たな知見 (2011)
  • Author(s): 齋藤滋
  • Organizer: 第18回産婦人科MEセミナー
  • Place of Presentation: 大阪(招待講演)
  • Year and Date: 2011-07-03
• [Presentation] 不育症治療の実際 (2011)
  • Author(s): 齋藤滋
  • Organizer: 第6回はびきやま産婦人科セミナー
  • Place of Presentation: 大阪(招待講演)
  • Year and Date: 2011-06-29
• [Presentation] 不育症治療に関する再評価と新たなる治療法の開発に関する研究 (2011)
  • Author(s): 齋藤滋
  • Organizer: 厚生労働科学研究費補助金成育疾患克服等次世代育成基盤研究推進事業講演会
  • Place of Presentation: 東京(招待講演)
  • Year and Date: 2011-03-01
• [Presentation] To detect intrauterine inflammation and to evaluate intra-amniotic infection predict the prognosis of preterm labor cases (2011)
  • Author(s): Saito S., Yoneda S., Yoneda N.
  • Organizer: 31^<st> Annual Meeting of The American Society for Eeproductive Immunology
  • Place of Presentation: Salt Lake City(招待講演)
• [Presentation] Regulatory T cells and regulatory NK cells play very important role for maintenance of pregnancy (2011)
  • Author(s): Saito S.
  • Organizer: Australian Society for Immunology International Conference
  • Place of Presentation: Adelaide(招待講演)
• [Presentation] The balance of immune system between Treg cells and NK cells in spontaneous abortion (2011)
  • Author(s): Nakashima T., Shima T., Inada K., Saito S.
  • Organizer: The First Clinical Reproductive Immunology Symposium, American Society for Eeproductive Immunology
  • Place of Presentation: Providence(招待講演)
• [Presentation] 厚生労働研究『早産・低出生体重児増加要因の分析とその結果に基づく予知・予防対策に関する研究』(岡井班内斎藤班):日本における妊娠34週未満の早産予知因子の検討-多施設共同前方視的早産研究- (2011)
  • Author(s): 塩崎有宏
  • Organizer: 第47回日本周産期・新生児医学会
  • Place of Presentation: 札幌
• [Presentation] 妊娠高血圧症候群ならびに妊娠高血圧腎症に与える胎児性別の影響 (2011)
  • Author(s): 塩崎有宏, 齋藤滋, 松田義雄
  • Organizer: 第63回日本産科婦人科学会学術集会
  • Place of Presentation: 大阪
• [Presentation] 母体背景,新生児予後の観点から見た単胎例における妊娠高血圧と妊娠高血圧腎症との相違点-日産婦DBからの解析- (2011)
  • Author(s): 塩崎有宏, 松田義雄, 佐藤昌司, 齋藤滋
  • Organizer: 第32回日本妊娠高血圧学会学術集会
  • Place of Presentation: 金沢
• [Presentation] 可溶型エンドリンによるオートファジーを介した胎盤形成不全への関与 (2011)
  • Author(s): 中島彰俊, 島友子, 稲田貢三子, 齋藤滋
  • Organizer: 第16回日本病態プロテアーゼ学会
  • Place of Presentation: 大阪
• [Presentation] シンポジウム「流産の原因と対策」免疫学的異常による流産原因の解明 (2011)
  • Author(s): 中島彰俊
  • Organizer: 第63回日本産科婦人科学会学術講演会
  • Place of Presentation: 大阪
• [Presentation] シンポジウム「細胞内ロジスティックスの融合研究」オートファジーの胎盤形成および妊娠高血圧症候群への関与 (2011)
  • Author(s): 中島彰俊, 島友子, 稲田貢三子, 齋藤滋
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 京都
• [Presentation] シンポジウム「胎盤にかかわる免疫の関与」オートファジーから見た胎盤形成と妊娠高血圧症候群との関連性 (2011)
  • Author(s): 中島彰俊, 島友子, 稲田貢三子, 齋藤滋
  • Organizer: 第19回日本胎盤学会学術集会
  • Place of Presentation: 東京
• [Presentation] 可溶型エンドリンによるオートファジー抑制を介した妊娠高血圧症候群発症への関与 (2011)
  • Author(s): 中島彰俊, 島友子, 稲田貢三子, 齋藤滋
  • Organizer: 第32回日本妊娠高血圧学会
  • Place of Presentation: 石川(学術奨励賞)
• [Presentation] オートファジーの胎盤形成および妊娠高血圧症候群への関与 (2011)
  • Author(s): 中島彰俊, 島友子, 稲田貢三子, 塩崎有宏, 齋藤滋
  • Organizer: 第26回日本生殖免疫学会
  • Place of Presentation: 名古屋
• [Presentation] 妊娠時における父親抗原特異的制御性T細胞の変動とその役割 (2011)
  • Author(s): 島友子, 稲田貢三子, 中島彰俊, 齋藤滋
  • Organizer: 第63回日本産科婦人科学会学術講演会
  • Place of Presentation: 大阪
• [Presentation] 精漿によるプライミングにより着床直前から父親抗原特異的制御性T細胞が増加する (2011)
  • Author(s): 島友子, 稲田貢三子, 中島彰俊, 齋藤滋
  • Organizer: 第26回日本生殖免疫学会
  • Place of Presentation: 名古屋
• [Presentation] 制御性T細胞は精漿のプライミングにより子宮内に増加し,着床および初期の妊娠維持に重要な役割を果たす (2011)
  • Author(s): 島友子, 稲田貢三子, 中島彰俊, 齋藤滋
  • Organizer: 第56回日本生殖医学会学術講演会
  • Place of Presentation: 横浜
• [Presentation] 早産の病態から見た管理.
  • Author(s): 齋藤 滋
  • Organizer: 成25年度岐阜大学医学部産科婦人科教室同門会（実帰会）通常総会
  • Place of Presentation: 岐阜
  • Invited
• [Presentation] 早産に関する最近の話題.
  • Author(s): 齋藤 滋
  • Organizer: 千葉県産科婦人科医学会平成25年度学術講演会
  • Place of Presentation: 千葉
  • Invited
• [Presentation] 不育症治療Up-To-Date.
  • Author(s): 齋藤 滋
  • Organizer: 第４１回北陸産科婦人科学会 ランチョンセミナー
  • Place of Presentation: 新潟
  • Invited
• [Presentation] 不育症 Up-to-Date
  • Author(s): 齋藤 滋
  • Organizer: 東部産婦人科医会講演会
  • Place of Presentation: 沼津
  • Invited
• [Presentation] 早産の病態を考える！－腟内細菌叢と腸内細菌叢の変化について
  • Author(s): 齋藤 滋
  • Organizer: 第65回日本周産期・新生児医学会学術集会 ランチョンセミナー
  • Place of Presentation: 横浜
  • Invited
• [Presentation] 免疫から見た妊娠維持機構とその破綻
  • Author(s): 齋藤 滋
  • Organizer: Expert Interactions in Clinical Intelligence (EICI)
  • Place of Presentation: 名古屋
  • Invited
• [Presentation] 不育症治療 Up-To-Date
  • Author(s): 齋藤 滋
  • Organizer: 第20回三重県生涯教育特別研修セミナー
  • Place of Presentation: 三重
  • Invited
• [Presentation] 免疫から見た妊娠維持機構とその破綻
  • Author(s): 齋藤 滋
  • Organizer: Expert Interactions in Clinical Intelligence (EICI)
  • Place of Presentation: 東京
  • Invited
• [Presentation] 不育症の基礎知識～不育の現状と課題～
  • Author(s): 齋藤 滋
  • Organizer: 母子保健指導者研修会
  • Place of Presentation: 大阪
  • Invited
• [Presentation] 子宮内炎症、感染の有無からみた早産予後と管理.
  • Author(s): 齋藤 滋
  • Organizer: 第216回三水会
  • Place of Presentation: 鹿児島
  • Invited
• [Presentation] The pathophysiology of poor plasentation in preeclampsia.
  • Author(s): Saito S.
  • Organizer: The 200th anniversary of Dept of Obestet. and Gynecol, Semmelweis University foundation
  • Place of Presentation: Budapest, Hungary
  • Invited
• [Presentation] The role of regulatory T cells and regulatory NK cells during pregnancy.
  • Author(s): Saito S.
  • Organizer: he Congress of the Hungarian Society for Reproductive Immunology
  • Place of Presentation: Pecs, Hungary
  • Invited
• [Presentation] 最新の不育症治療について.
  • Author(s): 齋藤 滋
  • Organizer: 岡山県産婦人科専門医会
  • Place of Presentation: 岡山
  • Invited
• [Presentation] 不育症に係わる最近の話題.
  • Author(s): 齋藤 滋
  • Organizer: 岩手県産婦人科学会学術講演会
  • Place of Presentation: 盛岡
  • Invited
• [Presentation] 不育症についての最新の話題.
  • Author(s): 齋藤 滋
  • Organizer: 第15回日本IVF学会ランチョンセミナー
  • Place of Presentation: 大阪
  • Invited
• [Presentation] 不育症に関する新しい考え方.
  • Author(s): 齋藤 滋
  • Organizer: 29回東京生殖医療懇談会
  • Place of Presentation: 東京
• [Presentation] 胎盤由来のマイクロRNA は妊娠期間中エクソソームを介して母体血球細胞に取り込まれている
  • Author(s): 神戸 沙織, 石田 洋一, 菊池 邦生, 大口 昭英, 松原 茂樹, 鈴木 光明, 竹下 俊行, 瀧澤 俊広
  • Organizer: 第64回日本産科婦人科学会学術講演会
  • Place of Presentation: 神戸
• [Presentation] microRNA（miR 210 及びmiR 518）の標的遺伝子産物HSD17B1 蛋白質の血漿レベル及び母体因子を用いた妊娠高血圧腎症の発症予知
  • Author(s): 大口 昭英, 平嶋 周子, 高橋 佳代, 大丸 貴子, 有賀 治子, 鈴木 寛正, 竹下 俊行, 松原 茂樹, 瀧澤 俊広, 鈴木 光明
  • Organizer: 第64回日本産科婦人科学会学術講演会
  • Place of Presentation: 神戸
• [Presentation] 胎盤栄養膜における接着因子CD44 の浸潤能と発現制御機構の解析
  • Author(s): 高橋 宏典, 菊池 邦生, 竹下 俊行, 松原 茂樹, 鈴木 光明, 瀧澤 俊広
  • Organizer: 第64回日本産科婦人科学会学術講演会
  • Place of Presentation: 神戸
• [Presentation] microRNA（マイクロRNA）の病態における役割解明と臨床応用
  • Author(s): 瀧澤 俊広
  • Organizer: 第27回日本Shock学会総会
  • Place of Presentation: 東京
  • Invited
• [Presentation] マイクロRNA 解析から見出された妊娠高血圧腎症の新規予知因子
  • Author(s): 瀧澤 俊広, 大口 昭英, 松原 茂樹, 竹下 俊行
  • Organizer: 第22回日本産婦人科・新生児血液学会
  • Place of Presentation: 津
  • Invited
• [Presentation] Hydroxysteroid (17-Beta) Dehydrogenase 1 (HSD17B1) is dysregulated by miR-210 and miR-518c in the human placenta complicated with preeclampsia: plasma levels of HSD17B1 as a novel marker for predicting late-onset preeclampsia.
  • Author(s): Takizawa T, Ohkuchi A, Ali MM, Luo SS, Takizawa T, Migita M, Ishikawa G, Matsubara S, Takeshita T.
  • Organizer: IFPA 2012 Hiroshima Meeting（第18回国際胎盤学会）
  • Place of Presentation: 広島
  • Invited
• [Presentation] Methylation profile of C19MC-miRNA CpG island in trophoblast cell lines.
  • Author(s): Kikuchi K, Qu G, Takahashi H, Kuwata T, Usui R, Ohkuchi A, Luo SS, Matsubara S, Suzuki M, Takizawa T.
  • Organizer: IFPA 2012 Hiroshima Meeting（第18回国際胎盤学会）
  • Place of Presentation: 広島
  • Invited
• [Presentation] BeWo-cell-derived miR-517a modulates the expression of PRKG1 in Jurkat cells via Exosomes.
  • Author(s): Ali MM, Takizawa T, Kikuchi K, Saito S, Takizawa T.
  • Organizer: IFPA 2012 Hiroshima Meeting（第18回国際胎盤学会）
  • Place of Presentation: 広島
• [Presentation] Circulating placenta-specific miRNAs are delivered to maternal immune cells during pregnancy.
  • Author(s): Kambe S, Ishida Y, Kikuchi K, Yoshitake H, Ohkuchi A, Matsubara S, Suzuki M, Saito S, Takeshita T, Takizawa T.
  • Organizer: IFPA 2012 Hiroshima Meeting（第18回国際胎盤学会）
  • Place of Presentation: 広島
• [Presentation] CD44 accelerates trophobalstic invasion: in vitro invasion analysis using HTR8/SVneo cells.
  • Author(s): Takahashi H, Kikuchi K, Kuwata T, Usui R, Ohkuchi A, Matsumoto H, Sato Y, Fujiwara H, Ui-Tei K, Matsubara S, Suzuki M, Takizawa T.
  • Organizer: IFPA 2012 Hiroshima Meeting（第18回国際胎盤学会）
  • Place of Presentation: 広島
• [Presentation] microRNAの網羅的解析手法と生殖免疫学分野での応用
  • Author(s): 菊池 邦生, アリ モハメド, 岩城 隼, 吉武 洋, 瀧澤 敬美, 石川 源, 松原 茂樹, 竹下 俊行, 瀧澤 俊広
  • Organizer: 第27回日本生殖免疫学会総会・学術集会
  • Place of Presentation: 大阪
  • Invited
• [Book] E-Book. Chapter "Pregnancy Disorders and Perinatal Outcomes" (2012)
  • Author(s): Saito S.
  • Publisher: Immune System and Perinatal Outcomes