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The multimodal approach to controlling intraocular neovascularization

Research Project

Project/Area Number 23390401
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Ophthalmology
Research InstitutionNagoya University

Principal Investigator

TERASAKI HIROKO  名古屋大学, 医学(系)研究科(研究院), 教授 (40207478)

Co-Investigator(Kenkyū-buntansha) ITO Yasuki  名古屋大学, 大学院・医学系研究科, 准教授 (10313991)
米今 敬一  名古屋大学, 医学部附属病院, 病院講師 (40362256)
Project Period (FY) 2011-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2013: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2012: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2011: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Keywords未熟児網膜症 / 網膜新生血管 / 脈絡膜新生血管 / ノックインマウス / ファイバーOCT / 光干渉断層計 / 糖尿病網膜症 / 加齢黄斑変性 / 眼内病的血管新生 / 光干渉断層計(OCT) / ファイバー型OCT / 網膜脈絡膜新生血管 / VEGF / Girdin
Research Abstract

In vivo animal experiments, it revealed that heparin potentially reduced experimental choroidal neovascularization. And that Girdin has an important role in the development retinal vessels. In functional assay with using electroretingraphy, it revealed that retinal functional recoveries were obtained after injections of anti-vascualr endothelial growth factor drugs. And that retinal functional recovery after the surgeries for epiretinal membrane was obtained correlated with the reduced rental thickness.
In the development of fiber-type optical coherence tomography (OCT), the OCT images of intraocular tissue at different site could be obtained in cadaver pig eye and in vivo rabbit eye. Its utility and safety was identified in human eyes.
In the measurement of intraoperative vitreous temperature, it was demonstrated that the vitreous temperature changed significantly during the operation and that there was a correlation between the number of photocoagulation and vitreous temperature.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • Research Products

    (111 results)

All 2014 2013 2012 2011

All Journal Article (70 results) (of which Peer Reviewed: 69 results,  Acknowledgement Compliant: 1 results) Presentation (38 results) (of which Invited: 4 results) Book (1 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Electroretinograms and level of aqueous vascular endothelial growth factor in eyes with hemicentral retinal vein occlusion or branch retinal vein occlusion2014

    • Author(s)
      Yasuda S, Terasaki H. (他5名)
    • Journal Title

      Jpn J Ophthalmol

      Volume: (in press)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Choroidal atrophy in a patient with paraneoplastic retinopathy and anti-TRPM1 antibody2014

    • Author(s)
      Ueno S, Ito Y, Terasaki H. (他2名)
    • Journal Title

      Clin Ophthalmol

      Volume: 8 Pages: 369-373

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Changes in vitreous temperature during intravitreal surgery2014

    • Author(s)
      Iguchi Y, Terasaki H. (他5名)
    • Journal Title

      Invest Ophthalmol Vis Sci

      Volume: 55(4) Pages: 2344-2349

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Choroidal atrophy in a patient with paraneoplastic retinopathy and anti-TRPM1 antibody.2014

    • Author(s)
      Ueno S, Ito Y, Maruko R, Kondo M, Terasaki H.
    • Journal Title

      Clin Ophthalmol.

      Volume: 8 Pages: 369-373

    • DOI

      10.2147/opth.s55124

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Changes in vitreous temperature during intravitreal surgery.2014

    • Author(s)
      Iguchi Y, Asami T, Ueno S, Ushida H, Maruko R, Oiwa K, Terasaki H.
    • Journal Title

      Invest Ophthalmol Vis Sci.

      Volume: 55(4) Issue: 4 Pages: 2344-2349

    • DOI

      10.1167/iovs.13-13065

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transient increase of retinal nerve fiber layer thickness after macular hole surgery.2014

    • Author(s)
      Hibi N, Kondo M, Ishikawa K, Ueno S, Komeima K, Terasaki H.
    • Journal Title

      Int Ophthalmol.

      Volume: 印刷中

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Electroretinograms and level of aqueous vascular endothelial growth factor in eyes with hemicentral retinal vein occlusion or branch retinal vein occlusion.2014

    • Author(s)
      Yasuda S, Kachi S, Ueno S, Ushida H, Piao CH, Kondo M, Terasaki H.
    • Journal Title

      Jpn J Ophthalmol.

      Volume: 印刷中

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Degeneration of retinal on bipolar cells induced by serum including autoantibody against TRPM1 in mouse model of paraneoplastic retinopathy2013

    • Author(s)
      Ueno S, Terasaki H. (他9名)
    • Journal Title

      PLoS One

      Volume: 8(11)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Relationship between retinal layer thickness and focal macular electroretinogram components after epiretinal membrane surgery2013

    • Author(s)
      Hibi N, Ito Y, Terasaki H. (他3名)
    • Journal Title

      Invest Ophthalmol Vis Sci

      Volume: 54(12) Pages: 7207-7214

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Age-dependent alteration of intraocular soluble heparan sulfate levels and implication for proliferative diabetic retinopathy2013

    • Author(s)
      Nishiguchi KM, Terasaki H. (他4名)
    • Journal Title

      Mol Vis

      Volume: 19 Pages: 1125-1131

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Bilateral central retinal artery occlusion and vein occlusion complicated by severe choroidopathy in systemic lupus erythematosus2013

    • Author(s)
      Nishiguchi K, Ito Y, Terasaki H
    • Journal Title

      Lupus

      Volume: 22(7) Pages: 733-735

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Scleral thickness in Highly myopic eyes measured by enhanced depth imaging optical coherence tomography2013

    • Author(s)
      Hayashi M, Ito Y, Terasaki H. (他2名)
    • Journal Title

      Eye (Lond)

      Volume: 27(3) Pages: 410-417

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Girdin and its phosphorylation dynamically regulate neonatal vascular development and pathological neovascularization in the retina2013

    • Author(s)
      Ito T, Terasaki H. (他7名)
    • Journal Title

      Am J Pathol

      Volume: 182(2) Pages: 586-589

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Influence of preoperative intravitreal bevacizumab on visual function in eyes with proliferative diabetic retinopathy2013

    • Author(s)
      Ushida H, Terasaki H. (他4名)
    • Journal Title

      Ophthalmic Res

      Volume: 49(1) Pages: 30-36

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Peripapillary crescent and related factors in highly myopic healthy eyes2013

    • Author(s)
      Takahashi A, Ito Y, Hayashi M, Kawano K, Terasaki H
    • Journal Title

      Jpn J ophthal

      Volume: 57(2) Pages: 233-238

    • NAID

      10031168382

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Displacement of foveal area toward optic disc after macular hole surgery with internal limiting membrane peeling2013

    • Author(s)
      Kawano K, Ito Y, Terasaki H. (他5名)
    • Journal Title

      Eye (Lond)

      Volume: 27(7) Pages: 871-878

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Age-dependent alteration of intraocular soluble heparan sulfate levels and its implications for proliferative diabetic retinopathy.2013

    • Author(s)
      Nishiguchi KM, Ushida H, Tomida D, Kachi S, Kondo M, Terasaki H
    • Journal Title

      Mol Vis.

      Volume: 19 Pages: 1125-1131

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Displacement of foveal area toward optic disc after macular hole surgery with internal limiting membrane peeling.2013

    • Author(s)
      Kawano K, Ito Y, Kondo M, Ishikawa K, Kachi S, Ueno S, Iguchi Y, Terasaki H
    • Journal Title

      Eye (Lond).

      Volume: 27(7) Issue: 7 Pages: 871-877

    • DOI

      10.1038/eye.2013.99

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bilateral central retinal artery occlusion and vein occlusion complicated by severe choroidopathy in systemic lupus erythematosus.2013

    • Author(s)
      Nishiguchi KM, Ito Y, Terasaki H.
    • Journal Title

      Lupus

      Volume: 22(7) Issue: 7 Pages: 733-735

    • DOI

      10.1177/0961203313490435

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Focal cone ERGs of rhodopsin Pro347Leu transgenic rabbits.2013

    • Author(s)
      Ueno S, Koyasu T, Kominami T, Sakai T, Kondo M, Yasuda S, Terasaki H
    • Journal Title

      Vision Res.

      Volume: 91 Pages: 118-123

    • DOI

      10.1016/j.visres.2013.08.006

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relationship between retinal layer thickness and focal macular electroretinogram components after epiretinal membrane surgery.2013

    • Author(s)
      Hibi N, Ueno S, Ito Y, Piao CH, Kondo M, Terasaki H.
    • Journal Title

      Invest Ophthalmol Vis Sci.

      Volume: 54(12) Issue: 12 Pages: 7207-7214

    • DOI

      10.1167/iovs.13-12884

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association of systemic characteristics and histological variations in a case study of adult-onset asthma and periocular xanthogranuloma.2013

    • Author(s)
      Kubota T, Moritani S, Ichihara S, Terasaki H.
    • Journal Title

      J Clin Pathol.

      Volume: 67(1) Issue: 1 Pages: 92-94

    • DOI

      10.1136/jclinpath-2013-201929

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Degeneration of retinal on bipolar cells induced by serum including autoantibody against TRPM1 in mouse model of paraneoplastic retinopathy.2013

    • Author(s)
      Ueno S, Nishiguchi KM, Tanioka H, Enomoto A, Yamanouchi T, Kondo M, Yasuma TR, Yasuda S, Kuno N, Takahashi M, Terasaki H.
    • Journal Title

      PLoS One

      Volume: 8(11) Issue: 11 Pages: e81507-e81507

    • DOI

      10.1371/journal.pone.0081507

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Scleral thickness in Highly myopic eyes measured by enhanced depth imaging optical coherence tomography.2013

    • Author(s)
      Hayashi M
    • Journal Title

      Eye (Lond).

      Volume: 27(3) Issue: 3 Pages: 410-417

    • DOI

      10.1038/eye.2012.289

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Girdin and its phosphorylation dynamically regulate neonatal vascular development and pathological neovascularization in the retina2013

    • Author(s)
      Takanori Ito, Keiichi Komeima, Tetsuhiro Yasuma, Atsushi Enomoto, Naoya Asai, Masato Asai, Sayoko Iwase, Masahide Takahashi, Hiroko Terasaki
    • Journal Title

      American Journal of Pathology

      Volume: 182 Issue: 2 Pages: 586-596

    • DOI

      10.1016/j.ajpath.2012.10.012

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Influence of preoperative intravitreal bevacizumab on visual function in eyes with proliferative diabetic retinopathy.2013

    • Author(s)
      Ushida H
    • Journal Title

      Ophthalmic Res.

      Volume: 49(1) Issue: 1 Pages: 30-36

    • DOI

      10.1159/000324135

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Peripapillary crescent and related factors in highly myopic healthy eyes.2013

    • Author(s)
      Takahashi A
    • Journal Title

      Jpn J ophthal

      Volume: 57(2) Issue: 2 Pages: 233-238

    • DOI

      10.1007/s10384-012-0224-6

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of different treatment intervals between bevacizumab injection and photodynamic therapy in combined therapy for age-related macular degeneration2012

    • Author(s)
      Sawa M, Terasaki H. (他4名)
    • Journal Title

      Jpn J Ophthalmol

      Volume: 56(5) Pages: 470-475

    • NAID

      10031039832

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Focal macular electroretinograms after intravitreal injections of bevacizumab for age-related macular degeneration2012

    • Author(s)
      Iwata E, Ito Y, Terasaki H. (他5名)
    • Journal Title

      Invest Ophthalmol Vis Sci

      Volume: 53(7) Pages: 4185-4190

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Photoreceptor and post-photoreceptoral contributions to photopic ERG a-wave in rhodopsin P347L transgenic rabbits2012

    • Author(s)
      Hirota R, Terasaki H. (他4名)
    • Journal Title

      Invest Ophthalmol Vis Sci

      Volume: 53(3) Pages: 1467-1472

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] C9-R95X Polymorphism in patients with neovascular age-related macular degeneration2012

    • Author(s)
      Nishiguchi KM, Terasaki H. (他9名)
    • Journal Title

      Invest Ophthalmol Vis Sci

      Volume: 53(1) Pages: 508-512

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Half-dose vs one-third-dose photodynamic therapy for chronic central serous chorioretinopathy2012

    • Author(s)
      Uetani R, Ito Y, Terasaki H. (他2名)
    • Journal Title

      Eye (Lond)

      Volume: 26(5) Pages: 640-649

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Axial length increases and related changes in highly myopic normal eyes with myopic complications in fellow eyes2012

    • Author(s)
      Takahashi A, Ito Y, Terasaki H. (他3名)
    • Journal Title

      Retina

      Volume: 32(1) Pages: 127-133

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Omentin as a novel biomarker of metabolic risk factors2012

    • Author(s)
      Shibata R, Ouchi N, Takahashi R, Terakura Y, Ohashi K, Ikeda N, Higuchi A, Terasaki H, Kihara S, Murohara T
    • Journal Title

      Diabetol Metab Syndr

      Volume: 4 Issue: 1 Pages: 37-37

    • DOI

      10.1186/1758-5996-4-37

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of different treatment intervals between bevacizumab injection and photodynamic therapy in combined therapy for age-related macular degeneration.2012

    • Author(s)
      Sawa M
    • Journal Title

      Jpn J Ophthalmol.

      Volume: 56(5) Issue: 5 Pages: 470-475

    • DOI

      10.1007/s10384-012-0154-3

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Retinal remodeling.2012

    • Author(s)
      Jones BW
    • Journal Title

      Jpn J Ophthalmol

      Volume: 56(4) Issue: 4 Pages: 289-306

    • DOI

      10.1007/s10384-012-0147-2

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transcorneal electrical stimulation promotes survival of photoreceptors and improves retinal function in rhodopsin P347L transgenic rabbits.2012

    • Author(s)
      Morimoto T
    • Journal Title

      Invest Ophthalmol Vis Sci

      Volume: 53 Issue: 7 Pages: 4254-4261

    • DOI

      10.1167/iovs.11-9067

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Focal macular electroretinograms after intravitreal injections of bevacizumab for age-related macular degeneration.2012

    • Author(s)
      Iwata E
    • Journal Title

      Invest Ophthalmol Vis Sci.

      Volume: 53(7) Issue: 7 Pages: 4185-4190

    • DOI

      10.1167/iovs.11-9335

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Real-time imaging of rabbit retina with retinal degeneration by using spectral-domain optical coherence tomography.2012

    • Author(s)
      Muraoka Y et al.
    • Journal Title

      PLoS One

      Volume: 7 Issue: 4 Pages: e36135-e36135

    • DOI

      10.1371/journal.pone.0036135

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Photoreceptor and post-photoreceptoral contributions to photopic ERG a-wave in rhodopsin P347L transgenic rabbits.2012

    • Author(s)
      Hirota R
    • Journal Title

      Invest Ophthalmol Vis Sci.

      Volume: 53(3) Issue: 3 Pages: 1467-1472

    • DOI

      10.1167/iovs.11-9006

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] C9-R95X Polymorphism in Patients with Neovascular Age-Related Macular Degeneration.2012

    • Author(s)
      Nishiguchi KM
    • Journal Title

      Invest Ophthalmol Vis Sci.

      Volume: 53(1) Issue: 1 Pages: 508-512

    • DOI

      10.1167/iovs.11-8425

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Visual function 5 years or more after macular translocation surgery for myopic choroidal neovascularisation and age-related macular degeneration2012

    • Author(s)
      Takeuchi K
    • Journal Title

      Eye(Lond)

      Volume: 26 Issue: 1 Pages: 51-60

    • DOI

      10.1038/eye.2011.302

    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Two Novel Mutations in the EYS Gene Are Possible Major Causes of Autosomal Recessive Retinitis Pigmentosa in the Japanese Population.2012

    • Author(s)
      Nakanishi H, Ueno S, Yokoi T, Hikoya A, Fujita T, Zhao Y, Nishina S, Shin JP, Kim IT, Yamamoto S, Azuma N, Terasaki H, Sato M, Kondo M, Minoshima M, Hotta Y.
    • Journal Title

      PLoS One

      Volume: 7(2) Issue: 2 Pages: e31036-e31036

    • DOI

      10.1371/journal.pone.0031036

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Half-dose vs one-third-dose photodynamic therapy for chronic central serous chorioretinopathy.2012

    • Author(s)
      Uetani R
    • Journal Title

      Eye (Lond)

      Volume: 26(5) Issue: 5 Pages: 640-649

    • DOI

      10.1038/eye.2012.66

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Choroid is thinner in inferior region of optic disks of normal eyes.2012

    • Author(s)
      Tanabe H
    • Journal Title

      Retina.

      Volume: 32(1) Pages: 134-139

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Axial length increases and related changes in highly myopic normal eyes with myopic complications in fellow eyes.2012

    • Author(s)
      Takahashi A
    • Journal Title

      Retina.

      Volume: 32(1) Pages: 127-133

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Short-interfering RNAs induce retinal degeneration via TLR3 and IRF32012

    • Author(s)
      Kleinman ME
    • Journal Title

      Mol Ther

      Volume: 20 Issue: 1 Pages: 101-8

    • DOI

      10.1038/mt.2011.212

    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A perspective from magnetic resonance imaging findings of the inner ear: Relationships among cerebrospinal, ocular and inner ear fluids.2012

    • Author(s)
      Nakashima T
    • Journal Title

      Auris Nasus Larynx.

      Volume: 39(4) Issue: 4 Pages: 345-355

    • DOI

      10.1016/j.anl.2011.05.005

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Half-dose versus one-third-dose photodynamic therapy for chronic central serous chorioretinopathy2012

    • Author(s)
      Uetani R
    • Journal Title

      Eye

      Volume: (in press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Photoreceptor and post-photoreceptoral contributions to photopic ERG a-wave in rhodopsin P347L transgenic rabbits2012

    • Author(s)
      Hirota R
    • Journal Title

      Invest Ophthalmol Vis Sci

      Volume: (in press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Two novel mutations in the EYS gene are possible major causes of autosomal recessive retinitis pigmentosa in the japanese population2012

    • Author(s)
      Hosono K
    • Journal Title

      PLoS One

      Volume: 7(2)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] C9-R95X polymorphism in patients with neovascular age-related macular degeneration2012

    • Author(s)
      Nishiguchi KM
    • Journal Title

      Invest Ophthalmol Vis Sci

      Volume: 53 Pages: 508-12

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Choroid is thinner in inferior region of optic discs of normal eyes2012

    • Author(s)
      Tanabe H
    • Journal Title

      Retina

      Volume: 32 Pages: 134-9

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Axial length increases and related changes in highly myopic normal eyes with myopic complications in fellow eyes2012

    • Author(s)
      Takahashi A
    • Journal Title

      Retina

      Volume: 32 Pages: 127-33

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Correlation between cross-sectional shape of choroidal veins and choroidal thickness2011

    • Author(s)
      Tanabe H, Ito Y, Terasaki H. (他3名)
    • Journal Title

      Jpn J Ophthalmol

      Volume: 55(6) Pages: 614-619

    • NAID

      10030247899

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Significant correlation between electroretinogram parameters and ocular vascular endothelial growth factor concentration in central retinal vein occlusion eyes2011

    • Author(s)
      Yasuda S, Terasaki H. (他6名)
    • Journal Title

      Invest Ophthalmol Vis Sci

      Volume: 52(8) Pages: 5737-5742

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Rebound of macular edema after intravitreal bevacizumab therapy in eyes with macular edema secondary to branch retinal vein occlusion2011

    • Author(s)
      Yasuda S, Ito Y, Terasaki H. (他4名)
    • Journal Title

      Retina

      Volume: 31(6) Pages: 1075-1082

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Suppression of choroidal neovascularization and quantitative and qualitative inhibition of VEGF and CCL2 by heparin2011

    • Author(s)
      Tomida D, Terasaki H. (他6名)
    • Journal Title

      Invest Ophthalmol Vis Sci

      Volume: 52(6) Pages: 3193-3199

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Changes in the area of capillary nonperfusion before and after intravitreal injection of bevacizumab in eyes with branch retinal vein occlusion2011

    • Author(s)
      Terui T, Ito Y, Terasaki H. (他5名)
    • Journal Title

      Retina

      Volume: 31(6) Pages: 1068-1074

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Influence of preoperative intravitreous bevacizumab in visual function for proliferative diabetic retinopathy eyes2011

    • Author(s)
      Ushida H
    • Journal Title

      Ophthalmic Research

      Volume: (in press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Terasaki H.Rebound of macular edema after intravitreal bevacizumab therapy in eyes with macular edema secondary to branch retinal vein cclusion2011

    • Author(s)
      Yasuda S
    • Journal Title

      Retina

      Volume: 31 Pages: 1075-82

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Suppression of choroidal neovascularization and quantitative and qualitative inhibition of VEGF and CCL2 by heparin2011

    • Author(s)
      Tomida D
    • Journal Title

      Invest Ophthalmol Vis Sci

      Volume: 52 Pages: 3193-9

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Changes in the area of capillary nonperfusion after intravitreal injection of bevacizumab in eyes with branch retinal vein occlusion2011

    • Author(s)
      Terui T
    • Journal Title

      Retina

      Volume: 31 Pages: 1068-74

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Focal macular electroretinograms after photodynamic therapy combined with intravitreal bevacizumab2011

    • Author(s)
      Ishikawa K
    • Journal Title

      Graefes Arch Clin Exp Ophthalmol

      Volume: 249 Pages: 273-80

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The roles of vitreal macrophages and circulating leukocytes in retinal neovascularization2011

    • Author(s)
      Kataoka K
    • Journal Title

      Invest Ophthalmol Vis Sci

      Volume: 52 Pages: 1431-8

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Correlation between cross-sectional shape of choroidal veinsand choroidal thickness2011

    • Author(s)
      Tanabe H
    • Journal Title

      Jpn J Ophthalmol

      Volume: 55 Pages: 614-9

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Retinal remodeling in the Tg P347L rabbit, a large-eye model of retinal degeneration2011

    • Author(s)
      Jones BW
    • Journal Title

      J Comp Neurol

      Volume: 519 Issue: 14 Pages: 2713-33

    • DOI

      10.1002/cne.22703

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enhancement of ON-bipolar cell responses of cone electroretinograms in rabbits with the Pro347Leu rhodopsin mutation2011

    • Author(s)
      Nishimura T
    • Journal Title

      Invest Ophthalmol Vis Sci

      Volume: 52 Pages: 5610-7

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Significant correlation between electroretinogram parametersand ocular vascular endothelial growth factor concentration in central retinal vein occlusion eyes2011

    • Author(s)
      Yasuda S
    • Journal Title

      Invest Ophthalmol Vis Sci

      Volume: 52 Pages: 5737-42

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of autoantibodies against TRPM1 in patients with paraneoplastic retinopathy associated with ON bipolar cell dysfunction2011

    • Author(s)
      Kondo M
    • Journal Title

      PLoS One

      Volume: 6(5)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] What can be seen using intraoperative OCT2014

    • Author(s)
      Terasaki H
    • Organizer
      18th Advanced Vitreous Surgery Course
    • Place of Presentation
      Durham, NC, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] What can be seen using intraoperative OCT.2014

    • Author(s)
      TERASAKI H
    • Organizer
      18th Advanced Vitreous Surgery Course
    • Place of Presentation
      Durham, NC, USA
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Vitrctomy for retinopathy ofprematurity.2014

    • Author(s)
      TERASAKI H
    • Organizer
      18th Advanced Vitreous Surgery Course
    • Place of Presentation
      Durham, NC, USA
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Vitrectomy for myopic traction maculopathy.2014

    • Author(s)
      TERASAKI H
    • Organizer
      18th Advanced Vitreous Surgery Course
    • Place of Presentation
      Durham, NC, USA
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] AO imaging after surgery for retinal detachment2013

    • Author(s)
      Terasaki H
    • Organizer
      ARVO 2013 SIG symposium
    • Place of Presentation
      Seattle, USA
    • Year and Date
      2013-05-06
    • Related Report
      2013 Final Research Report
  • [Presentation] Interleukin-18 induced retinal pigment eithelium cell death, but did not suppress choroidal neovascularization in mice2013

    • Author(s)
      Ijima R, Kaneko H, Kachi S, Terasaki H
    • Organizer
      2013 ARVO Annual Meeting
    • Place of Presentation
      Seattle, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] Interleukin-18 induced retinal pigment eithelium cell death, but did not suppress choroidal neovascularization in mice.2013

    • Author(s)
      Ijima R, Kaneko H, Kachi S, Terasaki H
    • Organizer
      2013 ARVO Annual Meeting
    • Place of Presentation
      Seattle, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] Anti-histamine receptor 4 therapy inhibits choroidal neovascularization in mice.2013

    • Author(s)
      Kaneko H, Ijima R, Kachi S, Terasaki H
    • Organizer
      2013 ARVO Annual Meeting
    • Place of Presentation
      Seattle, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] Change of retinochoroidal thickness after pars plana vitrectomy with endophotocoagulation for proliferative diabetic retinopathy.2013

    • Author(s)
      Yamamoto K, Iwase T, Ushida H, Terasaki H
    • Organizer
      2013 ARVO Annual Meeting
    • Place of Presentation
      Seattle, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] Parameters related to choroidal thickness.2013

    • Author(s)
      Ito Y, Oiwa K, Iwata E, Takahashi A, Yasuma T, Kawano K, Hamajima N, Terasaki H
    • Organizer
      2013 ARVO Annual Meeting
    • Place of Presentation
      Seattle, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] Over-expression of dystrophin isoform Dp71 does not alter the mouse ERG.2013

    • Author(s)
      Nagaya M, Ueno S, Kondo M, Furukawa T, Terasaki H
    • Organizer
      2013 ARVO Annual Meeting
    • Place of Presentation
      Seattle, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] Electronretinogram and aqueous vascular endotheril growth factor in the eyes with hemi-central retinal vein occlusion or branch retinal vein occlusion.2013

    • Author(s)
      Kachi S, Yasuda S, Ushida H, Kondo M, Ueno S, Piao CH, Terasaki H
    • Organizer
      2013 ARVO Annual Meeting
    • Place of Presentation
      Seattle, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] Movement of fovea toward optic disc after macular hole surgery with internal limiting membrane peeling.2013

    • Author(s)
      Kawano k, Ito Y, Kondo M, Terasaki H
    • Organizer
      2013 ARVO Annual Meeting
    • Place of Presentation
      Seattle, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] AO imaging after surgery for retinal detachment.2013

    • Author(s)
      Terasaki H
    • Organizer
      ARVO 2013 SIG symposium
    • Place of Presentation
      Seattle, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] Visual acuity outcomes in dosing subgroups of the GALILEO and COPERNICSU study in patients with macular edema secondary to central retinal veine occlusion under PRN treatment.2013

    • Author(s)
      Terasaki H
    • Organizer
      The 8th APVRS Congress & 第52回 日本網膜硝子体学会総会
    • Place of Presentation
      名古屋市 名古屋国際会議場
    • Related Report
      2013 Annual Research Report
  • [Presentation] Autoantibody against TRPM1 in sera of Japanease paraneoplastic retinopathy patients.2013

    • Author(s)
      Ueno S, Kondo M, Enomoto A, Kimura K, Machida S, Terasaki H
    • Organizer
      The 8th APVRS Congress & 第52回 日本網膜硝子体学会総会
    • Place of Presentation
      名古屋市 名古屋国際会議場
    • Related Report
      2013 Annual Research Report
  • [Presentation] Diurnal variations in ocular circulation and the relationship with systematic and ocular factors in healthy subjects.2013

    • Author(s)
      Iwase T, Yamamoto K, Ra E, Kitagawa S, Ito Y, Terasaki H
    • Organizer
      The 8th APVRS Congress & 第52回 日本網膜硝子体学会総会
    • Place of Presentation
      名古屋市 名古屋国際会議場
    • Related Report
      2013 Annual Research Report
  • [Presentation] Vitreous temperature after cataract surgery and various vitrectomy procedures2012

    • Author(s)
      Terasaki H, Iguchi Y, Ueno S, Ushida H, Iwata E, Yasuda S, Oiwa K
    • Organizer
      XXVIIIth Meeting of CLUB JULES GONIN
    • Place of Presentation
      Reykjavik, Iceland
    • Related Report
      2013 Final Research Report
  • [Presentation] On site OCT during vitrectomy procedures2012

    • Author(s)
      Terasaki H
    • Organizer
      7th APVRS
    • Place of Presentation
      Hong Kong, China
    • Related Report
      2013 Final Research Report
  • [Presentation] Changes in implicit times of 30Hz Flicker Electroretinograms after photocoagulation in eyes with central retinal vein occlusion.2012

    • Author(s)
      S Kachi, S Yasuda, H Ushida, R Uetani, M Kondo, H Terasaki.
    • Organizer
      2012 ARVO Annual Meeting
    • Place of Presentation
      Fort Lauderdale, USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] Whole genome analysis of 16 unrelated patients with autosomal recessive retinitis pigmentosa reveals novel single-base and large structural genomic mutations.2012

    • Author(s)
      Koji M. Nishiguchi, M Nakamura, M Kondo, S Ueno, T.R. Yasuma, R. Tearie, J. Beckmann, H. Terasaki, E.L. Berson, C.Rivalta.
    • Organizer
      2012 ARVO Annual Meeting
    • Place of Presentation
      Fort Lauderdale, USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] An adenine inserition between nucreotide positions 4957 and 4958 in the EYS Gene is a possible major cause of arRP in the Japanease popuration.2012

    • Author(s)
      K Hosono, C Ishigami, M Takahashi, Y Hirami, S Ueno, N Azuma, H Terasaki, M, Kondo, S Minoshima, Y Hotta.
    • Organizer
      2012 ARVO Annual Meeting
    • Place of Presentation
      Fort Lauderdale, USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] Focal macular electroretinogram elicited by hemicircular stimuli in eyes eith branchi retinal veine occlusion.2012

    • Author(s)
      S Yasuda, S Ueno, CH Piao, M Kondo, H Terasaki.
    • Organizer
      2012 ARVO Annual Meeting
    • Place of Presentation
      Fort Lauderdale, USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] Vitreous temperature after cataract surgery and various vitrectomy procedures.2012

    • Author(s)
      H Terasaki, Y Iguchi, S Ueno, H Ushida, E Iwata, S Yasuda, K Oiwa.
    • Organizer
      XXVIIIth Meeting of CLUB JULES GONIN
    • Place of Presentation
      Reykjavik, Iceland
    • Related Report
      2012 Annual Research Report
  • [Presentation] On site OCT during vitrectomy procedures.2012

    • Author(s)
      Terasaki H.
    • Organizer
      7th APVRS
    • Place of Presentation
      Hong Kong, China
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Prognosis and prognostic factors in chronic central serous chorioretinopathy after half dose verteporfin photodynamic therapy.2012

    • Author(s)
      Uetani R, Ito Y, Ishikawa K, Terasaki H.
    • Organizer
      7th APVRS
    • Place of Presentation
      Hong Kong, China
    • Related Report
      2012 Annual Research Report
  • [Presentation] Autologou plasmin-assidted vitrectomy for diabetic macular edema-12 months follow-up.2012

    • Author(s)
      Asami T, Ushida H, Ueno S, Terasaki H.
    • Organizer
      7th APVRS
    • Place of Presentation
      Hong Kong, China
    • Related Report
      2012 Annual Research Report
  • [Presentation] Scleral thickness in highly mynopic eyes mesurerd by enhance tomography.2012

    • Author(s)
      Hayashi M, Ito Y, Takahashi A, Kawano K, Terasaki H.
    • Organizer
      7th APVRS
    • Place of Presentation
      Hong Kong, China
    • Related Report
      2012 Annual Research Report
  • [Presentation] Case of cancer-associated retinopathy with electronegative ERGs2011

    • Author(s)
      Ueno S, Terasaki H
    • Organizer
      The 7^<th> KSCEV Symposium with the 2^<nd> J SCEV-KSCEV Joint Meeting
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2011-11-20
    • Related Report
      2011 Annual Research Report
  • [Presentation] Retinal function and morphology in the management of macular diseases2011

    • Author(s)
      Terasaki H
    • Organizer
      The 7th KSCEV Symposium with the 2nd JSCEV-KSCEV Joint Meeting
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2011-11-19
    • Related Report
      2013 Final Research Report
  • [Presentation] Retinal function and morphology in the management of Macular diseases2011

    • Author(s)
      Terasaki H
    • Organizer
      The 7^<th> KSCEV Symposium with the 2^<nd> J SCEV-KSCEV Joint Meeting
    • Place of Presentation
      Seoul, Korea(招待講演)
    • Year and Date
      2011-11-19
    • Related Report
      2011 Annual Research Report
  • [Presentation] Correlation between cross-sectional shape of choroidal vessels and choroidal thickness2011

    • Author(s)
      Tanabe H
    • Organizer
      2011 ARVO Annual Meeting
    • Place of Presentation
      Fort Lauderdale, USA
    • Year and Date
      2011-05-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] Longitudinal monitoring of photoreeptors in rabbit model of retinal degeneration by using spectral-domain optical coherence tomography2011

    • Author(s)
      Muraoka Y
    • Organizer
      2011 ARVO Annual Meeting
    • Place of Presentation
      Fort Lauderdale, USA
    • Year and Date
      2011-05-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] Correlations between the VEGF levels in aqueous humor and amplitudes and implicit times of different componentsof electroretinogram in eyes with CRVO2011

    • Author(s)
      Yasuda S
    • Organizer
      2011 ARVO Annual Meeting
    • Place of Presentation
      Fort Lauderdale, USA
    • Year and Date
      2011-05-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] Transcorneal electrical stimulation promotes the survival of photoreceptors and preserves retinal function in rhodopsin P3471 transgenic rabbits2011

    • Author(s)
      Morimoto T
    • Organizer
      2011 ARVO Annual Meeting
    • Place of Presentation
      Fort Lauderdale, USA
    • Year and Date
      2011-05-02
    • Related Report
      2011 Annual Research Report
  • [Presentation] Focal cone ERGs changes during retinal degeneration in rhodopsin Pro347Leu transgenic rabbits2011

    • Author(s)
      Ueno S
    • Organizer
      2011 ARVO Annual Meeting
    • Place of Presentation
      Fort Lauderdale, USA
    • Year and Date
      2011-05-01
    • Related Report
      2011 Annual Research Report
  • [Presentation] Unfolded protein response is associated with expression of vascular endothelial growth factor by retinal pigment epithelial cells2011

    • Author(s)
      Kachi S
    • Organizer
      2011 ARVO Annual Meeting
    • Place of Presentation
      Fort Lauderdale, USA
    • Year and Date
      2011-05-01
    • Related Report
      2011 Annual Research Report
  • [Presentation] Identification of autoantibodies against TRPM1 in sera of patients with paraneoplastic retinopathy associated with on bipolar cell dysfunction2011

    • Author(s)
      Kondo M
    • Organizer
      ISCEV@ARVO
    • Place of Presentation
      Fort Lauderdale, USA
    • Year and Date
      2011-04-30
    • Related Report
      2011 Annual Research Report
  • [Book] Macular Surgery2011

    • Author(s)
      Hiroko Terasaki
    • Publisher
      Lippincott Williams & Wilkins
    • Related Report
      2011 Annual Research Report
  • [Patent(Industrial Property Rights)] Fiber型小切開硝子体手術用光干渉断層計2013

    • Inventor(s)
      寺崎浩子, 西山潤平, 小林雅彦
    • Industrial Property Rights Holder
      名古屋大学, 株式会社 ニデック
    • Industrial Property Rights Type
      特許
    • Filing Date
      2013-06-14
    • Related Report
      2013 Final Research Report
  • [Patent(Industrial Property Rights)] Fiber型小切開硝子体手術用光干渉断層計2013

    • Inventor(s)
      寺﨑浩子、西山潤平、小林雅彦
    • Industrial Property Rights Holder
      名古屋大学、株式会社 ニデック
    • Industrial Property Rights Type
      特許
    • Filing Date
      2013-06-14
    • Related Report
      2013 Annual Research Report

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Published: 2011-04-06   Modified: 2019-07-29  

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