| Project/Area Number |
23390418
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Niigata University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
IZUMI Kenji 新潟大学, 医歯学系, 教授 (80242436)
INOUE Kayoko (NOZAWA Kayoko) 新潟大学, 医歯学系, 特任准教授 (90303130)
KAWANO Yoshiro 新潟大学, 医歯学系, 助教 (60303129)
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| Research Collaborator |
OHZAMA Atsushi 新潟大学, 医歯学系, 准教授 (40266169)
SUZUKI Akiko 新潟大学, 医歯学系, 特任助教
HARADA Fumiko 新潟大学, 医歯学系, 科研費雇用研究員
YOSHII Tomoko 新潟大学, 大学院・医歯学総合研究科, 大学院生(現研究員)
IHYO Chika 新潟大学, 大学院・医歯学総合研究科, 大学院生(現教務補佐員)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2013: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2012: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2011: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
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| Keywords | 歯根膜 / 機械受容器 / ルフィニ神経終末 / ASIC3 / イオンチャネル / 再生 / ASIC / 免疫細胞化学 / 三叉神経節 / 定量解析 |
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| Research Abstract |
This study examined the regeneration process of the periodontal Ruffini ending, an essential mecahnoreceptor, based on the changes in the expression pattern of acid-sensing ion channel-3 (ASIC3) at the periodontal ligament and trigeminal ganglion. The findings obtained from the nerve injury model (resection of the inferior alveoar nerve at one side) indicate that this molecule is not direcly involved in the axonal regeneration of the periodontal Ruffini endings but rather in neuron-glial interactions such as control of neuronal activity in the trigeminal ganglion.
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