Development of novel strategy for caries treatment based on techniques of dentin remineralization and regeneration
| Project/Area Number |
23390436
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Conservative dentistry
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| Research Institution | Health Sciences University of Hokkaido |
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Principal Investigator |
SAITO TAKASHI 北海道医療大学, 歯学部, 教授 (40265070)
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| Co-Investigator(Kenkyū-buntansha) |
ITO Shuichi 北海道医療大学, 歯学部, 准教授 (50382495)
BESSHO Kazuhisa 京都大学, 医学研究科, 教授 (90229138)
HANDA Keisuke 北海道医療大学, 歯学部, 講師 (40433429)
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| Project Period (FY) |
2011-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2014: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2013: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2012: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
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| Keywords | 保存修復学 / 齲蝕治療 / 象牙質再石灰化 / 修復象牙質誘導 / 修復象牙質形成 / 再生象牙質誘導 / フォスフォフォリン / RGD / 合成ペプチド / 覆髄処置 / 象牙質再生 / う蝕治療 |
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| Outline of Final Research Achievements |
The results of this research having the purpose of developing novel caries treatment materials, method based on dentin remineralization technology and dentin regeneration technology are as follows; Firstly, the mineral induction ability of CMET was confirmed and the high remineralization activity and the long-term durability at the adhesion interface of CMET containing adhesive materials were clarified. Furthermore, it was demonstrated that phosphohporyn RGD-peptides promoted odontoblast-differentiation in vitro and the reparative dentin formation in vivo. From these results, it was suggested the high possibility of these materials as novel caries treatment materials.
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Report
(5 results)
Research Products
(39 results)
