| Project/Area Number |
23390455
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Fukuoka Dental College |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KAWAGUCHI Minoru 福岡歯科大学, 口腔歯学部, 講師 (10122780)
大野 純 福岡歯科大学, 歯学部, 講師 (10152208)
土井 豊 朝日大学, 歯学部, その他 (40116067)
早川 徹 鶴見大学, 歯学部, 教授 (40172994)
岡畑 惠雄 (岡畑 恵雄) 山形大学, 理工学研究科, 教授 (80038017)
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| Co-Investigator(Renkei-kenkyūsha) |
OHNO Jun 福岡歯科大学, 口腔歯学部, 講師 (10152208)
DOI Yutaka 朝日大学, 歯学部, 教授 (40116067)
HAYAKAWA Tohru 鶴見大学, 歯学部, 教授 (40172994)
OKAHATA Yoshio 山形大学, 大学院・理工学研究科, 教授 (80038017)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2013: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2012: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000)
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| Keywords | DNA / プロタミン / 複合体 / 骨補填材 / インジェクション / 骨形成 / ペースト / 骨伝導性 / インジェクション型 / スキャフォールド / 骨再生 / 抗菌性 / スキャフォ-ルド / サイトカイン / 人工脂質 |
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| Research Abstract |
The DNA/protamine complex was prepared by reaction between salmon tests DNA and protamine in order to investigate the potentials of the complex for injectable bone graft materials. The complex became paste by kneading the complex powder and distilled water, and the paste upgrade the expression of bone-related genes. Moreover, the paste induced new bone formation in rat cranial defect. Therefore, the DNA/protamine complex paste will be a useful biomaterial for injectable bone graft material.
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