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Analysis of pain induced mechanism after trigeminal nerve injury

Research Project

Project/Area Number 23390461
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Surgical dentistry
Research InstitutionNiigata University

Principal Investigator

SEO KENJI  新潟大学, 医歯学系, 教授 (40242440)

Co-Investigator(Kenkyū-buntansha) MAEDA Takeyasu  新潟大学, 医歯学系, 教授 (40183941)
FUJIWARA Naoshi  新潟大学, 医歯学系, 教授 (70181419)
TERUMITSU Makoto  新潟大学, 医歯学系, 准教授 (60401767)
TSURUMAKI Tatsuru  新潟大学, 医歯学系, 助教 (10345522)
TANAKA Yutaka  新潟大学, 医歯学総合病院, 講師 (50323978)
YOSHIKAWA Hiroyuki  新潟大学, 医歯学総合病院, 医員 (20547575)
KURATA Shigenobu  新潟大学, 医歯学系, 助教 (20464018)
Project Period (FY) 2011-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2014: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Keywordstrigeminal nerve / nerve injury / regeneration / BDNF / Semaphrin-3A / 末梢神経再生 / セマフォリン3A / 下歯槽神経 / 三叉神経 / 神経損傷 / 神経再生 / neuroma / trigeminal / inferior alveolar nerve / 神経腫 / アザン染色 / PGP9.5 / Fluorogolg / 三叉神経節 / コラーゲン / 抗BDNF抗体
Outline of Final Research Achievements

When peripheral nerve is injured, the some local factors can be produced and affect the regeneration. Brain derived neurotrophic factor BDNFwas released from fibroblasts in the vicinity of the injury site, and its quantity increased within 24 hours after the incidence of injury and decreased after that, resulting in the disappearance. When this BDNF was inactivated at the local site immediately after the injury, elongation of neurites and reconnection of the injured axons were inhibited. This inactivation also inhibited regeneration of mechanical touch sensation, and allodynia, which appeared after the nerve injury, was inhibited. As another factor, the existence of nerve growth inhibitory protein semaphoring-3A was observed after the nerve injury. These results suggested that local facilitator and inhibitory factors are induced at the local site of nerve injury, and these can affect the regeneration, resulting in the prognosis.

Report

(5 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • Research Products

    (12 results)

All 2014 2013 Other

All Journal Article (2 results) (of which Peer Reviewed: 1 results,  Open Access: 2 results,  Acknowledgement Compliant: 1 results) Presentation (10 results)

  • [Journal Article] Effect of local application of an antibody against brain-derived neurotrophic factor on neuroma formation after transection of the inferior alveolar nerve in the rat.2014

    • Author(s)
      Valverde Guevara YM, Yoshikawa H, Saito I, Maeda T, Seo K.
    • Journal Title

      NeuroReport

      Volume: 25 Issue: 13 Pages: 1069-1074

    • DOI

      10.1097/wnr.0000000000000231

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 三叉神経損傷の臨床2014

    • Author(s)
      瀬尾憲司
    • Journal Title

      新潟歯学会雑誌

      Volume: 44 Pages: 1-13

    • Related Report
      2014 Annual Research Report
    • Open Access
  • [Presentation] Functional analysis of the regenerated inferior alveolar nerve after local administration of anti-BDNF antibody to the transected site2014

    • Author(s)
      H. YOSHIKAWA, Y. M. VALVERDE, T. MAEDA, M. KUROSE, K. YAMAMURA, K. SEO
    • Organizer
      Annual meeting, Society for Neuroscience
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      2014-11-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] Possible involvement of BDNF in neuroma formation after trigeminal nerve injury, 4th international congress on neuropathic pain2013

    • Author(s)
      H. Yoshikawa, Y. Valverde, J. Kitagawa, K. Yamamura, T. Maeda, K. Seo
    • Organizer
      Internationa association of study for the pain, Special interest group of neuropathic pain
    • Place of Presentation
      トロント(カナダ)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 末梢神経切断後の局所抗BDNF 抗体投与の軸索再生への影響2013

    • Author(s)
      吉川博之,Y.M. Valverde Guevara, 前田健康,黒瀬雅之,山村健介,瀬尾憲司
    • Organizer
      第35 回日本疼痛学会
    • Place of Presentation
      大宮市
    • Related Report
      2013 Annual Research Report
  • [Presentation] 神経損傷によるニューロトロフィンの変化を導くメカニズムについての検討2013

    • Author(s)
      吉川博之, 弦巻 立, 瀬尾憲司
    • Organizer
      第41 回日本歯科麻酔学会総会
    • Place of Presentation
      横浜市
    • Related Report
      2013 Annual Research Report
  • [Presentation] CONTRIBUTION OF BDNF TO NERVE REGENERATION AND NEUROMA FORMATION AFTER NERVE INJURY2013

    • Author(s)
      Kenji Seo, Hiroyuki Yoshikawa, Yessenia M. Valverde, Takeyasu Maeda, Masayuki Kurose, Kensuke Yamamura
    • Organizer
      8th Congress of the European Federation of IASP Chapters
    • Place of Presentation
      フィレンツェ(イタリア)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 下歯槽神経切断部位へのBDNF 抗体投与が知覚の再生に及ぼす影響

    • Author(s)
      吉川博之,Y.M. Valverde Guevara, 前田健康,黒瀬雅之,山村健介,瀬尾憲司
    • Organizer
      平成25 年度新潟歯学会第2 回例会
    • Place of Presentation
      新潟市
    • Related Report
      2013 Annual Research Report
  • [Presentation] Effects of antibody to BDNF on nerve regeneration following

    • Author(s)
      Y. M. VALVERDE GUEVARA
    • Organizer
      Annual meeting of Soiciety for neuroscience
    • Place of Presentation
      New Orleans, USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] Possible role of BDNF during nerve regeneration after inferior alveolar nerve injury

    • Author(s)
      Y. M. VALVERDE GUEVARA
    • Organizer
      The 46th General meeting of Niigata Dental Society
    • Place of Presentation
      新潟市(新潟大学)
    • Related Report
      2012 Annual Research Report
  • [Presentation] POSSIBLE INVOLVEMENT OF BDNF IN NEUROMA FORMATION AFTER TRIGEMINAL NERVE INJURY

    • Author(s)
      Hiroyuki Yoshikawa
    • Organizer
      4th International Congress on Neuropathic Pain
    • Place of Presentation
      Toronto, CANADA
    • Related Report
      2012 Annual Research Report
  • [Presentation] 末梢神経切断後の局所抗BDNF抗体投与の軸索再生への影響

    • Author(s)
      吉川博之
    • Organizer
      日本疼痛学会
    • Place of Presentation
      さいたま市(大宮ソニックシティー)
    • Related Report
      2012 Annual Research Report

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Published: 2011-04-06   Modified: 2019-07-29  

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