| Budget Amount *help |
¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2013: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2012: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
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| Research Abstract |
The aim of this research is the application of multipotent stem cells artificially induced from tissue cells to regenerative medicine.
We revealed that GSK3b inhibitor IX induced tooth pulp cells to pulp stem cells, and mediated marker of stem cell. As a result of the transplantation of induced pulp stem cell derived from human deciduous teeth to subcutaneous of mouse using hydroxyapatite as a carrier, hydroxyapatite was absorbed completely and produced substantial bone tissue included human derived blood cells. These results are the innovative discovery that artificial induction of tissue stem cells generated human bone marrow, and the method is expected as the applicable technique for the treatment of blood disorder such as leukemia.
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