| Project/Area Number |
23390472
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
OOSHIMA Takashi 大阪大学, 歯学研究科(研究院), 招へい教員 (80116003)
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| Co-Investigator(Kenkyū-buntansha) |
NAKANO Kazuhiko 大阪大学, 歯学研究科, 准教授 (00379083)
NOMURA Ryota 大阪大学, 歯学部附属病院, 講師 (90437385)
NEMOTO Hirotoshi 大阪大学, 歯学部附属病院, 医員 (80527226)
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| Research Collaborator |
UMEMURA Kazuo 浜松医科大学, 医学部, 教授 (40232912)
TANAKA Tokutaro 聖隷浜松病院, 脳神経外科, 部長 (90283366)
HOKAMURA Kazuya 浜松医科大学, 医学部, 助教 (90436965)
NAKA Shuhei 大阪大学, 歯学部附属病院, 医員 (10589774)
URATA Ayuchi 大阪大学, 歯学研究科, 特任研究員 (90589772)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2013: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2011: ¥10,140,000 (Direct Cost: ¥7,800,000、Indirect Cost: ¥2,340,000)
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| Keywords | 口腔細菌 / 全身疾患 / ミュータンスレンサ球菌 / う蝕 / 感染性心内膜炎 / 脳出血 / 炎症性腸炎 / 非アルコール性脂肪肝炎 / 齲蝕 / 歯周病 / 口腔レンサ球菌 / コラーゲン結合タンパク / 高ビルレンス株 / う触 / 血管肥厚 / 循環器疾患 / 脳血管疾患 / 消化器疾患 |
|---|
| Research Abstract |
Recently, the association of periodontitis with several systemic diseases has received attention. In the present study, the contribution of Streptococcus mutans, a major pathogen of dental caries, to the pathogenesis of infective endocarditis, cerebral hemorrhage, inflammatory bowel disease, and non-alcoholic steatohepatitis was investigated by focusing on cell surface collagen-binding proteins. Our results showed that S. mutans with collagen-binding proteins is possibly virulent for these diseases following invsion of the bloodstream.
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