| Project/Area Number |
23406029
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 海外学術 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Ibaraki Prefectural University of Health Science |
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Principal Investigator |
YAMAGUCHI Naoto 茨城県立医療大学, 保健医療学部, 教授 (40239900)
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| Co-Investigator(Kenkyū-buntansha) |
JESMIN Subrina 筑波大学, 医学医療系, 助教 (60374261)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2013: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2011: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
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| Keywords | 慢性腎臓病 / メタボリック症候群 / 東南アジア / 性差 / 閉経 / 地域横断的疫学調査 / 血管内皮増殖因子 / 推算GFR値 / VEGF / 糖尿病 / 低HDL血症 / ＶＥＧＦ / 慢性腎臓病(CKD) / eGFR |
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| Research Abstract |
The aim of this study is to reveal the prevalence of chronic kidney disease or reduced kidney function (CKD: eGFR<60ml/min/1.73m2) and to estimate its association with component of metabolic syndrome (MS), in view of differences between subgroups divided by gender or pre-/post-menopausal status in Bangladesh rural, based on a community based cross-sectional survey among 1,701 people (men166, women1,535), with 446 serum samples of creatinine. The total prevalence of CKD is 30% (men 25%, pre-menopausal 28%, and post-menopausal women 45%, p<0.05). Prevalence of CKD in patients with MS was higher than that in people without MS (p<0.01). Hyperglycemia and higher gravidity were well correlated with CKD in pre-menopausal women, and hyperlipidemia was correlated with CKD in post-menopausal. The mean level of eGFR was the lowest in post-menopausal among the subgroups of gender or menopausal status.These data suggest that slowing the rise in MS may contribute to prevent CKD in this area.
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