| Project/Area Number |
23500421
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | National Defense Medical College |
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Principal Investigator |
IMAMURA OSAMU 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究, 医学教育部医学科専門課程, 准教授 (40534954)
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| Co-Investigator(Kenkyū-buntansha) |
TAKISHIMA Kunio 防衛医科大学校, 医学教育部医学科専門課程, 教授 (50531365)
DATEKI Minori 防衛医科大学校, 医学教育部医学科専門課程, 助教 (00415879)
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 大脳皮質形成 / シグナル伝達 / 細胞移動 / ノックアウトマウス / 神経回路 / Erk1/2 / 神経突起 / 神経細胞移動 |
|---|
| Outline of Final Research Achievements |
The mitogen activated protein kinases, Erk1 and Erk2 (Erk1/2) are critical intracellular signaling intermediates in proliferation and differentiation. Erk1/2 is also essential for memory and learning in the brain. In this study, to elucidate the roles of Erk1/2 in the developing mouse cerebral cortex, we generated neuron-specific Erk1/2 double knockout mice using Synapcine-Cre mice and found that Erk signaling is required for radial migration, neuronal positioning and neuronal circuit formation.
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