Contribution of post-translational modifications of tubulins in neuronal morphogenesis
Project/Area Number |
23500443
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Neurochemistry/Neuropharmacology
|
Research Institution | University of Fukui |
Principal Investigator |
KONISHI Yoshiyuki 福井大学, 工学(系)研究科(研究院), 准教授 (00382838)
|
Project Period (FY) |
2011-04-28 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
|
Keywords | 微小管 / 翻訳後修飾 / 軸索 / 極性 / 樹状突起 / チュブリン / シグナル伝達 / 神経極性 / 細胞移動 / 神経細胞 / 神経 / ニューロフィラメント |
Outline of Final Research Achievements |
Microtubules play central roles in the regulation of cellular morphology. It could receive region dependent regulation within the cell, which is especially important in the regulation of complicated neuronal cell shape. In this project, we investigated the role of two types of post-translational modifications of tubulins, tyrosination and polyglutamylation in the regulation of neuronal structure. Especially, we found that polyglutamylation regulate the dendritic distribution of neurofilaments. In addition to these tubulin modifications, we investigated the neuronal subtype dependent regulation of morphogenesis.
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Report
(5 results)
Research Products
(12 results)