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Regulation of neuronal development by microRNAs

Research Project

Project/Area Number 23500458
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Neurochemistry/Neuropharmacology
Research InstitutionThe Institute of Physical and Chemical Research

Principal Investigator

ANDO Hideaki  独立行政法人理化学研究所, 脳科学総合研究センター, 研究員 (50373262)

Co-Investigator(Renkei-kenkyūsha) HISATSUNE Chihiro  独立行政法人理化学研究所, 脳科学総合研究センター, 研究員 (10321803)
SUGAWARA Takeyuki  独立行政法人理化学研究所, 脳科学総合研究センター, 研究員 (70584522)
FURUTA Toshiaki  東邦大学, 理学部, 教授 (90231571)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
KeywordsマイクロRNA / miRNA / カルシウム / IP3受容体
Research Abstract

MicroRNAs (miRNAs) are small non-coding RNAs. Abnormal brain development due to knockout of IP3 receptor, an intracellular calcium channel, may be attributable to aberrant expression of miRNAs. In this study, we searched and analyzed miRNAs regulated by calcium signaling. Additionally, we developed new technologies to analyzed miRNA functions.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (11 results)

All 2014 2013 2011 Other

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (2 results) Remarks (2 results) Patent(Industrial Property Rights) (1 results) (of which Overseas: 1 results)

  • [Journal Article] IRBIT: A regulator of ion channels and ion transporters2014

    • Author(s)
      Ando H, Kawaai K, Mikoshiba K
    • Journal Title

      Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

      Volume: 印刷中 Issue: 10 Pages: 2195-204

    • DOI

      10.1016/j.bbamcr.2014.01.031

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Irbit mediates synergy between ca(2+) and cAMP signaling pathways during epithelial transport in mice2013

    • Author(s)
      Park S, Shcheynikov N, Hong JH, Zheng C, Suh SH, Kawaai K, Ando H, Mizutani A, Abe T, Kiyonari H, Seki G, Yule D, Mikoshiba K, Muallem S
    • Journal Title

      Gastroenterology

      Volume: 145(1) Pages: 232-241

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] A genome-wide screen of CREB occupancy identifies the RhoA inhibitors Par6C and Rnd3 as regulators of BDNF-induced synaptogenesis2013

    • Author(s)
      Lesiak A, Pelz C, Ando H, Zhu M, Davare M, Lambert TJ, Hansen KF, Obrietan K, Appleyard SM, Impey S, Wayman GA
    • Journal Title

      PLoS One

      Volume: 8(6)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] A Genome-wide screen of CREB occupancy identifies the RhoA inhibitors Par6C and Rnd3 as regulators of BDNF-induced synaptogenesis2013

    • Author(s)
      Lesiak A, Pelz C, Ando H, Zhu M, Davare M, Lambert TJ, Hansen KF, Obrietan K, Appleyard SM, Impey S, Wayman GA
    • Journal Title

      PLOS ONE

      Volume: 8 Issue: 6 Pages: e64658-e64658

    • DOI

      10.1371/journal.pone.0064658

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Irbit Mediates Synergy Between Ca2+ and cAMP Signaling Pathways During Epithelial Transport in Mice.2013

    • Author(s)
      Park S, Shcheynikov N, Hong JH, Zheng C, Suh SH, Kawaai K, Ando H, Mizutani A, Abe T, Kiyonari H, Seki G, Yule D, Mikoshiba K, Muallem S
    • Journal Title

      Gastroenterology

      Volume: S0016-5085(13) Issue: 1 Pages: 232-241

    • DOI

      10.1053/j.gastro.2013.03.047

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] IRBIT governs epithelial secretion in mice by antagonizing the WNK/SPAK kinase pathway2011

    • Author(s)
      Yang D, Li Q, So I, Huang CL, Ando H, Mizutani A, Seki G, Mikoshiba K, Thomas PJ, Muallem S
    • Journal Title

      J. Clin. Invest

      Volume: 121(3) Pages: 956-965

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Presentation] Multiple functions of an IP3 receptor binding protein, IRBIT2011

    • Author(s)
      Ando H, Shirakabe K, Kiefer H, Mizutani A, Yamada H, Seki G, Yang D, Muallem S, Mikoshiba K
    • Organizer
      The 10th JBS Biofrontier Symposium: New Aspects of Phospholipid Biology and Medicine 2011
    • Place of Presentation
      ルイガンスホテル(福岡)
    • Year and Date
      2011-11-15
    • Related Report
      2013 Final Research Report
  • [Presentation] Multiple functions of an IP3 receptor binding protein, IRBIT2011

    • Author(s)
      Hideaki Ando
    • Organizer
      The 10th JBC Biofrontier Symposium, New Aspecs of Phospholipid Biology and Medicine 2011
    • Place of Presentation
      ルイガンスホテル(福岡)
    • Related Report
      2011 Research-status Report
  • [Remarks]

    • URL

      http://mikoshiba-lab.brain.riken.jp/indexj.html

    • Related Report
      2013 Final Research Report
  • [Remarks] 発生神経生物研究チームホームページ

    • URL

      http://mikoshiba-lab.brain.riken.jp/indexj.html

    • Related Report
      2013 Annual Research Report
  • [Patent(Industrial Property Rights)] Control of intercellular target molecule by IP3 receptor-binding protein2013

    • Inventor(s)
      Mikoshiba K, Ando H, Mizutani A
    • Industrial Property Rights Holder
      科学技術振興機構
    • Acquisition Date
      2013-03-13
    • Related Report
      2013 Final Research Report
    • Overseas

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Published: 2011-08-05   Modified: 2019-07-29  

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