Regulation of neuronal development by microRNAs

• Project/Area Number: 23500458
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurochemistry/Neuropharmacology
• Research Institution: The Institute of Physical and Chemical Research
• Principal Investigator: ANDO Hideaki 独立行政法人理化学研究所, 脳科学総合研究センター, 研究員 (50373262)
• Co-Investigator(Renkei-kenkyūsha): HISATSUNE Chihiro 独立行政法人理化学研究所, 脳科学総合研究センター, 研究員 (10321803) ; SUGAWARA Takeyuki 独立行政法人理化学研究所, 脳科学総合研究センター, 研究員 (70584522) ; FURUTA Toshiaki 東邦大学, 理学部, 教授 (90231571)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: マイクロRNA / miRNA / カルシウム / IP3受容体

Research Abstract

MicroRNAs (miRNAs) are small non-coding RNAs. Abnormal brain development due to knockout of IP3 receptor, an intracellular calcium channel, may be attributable to aberrant expression of miRNAs. In this study, we searched and analyzed miRNAs regulated by calcium signaling. Additionally, we developed new technologies to analyzed miRNA functions.

Research Products

• [Journal Article] IRBIT: A regulator of ion channels and ion transporters (2014)
  • Author(s): Ando H, Kawaai K, Mikoshiba K
  • Journal Title: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research Volume: 印刷中 Issue: 10 Pages: 2195-204
  • DOI: 10.1016/j.bbamcr.2014.01.031
  • Peer Reviewed
• [Journal Article] Irbit mediates synergy between ca(2+) and cAMP signaling pathways during epithelial transport in mice (2013)
  • Author(s): Park S, Shcheynikov N, Hong JH, Zheng C, Suh SH, Kawaai K, Ando H, Mizutani A, Abe T, Kiyonari H, Seki G, Yule D, Mikoshiba K, Muallem S
  • Journal Title: Gastroenterology Volume: 145(1) Pages: 232-241
  • Peer Reviewed
• [Journal Article] A genome-wide screen of CREB occupancy identifies the RhoA inhibitors Par6C and Rnd3 as regulators of BDNF-induced synaptogenesis (2013)
  • Author(s): Lesiak A, Pelz C, Ando H, Zhu M, Davare M, Lambert TJ, Hansen KF, Obrietan K, Appleyard SM, Impey S, Wayman GA
  • Journal Title: PLoS One Volume: 8(6)
  • Peer Reviewed
• [Journal Article] A Genome-wide screen of CREB occupancy identifies the RhoA inhibitors Par6C and Rnd3 as regulators of BDNF-induced synaptogenesis (2013)
  • Author(s): Lesiak A, Pelz C, Ando H, Zhu M, Davare M, Lambert TJ, Hansen KF, Obrietan K, Appleyard SM, Impey S, Wayman GA
  • Journal Title: PLOS ONE Volume: 8 Issue: 6 Pages: e64658-e64658
  • DOI: 10.1371/journal.pone.0064658
  • Peer Reviewed
• [Journal Article] Irbit Mediates Synergy Between Ca2+ and cAMP Signaling Pathways During Epithelial Transport in Mice. (2013)
  • Author(s): Park S, Shcheynikov N, Hong JH, Zheng C, Suh SH, Kawaai K, Ando H, Mizutani A, Abe T, Kiyonari H, Seki G, Yule D, Mikoshiba K, Muallem S
  • Journal Title: Gastroenterology Volume: S0016-5085(13) Issue: 1 Pages: 232-241
  • DOI: 10.1053/j.gastro.2013.03.047
  • Peer Reviewed
• [Journal Article] IRBIT governs epithelial secretion in mice by antagonizing the WNK/SPAK kinase pathway (2011)
  • Author(s): Yang D, Li Q, So I, Huang CL, Ando H, Mizutani A, Seki G, Mikoshiba K, Thomas PJ, Muallem S
  • Journal Title: J. Clin. Invest Volume: 121(3) Pages: 956-965
  • Peer Reviewed
• [Presentation] Multiple functions of an IP3 receptor binding protein, IRBIT (2011)
  • Author(s): Ando H, Shirakabe K, Kiefer H, Mizutani A, Yamada H, Seki G, Yang D, Muallem S, Mikoshiba K
  • Organizer: The 10th JBS Biofrontier Symposium: New Aspects of Phospholipid Biology and Medicine 2011
  • Place of Presentation: ルイガンスホテル(福岡)
  • Year and Date: 2011-11-15
• [Presentation] Multiple functions of an IP3 receptor binding protein, IRBIT (2011)
  • Author(s): Hideaki Ando
  • Organizer: The 10th JBC Biofrontier Symposium, New Aspecs of Phospholipid Biology and Medicine 2011
  • Place of Presentation: ルイガンスホテル（福岡）
• [Remarks]
  • URL: http://mikoshiba-lab.brain.riken.jp/indexj.html
• [Remarks] 発生神経生物研究チームホームページ
  • URL: http://mikoshiba-lab.brain.riken.jp/indexj.html
• [Patent(Industrial Property Rights)] Control of intercellular target molecule by IP3 receptor-binding protein (2013)
  • Inventor(s): Mikoshiba K, Ando H, Mizutani A
  • Industrial Property Rights Holder: 科学技術振興機構
  • Acquisition Date: 2013-03-13
  • Overseas