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Analysis of Multiple myeloma pahtophysiology using xenograft model having humanized BM microenvironment

Research Project

Project/Area Number 23500501
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Laboratory animal science
Research InstitutionTokai University

Principal Investigator

MUGURUMA Yukari  東海大学, 医学部, 助教 (80398750)

Co-Investigator(Kenkyū-buntansha) ANDO Kiyoshi  東海大学, 医学部, 教授 (70176014)
YAHATA Takashi  東海大学, 医学部, 准教授 (10398753)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywordsmultiple myeloma / humanized mice / xenograft / microenvironment / 多発性骨髄腫 / Notch / 骨髄微小環境
Research Abstract

Multiple myeloma is a hematopoietic malignancy characterized by proliferation of malignant plasma cells and concomitant hematopoietic suppression as well as bone disease. Although Notch signal has been implicated in pathogenesis of multiple myeloma, its precise role is unknown. We created a myeloma mouse model by transplanting human myeloma cells into previously established immunodeficient mice that express human Jagged1 in osteoblastic manner. We demonstrated that Jagged1-Notch signal supported survival and proliferation of myeloma cells in bone marrow. Furthermore, Jagged1-Nocth signal directly promoted drug resistance in vivo and in vitro.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (11 results)

All 2012 2011 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (6 results) Remarks (1 results)

  • [Journal Article] Establishment of a xenograft model of human myelodysplastic syndromes2011

    • Author(s)
      Muguruma Y, Matsushita H, Yahata T, Yumino S, Tanaka Y, Miyachi H, Ogawa Y, Kawada H, Ito M, Ando K
    • Journal Title

      Haematologica

      Volume: 96(4) Pages: 543-51

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Accumulation of oxidative DNA damage restricts the self-renewal capacity of human hematopoietic stem cells2011

    • Author(s)
      Yahata T, Takanashi T, Muguruma Y, Ibrahim AA, Matsuzawa H, Uno T, Sheng Y, Onizuka M, Ito M, Kato S, Ando K
    • Journal Title

      Blood

      Volume: 118(11) Pages: 2941-50

    • NAID

      40019489714

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Accumulation of oxidative DNA damage restricts the self-renewal capacity of human hematopoietic stem cells2011

    • Author(s)
      Yahata, T.
    • Journal Title

      Blood

      Volume: 118 Issue: 11 Pages: 2941-2950

    • DOI

      10.1182/blood-2011-01-330050

    • NAID

      40019489714

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Establishment of xenograft model of human myelodysplastic syndromes2011

    • Author(s)
      Muguruma Y, Matsushita H, Yahata H, Yumino S, Tanaka Y, Miyachi H, Ogawa Y, Kawada H, Ito M, Ando K
    • Journal Title

      Haematologica

      Volume: 96 Issue: 4 Pages: 543-551

    • DOI

      10.3324/haematol.2010.027557

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] CD34+/CD38+ cells from human cord blood initiate APL by induction of PML-RARA2012

    • Author(s)
      Matsushita H, Yahata T, Nakamura Y, Sheng Y, Muguruma Y, Matsuzawa H, Uno T, Takanashi T, Ando K
    • Organizer
      JSH International Symposium
    • Place of Presentation
      川越プリンスホテル
    • Related Report
      2013 Final Research Report
  • [Presentation] Non-telomeric stem cell aging in hematopoietic regeneration2012

    • Author(s)
      Yahata T, Takanashi T, Muguruma Y, Ibrahim AA, Matsuzawa H, Uno T, Sheng Y, Onizuka M, Ito M, Kato S, Ando K
    • Organizer
      第74回日本血液学会
    • Place of Presentation
      京都国際会議場
    • Related Report
      2013 Final Research Report
  • [Presentation] CD34+/CD38+ cells from human cord blood onotoate APL by induction of PML-RARA2012

    • Author(s)
      Hiromichi Matsushita, Takashi Yahata, Yoshihiko Nakamura, Yin Sheng, Yukari Muguruma, et al.
    • Organizer
      JSH International Symposium
    • Place of Presentation
      Kawagoe Prince Hotel
    • Related Report
      2012 Research-status Report
  • [Presentation] Non-telomeric stem cell aging in hematopoietic regeneration2012

    • Author(s)
      Takashi Yahata, Tomoni Takanashi, Yukari Muguruma, Abd Aziz Ibrahim, Hiedyuki Matsuzawa, Tomoko Uno, Yin Sheng, Makoto Onizuka, Mamoru Ito, Shyunichi Kato, Kiyoshi Ando
    • Organizer
      日本血液学会
    • Place of Presentation
      京都国際会議場
    • Related Report
      2012 Research-status Report
  • [Presentation] CD34+/CD38+ cells from human cord blood initiate APL by induction of PML-RARA2011

    • Author(s)
      Matsushita H, Yahata T, Nakamura Y, Sheng Y, Muguruma Y, Matsuzawa H, Uno T, Takanashi T, Ando K
    • Organizer
      第73回日本血液学会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2011-10-15
    • Related Report
      2013 Final Research Report
  • [Presentation] CD34+/CD38+cells from human cord blood initiate APL by induction of PML-RARA

    • Author(s)
      Hiromichi Matsushita, Takashi Yahata, Yoshihiko Nakamura, Yin Sheng, Yukari Muguruma, Hideyuki MAtsuzawa, Tomoko Uno, Tomomi Takanashi, Kiyoshi Ando
    • Organizer
      日本血液学会
    • Place of Presentation
      名古屋国際会議場
    • Related Report
      2011 Research-status Report
  • [Remarks]

    • URL

      http://www.med.u-tokai.ac.jp/daigakuin/web/saisei.html

    • Related Report
      2013 Final Research Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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