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A study of practical suppression method of alternans using both mathematical and animal models.

Research Project

Project/Area Number 23500524
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Biomedical engineering/Biological material science
Research InstitutionTokyo Metropolitan University

Principal Investigator

YAZAWA Toru  首都大学東京, 理工学研究科, 助教 (30106603)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords交互脈 / Alternans / 高カリウム / モデル / 心臓 / 不整脈 / イオン / 数理モデル / 生理学実験 / 甲殻類 / 動物モデル
Research Abstract

Alternans is called as harbinger of death rhythm, being well observable in a patient of ischemic heart disease. Mathematical model used my crab-heart data as a parameter of synaptic potentials. Then, the model could induce alternans, when extracellular potassium (K+) concentration was increased. I concluded that ionic concentration of K+ in the tissue fluid is a key factor to suppress generation of alternans.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (54 results)

All 2014 2013 2012 2011 Other

All Journal Article (22 results) (of which Peer Reviewed: 8 results) Presentation (20 results) (of which Invited: 2 results) Book (10 results) Remarks (2 results)

  • [Journal Article] Alternans-Arrhythmia: A Simulation Study Based on Invertebrate Heart Neurobiology2014

    • Author(s)
      Yazawa, T., and Kitajima, H
    • Journal Title

      Proceedings IMCIC2014

      Pages: 184-189

    • Related Report
      2013 Final Research Report
  • [Journal Article] Alternans-Arrhythmia: A Simulation Study Based on Invertebrate Heart Neurobiology.2014

    • Author(s)
      Yazawa, T., and Kitajima, H.
    • Journal Title

      Proceedings IMCIC2014

      Volume: - Pages: 184-189

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Simulation Study of Alternans-Arrhythmia Based on Physiology of Invertebrate Heart2013

    • Author(s)
      Yazawa, T., and Kitajima, H., and Shimizu, A
    • Journal Title

      Proceedings of The World Congress on Engineering and Computer Science 2013

      Pages: 604-609

    • Related Report
      2013 Final Research Report
  • [Journal Article] Measurement of Stress Using DFA Heartbeat Analysis2013

    • Author(s)
      Yazawa, T., Hutapea, A. M., Otomura, Y., Sagawa, K., Yamada, Y., Suzuki, T., and Katsuyama, T
    • Journal Title

      Proceedings of The World Congress on Engineering and Computer Science 2013

      Pages: 596-603

    • Related Report
      2013 Final Research Report
  • [Journal Article] DFA of Cardiac and Psychological Abnormality: A Test of Quantification Method on Models and Humans.2013

    • Author(s)
      Yazawa, T., Hutapea, A. M., Shimoda, Y., Otomura, Y., Sagawa, K., Yamada, Y., and Suzuki, T.
    • Journal Title

      Proceedings of The 17th World Multi-Conference on Systemics, Cybernetics and Informatics

      Volume: - Pages: 58-63

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Measurement of Stress Using DFA Heartbeat Analysis.2013

    • Author(s)
      Yazawa, T., Hutapea, A. M., Otomura, Y., Sagawa, K., Yamada, Y., Suzuki, T., and Katsuyama, T.
    • Journal Title

      Proceedings of The World Congress on Engineering and Computer Science 2013

      Volume: - Pages: 596-603

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Simulation Study of Alternans-Arrhythmia Based on Physiology of Invertebrate Heart.2013

    • Author(s)
      Yazawa, T., and Kitajima, H., and Shimizu, A.
    • Journal Title

      Proceedings of The World Congress on Engineering and Computer Science 2013

      Volume: - Pages: 604-609

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Athlete heartbeats engaged in ergometer exercise: A detrended fluctuation analysis checking the heart rhythm condition2012

    • Author(s)
      Yazawa, T., Hutapea, A., and Shimoda, Y
    • Journal Title

      Engineering Letters

      Volume: Vol. 20 Pages: 10-15

    • Related Report
      2013 Final Research Report
  • [Journal Article] Cardiac rhythm reflects mental condition as in chronic job stress: A detrended fluctuation analysis2012

    • Author(s)
      Hutapea, A. M., and Yazawa, T
    • Journal Title

      Proceedings, Fall 2012 IIIS Conference

      Volume: 1 Pages: 201-206

    • Related Report
      2013 Final Research Report
  • [Journal Article] Time Series Analysis of Heartbeat-Interval at the Subjects Ranging from Crustacean Animal to Human2012

    • Author(s)
      Yazawa, T., and Katsuyama, T
    • Journal Title

      Proceedings

      Pages: 94-99

    • Related Report
      2013 Final Research Report
  • [Journal Article] Neurodynamical control of the heart of freely moving animals including humans. Proceedings2012

    • Author(s)
      Yazawa, T., Shimoda, Y., Shimizu, S., and Katsuyama, T
    • Journal Title

      ASME 2012

      Pages: 1-10

    • Related Report
      2013 Final Research Report
  • [Journal Article] DFA Applied to the Neural-Regulation of the Heart2012

    • Author(s)
      Yazawa, T., and Shimoda, Y
    • Journal Title

      Proceedings

      Volume: 2 Pages: 715-720

    • Related Report
      2013 Final Research Report
  • [Journal Article] Athlete heartbeats engaged in ergometer exercise: A detrended fluctuation analysis checking the heart rhythm condition.2012

    • Author(s)
      Yazawa, T., Hutapea, A. M., Shimoda, Y.
    • Journal Title

      Engineering Letters

      Volume: 20 Pages: 10-15

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Neurodynamical control of the heart of freely moving animals including humans.2012

    • Author(s)
      Yazawa, T., Shimoda, Y., Shimizu, S., Katsuyama, T.
    • Journal Title

      ASME 2012 Proceedings, 論文番号IMECE2012-85872

      Volume: I Pages: 1-10

    • Related Report
      2012 Research-status Report
  • [Journal Article] Time Series Analysis of Heartbeat-Interval at the Subjects Ranging from Crustacean Animal to Human2012

    • Author(s)
      Yazawa, T., Katsuyama, T.,
    • Journal Title

      IIIS-IMETI2012 Proceedings

      Volume: I Pages: 94-99

    • Related Report
      2012 Research-status Report
  • [Journal Article] DFA Applied to the Neural-Regulation of the Heart.2012

    • Author(s)
      Yazawa, T., Shimoda, Y.
    • Journal Title

      WCECS- ICCB_14 Proceedings

      Volume: II Pages: 715-720

    • Related Report
      2012 Research-status Report
  • [Journal Article] Athlete Heartbeats Engaged in Ergometer Exercise: A Detrended Fluctuation Analysis Checking the Heart Rhythm Condition2012

    • Author(s)
      Toru Yazawa, Albert M. Hutapea, and Yukio Shimoda
    • Journal Title

      Engineering Letters

      Volume: 20 Pages: 10-15

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Analysis of a cardiac mathematical model for suppressing alternans2011

    • Author(s)
      Kitajima, H., and Yazawa, T
    • Journal Title

      IEICE Technical Report

      Pages: 61-64

    • Related Report
      2013 Final Research Report
  • [Journal Article] Detrended fluctuation analysis of arrhythmia: Scaling exponent as an index of heart wellness2011

    • Author(s)
      Yazawa, T., Hutapea, A., Katsuyama, T., and Shimoda, Y
    • Journal Title

      Proceedings ASME2011

      Pages: 10-10

    • Related Report
      2013 Final Research Report
  • [Journal Article] Quantification of athlete's heartbeats engaged in ergometer exercise: A detrended fluctuation analysis study checking the heart condition2011

    • Author(s)
      Yazawa, T., Hutapea, A., and Shimoda, Y
    • Journal Title

      Proceedings WCECS2011

      Volume: Vol. 2 Pages: 585-590

    • Related Report
      2013 Final Research Report
  • [Journal Article] Quantification of Athlete’s Heartbeats Engaged in Ergometer Exercise: A Detrended Fluctuation Analysis Study Checking the Heart Condition2011

    • Author(s)
      Toru Yazawa, Albert M. Hutapea, and Yukio Shimoda
    • Journal Title

      WCECS2011

      Volume: 2 Pages: 585-590

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Detrended Fluctuation Analysis of Arrhythmia: Scaling Exponent as an Index of Heart Wellness2011

    • Author(s)
      Toru Yazawa, Albert M. Hutaapea, Tomoo Katsuyama, and Yukio Shimoda
    • Journal Title

      ASME2011

      Volume: Proceedings Pages: 1-10

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] Alternans-Arrhythmia : A Simulation Study Based on Invertebrate Heart Neurobiology2014

    • Author(s)
      Yazawa, T., and Kitajima. H
    • Organizer
      The International Multi-Conference On Complexity And Cybernetics
    • Place of Presentation
      Orlando, FL, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] 招待講演 心臓はこころを映し出す窓22014

    • Author(s)
      矢澤徹
    • Organizer
      DVx Inc.
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] A Simulation Study of Alternans-Arrhythmia Based on Physiology of Invertebrate Heart2013

    • Author(s)
      Yazawa, T., Kitajima. H., and Shimizu, A
    • Organizer
      Proceedings of The World Congress on Engineering and Computer Science 2013
    • Place of Presentation
      UC Berkeley, CA, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] Measurements of stress by heartbeat analysis : an empirical work of DFA both in animal models and humans2013

    • Author(s)
      Yazawa, T
    • Organizer
      23rd Annual Conference Society for Chaos Theory in Psychology & Life Sciences
    • Place of Presentation
      Portland State University, Portland, Oregon, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] Measurements of stress by heartbeat analysis: an empirical work of DFA both in animal models and humans.2013

    • Author(s)
      Yazawa, T.
    • Organizer
      23rd Annual Conference Society for Chaos Theory in Psychology & Life Sciences.
    • Place of Presentation
      Portland State University, Portland, Oregon, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] ストレス・不安を数値判定する心拍ゆらぎ解析法の開発.2013

    • Author(s)
      矢澤徹
    • Organizer
      イノベーションジャパン.
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] Neurodynamical control of the heart of freely moving animals including humans2012

    • Author(s)
      Yazawa, T
    • Organizer
      International Mechanical Engineering Congress & Exposition ASME 2012.
    • Place of Presentation
      Houston, Texas, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] DFA Applied to the Neural-Regulation of the Heart2012

    • Author(s)
      Yazawa, T
    • Organizer
      WCECS2012
    • Place of Presentation
      UC Berkely, CA, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] Neurodynamical control of the heart of freely moving animals including humans.2012

    • Author(s)
      Toru Yazawa
    • Organizer
      ASME2012
    • Place of Presentation
      Houston, TX, USA
    • Related Report
      2012 Research-status Report
  • [Presentation] DFA Applied to the Neural-Regulation of the Heart.2012

    • Author(s)
      Toru Yazawa
    • Organizer
      WCECS2012
    • Place of Presentation
      UC Berkeley, CA, USA
    • Related Report
      2012 Research-status Report
  • [Presentation] Time series analysis of heartbeat-interval at the subjects ranging from crustacean animal to human.2012

    • Author(s)
      Toru Yazawa
    • Organizer
      5TH Int. Conf. Engeering, Technology and Innovation.
    • Place of Presentation
      Orlando, FL. USA
    • Related Report
      2012 Research-status Report
  • [Presentation] Scaling Exponent During Arrhythmia : Detrended Fluctuation Analysis is a Beneficial Biomedical Computation Tool2011

    • Author(s)
      Yazawa, T
    • Organizer
      International Mechanical Engineering Congress & Exposition ASME 2011
    • Place of Presentation
      Denver, Colorado, USA
    • Year and Date
      2011-11-16
    • Related Report
      2013 Final Research Report
  • [Presentation] Quantification of Athlete's Heartbeats Engaged in Ergometer Exercise : A Detrended Fluctuation Analysis Study Checking the Heart Condition2011

    • Author(s)
      Yazawa, T
    • Organizer
      International Conference on Computational Biology 2011
    • Place of Presentation
      San Francisco, CA, USA
    • Year and Date
      2011-10-21
    • Related Report
      2013 Final Research Report
  • [Presentation] Detrended Fluctuation Analysis of Heartbeats While Engaging in Ergometer Exercise : Checking the Heart Condition by Numerical Quantification Method2011

    • Author(s)
      Yazawa, T
    • Organizer
      The 5th International Symposium on Bio- and Medical Informatics and Cybernetics (BMIC 2011)
    • Place of Presentation
      Orlando, FL, USA
    • Year and Date
      2011-07-20
    • Related Report
      2013 Final Research Report
  • [Presentation] 突然の心停止の予知:心電図の状態空間イメージング2011

    • Author(s)
      矢澤徹、霜田幸雄
    • Organizer
      第20回日本バイオイメージング学会学術集会
    • Place of Presentation
      千歳
    • Related Report
      2011 Research-status Report
  • [Presentation] Detrended Fluctuation Analysis of Heartbeats While Engaging in Ergometer Exercise: Checking the Heart Condition by Numerical Quantification Method2011

    • Author(s)
      Toru Yazawa
    • Organizer
      The 5th International Symposium on Bio- and Medical Informatics and Cybernetics (BMIC 2011)
    • Place of Presentation
      Orlando, FL, USA
    • Related Report
      2011 Research-status Report
  • [Presentation] Quantification of Athlete's Heartbeats Engaged in Ergometer Exercise: A Detrended Fluctuation Analysis Study Checking the Heart Condition2011

    • Author(s)
      Toru Yazawa
    • Organizer
      International Conference on Computational Biology 2011
    • Place of Presentation
      San Francisco, CA, USA
    • Related Report
      2011 Research-status Report
  • [Presentation] Scaling Exponent During Arrhythmia: Detrended Fluctuation Analysis is a Beneficial Biomedical Computation Tool2011

    • Author(s)
      Toru Yazawa
    • Organizer
      ASME 2011 International Mechanical Engineering Congress & Exposition
    • Place of Presentation
      Denver, Colorado, USA
    • Related Report
      2011 Research-status Report
  • [Presentation] Quantification of stress by fluctuation analysis of heartbeat-interval time series.

    • Author(s)
      Toru Yazawa
    • Organizer
      sfn アメリカ北米神経科学学会
    • Place of Presentation
      New Orleans, USA
    • Related Report
      2012 Research-status Report
  • [Presentation] 心臓はこころを映し出す窓

    • Author(s)
      矢澤徹
    • Organizer
      DVX Inc.
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
    • Invited
  • [Book] Detrended Fluctuation Analysis : An Experiment about the Neural-Regulation of the Herat and Motor Vibration. IAENG Transactions on Engineering Technologies2014

    • Author(s)
      Yazawa, T., and Shimoda, Y
    • Publisher
      Springer Science+Business Media Dordrecht 2013(in press)
    • Related Report
      2013 Final Research Report
  • [Book] Quantification of Athlete's Heart Condition : A Detrended Fluctuation Analysis. In: IAENG Transactions on Engineering Technologies, Lecture Notes in Electrical Engineering2013

    • Author(s)
      Yazawa, T., Shimoda, Y., and Hutapea, A. M
    • Publisher
      Springer Science +Business Media Dordrecht
    • Related Report
      2013 Final Research Report
  • [Book] IAENG Transactions on Engineering Technologies, Lecture Notes in Electrical Engineering. Volume 170, Book Chapter 25, Quantification of Athlete’s Heart Condition: A Detrended Fluctuation Analysis.2013

    • Author(s)
      Yazawa, T., Shimoda, Y., and Hutapea, A. M.
    • Total Pages
      14
    • Publisher
      Springer Science +Business Media Dordrecht.
    • Related Report
      2013 Annual Research Report
  • [Book] Chap 20, Quantification of athlete’s heart condition: Detrended fluctuation analysis. IAENG Transactions on Engineering Technologies - Special Edition2012

    • Author(s)
      Yazawa, T., Shimoda, Y., Hutapea, A. M.
    • Total Pages
      15
    • Publisher
      Springer, New York.
    • Related Report
      2012 Research-status Report
  • [Book] DFA, a biomedical checking tool for the heart control system. In : Machine Learning and Systems Engineering2011

    • Author(s)
      Yazawa, T., Shimoda, Y., and Katsuyama, T
    • Related Report
      2013 Final Research Report
  • [Book] Low Scaling Exponent during Arrhythmia : Detrended Fluctuation Analysis is a Beneficial Biomedical Computation Tool. In: Biomedical Engineering, Trends, Research and Technologies, Malgorzata Anna Komorowska and Sylwia Olsztynska-Janus (Eds.)2011

    • Author(s)
      Yazawa, T., and Shimoda, Y
    • Publisher
      InTech
    • Related Report
      2013 Final Research Report
  • [Book] EVALUATION OF SLEEP BY DETRENDED FLUCTUATION ANALYSIS OF THE HEARTBEAT. In : IAENG Transactions on Engineering Technologies. S-L. Ao (Ed.)2011

    • Author(s)
      Yazawa, T., Shimoda, Y., and Hutapea, A
    • Publisher
      American Institute of Physics, AIP Book
    • Related Report
      2013 Final Research Report
  • [Book] Biomedical Engineering, Trends, Research and Technologies2011

    • Author(s)
      Toru Yazawa and Yukio Shimoda
    • Publisher
      Low Scaling Exponent during Arrhythmia: Detrended Fluctuation Analysis is a Beneficial Biomedical Computation Tool
    • Related Report
      2011 Research-status Report
  • [Book] IAENG Trans actions on Engineering Technologies2011

    • Author(s)
      Toru Yazawa , Yukio Shimoda and Albert M. Hutapea
    • Publisher
      EVALUATION OF SLEEP BY DETRENDED FLUCTUATION ANALYSIS OF THE HEARTBEAT
    • Related Report
      2011 Research-status Report
  • [Book] Machine Learnig and Systems Engineering2011

    • Author(s)
      Yazawa, T., Shimoda, Y., Katsuyama, T.
    • Publisher
      DFA, a biomedical checking tool for the heart control system
    • Related Report
      2011 Research-status Report
  • [Remarks]

    • URL

      http://www.tokyo-sangaku.jp/labo/%E7%9F%A2%E6%BE%A4-%E5%BE%B9/

    • Related Report
      2013 Final Research Report
  • [Remarks] 該当項目なし

    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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