| Project/Area Number |
23500574
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical systems
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| Research Institution | University of Occupational and Environmental Health, Japan |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OTSUJI Yutaka 産業医科大学, 医学部, 教授 (30264427)
HARUKI Nobuhiko 産業医科大学, 医学部, 助教 (70469394)
NISHIMURA Yosuke 産業医科大学, 大学病院, 准教授 (50301338)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
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| Keywords | 大動脈弁狭窄症 / 僧帽弁狭窄症 / 3次元心エコー |
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| Research Abstract |
The impact of mitral annular calcification on mitral valve (MV) function and the change of flow rate on MV dynamics has not been established in aortic stenosis (AS). 3D transesophageal images of MV were acquired in AS patients and control subjects. Outer and inner border of the mitral annular area (MAA) and mital valve area (MVA) were measured. Stress echocardiography had performed in 10 patients after aortic valve replacement. Inner MAA was significantly smaller in patients with AS compared to control. Maximal anterior and posterior leaflet opening angle and MVA was also significantly smaller. Multivariable analysis revealed that effective MAA and posterior leaflet opening angle were independent predictors for MVA. MVA became larger during stress echocardiography. Its increment was directly correlated to the change in diastolic flow rate.
Conclusion: Although calcific extension to MV in AS patients is associated with significant non-rheumatic mitral stenosis, MVA is flow-dependent.
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