Development of an image reconstruction algorithm for sensitivity improvement of ultra-high spatial resolution SPECT for molecular functional quantitation in a selected small region
| Project/Area Number |
23500575
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical systems
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| Research Institution | National Cardiovascular Center Research Institute |
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Principal Investigator |
ZENIYA Tsutomu 独立行政法人国立循環器病研究センター, 研究所, 室長 (50443487)
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| Co-Investigator(Renkei-kenkyūsha) |
IIDA Hidehiro 独立行政法人国立循環器病研究センター, 研究所, 部長 (30322720)
WATABE Hiroshi 大阪大学, 医学系研究科, 准教授 (40280820)
HAYASHI Takuya 独立行政法人理化学研究所, 分子イメージング科学研究センター, 副チームリーダー (50372115)
KOSHINO Kazuhiro 独立行政法人国立循環器病研究センター, 研究所, 研究員 (90393206)
HIRANO Yoshiyuki 独立行政法人国立循環器病研究センター, 研究所, 派遣研究員 (00423129)
KUDO Hiroyuki 筑波大学, システム情報工学研究科, 教授 (60221933)
TERAMOTO Noboru 大阪大学, 医学系研究科, 特任研究員 (40372114)
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 画像診断 / 核医学 / SPECT / 画像再構成アルゴリズム / 分子機能定量 / 高解像度 / トランケーション / マルチピンホールコリメータ / 医療 / 生体機能 / 放射線 / 画像 / アルゴリズム |
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| Outline of Final Research Achievements |
We developed an image reconstruction algorithm for ultra-high spatial resolution SPECT system to quantify molecular functions in a selected small region. This algorithm is not affected by lack of data (i.e. truncation). In addition, we improved this algorithm for multi-pinhole SPECT system to improve sensitivity. SPECT study was performed using 8-pinhole collimator with 55-mm field of view. This study showed significant sensitivity improvement which permits short scan.
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Report
(5 results)
Research Products
(19 results)
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[Journal Article] Three-dimensional quantitation of regional cerebral blood flow in mice using a high-resolution pinhole SPECT system and (123)I-iodoamphetamine2011
Author(s)
Zeniya T, Watabe H, Hayashi T, Ose T, Myojin K, Taguchi A, Yamamoto A, Teramoto N, Kanagawa M, Yamamichi Y, Iida H
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Journal Title
Nuclear Medicine and Biology
Volume: 38
Issue: 8
Pages: 1157-1164
DOI
Related Report
Peer Reviewed
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