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Development of an image reconstruction algorithm for sensitivity improvement of ultra-high spatial resolution SPECT for molecular functional quantitation in a selected small region

Research Project

Project/Area Number 23500575
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Medical systems
Research InstitutionNational Cardiovascular Center Research Institute

Principal Investigator

ZENIYA Tsutomu  独立行政法人国立循環器病研究センター, 研究所, 室長 (50443487)

Co-Investigator(Renkei-kenkyūsha) IIDA Hidehiro  独立行政法人国立循環器病研究センター, 研究所, 部長 (30322720)
WATABE Hiroshi  大阪大学, 医学系研究科, 准教授 (40280820)
HAYASHI Takuya  独立行政法人理化学研究所, 分子イメージング科学研究センター, 副チームリーダー (50372115)
KOSHINO Kazuhiro  独立行政法人国立循環器病研究センター, 研究所, 研究員 (90393206)
HIRANO Yoshiyuki  独立行政法人国立循環器病研究センター, 研究所, 派遣研究員 (00423129)
KUDO Hiroyuki  筑波大学, システム情報工学研究科, 教授 (60221933)
TERAMOTO Noboru  大阪大学, 医学系研究科, 特任研究員 (40372114)
Project Period (FY) 2011-04-28 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords画像診断 / 核医学 / SPECT / 画像再構成アルゴリズム / 分子機能定量 / 高解像度 / トランケーション / マルチピンホールコリメータ / 医療 / 生体機能 / 放射線 / 画像 / アルゴリズム
Outline of Final Research Achievements

We developed an image reconstruction algorithm for ultra-high spatial resolution SPECT system to quantify molecular functions in a selected small region. This algorithm is not affected by lack of data (i.e. truncation). In addition, we improved this algorithm for multi-pinhole SPECT system to improve sensitivity. SPECT study was performed using 8-pinhole collimator with 55-mm field of view. This study showed significant sensitivity improvement which permits short scan.

Report

(5 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (19 results)

All 2015 2014 2013 2012 2011

All Journal Article (7 results) (of which Peer Reviewed: 2 results) Presentation (12 results)

  • [Journal Article] マルチピンホールによる蛍光X線CTの検出限界の改善2015

    • Author(s)
      笹谷典太,砂口尚輝,青木大,湯浅哲也,兵藤一行,銭谷勉
    • Journal Title

      電子情報通信学会技術報告

      Volume: 114 Pages: 161-166

    • Related Report
      2014 Annual Research Report
  • [Journal Article] 生体機能定量SPECTイメージングにおける高解像度化2014

    • Author(s)
      銭谷勉,飯田秀博
    • Journal Title

      第57回自動制御連合講演予稿集

      Volume: CD-ROM Pages: 2016-2017

    • NAID

      130005146166

    • Related Report
      2014 Annual Research Report
  • [Journal Article] 頭部用高解像度SPECTのための高精細マルチアノード光電子増倍管を用いたフルデジタル高解像度検出器の開発2014

    • Author(s)
      賀久和弥,銭谷 勉,平野祥之,高井雄紀,堀 祐樹,森口哲朗,越野一博,佐藤哲大,金谷重彦,飯田秀博
    • Journal Title

      信学技報

      Volume: 113 Pages: 275-280

    • Related Report
      2013 Research-status Report
  • [Journal Article] Monte Carlo simulation of scintillation photons for the design of a high-resolution SPECT detector dedicated to human brain2012

    • Author(s)
      Yoshiyuki Hirano, Tsutomu Zeniya and Hidehiro Iida
    • Journal Title

      Annals of Nuclear Medicine

      Volume: Vol.26, No.3 Issue: 3 Pages: 214-221

    • DOI

      10.1007/s12149-011-0561-4

    • NAID

      10030623783

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Three-dimensional quantitation of regional cerebral blood flow in mice using a high-resolution pinhole SPECT system and (123)I-iodoamphetamine2011

    • Author(s)
      Zeniya T, Watabe H, Hayashi T, Ose T, Myojin K, Taguchi A, Yamamoto A, Teramoto N, Kanagawa M, Yamamichi Y, Iida H
    • Journal Title

      Nuclear Medicine and Biology

      Volume: 38 Issue: 8 Pages: 1157-1164

    • DOI

      10.1016/j.nucmedbio.2011.04.007

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Conceptual design of high spatial-resolution SPECT system for human brain2011

    • Author(s)
      Zeniya T, Hirano Y, Tominaga T, Hori Y, Watabe H, Sakimoto T, Sohlberg A, Minato K, Hatazawa J, Iida H
    • Journal Title

      2011 IEEE Nuclear Science Symposium Conferece Record

      Volume: - Pages: 3426-3428

    • Related Report
      2011 Research-status Report
  • [Journal Article] Evaluation of a brain imaging system with combined parallel hole and pinhole collimation2011

    • Author(s)
      Huang Q, Zeniya T, Hirano Y, Kudo H, Iida H, Gullberg GT
    • Journal Title

      Proceedings of 11th International Meeting on Fully Three-Dimensional Image Reconstruction in Radiology and Nuclear Medicine

      Volume: - Pages: 246-249

    • Related Report
      2011 Research-status Report
  • [Presentation] マルチピンホールによる蛍光X線CTの検出限界の改善2015

    • Author(s)
      笹谷典太,砂口尚輝,青木大,湯浅哲也,兵藤一行,銭谷勉
    • Organizer
      電子情報通信学会医用画像研究会
    • Place of Presentation
      石垣島,ホテルミヤヒラ
    • Year and Date
      2015-03-02 – 2015-03-03
    • Related Report
      2014 Annual Research Report
  • [Presentation] 生体機能定量SPECTイメージングにおける高解像度化2014

    • Author(s)
      銭谷勉,飯田秀博
    • Organizer
      第57回自動制御連合講演会
    • Place of Presentation
      群馬伊香保,ホテル天坊
    • Year and Date
      2014-11-10 – 2014-11-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] SPECT定量化におけるコリメータ開口補正のインパクト2014

    • Author(s)
      銭谷勉,越野一博,森口哲朗,堀祐樹,圓見純一郎,井口智史,山本明秀,飯田秀博
    • Organizer
      日本分子イメージング学会第9回学会総会・学術集会
    • Place of Presentation
      豊中,千里ライフサイエンスセンター
    • Year and Date
      2014-05-22 – 2014-05-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] 頭部用高解像度SPECTのための高精細マルチアノード光電子増倍管を用いたフルデジタル高解像度検出器の開発2014

    • Author(s)
      賀久和弥
    • Organizer
      電子情報通信学会医用画像研究会
    • Place of Presentation
      沖縄ぶんかテンブス館4F テンブスホール(那覇)
    • Related Report
      2013 Research-status Report
  • [Presentation] レポーター遺伝子とSPECTを用いた心筋梗塞モデルラットにおける移植細胞シートの機能定量イメージング2013

    • Author(s)
      銭谷 勉
    • Organizer
      日本分子イメージング学会第8回学会総会・学術集会
    • Place of Presentation
      横浜赤レンガ倉庫1号館(横浜)
    • Related Report
      2013 Research-status Report
  • [Presentation] Tracking of transplanted stem cells in myocardial infarction model rat: validation of simultaneous dual-isotope SPECT imaging with Tc-99m and Tl-2012012

    • Author(s)
      Zeniya T
    • Organizer
      2012 World Molecular Imaging Congress
    • Place of Presentation
      Convention Centre Dublin(Dublin, Ireland)
    • Related Report
      2012 Research-status Report
  • [Presentation] 位置感応型光電子増倍管とデジタル位置演算による高解像度SPECT検出器の開発2012

    • Author(s)
      銭谷 勉
    • Organizer
      第52回日本核医学会学術総会
    • Place of Presentation
      ロイトン札幌、ニトリ文化ホール(札幌市)
    • Related Report
      2012 Research-status Report
  • [Presentation] 心筋梗塞モデルラットの移植幹細胞トラッキング2012

    • Author(s)
      銭谷 勉
    • Organizer
      日本分子イメージング学会第7回学会総会・学術集会
    • Place of Presentation
      アクトシティ浜松コングレスセンター
    • Related Report
      2012 Research-status Report
  • [Presentation] Conceptual design of high spatial-resolution SPECT system for human brain2011

    • Author(s)
      Zeniya T
    • Organizer
      2011 IEEE Nuclear Science Symposium and Medical Imaging Conference
    • Place of Presentation
      Valencia Convention Center(Valencia, Spain)
    • Related Report
      2011 Research-status Report
  • [Presentation] Optimization of multi-pinhole SPECT imaging for measuring quantitative cerebral blood flow in rats2011

    • Author(s)
      Zeniya T
    • Organizer
      Society of Nuclear Medicine’s 58th Annual Meeting
    • Place of Presentation
      San Antonio Convention Center(San Antonio, Texas)
    • Related Report
      2011 Research-status Report
  • [Presentation] ラット脳血流定量のためのマルチピンホールSPECT撮像の最適化2011

    • Author(s)
      銭谷 勉
    • Organizer
      第51回日本核医学会学術総会
    • Place of Presentation
      つくば国際会議場(茨城県つくば市)
    • Related Report
      2011 Research-status Report
  • [Presentation] 頭部用高解像度SPECT装置の概念設計2011

    • Author(s)
      銭谷 勉
    • Organizer
      第51回日本核医学会総会
    • Place of Presentation
      つくば国際会議場(茨城県つくば市)
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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