A study of the functional recovery on the motor learning and activity, and changes expression of neurotrophic factors and neurotransmitter levels after brain injury

• Project/Area Number: 23500594
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Rehabilitation science/Welfare engineering
• Research Institution: Kagoshima University
• Principal Investigator: AKIHIKO OHWATASHI 鹿児島大学, 医学部, 助教 (30295282)
• Co-Investigator(Kenkyū-buntansha): IKEDA Satoshi 鹿児島大学, 医学部・歯学部附属病院, 講師 (00343369) ; YOSHIDA Akira 鹿児島大学, 医歯学総合研究科, 助教 (40347109) ; KAWAHIRA Kazumi 鹿児島大学, 医歯学総合研究科, 客員研究員 (20117493)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: マイクロダイアリシス / 神経伝達物質 / 脳の可塑性 / 運動療法 / 機能回復

Research Abstract

Extracellular concentrations of monoamines were investigated in the striatum, hippocampus, primary cortex, hindlimb region and ventral tegmental area using microdialysis technique. We confirmed that monoamine levels were increased during treadmill running. Nerve activity becomes active by compulsorily exercise, but is not efficient for the functional recovery. We pay our attention to change of dopamine levels as the reward material and examine a method to restore motor function effectively.

Research Products

• [Journal Article] Effects of edaravone, a free radical scavenger, on photochemically induced cerebral infarction in a rat hemiplegic model. (2013)
  • Author(s): Satoshi Ikeda, Katsuhiro Harada, Akihiko Ohwatashi, Yurie Kamikawa.
  • Journal Title: The Scientific World Journal Volume: Volume 2013 Issue: 1 Pages: 175280-175280
  • DOI: 10.1186/2193-1801-2-517
  • Peer Reviewed
• [Journal Article] Exercise enhanced functional recovery and expression of GDNF after photochemically induced cerebral infarction in the rat (2013)
  • Author(s): Akihiko Ohwatashi, Satoshi Ikeda, Katsuhiro Harada, Yurie Kamikawa , Akira Yoshida
  • Journal Title: EXCLI journal Volume: Vol. 12 Pages: 693-700
  • URL: http://www.excli.de/volume12.php
  • Peer Reviewed
• [Journal Article] The effect of anabolic steroid administration on passive stretching-induced expression of mechano-growth factor in skeletal muscle. (2013)
  • Author(s): Satoshi Ikeda, Yurie Kamikawa, Akihiko Ohwatashi, Katsuhiro Harada, Akira Yoshida.
  • Journal Title: The Scientific World Journal Volume: Volume 2013 Issue: 1 Pages: 313605-313605
  • DOI: 10.1155/2013/313605
  • Peer Reviewed
• [Journal Article] Contralateral cortical role on functional recovery in a Rat Model of Photochemically induced cerebral infarction (2013)
  • Author(s): Satoshi Ikeda, Katsuhiro Harada, Akihiko Ohwatashi, Yurie Kamikawa, Akira Yoshida
  • Journal Title: EXCLI journal Volume: Vol. 12 Pages: 641-646
  • URL: http://www.excli.de/volume12.php
  • Peer Reviewed
• [Journal Article] Effects of edaravone, a free radical scavenger, on photochemically induced cerebral infarction in a rat hemiplegic model (2013)
  • Author(s): Satoshi Ikeda, Katsuhiro Harada, Akihiko Ohwatashi, Yurie Kamikawa
  • Journal Title: The Scientific World Journal Volume: 2013 Issue: 1
  • DOI: 10.1155/2013/175280
  • Peer Reviewed
• [Journal Article] Passive Repetitive stretching short duration within a week increases myogenic regulatory factors and myosin heavy chain mRNA in rat skeletal muscles. (2013)
  • Author(s): Yurie Kamikawa, Satoshi Ikeda, Katsuhiro Harada, Akihiko Ohwatashi, Akira Yoshida.
  • Journal Title: The Scientific World Journal Volume: Volume 2013 Issue: 1 Pages: 493656-493656
  • DOI: 10.1155/2013/493656
  • Peer Reviewed
• [Journal Article] A New Non-Human Primate Model of Photochemically Induced Cerebral Infarction (2013)
  • Author(s): Satoshi Ikeda, Katsuhiro Harada, Akihiko Ohwatashi, Yurie Kamikawa, Akira Yoshida, Kazumi Kawahira
  • Journal Title: PLoS ONE Volume: 8 Issue: 3 Pages: e60037-e60037
  • DOI: 10.1371/journal.pone.0060037
  • Peer Reviewed
• [Journal Article] Benefits of a repetitive facilitative exercise program for the upper paretic extremity after subacute stroke: a randomized controlled trial (2013)
  • Author(s): Shimodozono M, Noma T, Nomoto Y, Hisamatsu N, Kamada K, Miyata R, Matsumoto S, Ogata A, Etoh S, Basford JR, Kawahira K
  • Journal Title: Neurorehabil Neural Repair Volume: 27(4) Issue: 4 Pages: 296-305
  • DOI: 10.1177/1545968312465896
  • Peer Reviewed
• [Journal Article] Contralateral cortical role on functional recovery in a Rat Model of Photochemically induced cerebral infarction. (2013)
  • Author(s): Satoshi Ikeda, Katsuhiro Harada, Akihiko Ohwatashi, Yurie Kamikawa, Akira Yoshida.
  • Journal Title: EXCLI journal Volume: Vol.12 Pages: 641-646
  • Peer Reviewed
• [Journal Article] Exercise enhanced functional recovery and expression of GDNF after photochemically induced cerebral infarction in the rat. (2013)
  • Author(s): Akihiko Ohwatashi, Satoshi Ikeda, Katsuhiro Harada, Yurie Kamikawa , Akira Yoshida.
  • Journal Title: EXCLI journal Volume: Vol.12 Pages: 693-700
  • Peer Reviewed
• [Journal Article] 歩幅の違いが足趾荷重量と中足趾節関節の最大伸展角度に与える影響 (2013)
  • Author(s): 上野友愛，木山良二，川田将之，大渡昭彦，福留清博，米和徳，吉元洋一，大重匡，前田哲男
  • Journal Title: 理学療法科学 Volume: Vol.28(6) Pages: 727-730
  • NAID: 130004432919
  • Peer Reviewed
• [Journal Article] Relationship between Physical Activity Level and Hip Joint Pain in Adult Women with Chiari Pelvic Osteotomy (2012)
  • Author(s): Yoshiharu Nagai, Tetsuo Maeda, Ryoji Kiyama, Akihiko Ohwatashi, Hideo Kaneko, Kensuke Matsuda, Masami Nakahara, Hiroyuki Tahara, Kazunori Yone, Akio Inoue
  • Journal Title: Journal of the physical Therapy Science Volume: Vol. 24 Pages: 561-565
  • NAID: 10031076783
  • Peer Reviewed
• [Journal Article] Anti-spastic effects of the direct application of vibratory stimuli to the spastic muscles of hemiplegic limbs in post-stroke patients : a proof-of-principle study (2012)
  • Author(s): Noma T, Matsumoto S, Shimodozono M, Etoh S, Kawahira K
  • Journal Title: J Rehabil Med Volume: 44(4) Issue: 4 Pages: 325-30
  • DOI: 10.2340/16501977-0946
  • Peer Reviewed
• [Journal Article] Relationship between Physical Activity Level and Hip Joint Pain in Adult Women with Chiari Pelvic Osteotomy (2012)
  • Author(s): Yoshiharu Nagai, Tetsuo Maeda, Ryoji Kiyama, Akihiko Oowatashi, Hideo Kaneko, Kensuke Matsuda, Masami Nakahara, Hiroyuki Tahara, Kazunori Yone, Akio Inoue
  • Journal Title: Journal of Physical Therapy Science Volume: 24 Issue: 7 Pages: 561-565
  • DOI: 10.1589/jpts.24.561
  • NAID: 130004431820
  • ISSN: 0915-5287, 2187-5626
  • Peer Reviewed
• [Journal Article] Physical Activity and Health-Related Quality of Life in Adult Women with Chiari Pelvic Osteotomy: What Level of Physical Activity Overloads the Hip Joint? (2012)
  • Author(s): 永井良治，前田哲男，木山良二，金子秀雄，松田憲亮，中原雅美，大渡昭彦，田原弘幸，米和徳，井上明生
  • Journal Title: Rigakuryoho Kagaku Volume: 27 Issue: 6 Pages: 671-676
  • DOI: 10.1589/rika.27.671
  • NAID: 130004432803
  • ISSN: 1341-1667, 2434-2807
  • Peer Reviewed
• [Journal Article] Effect of cilostazol administration on cerebral hemodynamics and rehabilitation outcomes in poststroke patients (2011)
  • Author(s): Matsumoto S, Shimodozono M, Miyata R, Kawahira K
  • Journal Title: Int J Neurosci Volume: 121(5) Issue: 5 Pages: 271-8
  • DOI: 10.3109/00207454.2010.551431
  • Peer Reviewed
• [Presentation] ラット排尿反射に対する温熱の影響 (2013)
  • Author(s): 吉田輝, 大渡昭彦, 池田聡
  • Organizer: 第20回日本排尿機能学会
  • Place of Presentation: 静岡
  • Year and Date: 2013-09-19
• [Presentation] Functional recovery on Marmoset model of photochemically induced cerebral infarction (2013)
  • Author(s): Satoshi Ikeda, Katsuhoro Harada, Akihiko Ohwatashi
  • Organizer: 2nd Japan-Korea NeuroRehabilitation Conference
  • Place of Presentation: Okayama
  • Year and Date: 2013-02-16
• [Presentation] Exercise accelerates the functional recovery and induces neurotrophic factor NGF on the rat cerebral infarction model (2012)
  • Author(s): Satoshi Ikeda, Kayo Nakamura, Katsuhiro Harada, Akihiko Ohwatashi, Yurie Kamikawa, Akira Yoshida, Kazumi Kawahira
  • Organizer: The 11th Congress of European Forum for research in Rehabilitation
  • Place of Presentation: Riva del Garda, Italy
  • Year and Date: 2012-05-27
• [Presentation] トレッドミル運動が線条体と海馬のモノアミン細胞外濃度に与える影響 (2012)
  • Author(s): 大渡昭彦, 池田聡, 吉田輝, 原田雄大, 上川百合恵, 根路銘周子, 川平和美
  • Organizer: 第47回日本理学療法学術大会
  • Place of Presentation: 神戸
  • Year and Date: 2012-05-26
• [Presentation] 霊長類を用いた脳梗塞片麻痺長期生存モデルの作成と機能回復に関する研究 (2011)
  • Author(s): 原田雄大, 池田聡, 大渡昭彦, 上川百合恵, 吉田輝, 根路銘周子, 山下真紀, 川平和美
  • Organizer: 第48回日本リハビリテーション医学会学術集会
  • Place of Presentation: 千葉
  • Year and Date: 2011-11-02
• [Presentation] 変形性股関節症術後患者の身体活動量に関する研究股関節に過負荷になる身体活動量について (2011)
  • Author(s): 永井良治, 前田哲男, 金子秀雄, 吉住浩平, 中原雅美, 松田憲亮, 木山良二, 大渡昭彦, 米和徳, 井上明生
  • Organizer: 第46回日本理学療法学術大会
  • Place of Presentation: 宮崎
  • Year and Date: 2011-05-28