| Project/Area Number |
23500620
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | Juntendo University |
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Principal Investigator |
SHIMADA Kazunori 順天堂大学, 医学(系)研究科(研究院), 准教授 (60327814)
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| Co-Investigator(Renkei-kenkyūsha) |
NAITO Hisashi 順天堂大学, スポーツ健康科学研究科, 教授 (70188861)
IWABUCHI Kazuhisa 順天堂大学, 医療看護学研究科, 教授 (10184897)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 動脈硬化 / マクロファージ / 骨格筋 |
|---|
| Research Abstract |
M1 macrophages, but not M0 or M2 macrophages, which characteristically respond to oxLDL, were associated with NF-kB signaling. M1 was dominant in aneurysmal lesions and peritoneal macrophages. Inflammatory cells were detected in skeletal muscles in mice with atherosclerotic formation. Voluntary exercise as well as forced exercise reduced atherosclerotic formation via inhibition of macrophage accumulation and inflammatory reaction. Cardiac rehabilitation improved muscle mass, muscle strength, and exercise tolerance. Exercise capacity was associated with clinical prognosis. These results suggested that maintaining physical activity may ameliorate the initiation and progression of atherosclerosis through anti-inflammatory effects.
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