| Project/Area Number |
23500640
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | Tohoku University |
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Principal Investigator |
MITSUHIRO Kano 東北大学, 歯学研究科(研究院), 大学院非常勤講師 (10419236)
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| Co-Investigator(Renkei-kenkyūsha) |
ICHIKAWA Hiroyuki 東北大学, 大学院・歯学研究科, 教授 (20193435)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
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| Keywords | 嚥下機能 / リハビリテーション / 誤嚥モデル / 神経機能 / 感覚刺激 / 嚥下 |
|---|
| Research Abstract |
Damage of sensory neurons innervating the pharynx can cause swallowing dysfunction in animal models. In this study, distribution of sensory nerve fibers was examined in the rat epiglottis and pharynx by immunohistochemical methods. Pituitary adenylate cyclase-activating polypeptide-immunoreactive (PACAP-IR) nerve fibers were located beneath the mucous epithelium, and occasionally penetrated the epithelium. PACAP-IR nerve fibers were also detected in taste buds within the epiglottis and pharynx. Retrograde tracing method also demonstrated that PACAP was expressed by vagal and glossopharyngeal sensory neurons innervating the pharynx. These findings suggest that PACAP-IR nerve fibers in the epithelium and taste bud of the epiglottis and pharynx which originate from the vagal and glossopharyngeal sensory ganglia include nociceptors and chemoreceptors. Injury of PACAP-IR neurons innervating the pharynx and epiglottis may cause swallowing dysfunction.
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