| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
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| Research Abstract |
The purpose of this study was to determine the effects of 10 weeks of voluntary wheel running and aging on the threshold and amplitude of mechanical vasodilation in the feed arteries of rat skeletal muscle. The threshold transmural pressure of the mechanical vasodilation was 0 mmHg in cage control, VR and aged rats. The amplitude of mechanical vasodilation of the feed arteries in VR rats was significantly larger than that in cage control and aged rats (p<0.001). The amplitude of mechanical vasodilation was decreased significantly (p<0.001) following removal of the endothelium by air. These results indicate that the threshold transmural pressure of mechanical vasodilation of the soleus feed arteries was not altered by VR and aging, whereas the amplitude of mechanical vasodilation was increased by VR.
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