A basic study of mobilization of endothelial progenitor cells of bone marrow origin by physical training state after cerebral ischemia
| Project/Area Number |
23500772
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Sports science
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| Research Institution | Akita University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 内皮細胞 / 内皮幹細胞 / 樹状細胞 / 脳虚血障害 / 運動療法 / 骨髄キメラ / 脳血液脳関門 / 血管新生 / 血液脳関門 |
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| Research Abstract |
A correlation between mobilization of endothelial progenitor cells of bone marrow origin and physical training state after cerebral ischemia were studied using bone-marrow-transplanted chimeric mice. The results were as follows. 1) Endothelial and dendritic cells of bone marrow origin were seen at the blood-brain barrier. 2) Endothelial, dendritic, and smooth muscle cells of bone marrow origin were seen at the stenotic carotid artery. 3) Endothelial cell of bone marrow origin was seen at the orifice of the ascending aorta and aortic valve. Many dendritic cells of bone marrow origin were seen at the aorta. But, a distinct mobilization of endothelial progenitor cells of bone marrow origin by physical training state after cerebral ischemia could not be clearly confirmed in this study.
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Report
(4 results)
Research Products
(11 results)
