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A basic study of mobilization of endothelial progenitor cells of bone marrow origin by physical training state after cerebral ischemia

Research Project

Project/Area Number 23500772
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Sports science
Research InstitutionAkita University

Principal Investigator

NANJO Hiroshi  秋田大学, 医学部, 准教授 (70250892)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords内皮細胞 / 内皮幹細胞 / 樹状細胞 / 脳虚血障害 / 運動療法 / 骨髄キメラ / 脳血液脳関門 / 血管新生 / 血液脳関門
Research Abstract

A correlation between mobilization of endothelial progenitor cells of bone marrow origin and physical training state after cerebral ischemia were studied using bone-marrow-transplanted chimeric mice. The results were as follows. 1) Endothelial and dendritic cells of bone marrow origin were seen at the blood-brain barrier. 2) Endothelial, dendritic, and smooth muscle cells of bone marrow origin were seen at the stenotic carotid artery. 3) Endothelial cell of bone marrow origin was seen at the orifice of the ascending aorta and aortic valve. Many dendritic cells of bone marrow origin were seen at the aorta. But, a distinct mobilization of endothelial progenitor cells of bone marrow origin by physical training state after cerebral ischemia could not be clearly confirmed in this study.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (11 results)

All 2014 2013 2012 2011

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (9 results)

  • [Journal Article] 電子顕微鏡から読み解く心血管リモデリング2014

    • Author(s)
      吉田誠, 南條博, 庄永傑, 川村公一, 後藤明輝, 増田弘毅
    • Journal Title

      病理と臨床

      Volume: Vol.32, No.1 Pages: 85-90

    • URL

      http://www.medicalonline.jp/

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 電子顕微鏡から読み解く心血管リモデリング2014

    • Author(s)
      吉田 誠,南條 博,庄 永傑,川村 公一,後藤 明輝,増田 弘毅
    • Journal Title

      病理と臨床

      Volume: Vol.32 Pages: 85-90

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] 静脈への動脈パッチ移植することにより発生した新生血管の研究2013

    • Author(s)
      伊藤行信, 吉田誠, 高橋正人, 南條博, 川村公一, 後藤明輝
    • Organizer
      第102回日本病理学会総会
    • Place of Presentation
      札幌
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] 動静脈吻合後の静脈狭窄に関する実験病理学的検討2013

    • Author(s)
      高橋正人, 吉田誠, 伊藤行信, 川村公一, 南條博, 増田弘毅, 後藤明輝
    • Organizer
      第102回日本病理学会総会
    • Place of Presentation
      札幌
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] 動脈リモデリングの解析-血流負荷家兎総頸動脈における内弾性板ギャップの 発生メカニズム2013

    • Author(s)
      増田弘毅,吉田 誠,高橋正人,伊藤 行信,川村公一,後藤 明輝
    • Organizer
      第102回日本病理学会総会
    • Place of Presentation
      札幌
    • Related Report
      2013 Annual Research Report
  • [Presentation] Mobilization of endothelial cell and vascular dendritic cells of bone marrow origin in the organs2012

    • Author(s)
      南條博, 小林実貴夫, 吉成由樹, 廣嶋優子, 高橋正人, 川村公一, 吉田誠, 後藤明輝, 増田弘毅
    • Organizer
      第101回日本病理学会総会
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report
  • [Presentation] Mobilization of endothelial cells and vascular dendritic cells of bone marrow origin in the organs2012

    • Author(s)
      南條 博,小林実貴夫,吉成由樹,廣嶋優子,高橋正人,川村公一,吉田 誠,後藤明輝,増田弘毅
    • Organizer
      第101回日本病理学会総会
    • Place of Presentation
      京王プラザホテル(東京)
    • Related Report
      2012 Research-status Report
  • [Presentation] Distribution of vascular dendritic cells of bone marrow origin at the non-atherosclerotic aorta in mice2011

    • Author(s)
      南條博, 小林実貴夫, 吉成由樹, 高橋正人, 廣嶋優子, 川村公一, 増田弘毅
    • Organizer
      第100回日本病理学会総会
    • Place of Presentation
      横浜
    • Related Report
      2013 Final Research Report
  • [Presentation] 大動脈内皮細胞のターンオーバーは, 一過性増殖によって行われている2011

    • Author(s)
      高橋正人, 小林実貴夫, 廣嶋優子, 川村公一, 南條博, 杉山達朗, 増田弘毅
    • Organizer
      第100回日本病理学会総会
    • Place of Presentation
      横浜
    • Related Report
      2013 Final Research Report
  • [Presentation] Distribution of vascular dendritic cells of bone marrow origin at non-atherosclerotic aorta in mice2011

    • Author(s)
      南條 博,小林実貴夫,吉成由樹,高橋正人,廣嶋優子,川村公一,増田弘毅
    • Organizer
      第100回日本病理学会総会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Related Report
      2011 Research-status Report
  • [Presentation] 大動脈内皮細胞のターンオーバーは、一過性増殖によって行われている2011

    • Author(s)
      高橋正人,小林実貴夫,廣嶋優子,川村公一,南條 博,杉山達朗,増田弘毅
    • Organizer
      第100回日本病理学会総会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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