| Project/Area Number |
23500846
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied health science
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| Research Institution | Oita University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SEIKE Masataka 大分大学, 医学部, 助教 (40253794)
MASAKI Takayuki 大分大学, 医学部, 助教 (00423715)
吉松 博信 大分大学, 医学部, 教授 (00166993)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | 脂肪肝 / 脾臓摘出 / 炎症性サイトカイン / 脂肪性肝炎 / IL-10 / 過栄養性脂肪肝 / 摂食リズム障害 / 肥満症 / IL-10欠損マウス / 肥満 / ８オキソグアニン / チアゾリジン誘導体 / PPARγ |
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| Research Abstract |
In liver of splenectomy-treated diet induced obese rats, the expression of the proinflammatory cytokines induced and the oxystress-induced markers, 8-oxoG and 4-HNE, increased significantly. At 6 months after splenectomy, fibrotic changes were observed in the liver of rats. This result indicates that the loss of spleen contributes to the progression of hepatic steatosis to steatohepatitis in obese rats. These splenectomy-induced changes were inhibited by systemic administration of IL-10. We demonstrated that the spleen-derived IL-10 has a key molecule for the progression of hepatic steatosis to steatohepatitis.
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